{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:07Z","timestamp":1790140567842,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ecoenv.2024.116072","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T06:29:16Z","timestamp":1707546556000},"page":"116072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice"],"prefix":"10.1016","volume":"272","author":[{"given":"Haoran","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinliang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116072_bib1","series-title":"Guide for the Care and Use of Laboratory Animals","first-page":"267","volume":"46","author":"Albus","year":"2012"},{"key":"10.1016\/j.ecoenv.2024.116072_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.667","article-title":"Antiviral activity of triptolide on herpes simplex virus in vitro","volume":"10","author":"Aliabadi","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.ecoenv.2024.116072_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00296-011-1841-y","article-title":"A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety","volume":"31","author":"Bao","year":"2011","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ecoenv.2024.116072_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T Cells by NKG2D, a REceptor For Stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2024.116072_bib5","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.4049\/jimmunol.176.12.7438","article-title":"T Cell-Independent, TLR-Induced IL-12p70 production in primary human monocytes","volume":"176","author":"Bekeredjian-Ding","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2249.2008.03815.x","article-title":"Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained","volume":"155","author":"Blom","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1084\/jem.20030788","article-title":"Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule","volume":"198","author":"Bottino","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ecoenv.2024.116072_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40164-022-00276-z","article-title":"Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways","volume":"11","author":"Chen","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/hep.23320","article-title":"Natural killer group 2 member D, its ligands, and liver disease: Good or bad?","volume":"51","author":"Gao","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2024.116072_bib10","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.7150\/thno.57745","article-title":"Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives","volume":"11","author":"Gao","year":"2021","journal-title":"Theranostics."},{"key":"10.1016\/j.ecoenv.2024.116072_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114963","article-title":"Toxicological mechanism of triptolide-induced liver injury: Caspase3-GSDME-mediated pyroptosis of Kupffer cell","volume":"258","author":"Han","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116072_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10565-018-9447-8","article-title":"Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity","volume":"35","author":"Hasnat","year":"2019","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib13","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/hep.22725","article-title":"NKG2D\u2013retinoic acid early inducible-1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell\u2013dependent fulminant hepatitis","volume":"49","author":"Hou","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2024.116072_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153739","article-title":"Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis","volume":"92","author":"Huang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2024.116072_bib15","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/jat.3837","article-title":"Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish","volume":"39","author":"Huo","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.it.2013.01.003","article-title":"Activating natural cytotoxicity receptors of natural killer cells in cancer and infection","volume":"34","author":"Koch","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib17","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1002\/1521-4141(2001010)31:10<3026::AID-IMMU3026>3.0.CO;2-H","article-title":"Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12","volume":"31","author":"Krug","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/imm.12921","article-title":"Natural killer cell cytotoxicity and its regulation by inhibitory receptors","volume":"154","author":"Kumar","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.ecoenv.2024.116072_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.immuni.2007.04.001","article-title":"Ready for prime time: NK cell priming by dendritic cells","volume":"26","author":"Long","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.ecoenv.2024.116072_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12906-016-1504-3","article-title":"Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes","volume":"17","author":"Lu","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ecoenv.2024.116072_bib22","article-title":"Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq","volume":"14","author":"Luo","year":"2023","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ecoenv.2024.116072_bib23","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1158\/1078-0432.CCR-04-0730","article-title":"A phase II study of etanercept (Enbrel), a tumor necrosis factor \u03b1 inhibitor in patients with metastatic breast cancer","volume":"10","author":"Madhusudan","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ecoenv.2024.116072_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.emboj.7600019","article-title":"Unravelling natural killer cell function: triggering and inhibitory human NK receptors","volume":"23","author":"Moretta","year":"2004","journal-title":"EMBO. J."},{"key":"10.1016\/j.ecoenv.2024.116072_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12951-021-01157-z","article-title":"Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis","volume":"19","author":"Ren","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02337","article-title":"The central nervous system contains ILC1s that differ from NK cells in the response to inflammation","volume":"10","author":"Romero-Su\u00e1rez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib27","first-page":"201","article-title":"Production and distribution of interleukin 15 and its receptors (IL\u201015R\u03b1 and IL\u2010R2\u03b2) in the implant interface tissues obtained during revision of failed total joint replacement","volume":"82","author":"Saeed","year":"2001","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.189.1.1","article-title":"Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon \u03b3, and IL-10: role of B cells in the maintenance of T cell responses","volume":"189","author":"Schultze","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ecoenv.2024.116072_bib29","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1016\/j.celrep.2018.03.023","article-title":"The murine natural cytotoxic receptor NKp46\/NCR1 controls TRAIL protein expression in NK cells and ILC1s","volume":"22","author":"Sheppard","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2024.116072_bib30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2017.07.018","article-title":"A liver capsular network of monocyte-derived macrophages restricts hepatic dissemination of intraperitoneal bacteria by neutrophil recruitment","volume":"47","author":"Sierro","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ecoenv.2024.116072_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1631\/jzus.B1900607","article-title":"Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects","volume":"21","author":"Song","year":"2020","journal-title":"J. Zhejiang Univ. -Sci. B"},{"key":"10.1016\/j.ecoenv.2024.116072_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cellimm.2006.09.002","article-title":"IL-2\/IL-18 prevent the down-modulation of NKG2D by TGF-\u03b2 in NK cells via the c-Jun N-terminal kinase (JNK) pathway","volume":"242","author":"Song","year":"2006","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-065X.2006.00453.x","article-title":"NK cell regulation by SLAM family receptors and SAP-related adapters","volume":"214","author":"Veillette","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ecoenv.2024.116072_bib34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib35","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4049\/jimmunol.172.2.954","article-title":"IL-12p70-Dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA","volume":"172","author":"Wagner","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.fitote.2014.01.006","article-title":"Th17\/Treg imbalance in triptolide-induced liver injury","volume":"93","author":"Wang","year":"2014","journal-title":"Fitoterapia."},{"key":"10.1016\/j.ecoenv.2024.116072_bib37","first-page":"653","article-title":"The role of neutrophils in triptolide-induced liver injury","volume":"16","author":"Wang","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.ecoenv.2024.116072_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004867","article-title":"Dependence of innate lymphoid cell 1 development on NKp46","volume":"16","author":"Wang","year":"2018","journal-title":"PLOS Biol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib39","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1073\/pnas.1833166100","article-title":"The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion","volume":"100","author":"Wilson Michael","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2024.116072_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.taap.2018.07.011","article-title":"Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes","volume":"355","author":"Xi","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030649","article-title":"Interleukin-18 in health and disease","volume":"Vol. 20","author":"Yasuda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116072_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00813","article-title":"Triptolide induces apoptosis through fas death and mitochondrial pathways in HepaRG Cell line","volume":"9","author":"You","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1032722","article-title":"Triptolide increases resistance to bile duct ligation-induced liver injury and fibrosis in mice by inhibiting RELB","volume":"9","author":"Yuan","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2024.116072_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110508","article-title":"Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes","volume":"101","author":"Yuan","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ecoenv.2024.116072_bib45","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.humimm.2008.06.004","article-title":"Interleukin-12 improves cytotoxicity of natural killer cells via upregulated expression of NKG2D","volume":"69","author":"Zhang","year":"2008","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115422","article-title":"Th17\/Treg imbalance mediates hepatic intolerance to exogenous lipopolysaccharide and exacerbates liver injury in triptolide induced excessive immune response","volume":"295","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2024.116072_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154621","article-title":"Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules","volume":"109","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2024.116072_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4299","article-title":"Metabolic alterations in triptolide-induced acute hepatotoxicity","volume":"32","author":"Zhao","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ecoenv.2024.116072_bib49","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/ard.62.6.561","article-title":"Up regulation of the production of tumour necrosis factor \u03b1 and interferon \u03b3 by T cells in ankylosing spondylitis during treatment with etanercept","volume":"62","author":"Zou","year":"2003","journal-title":"Ann. Rheum. Dis."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324001477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324001477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:34:10Z","timestamp":1758954850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324001477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":49,"alternative-id":["S0147651324001477"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116072","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116072"}}