{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:38:47Z","timestamp":1770277127215,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872567"],"award-info":[{"award-number":["81872567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ecoenv.2023.115748","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:34:17Z","timestamp":1701153257000},"page":"115748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ER\u03b1\/PI3K\/Akt signaling pathway"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-6899","authenticated-orcid":false,"given":"Haobiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mumba Mulutula","family":"Chilufya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoye","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-8926","authenticated-orcid":false,"given":"Rongqi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-8642","authenticated-orcid":false,"given":"Huifang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-0114","authenticated-orcid":false,"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.115748_bib1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1089\/ars.2009.2890","article-title":"Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis","volume":"12","author":"Arbogast","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.ecoenv.2023.115748_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/0192623309332992","article-title":"Discovery of metabolomics biomarkers for early detection of nephrotoxicity","volume":"37","author":"Boudonck","year":"2009","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cbi.2019.01.009","article-title":"The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy","volume":"300","author":"Chen","year":"2019","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2023.115748_bib5","article-title":"Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment","author":"Deng","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib6","unstructured":"EC, 2013. Commission Recommendation (EU) on the presence of T-2 and HT-2 toxin in cereals and cereal products."},{"key":"10.1016\/j.ecoenv.2023.115748_bib7","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0002-9440(10)64277-0","article-title":"Estrogen deficiency accelerates progression of glomerulosclerosis in susceptible mice","volume":"162","author":"Elliot","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2796.1999.00545.x","article-title":"Oestrogen receptors - an overview","volume":"246","author":"Enmark","year":"1999","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ecoenv.2023.115748_bib9","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: validity of the widely cited 'FAO estimate' of 25","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ecoenv.2023.115748_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11110634","article-title":"Trichothecenes in Cereal Grains - An Update","volume":"11","author":"Foroud","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2023.115748_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11070375","article-title":"Global mycotoxin occurrence in feed: a ten-year survey","volume":"11","author":"Gruber-Dorninger","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2023.115748_bib12","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","article-title":"Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease","volume":"22","author":"Guo","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ecoenv.2023.115748_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121047","article-title":"Nano-elemental selenium particle developed via supramolecular self-assembly of chondroitin sulfate A and Na(2)SeO(3) to repair cartilage lesions.","volume":"316","author":"Han","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ecoenv.2023.115748_bib14","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2023.115748_bib15","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1073\/pnas.1611576114","article-title":"Selenium deficiency risk predicted to increase under future climate change","volume":"114","author":"Jones","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2023.115748_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030369","article-title":"Nexus between PI3K\/AKT and estrogen receptor signaling in breast cancer","volume":"13","author":"Khatpe","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ecoenv.2023.115748_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12011-007-8087-2","article-title":"Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls","volume":"123","author":"Kilinc","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/C5TX00377F","article-title":"The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review","volume":"5","author":"Li","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2011.02.040","article-title":"Medical geology of arsenic, selenium and thallium in China","volume":"421\u2013422","author":"Li","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115748_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113392","article-title":"Toxicity and detoxification of T-2 toxin in poultry","volume":"169","author":"Li","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib21","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1021\/jf200767q","article-title":"T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods","volume":"59","author":"Li","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s12011-021-02730-1","article-title":"Selenium deficiency leads to changes in renal fibrosis marker proteins and wnt\/\u03b2-catenin signaling pathway components","volume":"200","author":"Lin","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115242","article-title":"Protective effects of the Bupi Yishen formula on renal fibrosis through PI3K\/AKT signaling inhibition","volume":"293","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/0886022X.2021.1901739","article-title":"Estrogen and estrogen receptors in kidney diseases","volume":"43","author":"Ma","year":"2021","journal-title":"Ren. Fail."},{"key":"10.1016\/j.ecoenv.2023.115748_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.fsi.2016.11.032","article-title":"Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L","volume":"60","author":"Matejova","year":"2017","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu14122410","article-title":"Protective effect of mitophagy regulated by mTOR signaling pathway in liver fibrosis associated with selenium","volume":"14","author":"Qiao","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2023.115748_bib28","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2023.115748_bib29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2023.115748_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ecoenv.2023.115748_bib31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-2952(88)90739-3","article-title":"Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical","volume":"37","author":"Spector","year":"1988","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.ecoenv.2023.115748_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12011-014-0196-0","article-title":"Effects of selenium deficiency on principal indexes of chicken kidney function","volume":"164","author":"Sun","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12011-012-9469-7","article-title":"T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province","volume":"150","author":"Sun","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2023.115748_bib34","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.biotechadv.2016.05.005","article-title":"Selenium: environmental significance, pollution, and biological treatment technologies","volume":"34","author":"Tan","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ecoenv.2023.115748_bib35","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/acs.jafc.5b05076","article-title":"Systemic metabolic responses of broiler chickens and piglets to acute T-2 toxin intravenous exposure","volume":"64","author":"Wan","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/es203434d","article-title":"Environmental selenium research: from microscopic processes to global understanding","volume":"46","author":"Winkel","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.toxlet.2014.12.016","article-title":"T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway","volume":"232","author":"Wu","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.115748_bib38","doi-asserted-by":"crossref","first-page":"F145","DOI":"10.1152\/ajprenal.00092.2008","article-title":"Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K\/Akt signaling-dependent and -independent mechanisms","volume":"295","author":"Xing","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib39","article-title":"Gypenoside XVII prevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress: insight into the ER\u03b1-Mediated PI3K\/Akt pathway","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.115748_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1021\/acs.jafc.9b07880","article-title":"Review of the reproductive Toxicity of T-2 Toxin","volume":"68","author":"Yang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.acc.2014.11.006","article-title":"Selenium and selenium-dependent antioxidants in chronic kidney disease","volume":"68","author":"Zachara","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0946-672X(04)80031-2","article-title":"Selenium and glutathione peroxidases in blood of patients with different stages of chronic renal failure","volume":"17","author":"Zachara","year":"2004","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2023.115748_bib43","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1111\/bph.14842","article-title":"Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation-related signalling pathways","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ecoenv.2023.115748_bib44","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1021\/acs.jafc.2c05816","article-title":"T-2 Toxin Induces Kidney Fibrosis via the mtROS-NLRP3-Wnt\/\u03b2-Catenin Axis","volume":"70","author":"Zhang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2023.115748_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12011-018-1302-5","article-title":"Prevention of keshan disease by selenium supplementation: a systematic review and meta-analysis","volume":"186","author":"Zhou","year":"2018","journal-title":"Biol. Trace Elem. Res"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323012526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323012526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:19:30Z","timestamp":1758953970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323012526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"alternative-id":["S0147651323012526"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115748","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ER\u03b1\/PI3K\/Akt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115748"}}