{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:46:34Z","timestamp":1789577194159,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270792"],"award-info":[{"award-number":["32270792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ecoenv.2023.115810","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T23:17:06Z","timestamp":1702509426000},"page":"115810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway"],"prefix":"10.1016","volume":"269","author":[{"given":"Hong-Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Shuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Shuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib1","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115810_bib2","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","article-title":"An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen","volume":"98","author":"Chan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115810_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084429","article-title":"S-acetyl-glutathione attenuates carbon tetrachloride-induced liver injury by modulating oxidative imbalance and inflammation","volume":"23","author":"Di Paola","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.115810_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7067619","article-title":"Methane alleviates acetaminophen-induced liver injury by inhibiting inflammation, oxidative stress, endoplasmic reticulum stress, and apoptosis through the Nrf2\/HO-1\/NQO1 Signaling Pathway","volume":"2019","author":"Feng","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115810_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.236","article-title":"Brg1-mediated Nrf2\/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury","volume":"8","author":"Ge","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2023.115810_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108704","article-title":"Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation","volume":"112","author":"Guo","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2023.115810_bib7","article-title":"Roflumilast attenuates neuroinflammation post retinal ischemia\/reperfusion injury by regulating microglia phenotype via the Nrf2\/STING\/NF-\u03baB pathway","volume":"124","author":"Guo","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2023.115810_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.746964","article-title":"Tanreqing inhibits LPS-Induced acute lung injury in vivo and in vitro through downregulating STING signaling pathway","volume":"12","author":"He","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.ecoenv.2023.115810_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.672150","article-title":"Jujuboside B inhibits neointimal hyperplasia and prevents vascular smooth muscle cell dedifferentiation, proliferation, and migration via activation of AMPK\/PPAR-gamma signaling","volume":"12","author":"Ji","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.ecoenv.2023.115810_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173041","article-title":"Jujuboside B promotes the death of acute leukemia cell in a RIPK1\/RIPK3\/MLKL pathway-dependent manner","volume":"876","author":"Jia","year":"2020","journal-title":"Eur. J. Pharm."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11418-022-01648-9","article-title":"Hepatoprotective functions of jujuboside B","volume":"77","author":"Kim","year":"2023","journal-title":"J. Nat. Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1089\/jmf.2022.K.0099","article-title":"Jujuboside B inhibited high mobility group box protein 1-mediated severe inflammatory responses in human endothelial cells and mice","volume":"26","author":"Kim","year":"2023","journal-title":"J. Med Food"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1158\/2159-8290.CD-19-0761","article-title":"The cytosolic DNA-Sensing cGAS-STING pathway in cancer","volume":"10","author":"Kwon","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ecoenv.2023.115810_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2023.03.026","article-title":"Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway","volume":"203","author":"Li","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115810_bib15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ymthe.2016.12.016","article-title":"AAV-Nrf2 promotes protection and recovery in animal models of oxidative stress","volume":"25","author":"Liang","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ecoenv.2023.115810_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115810_bib17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2023.115810_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3320325","article-title":"Drug-induced liver injury: clinical evidence of N-Acetyl cysteine protective effects","volume":"2021","author":"Ntamo","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05861-7","article-title":"Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming","volume":"9","author":"Olagnier","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05861-7","article-title":"Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming","volume":"9","author":"Olagnier","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2023.115810_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01070","article-title":"Montelukast prevents mice against acetaminophen-induced liver injury","volume":"10","author":"Pu","year":"2019","journal-title":"Front Pharm."},{"key":"10.1016\/j.ecoenv.2023.115810_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.metabol.2017.09.010","article-title":"Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease","volume":"81","author":"Qiao","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.ecoenv.2023.115810_bib23","first-page":"1","article-title":"Jujuboside B post-treatment attenuates PM(2.5)-induced lung injury in mice","author":"Ryu","year":"2022","journal-title":"Int J. Environ. Health Res"},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115810_bib24","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1111\/jcmm.14293","article-title":"Aucubin inhibited lipid accumulation and oxidative stress via Nrf2\/HO-1 and AMPK signalling pathways","volume":"23","author":"Shen","year":"2019","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.ecoenv.2023.115810_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101309","article-title":"The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-kappab signaling.","volume":"28","author":"Sun","year":"2020","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115810_bib26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1053\/j.gastro.2019.04.023","article-title":"Endoplasmic reticulum stress-induced upregulation of STARD1 promotes acetaminophen-induced acute liver failure","volume":"157","author":"Torres","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2023.115810_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.115810_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5211368","article-title":"Jujuboside B reverse CUMS-Promoted tumor progression via blocking PI3K\/Akt and MAPK\/ERK and dephosphorylating CREB signaling","volume":"2022","author":"Yang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.ecoenv.2023.115810_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113773","article-title":"Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway","volume":"241","author":"Yao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.115810_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s10565-023-09800-1","article-title":"P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway","author":"Yu","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115810_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102367","article-title":"STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice","volume":"54","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.115810_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102367","article-title":"STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice","volume":"54","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5582\/bst.2018.01247","article-title":"Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury","volume":"13","author":"Zhang","year":"2019","journal-title":"Biosci. Trends"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115810_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149386","article-title":"Jujuboside B reduces vascular tension by increasing Ca2+ influx and activating endothelial nitric oxide synthase","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115810_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsb.2020.06.016","article-title":"SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation","volume":"11","author":"Zhou","year":"2021","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323013143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323013143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:29:26Z","timestamp":1758954566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323013143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"alternative-id":["S0147651323013143"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115810","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115810"}}