{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:31:09Z","timestamp":1793377869933,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271178"],"award-info":[{"award-number":["32271178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ecoenv.2023.115925","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T14:47:48Z","timestamp":1704466068000},"page":"115925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Exposure to disinfection by-products and risk of cancer: A systematic review and dose-response meta-analysis"],"prefix":"10.1016","volume":"270","author":[{"given":"Jingyi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.115925_bib1","doi-asserted-by":"crossref","DOI":"10.1289\/EHP89","article-title":"Bladder cancer and water disinfection by-product exposures through multiple routes: a population-based case-control study (New England, USA)","volume":"125","author":"Beane Freeman","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib2","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9895","article-title":"Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case\u2013Control Studies","volume":"130","author":"Beane Freeman","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/j.1551-8833.1974.tb02129.x","article-title":"The occurrence of organohalides in chlorinated drinking waters","volume":"66","author":"Bellar","year":"1974","journal-title":"J. -Am. Water Works Assoc."},{"key":"10.1016\/j.ecoenv.2023.115925_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/1476-072X-6-18","article-title":"Case control study of the geographic variability of exposure to disinfectant byproducts and risk for rectal cancer","volume":"6","author":"Bove","year":"2007","journal-title":"Int J. Health Geogr."},{"key":"10.1016\/j.ecoenv.2023.115925_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3200\/AEOH.62.1.39-47","article-title":"Case-control study of the effects of trihalomethanes on urinary bladder cancer risk","volume":"62","author":"Bove","year":"2007","journal-title":"Arch. Environ. Occup. Health"},{"key":"10.1016\/j.ecoenv.2023.115925_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/01635589709514619","article-title":"Fluid intake and the incidence of bladder cancer among middle-aged men and women in a three-county area of western Washington","volume":"29","author":"Bruemmer","year":"1997","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.ecoenv.2023.115925_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00001648-199801000-00007","article-title":"Drinking water source and chlorination byproducts. I. Risk of bladder cancer","volume":"9","author":"Cantor","year":"1998","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.aje.a010052","article-title":"Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer","volume":"150","author":"Cantor","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib9","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1289\/ehp.1002206","article-title":"Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain","volume":"118","author":"Cantor","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib10","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1080\/15287390701459031","article-title":"Bladder cancer in Taiwan: relationship to trihalomethane concentrations present in drinking-water supplies","volume":"70","author":"Chang","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ecoenv.2023.115925_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2018.04.005","article-title":"Genotoxicity of disinfection byproducts and disinfected waters: a review of recent literature","volume":"831","author":"Cort\u00e9s","year":"2018","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.ecoenv.2023.115925_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/oem.2010.062703","article-title":"Water disinfection by-products and bladder cancer: is there a European specificity? A pooled and meta-analysis of European case-control studies","volume":"68","author":"Costet","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2023.115925_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/awwa.1210","article-title":"Trihalomethanes: concentrations, cancer risks, and regulations","volume":"111","author":"Cotruvo","year":"2019","journal-title":"J. -Am. Water Works Assoc."},{"key":"10.1016\/j.ecoenv.2023.115925_bib14","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.est.7b04290","article-title":"Haloacetic acid water disinfection byproducts affect pyruvate dehydrogenase activity and disrupt cellular metabolism","volume":"52","author":"Dad","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib15","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1007\/s11356-018-3949-z","article-title":"Toxicological aspects of trihalomethanes: a systematic review","volume":"26","author":"de Castro Medeiros","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.115925_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1098-2280(1997)30:4<440::AID-EM9>3.0.CO;2-M","article-title":"Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in Salmonella","volume":"30","author":"DeMarini","year":"1997","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.ecoenv.2023.115925_bib17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/em.22378","article-title":"A review on the 40th anniversary of the first regulation of drinking water disinfection by-products","volume":"61","author":"DeMarini","year":"2020","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.ecoenv.2023.115925_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin. Trials"},{"key":"10.1016\/j.ecoenv.2023.115925_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1289\/ehp.7403","article-title":"Chlorination disinfection by-products and pancreatic cancer risk","volume":"113","author":"Do","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib20","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2105\/AJPH.87.7.1168","article-title":"The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study","volume":"87","author":"Doyle","year":"1997","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.ecoenv.2023.115925_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105879","article-title":"Cadmium exposure and risk of breast cancer: a dose-response meta-analysis of cohort studies","volume":"142","author":"Filippini","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2023.115925_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.envint.2017.12.031","article-title":"Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN)","volume":"112","author":"Font-Ribera","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2023.115925_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-1218(90)90036-2","article-title":"Acute and subacute cytogenetic effects of the trihalomethanes on rat bone marrow cells in vivo","volume":"242","author":"Fujie","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2023.115925_bib24","unstructured":"GBD 2017 Risk Factor Collaborators, C., 2018. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1923\u20131994."},{"key":"10.1016\/j.ecoenv.2023.115925_bib25","doi-asserted-by":"crossref","DOI":"10.14311\/334","article-title":"Formation of haloforms during chlorination of natural waters","volume":"42","author":"Gr\u00fcnwald","year":"2002","journal-title":"Acta Polytech."},{"key":"10.1016\/j.ecoenv.2023.115925_bib26","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1021\/acs.est.0c08565","article-title":"How much of the total organic halogen and developmental toxicity of chlorinated drinking water might be attributed to aromatic halogenated DBPs?","volume":"55","author":"Han","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib27","doi-asserted-by":"crossref","first-page":"10552","DOI":"10.1021\/acs.est.8b02054","article-title":"Evaluating the comparative toxicity of DBP mixtures from different disinfection scenarios: a new approach by combining freeze-drying or rotoevaporation with a marine polychaete bioassay","volume":"52","author":"Han","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib28","doi-asserted-by":"crossref","unstructured":"Harrell F.E., 2015. Regression Modeling Strategies With Applications To Linear Models, Logistic And Ordinal Regression, And Survival Analysis. pdf.","DOI":"10.1007\/978-3-319-19425-7"},{"key":"10.1016\/j.ecoenv.2023.115925_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118202","article-title":"Chlorination by-products in drinking water and risk of bladder cancer - a population-based cohort study","volume":"214","author":"Helte","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2023.115925_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djad145","article-title":"Disinfection by-products in drinking water and risk of colorectal cancer: a population-based cohort study","author":"Helte","year":"2023","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ecoenv.2023.115925_bib31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.ecoenv.2023.115925_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00001648-199801000-00008","article-title":"Drinking water source and chlorination byproducts. II. Risk of colon and rectal cancers","volume":"9","author":"Hildesheim","year":"1998","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib33","first-page":"1","article-title":"Chlorinated drinking-water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds. International Agency for Research on Cancer (IARC) Working Group, Lyon, 12-19 June 1990","volume":"52","author":"IARC","year":"1991","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2023.115925_bib34","first-page":"1","article-title":"Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Proceedings of the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, France, 17-24 February 1998","volume":"71","author":"IARC","year":"1999","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.ecoenv.2023.115925_bib35","first-page":"9","article-title":"Some chemicals present in industrial and consumer products, food and drinking-water","volume":"101","author":"IARC","year":"2013","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.ecoenv.2023.115925_bib36","first-page":"1","article-title":"Trichloroethylene, tetrachloroethylene, and some other chlorinated agents","volume":"106","author":"IARC","year":"2014","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.ecoenv.2023.115925_bib37","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/EDE.0000000000000647","article-title":"Ingested nitrate, disinfection by-products, and kidney cancer risk in older women","volume":"28","author":"Jones","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.envint.2019.02.010","article-title":"Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort","volume":"126","author":"Jones","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2023.115925_bib39","first-page":"4371","article-title":"Frequency of urination and its effects on metabolism, pharmacokinetics, blood hemoglobin adduct formation, and liver and urinary bladder DNA adduct levels in beagle dogs given the carcinogen 4-aminobiphenyl","volume":"51","author":"Kadlubar","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.ecoenv.2023.115925_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/aje\/kwj020","article-title":"Chlorination disinfection by-products in drinking water and the risk of adult leukemia in Canada","volume":"163","author":"Kasim","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib41","first-page":"813","article-title":"Case-control study of colon and rectal cancers and chlorination by-products in treated water","volume":"9","author":"King","year":"2000","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ecoenv.2023.115925_bib42","first-page":"596","article-title":"Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada)","volume":"7","author":"King","year":"1996","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ecoenv.2023.115925_bib43","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection byproducts","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26444\/aaem\/94299","article-title":"Environmental risk factors for cancer - review paper","volume":"26","author":"Lewandowska","year":"2019","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.ecoenv.2023.115925_bib45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1056\/NEJM200007133430201","article-title":"Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland","volume":"343","author":"Lichtenstein","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ecoenv.2023.115925_bib46","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1021\/es903593w","article-title":"Genotoxicity of water concentrates from recreational pools after various disinfection methods","volume":"44","author":"Liviac","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib47","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ecoenv.2023.115925_bib48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00001648-199803000-00009","article-title":"Female breast cancer and trihalomethane levels in drinking water in North Carolina","volume":"9","author":"Marcus","year":"1998","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2018.04.004","article-title":"Hazard assessment of three haloacetic acids, as byproducts of water disinfection, in human urothelial cells","volume":"347","author":"Mars\u00e0","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2023.115925_bib50","doi-asserted-by":"crossref","first-page":"57012","DOI":"10.1289\/EHP10207","article-title":"Drinking water disinfection byproducts, ingested nitrate, and risk of endometrial cancer in postmenopausal women","volume":"130","author":"Medgyesi","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/10937400290070080","article-title":"Chloroform: exposure estimation, hazard characterization, and exposure-response analysis","volume":"5","author":"Meek","year":"2002","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.ecoenv.2023.115925_bib52","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1289\/ehp.10281","article-title":"Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancer","volume":"115","author":"Michaud","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0013-9351(83)90193-7","article-title":"Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo","volume":"32","author":"Morimoto","year":"1983","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2023.115925_bib54","first-page":"34","article-title":"Bromodichloromethane","volume":"10","author":"National Toxicology, P","year":"2002","journal-title":"Rep. Carcinog."},{"key":"10.1016\/j.ecoenv.2023.115925_bib55","first-page":"1","article-title":"Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344\/N rats and B6C3F1 mice (drinking water studies)","author":"National Toxicology, P","year":"2007","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"key":"10.1016\/j.ecoenv.2023.115925_bib56","first-page":"97","article-title":"Chloroform","volume":"12","author":"National Toxicology, P","year":"2011","journal-title":"Rep. Carcinog."},{"key":"10.1016\/j.ecoenv.2023.115925_bib57","unstructured":"National Toxicology, P, RoC Monograph Series. Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products: RoC Monograph 12. National Toxicology Program, Research Triangle Park (NC), 2018."},{"key":"10.1016\/j.ecoenv.2023.115925_bib58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/aje\/kwr265","article-title":"Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software","volume":"175","author":"Orsini","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib59","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"10.1016\/j.ecoenv.2023.115925_bib60","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1021\/es2008159","article-title":"Biological mechanism for the toxicity of haloacetic acid drinking water disinfection byproducts","volume":"45","author":"Pals","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib61","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/taap.1997.8123","article-title":"Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform","volume":"144","author":"Pegram","year":"1997","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2023.115925_bib62","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ijc.31055","article-title":"Ingested nitrate and nitrite, disinfection by-products, and pancreatic cancer risk in postmenopausal women","volume":"142","author":"Quist","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ecoenv.2023.115925_bib63","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res. \/Rev. Mutat. Res."},{"key":"10.1016\/j.ecoenv.2023.115925_bib64","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.taap.2003.11.019","article-title":"In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1","volume":"195","author":"Ross","year":"2004","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2023.115925_bib65","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/aje\/kwt009","article-title":"Biological and statistical approaches for modeling exposure to specific trihalomethanes and bladder cancer risk","volume":"178","author":"Salas","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib66","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1097\/00001648-199607001-00179","article-title":"Comparison of bladder and rectal cancer incidence with trihalomethanes in drinking water: P 178","volume":"7","author":"Savrin","year":"1996","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib67","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib68","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2023.115925_bib69","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.ede.0000121380.02594.fc","article-title":"Disinfection byproducts and bladder cancer: a pooled analysis","volume":"15","author":"Villanueva","year":"2004","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2023.115925_bib70","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/ijc.21587","article-title":"Total and specific fluid consumption as determinants of bladder cancer risk","volume":"118","author":"Villanueva","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ecoenv.2023.115925_bib71","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/aje\/kwj364","article-title":"Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools","volume":"165","author":"Villanueva","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2023.115925_bib72","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1289\/EHP155","article-title":"Colorectal cancer and long-term exposure to trihalomethanes in drinking water: a multicenter case-control study in Spain and Italy","volume":"125","author":"Villanueva","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib73","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1289\/EHP155","article-title":"Colorectal cancer and long-term exposure to trihalomethanes in drinking water: a multicenter case-control study in Spain and Italy","volume":"125","author":"Villanueva","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115925_bib74","unstructured":"World Health, O, 2017. Guidelines for drinking-water quality: first addendum to the fourth edition."},{"key":"10.1016\/j.ecoenv.2023.115925_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111392","article-title":"Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people","volume":"200","author":"Zumel-Marne","year":"2021","journal-title":"Environ. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132301429X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132301429X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:32:15Z","timestamp":1758954735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132301429X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":75,"alternative-id":["S014765132301429X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115925","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to disinfection by-products and risk of cancer: A systematic review and dose-response meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115925"}}