{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:23:27Z","timestamp":1782937407628,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ecoenv.2024.116309","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:01:20Z","timestamp":1712707280000},"page":"116309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Biomass fuels related-PM2.5 promotes lung fibroblast-myofibroblast transition through PI3K\/AKT\/TRPC1 pathway"],"prefix":"10.1016","volume":"276","author":[{"given":"Shuni","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuping","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116309_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10060312","article-title":"Impact of particles on pulmonary endothelial cells","volume":"10","author":"Almeida-Silva","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2024.116309_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41419-020-2360-0","article-title":"TRPC6-dependent Ca(2+) signaling mediates airway inflammation in response to oxidative stress via ERK pathway.","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2024.116309_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yexcr.2019.02.013","article-title":"TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-\u03baB activation and ICAM-1 expression with ozone exposure","volume":"377","author":"Chen","year":"2019","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.ecoenv.2024.116309_bib4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/ina.12521","article-title":"Different health effects of indoor- and outdoor-originated PM(2.5) on cardiopulmonary function in COPD patients and healthy elderly adults","volume":"29","author":"Chi","year":"2019","journal-title":"Indoor Air"},{"key":"10.1016\/j.ecoenv.2024.116309_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107020","article-title":"Global health burden of ambient PM(2.5) and the contribution of anthropogenic black carbon and organic aerosols.","volume":"159","author":"Chowdhury","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116309_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107835","article-title":"A global review of the state of the evidence of household air pollution's contribution to ambient fine particulate matter and their related health impacts","volume":"173","author":"Chowdhury","year":"2023","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116309_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcdb.2019.02.001","article-title":"TRPC-mediated Ca(2+) signaling and control of cellular functions.","volume":"94","author":"Curcic","year":"2019","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.devcel.2012.08.017","article-title":"A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo","volume":"23","author":"Davis","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ecoenv.2024.116309_bib9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.envpol.2018.02.054","article-title":"Household air pollution and personal exposure to air pollutants in rural China \u2013 A review","volume":"237","author":"Du","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116309_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.rser.2023.113657","article-title":"Biomass as residential energy in China: Current status and future perspectives","volume":"186","author":"Du","year":"2023","journal-title":"Renew. Sustain. Energy Rev."},{"key":"10.1016\/j.ecoenv.2024.116309_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118464","article-title":"Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells","volume":"292","author":"Gao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116309_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118464","article-title":"Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells","volume":"292","author":"Gao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116309_bib13","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1083\/jcb.201501060","article-title":"Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels","volume":"210","author":"Gopal","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101346","article-title":"Immune induction of airway remodeling","volume":"46","author":"Guida","year":"2019","journal-title":"Semin Immunol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1164\/rccm.202103-0604OC","article-title":"Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study","volume":"205","author":"Hansel","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.ecoenv.2024.116309_bib16","article-title":"Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116309_bib17","series-title":"State of Global Air 2020","author":"Institute","year":"2020"},{"key":"10.1016\/j.ecoenv.2024.116309_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/cells8040342","article-title":"Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?","volume":"8","author":"Ito","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2024.116309_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152581","article-title":"Fine particulate matter exposure induces DNA damage by downregulating Rad51 expression in human bronchial epithelial Beas-2B cells in vitro","volume":"444","author":"Liu","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.116309_bib20","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1007\/s00018-018-2899-4","article-title":"Fibroblast-to-myofibroblast transition in bronchial asthma","volume":"75","author":"Michalik","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2024.116309_bib21","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1183\/09031936.00017712","article-title":"Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition","volume":"41","author":"Milara","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ecoenv.2024.116309_bib22","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3390\/ijms22052783","article-title":"Trp channels as cellular targets of particulate matter","volume":"22","author":"Milici","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116309_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010067","article-title":"Mechanisms of Lung Damage and Development of COPD Due to Household Biomass-Smoke Exposure: Inflammation, Oxidative Stress, MicroRNAs, and Gene Polymorphisms","volume":"12","author":"Ortiz-Quintero","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2024.116309_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12931-018-0943-4","article-title":"Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers","volume":"19","author":"P\u00e9rez-Bautista","year":"2018","journal-title":"Respir. Res"},{"key":"10.1016\/j.ecoenv.2024.116309_bib25","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-environ-012220-010602","article-title":"Indoor Air Pollution and Health: Bridging Perspectives from Developing and Developed Countries","volume":"47","author":"Pillarisetti","year":"2022","journal-title":"Annu. Rev. Environ. Resour."},{"key":"10.1016\/j.ecoenv.2024.116309_bib26","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.jaip.2022.08.031","article-title":"Lung Effects of Household Air Pollution","volume":"10","author":"Qiu","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pr."},{"key":"10.1016\/j.ecoenv.2024.116309_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174692","article-title":"Transient receptor potential cation channel subfamily V (TRPV) and its importance in asthma","volume":"915","author":"Reyes-Garc\u00eda","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/lsm.22441","article-title":"Low intensity 635\u2009nm diode laser irradiation inhibits fibroblast-myofibroblast transition reducing TRPC1 channel expression\/activity: New perspectives for tissue fibrosis treatment","volume":"48","author":"Sassoli","year":"2016","journal-title":"Lasers Surg. Med"},{"key":"10.1016\/j.ecoenv.2024.116309_bib29","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041231","article-title":"The role of myofibroblasts in physiological and pathological tissue repair","volume":"15","author":"Schuster","year":"2023","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12931-023-02529-9","article-title":"Rhinovirus induces airway remodeling: what are the physiological consequences?","volume":"24","author":"Spector","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.ecoenv.2024.116309_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101264","article-title":"The effect of exposure time and concentration of airborne PM(2.5) on lung injury in mice: A transcriptome analysis.","volume":"26","author":"Wang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/COPD.S402122","article-title":"The Effects and Pathogenesis of PM2. 5 and Its Components on Chronic Obstructive Pulmonary Disease","author":"Wang","year":"2023","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.ecoenv.2024.116309_bib33","article-title":"Combined effect of ozone and household air pollution on COPD in people aged less than 50 years old","author":"Xing","year":"2023","journal-title":"Thorax"},{"key":"10.1016\/j.ecoenv.2024.116309_bib34","article-title":"Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease","volume":"96","author":"Xu","year":"2017","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.ecoenv.2024.116309_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1281420","article-title":"Scutellaria baicalensis Attenuates Airway Remodeling via PI3K\/Akt\/NF-\u03baB Pathway in Cigarette Smoke Mediated-COPD Rats Model","volume":"2018","author":"Xu","year":"2018","journal-title":"Evid. Based Complement Altern. Med"},{"key":"10.1016\/j.ecoenv.2024.116309_bib36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ecoenv.2018.12.061","article-title":"PM(2.5) induced pulmonary fibrosis in vivo and in vitro.","volume":"171","author":"Xu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116309_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148819","article-title":"Global burden of COPD attributable to ambient PM2.5 in 204 countries and territories, 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"796","author":"Yang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116309_bib38","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3892\/mmr.2017.7212","article-title":"TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs","volume":"16","author":"Ye","year":"2017","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.ecoenv.2024.116309_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-017-0702-y","article-title":"PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway","volume":"19","author":"Ye","year":"2018","journal-title":"Respir. Res"},{"key":"10.1016\/j.ecoenv.2024.116309_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/biom9020067","article-title":"Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K","volume":"9","author":"Yudushkin","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2024.116309_bib41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/1568026611313030005","article-title":"Transient receptor potential (TRP) channels and cardiac fibrosis","volume":"13","author":"Yue","year":"2013","journal-title":"Curr. Top. Med Chem."},{"key":"10.1016\/j.ecoenv.2024.116309_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba7621","article-title":"Residential solid fuel emissions contribute significantly to air pollution and associated health impacts in China","volume":"6","author":"Yun","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2024.116309_bib43","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1021\/acs.est.1c01148","article-title":"Coal Is Dirty, but Where It Is Burned Especially Matters","volume":"55","author":"Yun","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116309_bib44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12931-019-1081-3","article-title":"Role of PM2.5 in the development and progression of COPD and its mechanisms","volume":"20","author":"Zhao","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.ecoenv.2024.116309_bib45","doi-asserted-by":"crossref","first-page":"C278","DOI":"10.1152\/ajpcell.00117.2017","article-title":"TRPC6 contributes to LPS-induced inflammation through ERK1\/2 and p38 pathways in bronchial epithelial cells","volume":"314","author":"Zhou","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324003853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324003853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T20:35:16Z","timestamp":1714163716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324003853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":45,"alternative-id":["S0147651324003853"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116309","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomass fuels related-PM2.5 promotes lung fibroblast-myofibroblast transition through PI3K\/AKT\/TRPC1 pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116309"}}