{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:49:59Z","timestamp":1789732199130,"version":"4.0.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ecoenv.2024.116116","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T18:37:55Z","timestamp":1708540675000},"page":"116116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2\/HO-1 and JAK\/STAT3 signaling pathways"],"prefix":"10.1016","volume":"273","author":[{"given":"Hongping","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ecoenv.2024.116116_bib1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/1535-7163.MCT-22-0323","article-title":"JAK: Not just another kinase","volume":"21","author":"Agashe","year":"2022","journal-title":"Mol. Cancer Ther."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116116_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103780","article-title":"Esculeoside A alleviates reproductive toxicity in streptozotocin-diabetic rats' s model by activating Nrf2 signaling","volume":"30","author":"AlTamimi","year":"2023","journal-title":"Saudi J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116116_bib3","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1210\/jc.2003-031786","article-title":"Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls","volume":"89","author":"Andersson","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"49","key":"10.1016\/j.ecoenv.2024.116116_bib4","doi-asserted-by":"crossref","first-page":"46583","DOI":"10.1074\/jbc.M107815200","article-title":"Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells","volume":"276","author":"Artemenko","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2024.116116_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1477-7827-8-65","article-title":"Impact of methoxyacetic acid on mouse Leydig cell gene expression","volume":"8","author":"Bagchi","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116116_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116116_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060244","article-title":"Fusarium molds and mycotoxins: potential species-specific effects","volume":"10","author":"Bertero","year":"2018","journal-title":"Toxins (Basel)"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116116_bib8","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1021\/acsomega.9b01142","article-title":"Comparison of cytotoxicity evaluation of anticancer drugs between real-time cell analysis and CCK-8 method","volume":"4","author":"Cai","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.ecoenv.2024.116116_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mce.2015.03.013","article-title":"Knockout of the transcription factor Nrf2: effects on testosterone production by aging mouse Leydig cells","volume":"409","author":"Chen","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116116_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14100714","article-title":"In vitro effects of enniatin a on steroidogenesis and proliferation of bovine granulosa cells","volume":"14","author":"Chiminelli","year":"2022","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.33549\/physiolres.935014","article-title":"Steroidogenic enzyme gene expression and testosterone production are developmentally modulated by bone morphogenetic protein receptor-1B in mouse testis","volume":"72","author":"Ciller","year":"2023","journal-title":"Physiol. Res"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116116_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/foods10071630","article-title":"Transcriptional changes after enniatins A, A1, B and B1 ingestion in rat stomach, liver, kidney and lower intestine","volume":"10","author":"Cimbalo","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.ecoenv.2024.116116_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112130","article-title":"Proteomics evaluation of enniatins acute toxicity in rat liver","volume":"151","author":"Cimbalo","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib15","doi-asserted-by":"crossref","first-page":"1012119","DOI":"10.3389\/fendo.2022.1012119","article-title":"Testicular aging, male fertility and beyond","volume":"13","author":"Dong","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/tx600259t","article-title":"Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells","volume":"20","author":"Dornetshuber","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bcp.2014.12.013","article-title":"The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo","volume":"93","author":"Dornetshuber-Fleiss","year":"2015","journal-title":"Biochem Pharm."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116116_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15060383","article-title":"Enniatin B1: Emerging Mycotoxin and Emerging Issues","volume":"15","author":"De Felice","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116116_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9070228","article-title":"Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics","volume":"9","author":"Fraeyman","year":"2017","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1159\/000481755","article-title":"Remote limb ischaemic postconditioning protects against myocardial ischaemia\/reperfusion injury in mice: activation of JAK\/STAT3-mediated Nrf2-antioxidant signalling","volume":"43","author":"Gao","year":"2017","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.ecoenv.2024.116116_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s44319-024-00074-0","article-title":"Interaction network of human early embryonic transcription factors","author":"Gawriyski","year":"2024","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1081\/DCT-120005891","article-title":"Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress","volume":"25","author":"Ghosh","year":"2002","journal-title":"Drug Chem. Toxicol."},{"issue":"5-6","key":"10.1016\/j.ecoenv.2024.116116_bib23","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0887-2333(03)00097-3","article-title":"A new method for in vitro detection of microbially produced mitochondrial toxins","volume":"17","author":"Hoornstra","year":"2003","journal-title":"Toxicol. Vitr."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/tox.22656","article-title":"Enniatin B1 exerts embryotoxic effects on mouse blastocysts and induces oxidative stress and immunotoxicity during embryo development","volume":"34","author":"Huang","year":"2019","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1210\/me.2009-0303","article-title":"Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes","volume":"24","author":"Hu","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116116_bib26","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1080\/01480545.2020.1838537","article-title":"Enniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development","volume":"45","author":"Huang","year":"2022","journal-title":"Drug Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116116_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060357","article-title":"Emerging fusarium mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin in Serbian Maize","volume":"11","author":"Jajic","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116116_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116116_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.foodchem.2012.08.021","article-title":"Evaluation of beauvericin and enniatins in Italian cereal products and multicereal food by liquid chromatography coupled to triple quadrupole mass spectrometry","volume":"140","author":"Juan","year":"2013","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.15430\/JCP.2017.22.3.189","article-title":"Peroxisome proliferator-activated receptor-gamma inhibits the activation of STAT3 in cerulein-stimulated pancreatic acinar cells","volume":"22","author":"Ju","year":"2017","journal-title":"J. Cancer Prev."},{"issue":"19","key":"10.1016\/j.ecoenv.2024.116116_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116116_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2015.01.014","article-title":"An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays","volume":"233","author":"Kalayou","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2024.116116_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.apcsb.2021.01.003","article-title":"Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis","volume":"125","author":"Kashyap","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116116_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092708","article-title":"Protein tyrosine phosphatases as potential regulators of STAT3 signaling","volume":"19","author":"Kim","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib35","doi-asserted-by":"crossref","first-page":"824","DOI":"10.2741\/3959","article-title":"Gonadal transactivation of STARD1, CYP11A1 and HSD3B","volume":"17","author":"King","year":"2012","journal-title":"Front Biosci. (Landmark Ed. )"},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116116_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197406","article-title":"Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells","volume":"13","author":"Krug","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.116116_bib37","article-title":"Asiaticoside prevents oxidative stress and apoptosis in endothelial cells by activating ROS-dependent p53\/Bcl-2\/caspase-3 signaling pathway","author":"Liang","year":"2022","journal-title":"Curr. Mol. Med"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib38","first-page":"289","article-title":"Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells","volume":"5","author":"Lim","year":"2015","journal-title":"Am. J. Cancer Res"},{"key":"10.1016\/j.ecoenv.2024.116116_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.reprotox.2015.02.007","article-title":"Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmic reticulum stress-dependent signalling pathway","volume":"52","author":"Lin","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104154","article-title":"Role of epigenetics in mycotoxin toxicity: a review","volume":"100","author":"Li","year":"2023","journal-title":"Environ. Toxicol. Pharm."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116116_bib41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/dbio.1996.0276","article-title":"Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis","volume":"179","author":"Lindsey","year":"1996","journal-title":"Dev. Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116116_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.422","article-title":"Apatinib promotes autophagy and apoptosis through VEGFR2\/STAT3\/BCL-2 signaling in osteosarcoma","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.ecoenv.2024.116116_bib43","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-201X.2003.01095.x","article-title":"Effect of intensive exercise-induced testicular gametogenic and steroidogenic disorders in mature male Wistar strain rats: a correlative approach to oxidative stress","volume":"178","author":"Manna","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ecoenv.2024.116116_bib45","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fct.2013.07.047","article-title":"Mycotoxins: occurrence, toxicology, and exposure assessment","volume":"60","author":"Marin","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116116_bib46","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/iub.2555","article-title":"Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma","volume":"73","author":"Mohan","year":"2021","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ecoenv.2024.116116_bib47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chemosphere.2018.08.112","article-title":"Sodium fluoride disrupts testosterone biosynthesis by affecting the steroidogenic pathway in TM3 Leydig cells","volume":"212","author":"Orta Yilmaz","year":"2018","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116116_bib48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ucl.2019.12.001","article-title":"Cutting-Edge Evaluation of Male Infertility","volume":"47","author":"Pathak","year":"2020","journal-title":"Urol. Clin. North Am."},{"issue":"1-3","key":"10.1016\/j.ecoenv.2024.116116_bib49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.regpep.2012.07.003","article-title":"Insulin-like peptide 3 stimulates testosterone secretion in mouse Leydig cells via cAMP pathway","volume":"178","author":"Pathirana","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ecoenv.2024.116116_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113361","article-title":"Enniatins A1 and B1 alter calcium homeostasis of neuronal cells leading to apoptotic death","volume":"168","author":"Perez-Fuentes","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tiv.2013.06.021","article-title":"Interaction effects of Fusarium enniatins (A, A1, B and B1) combinations on in vitro cytotoxicity of Caco-2 cells","volume":"28","author":"Prosperini","year":"2014","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2024.116116_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fpubh.2017.00304","article-title":"A Review of the Mycotoxin Enniatin B","volume":"5","author":"Prosperini","year":"2017","journal-title":"Front Public Health"},{"issue":"22","key":"10.1016\/j.ecoenv.2024.116116_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225474","article-title":"An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116116_bib54","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1210\/en.2014-1931","article-title":"GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells","volume":"156","author":"Schrade","year":"2015","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116116_bib55","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2741\/e415","article-title":"Apoptosis, spermatogenesis and male infertility.","volume":"4","author":"Shukla","year":"2012","journal-title":"Front Biosci. (Elite Ed. )"},{"key":"10.1016\/j.ecoenv.2024.116116_bib56","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib57","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1096-911X(199907)33:1<2::AID-MPO2>3.0.CO;2-7","article-title":"Reproductive physiology and treatment-related loss of sex hormone production","volume":"33","author":"Sklar","year":"1999","journal-title":"Med Pedia Oncol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112819","article-title":"Beauvericin (BEA) and enniatin B (ENNB)-induced impairment of mitochondria and lysosomes - Potential sources of intracellular reactive iron triggering ferroptosis in Atlantic salmon primary hepatocytes","volume":"161","author":"Soderstrom","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116116_bib60","first-page":"281","article-title":"Toxic effects of atrazine on reproductive system of male rats","volume":"27","author":"Song","year":"2014","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2024.116116_bib61","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.fct.2018.03.027","article-title":"Protection of cyanidin-3-O-glucoside against acrylamide- and glycidamide-induced reproductive toxicity in leydig cells","volume":"119","author":"Sun","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2024.116116_bib62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2015.06.006","article-title":"Molecular basis of the Keap1-Nrf2 system","volume":"88","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med"},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116116_bib63","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/tox.22367","article-title":"Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform","volume":"32","author":"Svingen","year":"2017","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2010.07.001","article-title":"The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis","volume":"276","author":"Tonshin","year":"2010","journal-title":"Toxicology"},{"issue":"1-2","key":"10.1016\/j.ecoenv.2024.116116_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijfoodmicro.2007.07.021","article-title":"Fusarium avenaceum -- the North European situation","volume":"119","author":"Uhlig","year":"2007","journal-title":"Int J. Food Microbiol"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.fertnstert.2015.04.020","article-title":"Infertility as a proxy of general male health: results of a cross-sectional survey","volume":"104","author":"Ventimiglia","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2024.116116_bib67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mce.2017.11.016","article-title":"Interleukin 6 inhibits the differentiation of rat stem Leydig cells","volume":"472","author":"Wang","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116116_bib68","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/mnfr.200700428","article-title":"Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation","volume":"53","author":"Watjen","year":"2009","journal-title":"Mol. Nutr. Food Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib69","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180992","article-title":"Apoptosis and apoptotic body: disease message and therapeutic target potentials","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116116_bib70","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/hs0102.100208","article-title":"Oxidative stress in rats with heatstroke-induced cerebral ischemia","volume":"33","author":"Yang","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.ecoenv.2024.116116_bib71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.canlet.2020.04.003","article-title":"DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo","volume":"483","author":"Yao","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ecoenv.2024.116116_bib72","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cbpc.2015.12.005","article-title":"T-2 toxin-induced cytotoxicity and damage on TM3 Leydig cells","volume":"181-182","author":"Yuan","year":"2016","journal-title":"Comp. Biochem Physiol. C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116116_bib73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13046-016-0312-4","article-title":"Anti-tumor effects of Atractylenolide I on bladder cancer cells","volume":"35","author":"Yu","year":"2016","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116116_bib74","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/tox.23690","article-title":"Bisphenol A (BPA) induces apoptosis of mouse Leydig cells via oxidative stress","volume":"38","author":"Zhang","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116116_bib75","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopha.2018.10.161","article-title":"Puerarin attenuates neurological deficits via Bcl-2\/Bax\/cleaved caspase-3 and Sirt3\/SOD2 apoptotic pathways in subarachnoid hemorrhage mice","volume":"109","author":"Zhang","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"14","key":"10.1016\/j.ecoenv.2024.116116_bib76","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00018-019-03101-9","article-title":"The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis","volume":"76","author":"Zhou","year":"2019","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116116_bib77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132400191X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132400191X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:30:42Z","timestamp":1758954642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132400191X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":77,"alternative-id":["S014765132400191X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116116","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2\/HO-1 and JAK\/STAT3 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116116"}}