{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:12:24Z","timestamp":1788361944501,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016802","name":"Natural Science Foundation of Changzhou Municipality","doi-asserted-by":"publisher","award":["kq2004154"],"award-info":[{"award-number":["kq2004154"]}],"id":[{"id":"10.13039\/100016802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ecoenv.2024.116142","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:15:46Z","timestamp":1708564546000},"page":"116142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population"],"prefix":"10.1016","volume":"273","author":[{"given":"Xiong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuoHuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianFeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiLong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiJin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QianLe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116142_bib1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cgh.2019.05.051","article-title":"Development and validation of hepamet fibrosis scoring system-A simple, noninvasive test to identify patients with nonalcoholic fatty liver disease with advanced fibrosis","volume":"18","author":"Ampuero","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/metabo11100657","article-title":"In utero exposure to persistent organic pollutants and childhood lipid levels","volume":"11","author":"Boutot","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.ecoenv.2024.116142_bib3","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.ecoenv.2024.116142_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112295","article-title":"Copper exposure association with prevalence of non-alcoholic fatty liver disease and insulin resistance among US adults (NHANES 2011-2014)","volume":"218","author":"Chen","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116142_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118297","article-title":"High-fat diet exacerbated decabromodiphenyl ether-induced hepatocyte apoptosis via intensifying the transfer of Ca2+ from endoplasmic reticulum to mitochondria","volume":"292","author":"Chen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116142_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00128-016-1886-4","article-title":"Occurrence and distribution pattern of alkylphenol ethoxylates and brominated flame retardants in sediment samples from Vaal River, South Africa","volume":"97","author":"Chokwe","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chemosphere.2008.02.059","article-title":"Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in human liver and adipose tissue samples from Belgium","volume":"73","author":"Covaci","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116142_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ecoenv.2014.08.030","article-title":"Ecotoxicity and biodegradability of new brominated flame retardants: a review","volume":"110","author":"Ezechi\u00e1\u0161","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116142_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117475","article-title":"Health toxicity effects of brominated flame retardants: from environmental to human exposure","volume":"285","author":"Feiteiro","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116142_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med"},{"key":"10.1016\/j.ecoenv.2024.116142_bib12","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1038\/s41598-020-65593-x","article-title":"Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations","volume":"10","author":"Greeson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116142_bib13","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1021\/acs.est.1c01476","article-title":"Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant","volume":"55","author":"Guo","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115253","article-title":"Association between brominated flame retardants exposure and markers of oxidative stress in US adults: an analysis based on the National Health and Nutrition Examination Survey 2007-2016","volume":"263","author":"Han","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116142_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.115146","article-title":"Elimination of PBB-153; findings from a cohort of Michigan adults","volume":"220","author":"Hood","year":"2023","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2024.116142_bib17","first-page":"1","article-title":"National health and nutrition examination survey: analytic guidelines, 1999-2010","volume":"2","author":"Johnson","year":"2013","journal-title":"Vital.-. Health Stat."},{"key":"10.1016\/j.ecoenv.2024.116142_bib18","doi-asserted-by":"crossref","first-page":"47004","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116142_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12072-018-09926-z","article-title":"Race\/ethnicity-based temporal changes in prevalence of NAFLD-related advanced fibrosis in the United States, 2005-2016","volume":"13","author":"Kim","year":"2019","journal-title":"Hepatol. Int"},{"key":"10.1016\/j.ecoenv.2024.116142_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.chemosphere.2005.12.007","article-title":"Levels and trends of brominated flame retardants in the European environment","volume":"64","author":"Law","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116142_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chemosphere.2018.03.133","article-title":"Human exposure to brominated flame retardants through dust in different indoor environments: Identifying the sources of concentration differences in hair from men and women","volume":"205","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116142_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139753","article-title":"Single-chemical and mixture effects of multiple volatile organic compounds exposure on liver injury and risk of non-alcoholic fatty liver disease in a representative general adult population","volume":"339","author":"Liu","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116142_bib23","doi-asserted-by":"crossref","first-page":"11567","DOI":"10.3748\/wjg.v21.i41.11567","article-title":"Non-invasive diagnosis of liver fibrosis and cirrhosis","volume":"21","author":"Lurie","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.envint.2014.09.006","article-title":"Human health risk associated with brominated flame-retardants (BFRs)","volume":"74","author":"Lyche","year":"2015","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116142_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118639","article-title":"Impact of brominated flame retardants on lipid metabolism: an in vitro approach","volume":"294","author":"Maia","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116142_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2017-314924","article-title":"Guidelines on the management of abnormal liver blood tests","volume":"67","author":"Newsome","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2024.116142_bib27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1542\/peds.113.S3.1097","article-title":"Liver","volume":"113","author":"Pi\u00f1eiro-Carrero","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.ecoenv.2024.116142_bib28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.scitotenv.2016.02.021","article-title":"Dioxins, PCBs, chlorinated pesticides and brominated flame retardants in free-range chicken eggs from peri-urban areas in Arusha, Tanzania: levels and implications for human health","volume":"551\u2013552","author":"Polder","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116142_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115998","article-title":"An updated review on environmental occurrence, scientific assessment and removal of brominated flame retardants by engineered nanomaterials","volume":"321","author":"Rani","year":"2022","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ecoenv.2024.116142_bib30","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1111\/liv.12834","article-title":"The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity","volume":"35","author":"Robles-Diaz","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.ecoenv.2024.116142_bib31","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1289\/ehp.1204932","article-title":"Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust","volume":"120","author":"Springer","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116142_bib32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chemosphere.2014.01.083","article-title":"Assessing the persistence, bioaccumulation potential and toxicity of brominated flame retardants: data availability and quality for 36 alternative brominated flame retardants","volume":"116","author":"Stieger","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116142_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2217\/epi-2019-0315","article-title":"Rat liver epigenome programing by perinatal exposure to 2,2\u2019,4\u20194\u2019-tetrabromodiphenyl ether","volume":"12","author":"Suvorov","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.ecoenv.2024.116142_bib34","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib35","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1021\/es0307221","article-title":"Brominated organic contaminants in the liver and egg of the common cormorants (Phalacrocorax carbo) from Japan","volume":"38","author":"Watanabe","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00244-008-9186-6","article-title":"Tissue-specific contaminant accumulation and associated effects on hepatic serum analytes and cytochrome P450 enzyme activities in hooded seals (Cystophora cristata) from the Gulf of St. Lawrence","volume":"56","author":"Wolkers","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcna.2013.09.005","article-title":"Evaluation of abnormal liver tests","volume":"98","author":"Woreta","year":"2014","journal-title":"Med Clin. North Am."},{"key":"10.1016\/j.ecoenv.2024.116142_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113543","article-title":"Human developmental toxicity mechanism of polybrominated biphenyl exposure and health risk regulation strategy for special populations","volume":"237","author":"Yang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116142_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.orcp.2023.01.004","article-title":"Associations of different serum folate forms with indices of nonalcoholic fatty liver disease and advanced fibrosis","volume":"17","author":"Yang","year":"2023","journal-title":"Obes. Res Clin. Pr."},{"key":"10.1016\/j.ecoenv.2024.116142_bib40","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1021\/acs.est.1c01726","article-title":"Toxicity of tetrabromobisphenol A and its derivative in the mouse liver following oral exposure at environmentally relevant levels","volume":"55","author":"Yao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2024.116142_bib42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.scitotenv.2017.11.247","article-title":"Brominated flame retardants and toxic elements in the meat and liver of red deer (Cervus elaphus), wild boar (Sus scrofa), and moose (Alces alces) from Latvian wildlife","volume":"621","author":"Zacs","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116142_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114096","article-title":"Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and blood lipids in women of Shantou, China","volume":"214","author":"Zhang","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2024.116142_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.scitotenv.2014.02.023","article-title":"Occurrence of brominated flame retardants (BFRs), organochlorine pesticides (OCPs), and polychlorinated biphenyls (PCBs) in agricultural soils in a BFR-manufacturing region of North China","volume":"481","author":"Zhu","year":"2014","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324002173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324002173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:31:26Z","timestamp":1758954686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324002173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"alternative-id":["S0147651324002173"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116142","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116142"}}