{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:42:41Z","timestamp":1789040561879,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019580","name":"Swedish Research Council Formas","doi-asserted-by":"publisher","award":["2018-00855"],"award-info":[{"award-number":["2018-00855"]}],"id":[{"id":"10.13039\/100019580","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ecoenv.2023.115876","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:30:16Z","timestamp":1703633416000},"page":"115876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Impaired spermatogenesis and associated endocrine effects of azole fungicides in peripubertal Xenopus tropicalis"],"prefix":"10.1016","volume":"270","author":[{"given":"Sofie","family":"Svanholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Brouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Roza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.115876_bib1","first-page":"1979","article-title":"Anti-androgenic activities of environmental pesticides in the MDA-kb2 reporter cell line","volume":"Vitr. 24","author":"A\u00eft-A\u00efssa","year":"2010","journal-title":"Toxicol"},{"key":"10.1016\/j.ecoenv.2023.115876_bib2","unstructured":"Andersson, A., Broman, F., Hellstr\u00f6m, A., \u00d6sterdahl, B.-G., 2010. The Swedish Monitoring of Pesticide Residues in Food of Plant Origin: 2008."},{"key":"10.1016\/j.ecoenv.2023.115876_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2019.124970","article-title":"Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics","volume":"240","author":"Ayobahan","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115876_bib4","article-title":"Estimated annual agricultural pesticide use for counties of the conterminous United States, 2008-12. Reston","author":"Baker","year":"2015","journal-title":"VA"},{"key":"10.1016\/j.ecoenv.2023.115876_bib5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0015-0282(03)02161-7","article-title":"Spermatogonial proliferation patterns in men with azoospermia of different etiologies","volume":"80","author":"Bar-Shira Maymon","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2023.115876_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tox.2012.04.012","article-title":"A critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on testicular steroidogenesis in adult zebrafish","volume":"298","author":"Baudiffier","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.115876_bib7","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1007\/s11356-013-1474-7","article-title":"Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function","volume":"20","author":"Baudiffier","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2023.115876_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aquatox.2018.02.016","article-title":"Azoles additively inhibit cytochrome P450 1 (EROD) and 19 (aromatase) in rainbow trout (Oncorhynchus mykiss)","volume":"198","author":"Beijer","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib9","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-4939-9182-2_12","article-title":"The Xenopus tropicalis model for studies of developmental and reproductive toxicity","author":"Berg","year":"2019"},{"key":"10.1016\/j.ecoenv.2023.115876_bib10","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1002\/etc.5620190802","article-title":"Pesticide residues in the aquatic environment of banana plantation: areas in the north Atlantic zone of Costa Rica","volume":"19","author":"Castillo","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2023.115876_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cbpc.2007.10.001","article-title":"Endocrine disrupting chemicals (EDC) with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: II. Effects on gonad histomorphology","volume":"147","author":"Cevasco","year":"2008","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112040","article-title":"Effects of endocrine disrupting chemicals on gonad development: mechanistic insights from fish and mammals","volume":"204","author":"Delbes","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2023.115876_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.taap.2017.03.001","article-title":"Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis","volume":"322","author":"Dimopoulou","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib14","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1002\/dvdy.21692","article-title":"Sex-specific expression of SOX9 during gonadogenesis in the amphibian Xenopus tropicalis","volume":"237","author":"El Jamil","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2023.115876_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biom9120775","article-title":"Retinoic acid and germ cell development in the ovary and testis","author":"Endo","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2023.115876_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aquatox.2008.06.019","article-title":"Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiol","volume":"91","author":"Gyllenhammar","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.zool.2017.01.003","article-title":"Prespermatogenesis and early spermatogenesis in frogs","volume":"122","author":"Haczkiewicz","year":"2017","journal-title":"Zoology"},{"key":"10.1016\/j.ecoenv.2023.115876_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/bdrc.20202","article-title":"Embryos as targets of endocrine disrupting contaminants in wildlife","author":"Hamlin","year":"2011","journal-title":"Birth Defects Res. Part C. Embryo Today Rev."},{"key":"10.1016\/j.ecoenv.2023.115876_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.aquatox.2018.03.013","article-title":"Effects of multiple life stage exposure to the fungicide prochloraz in Xenopus laevis: manifestations of antiandrogenic and other modes of toxicity","volume":"199","author":"Haselman","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib20","article-title":"The early development of xenopus laevis","author":"Hausen","year":"1991","journal-title":"Atlas Histol. Springe Berl. Ger."},{"key":"10.1016\/j.ecoenv.2023.115876_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/dvdy.10178","article-title":"Xenopus, the next generation: X. tropicalis genetics and genomics","volume":"225","author":"Hirsch","year":"2002","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2023.115876_bib22","unstructured":"IPBES, 2019. Global assessment report of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, Debating Nature\u2019s Value."},{"key":"10.1016\/j.ecoenv.2023.115876_bib23","unstructured":"IPCS, 2002. Global assessment of the state-of-the-science of endocrine disruptors., WHO publication no. WHO\/PCS\/EDC\/02.2."},{"key":"10.1016\/j.ecoenv.2023.115876_bib24","unstructured":"Jansson, A., Fogelberg, P., 2018. Kontroll av bek\u00e4mpnings- medelsrester i livsmedel 2016. Uppsala."},{"key":"10.1016\/j.ecoenv.2023.115876_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/jaoac\/93.6.1732","article-title":"Multiresidue analysis of 95 pesticides at low nanogram\/liter levels in surface waters using online preconcentration and high performance liquid chromatography\/tandem mass spectrometry","author":"Jansson","year":"2010","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.ecoenv.2023.115876_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ygcen.2016.03.018","article-title":"Sex-dependent expression of anti-M\u00fcllerian hormone (amh) and amh receptor 2 during sex organ differentiation and characterization of the M\u00fcllerian duct development in Xenopus tropicalis","volume":"229","author":"Jansson","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib27","article-title":"Environmental impacts on male reproductive development: lessons from experimental models","author":"Jorgensen","year":"2021","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ecoenv.2023.115876_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jez.1401950306","article-title":"Morphology and kinetics of spermatogenesis in Xenopus laevis","volume":"195","author":"Kalt","year":"1976","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ecoenv.2023.115876_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145771","article-title":"Pesticide-induced multigenerational effects on amphibian reproduction and metabolism","volume":"775","author":"Karlsson","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115876_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.reprotox.2010.07.009","article-title":"Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals","volume":"30","author":"Kj\u00e6rstad","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.taap.2013.06.028","article-title":"Currently used pesticides and their mixtures affect the function of sex hormone receptors and aromatase enzyme activity","volume":"272","author":"Kjeldsen","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib32","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1289\/ehp.6649","article-title":"Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells","volume":"112","author":"Kojima","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115876_bib33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/dbio.1994.1093","article-title":"Isolation and characterization of a novel gene of the DEAD box protein family which is specifically expressed in germ cells of Xenopus laevis","volume":"162","author":"Komiya","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112584","article-title":"Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans","author":"Marlatt","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2023.115876_bib35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/dbio.2000.9625","article-title":"Regulation of germ cell and sertoli cell development by activin, follistatin, and FSH","volume":"220","author":"Meehan","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib36","unstructured":"Ministry of the Environment Government of Japan, 2004. FY 2003 Survey Results of Water Pollution by Agricultural Chemicals Used at Golf Courses [WWW Document]. URL \u3008http:\/\/www.env.go.jp\/en\/press\/2004\/1112a.html\u3009 (accessed 6.26.20)."},{"key":"10.1016\/j.ecoenv.2023.115876_bib37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/dev.113.2.613","article-title":"Expression of the mouse anti-Mullerian hormone gene suggests a role in both male and female sexual differentiation","volume":"113","author":"Munsterberg","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2023.115876_bib38","first-page":"34","article-title":"Gonadotropin regulation of retinoic acid activity in the testis","volume":"56","author":"Nourashrafeddin","year":"2018","journal-title":"Acta Med. Iran."},{"key":"10.1016\/j.ecoenv.2023.115876_bib39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1095\/biolreprod.111.091330","article-title":"Inhibitor of DNA Binding 4 Is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice","volume":"85","author":"Oatley","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2023.115876_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1163\/156853899X00286","article-title":"Development of testes and differentiation of germ cells in water frogs of the Rana esculenta - Complex (Amphibia, Anura)","volume":"20","author":"Ogielska","year":"1999","journal-title":"Amphib. Reptil."},{"key":"10.1016\/j.ecoenv.2023.115876_bib41","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/brv.12147","article-title":"Do hormone-modulating chemicals impact on reproduction and development of wild amphibians?","volume":"90","author":"Orton","year":"2015","journal-title":"Biol. Rev."},{"key":"10.1016\/j.ecoenv.2023.115876_bib42","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1289\/ehp.1002895","article-title":"Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens","volume":"119","author":"Orton","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115876_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-27161-2","article-title":"Exposure to an anti-androgenic herbicide negatively impacts reproductive physiology and fertility in Xenopus tropicalis","volume":"8","author":"Orton","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2023.115876_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241625","article-title":"A laboratory investigation into features of morphology and physiology for their potential to predict reproductive success in male frogs","volume":"15","author":"Orton","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2023.115876_bib45","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1897\/06-464R.1","article-title":"Environmentally relevant concentrations of ethynylestradiol cause female-biased sex ratios in Xenopus tropicalis and Rana temporaria","volume":"26","author":"Pettersson","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2023.115876_bib46","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.diff.2018.02.004","article-title":"Transcriptome analysis identifies genes involved in sex determination and development of Xenopus laevis gonads","volume":"100","author":"Piprek","year":"2018","journal-title":"Differentiation"},{"key":"10.1016\/j.ecoenv.2023.115876_bib47","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1073\/pnas.95.2.594","article-title":"Receptors for anti-M\u00fcllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation","volume":"95","author":"Racine","year":"1998","journal-title":"Proc. Natl. Acad."},{"key":"10.1016\/j.ecoenv.2023.115876_bib48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.reprotox.2012.05.088","article-title":"Triazole induced concentration-related gene signatures in rat whole embryo culture","volume":"34","author":"Robinson","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib49","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.reprotox.2006.05.008","article-title":"Effect of conazole fungicides on reproductive development in the female rat","volume":"22","author":"Rockett","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib50","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/genes12040578","article-title":"Testis development and differentiation in amphibians","volume":"12","author":"Roco","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.ecoenv.2023.115876_bib51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.taap.2013.01.033","article-title":"The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay","volume":"268","author":"Roelofs","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/molehr\/4.3.227","article-title":"The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen","volume":"4","author":"Steger","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2023.115876_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141940","article-title":"Developmental reproductive toxicity and endocrine activity of propiconazole in the Xenopus tropicalis model","volume":"753","author":"Svanholm","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115876_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108435","article-title":"Pubertal sexual development and endpoints for disrupted spermatogenesis in the model Xenopus tropicalis","volume":"120","author":"Svanholm","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib55","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1095\/biolreprod.103.026096","article-title":"Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids","volume":"70","author":"Takahashi","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2023.115876_bib56","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2108\/zsj.18.577","article-title":"The first and the second mitotic phases of spermatogonial stage in Xenopus laevis: secondary spermatogonia which have differentiated after completion of the first mitotic phase acquire an ability of mitosis to meiosis conversion","volume":"18","author":"Takamune","year":"2001","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ecoenv.2023.115876_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105384","article-title":"Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio)","volume":"135","author":"Teng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2023.115876_bib58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2009.01.001","article-title":"Fluconazole alters CYP26 gene expression in mouse embryos","volume":"27","author":"Tiboni","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1081\/ERC-200035093","article-title":"Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans","volume":"30","author":"Tr\u00f6sken","year":"2004","journal-title":"Endocr. Res."},{"key":"10.1016\/j.ecoenv.2023.115876_bib60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2005.10.020","article-title":"Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS\/MS method for the analysis of estradiol product formation","volume":"219","author":"Tr\u00f6sken","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.115876_bib61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/0261192919862936","article-title":"Reference gene validation for quantitative real-time PCR studies in amphibian kidney-derived A6 epithelial cells","volume":"47","author":"Verbrugghe","year":"2019","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.ecoenv.2023.115876_bib62","first-page":"227","article-title":"Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro","volume":"Vitr. 14","author":"Vinggaard","year":"2000","journal-title":"Toxicol"},{"key":"10.1016\/j.ecoenv.2023.115876_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2013.08.011","article-title":"The adverse outcome pathway concept: a pragmatic tool in toxicology","author":"Vinken","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.115876_bib64","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/JOE-09-0050","article-title":"Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis","volume":"202","author":"de Waal","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib65","first-page":"1159","article-title":"Amphibian vitellogenin: properties, hormonal regulation of hepatic synthesis and ovarian uptake, and conversion to yolk proteins","volume":"14","author":"Wallace","year":"1974","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.ecoenv.2023.115876_bib66","article-title":"Comparative distributions of RSBN1 and methylated histone H4 Lysine 20 in the mouse spermatogenesis","volume":"16","author":"Wang","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2023.115876_bib67","series-title":"State of the science of endocrine disrupting chemicals 2012","author":"WHO\/UNEP","year":"2013"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323013805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323013805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:25:43Z","timestamp":1758954343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323013805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":67,"alternative-id":["S0147651323013805"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115876","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired spermatogenesis and associated endocrine effects of azole fungicides in peripubertal Xenopus tropicalis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115876","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115876"}}