{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:11:01Z","timestamp":1792545061715,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y2020230"],"award-info":[{"award-number":["Y2020230"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["11-CX29"],"award-info":[{"award-number":["11-CX29"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ecoenv.2024.116173","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T13:03:29Z","timestamp":1709730209000},"page":"116173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Per- and polyfluoroalkyl substances inhibit human and rat 17\u03b2-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis"],"prefix":"10.1016","volume":"273","author":[{"given":"Chao","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfen","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-shan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116173_bib1","doi-asserted-by":"crossref","first-page":"A319","DOI":"10.2307\/3434054","article-title":"The state of the science on endocrine disruptors","volume":"106","author":"Anonymous","year":"1998","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116173_bib2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nsb0896-665","article-title":"Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol","volume":"3","author":"Azzi","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1677\/JOE-08-0460","article-title":"Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells","volume":"201","author":"Bak","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0969-2126(96)00098-6","article-title":"The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitor","volume":"4","author":"Breton","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.ecoenv.2024.116173_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114052","article-title":"Bisphenol analogues inhibit human and rat 17beta-hydroxysteroid dehydrogenase 1: 3D-quantitative structure-activity relationship (3D-QSAR) and in silico docking analysis","volume":"181","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1749-6632.1995.tb31388.x","article-title":"Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function","volume":"761","author":"Ghosh","year":"1995","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ecoenv.2024.116173_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104921","article-title":"Reduction of hazardous chemicals in Swedish preschool dust through article substitution actions","volume":"130","author":"Giovanoulis","year":"2019","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116173_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106123","article-title":"Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019","volume":"145","author":"Gockener","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116173_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","article-title":"ZINC--a free database of commercially available compounds for virtual screening","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.ecoenv.2024.116173_bib10","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/febs.14784","article-title":"Crystal structures of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP(+) reveal the mechanism of substrate inhibition","volume":"286","author":"Li","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.ecoenv.2024.116173_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106246","article-title":"New insights into the substrate inhibition of human 17beta-hydroxysteroid dehydrogenase type 1","volume":"228","author":"Li","year":"2023","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib12","doi-asserted-by":"crossref","first-page":"16182","DOI":"10.1016\/S0021-9258(18)41984-9","article-title":"Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta","volume":"267","author":"Lin","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"Suppl","key":"10.1016\/j.ecoenv.2024.116173_bib13","first-page":"S13","article-title":"Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase","volume":"150","author":"Lin","year":"1996","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010969","article-title":"Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1","volume":"5","author":"Moller","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.116173_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1677\/jme.1.02043","article-title":"Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.","volume":"37","author":"Ohnesorg","year":"2006","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116173_bib17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yrtph.2019.05.008","article-title":"Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria","volume":"106","author":"Pizzurro","year":"2019","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116173_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2008.12.024","article-title":"Recent advances in 17beta-hydroxysteroid dehydrogenases","volume":"114","author":"Prehn","year":"2009","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib19","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1021\/acs.est.9b07295","article-title":"Perfluoroalkyl substances stimulate insulin secretion by islet beta cells via g protein-coupled receptor 40","volume":"54","author":"Qin","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib20","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1096\/fj.02-0026fje","article-title":"A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.","volume":"16","author":"Qiu","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2024.116173_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00204-014-1258-y","article-title":"Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor","volume":"89","author":"Ren","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/livers1040017","article-title":"Perfluoroalkyl carboxylic acids interact with the human bile acid transporter NTCP","volume":"1","author":"Ruggiero","year":"2021","journal-title":"Livers"},{"key":"10.1016\/j.ecoenv.2024.116173_bib23","doi-asserted-by":"crossref","first-page":"A220","DOI":"10.2307\/3433998","article-title":"Endocrine disruptors and testis development","volume":"106","author":"Sharpe","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116173_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.chemosphere.2016.11.050","article-title":"Occurrence of perfluoroalkyl substances in cord serum and association with growth indicators in newborns from Beijing","volume":"169","author":"Shi","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116173_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18073794","article-title":"Perfluoroalkyl chemicals and male reproductive health: do PFOA and PFOS increase risk for male infertility?","volume":"18","author":"Tarapore","year":"2021","journal-title":"Int J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2024.116173_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-291X(03)00694-6","article-title":"Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7","volume":"305","author":"Torn","year":"2003","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2024.116173_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.envint.2016.10.008","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in cord blood of newborns in Shanghai, China: Implications for risk assessment","volume":"97","author":"Wang","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116173_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153334","article-title":"Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3beta-hydroxysteroid dehydrogenase activity","volume":"480","author":"Wang","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.116173_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.reprotox.2016.04.004","article-title":"Structure-activity relationships of phthalates in inhibition of human placental 3beta-hydroxysteroid dehydrogenase 1 and aromatase","volume":"61","author":"Xu","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116173_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153484","article-title":"Direct inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 by per- and polyfluoroalkyl substances: structure-activity relationship and in silico docking analysis.","volume":"488","author":"Zhao","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.116173_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126764","article-title":"Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors","volume":"253","author":"Zhu","year":"2020","journal-title":"Chemosphere"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324002483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324002483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:04:18Z","timestamp":1777489458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324002483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":31,"alternative-id":["S0147651324002483"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116173","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Per- and polyfluoroalkyl substances inhibit human and rat 17\u03b2-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116173"}}