{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:59:43Z","timestamp":1793681983867,"version":"4.5.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012325","name":"National Office for Philosophy and Social Sciences","doi-asserted-by":"publisher","award":["ZD187"],"award-info":[{"award-number":["ZD187"]}],"id":[{"id":"10.13039\/501100012325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013071","name":"Major Program of National Fund of Philosophy and Social Science of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFC2705205"],"award-info":[{"award-number":["2022YFC2705205"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFC2701101"],"award-info":[{"award-number":["2021YFC2701101"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ecoenv.2024.116271","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T21:10:08Z","timestamp":1712005808000},"page":"116271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Inadvertent antibiotic exposure during pregnancy may increase the risk for neural tube defects in offspring"],"prefix":"10.1016","volume":"275","author":[{"given":"Qianhui","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116271_bib1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/bdra.23570","article-title":"Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, national birth defects prevention study 1997 to 2011","volume":"106","author":"Ailes","year":"2016","journal-title":"Birth Defects Res A Clin. Mol. Teratol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib2","doi-asserted-by":"crossref","first-page":"n107","DOI":"10.1136\/bmj.n107","article-title":"Association between use of macrolides in pregnancy and risk of major birth defects: Nationwide, register based cohort study","volume":"372","author":"Andersson","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2024.116271_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1528-1157.2002.28999.x","article-title":"Embryonic arrhythmia by inhibition of herg channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?","volume":"43","author":"Azarbayjani","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.ecoenv.2024.116271_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/nyas.13548","article-title":"Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis","volume":"1414","author":"Blencowe","year":"2018","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ecoenv.2024.116271_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostatistics"},{"key":"10.1016\/j.ecoenv.2024.116271_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.ctdb.2022.10.007","article-title":"Gene-environment interactions underlying the etiology of neural tube defects","volume":"152","author":"Caiaffa","year":"2023","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.ecoenv.2024.116271_bib8","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1021\/acs.jafc.9b01334","article-title":"Antibiotic residues in food: extraction, analysis, and human health concerns","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2024.116271_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ecoenv.2024.116271_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-3016.2008.00978.x","article-title":"Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations","volume":"23","author":"Cooper","year":"2009","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1474-4422(13)70110-8","article-title":"Neural tube defects: Recent advances, unsolved questions, and controversies","volume":"12","author":"Copp","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archpediatrics.2009.188","article-title":"Antibacterial medication use during pregnancy and risk of birth defects: national birth defects prevention study","volume":"163","author":"Crider","year":"2009","journal-title":"Arch. Pedia Adolesc. Med"},{"key":"10.1016\/j.ecoenv.2024.116271_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.78.1.15","article-title":"Developmental changes in ionic channel activity in the embryonic murine heart","volume":"78","author":"Davies","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.ecoenv.2024.116271_bib14","first-page":"1543","article-title":"Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances","volume":"6","author":"Francino","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ecoenv.2024.116271_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jchromb.2014.11.008","article-title":"Multidetection of antibiotics in liver tissue by ultra-high-pressure-liquid-chromatography-tandem mass spectrometry","volume":"976-977","author":"Freitas","year":"2015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ecoenv.2024.116271_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106164","article-title":"Urinary antibiotic exposure across pregnancy from chinese pregnant women and health risk assessment: repeated measures analysis","volume":"145","author":"Geng","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116271_bib17","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"Hern\u00e1ndez-D\u00edaz","year":"2000","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ecoenv.2024.116271_bib18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/aje\/153.10.961","article-title":"Neural tube defects in relation to use of folic acid antagonists during pregnancy","volume":"153","author":"Hern\u00e1ndez-D\u00edaz","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.envres.2010.06.008","article-title":"Influence of water and food consumption on inadvertent antibiotics intake among general population","volume":"110","author":"Ji","year":"2010","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2024.116271_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.reprotox.2005.01.010","article-title":"Is erythromycin therapy teratogenic in humans?","volume":"20","author":"K\u00e4ll\u00e9n","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib21","doi-asserted-by":"crossref","first-page":"47004","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116271_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/636157","article-title":"Macrolide therapy in chronic inflammatory diseases","volume":"2012","author":"Kwiatkowska","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ecoenv.2024.116271_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/bdra.23486","article-title":"Prevalence and trend of neural tube defects in five counties in Shanxi province of northern China, 2000 to 2014","volume":"106","author":"Liu","year":"2016","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.envint.2013.06.012","article-title":"Pharmaceuticals and personal care products (ppcps): a review on environmental contamination in China","volume":"59","author":"Liu","year":"2013","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116271_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/pds.900","article-title":"The use of drugs in mothers of offspring with neural-tube defects","volume":"13","author":"Medveczky","year":"2004","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.ecoenv.2024.116271_bib26","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1111\/bcp.13364","article-title":"Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study","volume":"83","author":"Muanda","year":"2017","journal-title":"Br. J. Clin. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116271_bib27","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1056\/NEJMp1408040","article-title":"Antibiotic resistance--problems, progress, and prospects","volume":"371","author":"Nathan","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ecoenv.2024.116271_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/bdrb.21107","article-title":"Effects of macrolide antibiotics on rat embryonic heart function in vitro","volume":"101","author":"Nilsson","year":"2014","journal-title":"Birth Defects Res B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5414\/CPP44057","article-title":"Placental transfer of antibiotics administered to the mother: a review","volume":"44","author":"Pacifici","year":"2006","journal-title":"Int J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ecoenv.2024.116271_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123009","article-title":"Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring","volume":"399","author":"Qiu","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2024.116271_bib31","doi-asserted-by":"crossref","first-page":"12770","DOI":"10.1073\/pnas.1105209108","article-title":"Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects","volume":"108","author":"Ren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2024.116271_bib32","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/ajmg.a.33636","article-title":"Examining the evidence for vascular pathogenesis of selected birth defects","volume":"152a","author":"Sadler","year":"2010","journal-title":"Am. J. Med. Genet A"},{"key":"10.1016\/j.ecoenv.2024.116271_bib33","first-page":"835","article-title":"Regulation of cartilage collagenase by doxycycline","volume":"28","author":"Shlopov","year":"2001","journal-title":"J. Rheuma"},{"key":"10.1016\/j.ecoenv.2024.116271_bib34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/tera.1084","article-title":"Stage-specific skeletal and visceral defects of the i (kr)-blocker almokalant: further evidence for teratogenicity via a hypoxia-related mechanism","volume":"64","author":"Sk\u00f6ld","year":"2001","journal-title":"Teratology"},{"key":"10.1016\/j.ecoenv.2024.116271_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0890-6238(02)00042-4","article-title":"Teratogenicity of the i (kr)-blocker cisapride: relation to embryonic cardiac arrhythmia","volume":"16","author":"Sk\u00f6ld","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1027309703313","article-title":"Characterization of the inhibitory effects of erythromycin and clarithromycin on the herg potassium channel","volume":"254","author":"Stanat","year":"2003","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.ecoenv.2024.116271_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117203","article-title":"Single and mixed effects of metallic elements in maternal serum during pregnancy on risk for fetal neural tube defects: a Bayesian kernel regression approach","volume":"285","author":"Tian","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116271_bib38","unstructured":"United States Environmental Protection Agency. 2016. Contaminant Candidate List (CCL) and Regulatory Determination. \u3008https:\/\/www.epa.gov\/ccl\/contaminant-candidate-list-4-ccl-4-0\u3009. (accessed 2023.09.01)."},{"key":"10.1016\/j.ecoenv.2024.116271_bib39","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/jpet.302.1.320","article-title":"Blockade of human cardiac potassium channel human ether-a-go-go-related gene (herg) by macrolide antibiotics","volume":"302","author":"Volberg","year":"2002","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.ecoenv.2024.116271_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2745-3","article-title":"The maternal microbiome modulates fetal neurodevelopment in mice","volume":"586","author":"Vuong","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2024.116271_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/science.1222002","article-title":"The continuing challenge of understanding, preventing, and treating neural tube defects","volume":"339","author":"Wallingford","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2024.116271_bib42","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00381-013-2305-3","article-title":"Maternal flu or fever, medications use in the first trimester and the risk for neural tube defects: A hospital-based case-control study in China","volume":"30","author":"Wang","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.ecoenv.2024.116271_bib43","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1021\/acs.est.6b06474","article-title":"Urinary antibiotics of pregnant women in eastern China and cumulative health risk assessment","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodcont.2017.04.034","article-title":"Antibiotic residues in meat, milk and aquatic products in shanghai and human exposure assessment","volume":"80","author":"Wang","year":"2017","journal-title":"Food Control"},{"key":"10.1016\/j.ecoenv.2024.116271_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.RES.79.1.79","article-title":"Developmental changes in the delayed rectifier k+ channels in mouse heart","volume":"79","author":"Wang","year":"1996","journal-title":"Circ. Res"},{"key":"10.1016\/j.ecoenv.2024.116271_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105688","article-title":"Essential trace elements in placental tissue and risk for fetal neural tube defects","volume":"139","author":"Yin","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116271_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105638","article-title":"Maternal antibiotic concentrations in pregnant women in shanghai and their determinants: a biomonitoring-based prospective study","volume":"138","author":"Zeng","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116271_bib48","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116271_bib49","article-title":"Association of mastitis and farm management with contamination of antibiotics in bulk tank milk in southwest, China","volume":"12","author":"Zhang","year":"2022","journal-title":"Animal"},{"key":"10.1016\/j.ecoenv.2024.116271_bib50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.envint.2018.11.053","article-title":"Determination of antibiotic concentration in meconium and its association with fetal growth and development","volume":"123","author":"Zhao","year":"2019","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116271_bib51","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/19393210.2012.727189","article-title":"Occurrence of several main antibiotic residues in raw milk in 10 provinces of China","volume":"6","author":"Zheng","year":"2013","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"10.1016\/j.ecoenv.2024.116271_bib52","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.envpol.2011.03.034","article-title":"Trends in the occurrence of human and veterinary antibiotics in the sediments of the yellow river, Hai river and Liao river in northern China","volume":"159","author":"Zhou","year":"2011","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116271_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165586","article-title":"Associations among bisphenol a, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: a case-control study","volume":"900","author":"Zhu","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324003476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324003476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T17:44:06Z","timestamp":1724175846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324003476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":53,"alternative-id":["S0147651324003476"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116271","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inadvertent antibiotic exposure during pregnancy may increase the risk for neural tube defects in offspring","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116271"}}