{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:02:31Z","timestamp":1793347351281,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360290"],"award-info":[{"award-number":["82360290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ecoenv.2024.116439","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:23:00Z","timestamp":1715260980000},"page":"116439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice"],"prefix":"10.1016","volume":"278","author":[{"given":"Yiqian","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116439_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2023.1193386","article-title":"Toxicological impact of microplastics and nanoplastics on humans: understanding the mechanistic aspect of the interaction","volume":"5","author":"Alqahtani","year":"2023","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126124","article-title":"Presence of airborne microplastics in human lung tissue","volume":"416","author":"Amato-Louren\u00e7o","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116439_bib3","doi-asserted-by":"crossref","first-page":"11332","DOI":"10.1007\/s11356-021-15920-0","article-title":"Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats","volume":"29","author":"Babaei","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2024.116439_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting Edge: NF-\u03baB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta-Mol. Cell. Res."},{"key":"10.1016\/j.ecoenv.2024.116439_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116523","article-title":"Toxicity assessment of microplastic (MPs); a threat to the ecosystem","volume":"234","author":"Bostan","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2024.116439_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/pharmaceutics13070921","article-title":"Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting","volume":"13","author":"Braun","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ecoenv.2024.116439_bib8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10311-022-01560-4","article-title":"Higher number of microplastics in tumoral colon tissues from patients with colorectal adenocarcinoma","volume":"21","author":"Cetin","year":"2023","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.ecoenv.2024.116439_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155984","article-title":"Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data","volume":"839","author":"Chen","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/17435390.2021.1996650","article-title":"In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice","volume":"15","author":"Choi","year":"2021","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2024.116439_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165076","article-title":"The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS)","volume":"895","author":"Das","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib12","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116439_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116974","article-title":"Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells","volume":"280","author":"Ding","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116439_bib14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop Between NLRP3 Inflammasome and Reactive Oxygen Species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2024.116439_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/15376516.2023.2191270","article-title":"Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin","volume":"33","author":"Elsheikh","year":"2023","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ecoenv.2024.116439_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132607","article-title":"Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice","volume":"288","author":"Fan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116439_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a Caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib18","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1089\/ars.2009.2463","article-title":"Redox Regulation of Nuclear Post-Translational Modifications During NF-\u03baB Activation","volume":"11","author":"Gloire","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2024.116439_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2022.07.131","article-title":"Dietary and inhalation exposure to nano- and microplastic particles: potential implications for human health","volume":"368","author":"Gouin","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2024.116439_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130138","article-title":"The landscape of micron-scale particles including microplastics in human enclosed body fluids","volume":"442","author":"Guan","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116439_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138180","article-title":"Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells","volume":"723","author":"He","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135662","article-title":"Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-\u043aB\/NLRP3 pathway","volume":"307","author":"He","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116439_bib23","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3390\/ijms21134777","article-title":"NRF2, a Transcription Factor for Stress Response and Beyond","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116439_bib24","doi-asserted-by":"crossref","first-page":"12300","DOI":"10.1021\/acs.est.9b02540","article-title":"Plastic Teabags Release Billions of Microparticles and Nanoparticles into Tea","volume":"53","author":"Hernandez","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3390\/toxics10080414","article-title":"Preliminary Findings of the High Quantity of Microplastics in Faeces of Hong Kong Residents","volume":"10","author":"Ho","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2024.116439_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics detected in cirrhotic liver tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ecoenv.2024.116439_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115447","article-title":"Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems","volume":"264","author":"Huang","year":"2023","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2024.116439_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112803","article-title":"Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring","volume":"160","author":"Huang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jgh3.12457","article-title":"Detection of microplastics in human colectomy specimens","volume":"5","author":"Ibrahim","year":"2021","journal-title":"Jgh. Open."},{"key":"10.1016\/j.ecoenv.2024.116439_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue using \u03bcFTIR spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib31","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1038\/s41467-023-38613-3","article-title":"Stakeholder alliances are essential to reduce the scourge of plastic pollution","volume":"14","author":"Lampitt","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2024.116439_bib32","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/acs.est.8b05512","article-title":"Emergence of Nanoplastic in the Environment and Possible Impact on Human Health","volume":"53","author":"Lehner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116439_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110502","article-title":"ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells","volume":"379","author":"Li","year":"2023","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.ecoenv.2024.116439_bib35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158699","article-title":"Detection of various microplastics in placentas, meconium, infant feces, breastmilk and infant formula: A pilot prospective study","volume":"854","author":"Liu","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib37","doi-asserted-by":"crossref","first-page":"17774","DOI":"10.1021\/acs.est.2c04706","article-title":"The Association Between Microplastics and Microbiota in Placentas and Meconium: The First Evidence in Humans","volume":"57","author":"Liu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-\u03baB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta-Mol. Cell. Res."},{"key":"10.1016\/j.ecoenv.2024.116439_bib39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/environments8120138","article-title":"Microplastic Contamination in Human Stools, Foods, and Drinking Water Associated with Indonesian Coastal Population","volume":"8","author":"Luqman","year":"2021","journal-title":"Environments"},{"key":"10.1016\/j.ecoenv.2024.116439_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.intimp.2018.09.019","article-title":"Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-\u03baB in mice","volume":"65","author":"Lv","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164687","article-title":"Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages","volume":"892","author":"Meng","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib42","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2024.116439_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132944","article-title":"Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116439_bib44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/toxics11010040","article-title":"First Evidence of Microplastics in Human Urine, a Preliminary Study of Intake in the Human Body","volume":"11","author":"Pironti","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2024.116439_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116439_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.abh0945","article-title":"Plastic ingestion as an evolutionary trap: Toward a holistic understanding","volume":"373","author":"Santos","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2024.116439_bib47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of Various Microplastics in Human Stool: A Prospective Case Series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ecoenv.2024.116439_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124004","article-title":"Estimation of the mass of microplastics ingested - A pivotal first step towards human health risk assessment","volume":"404","author":"Senathirajah","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116439_bib49","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s10311-022-01539-1","article-title":"Nanoplastics are potentially more dangerous than microplastics","volume":"21","author":"Sharma","year":"2023","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.ecoenv.2024.116439_bib50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/bab.1700","article-title":"Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation","volume":"66","author":"Sho","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.ecoenv.2024.116439_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114796","article-title":"Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells","volume":"255","author":"Sun","year":"2023","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2024.116439_bib52","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional Regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2024.116439_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113540","article-title":"Enrichment of polystyrene microplastics induces histological damage, oxidative stress, Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus)","volume":"237","author":"Wang","year":"2022","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2024.116439_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138255","article-title":"Effects of polystyrene nanoplastic gestational exposure on mice","volume":"324","author":"Wang","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116439_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158111","article-title":"A review of potential human health impacts of micro- and nanoplastics exposure","volume":"851","author":"Xu","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126092","article-title":"Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells","volume":"417","author":"Xu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116439_bib57","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1021\/acs.est.1c03924","article-title":"Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status","volume":"56","author":"Yan","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib58","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1021\/acs.est.2c07179","article-title":"Detection of Various Microplastics in Patients Undergoing Cardiac Surgery","volume":"57","author":"Yang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib59","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/toxics10100586","article-title":"Nanoplastics and Microplastics May Be Damaging Our Livers","volume":"10","author":"Yin","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2024.116439_bib60","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cellsig.2011.01.014","article-title":"Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway","volume":"23","author":"Yu","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ecoenv.2024.116439_bib61","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.1021\/acs.est.1c06768","article-title":"Common Single-Use Consumer Plastic Products Release Trillions of Sub-100 nm Nanoparticles per Liter into Water during Normal Use","volume":"56","author":"Zangmeister","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144345","article-title":"You are what you eat: Microplastics in the feces of young men living in Beijing","volume":"767","author":"Zhang","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib63","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1021\/acs.est.3c00842","article-title":"Identification of Poly (ethylene terephthalate) Nanoplastics in Commercially Bottled Drinking Water Using Surface-Enhanced Raman Spectroscopy","volume":"57","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116439_bib64","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/acs.estlett.1c00559","article-title":"Occurrence of Polyethylene Terephthalate and Polycarbonate Microplastics in Infant and Adult Feces","volume":"8","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.ecoenv.2024.116439_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112882","article-title":"Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL\/6J mice through polarization of macrophages and increased infiltration of natural killer cells","volume":"227","author":"Zhao","year":"2021","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2024.116439_bib66","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2010.11.001","article-title":"Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice","volume":"200","author":"Zhao","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2024.116439_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111074","article-title":"Size-dependent oxidative stress effect of nano\/micro-scaled polystyrene on Karenia mikimotoi","volume":"154","author":"Zhao","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2024.116439_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162713","article-title":"Detection and characterization of microplastics in the human testis and semen","volume":"877","author":"Zhao","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2024.116439_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159060","article-title":"Identification of microplastics in human placenta using laser direct infrared spectroscopy","volume":"856","author":"Zhu","year":"2023","journal-title":"Sci. Total. Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324005153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324005153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T01:04:59Z","timestamp":1742346299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324005153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":69,"alternative-id":["S0147651324005153"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116439","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116439"}}