{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:24:20Z","timestamp":1793892260516,"version":"4.8.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022230","name":"Princess Nourah bint Abdulrahman University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["PNURSP2024R30"],"award-info":[{"award-number":["PNURSP2024R30"]}],"id":[{"id":"10.13039\/501100022230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011665","name":"King Saud University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["RSPD2024R811"],"award-info":[{"award-number":["RSPD2024R811"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ecoenv.2024.116522","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T15:37:38Z","timestamp":1717601858000},"page":"116522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Synergistic effect of green synthesis magnesium oxide nanoparticles and seaweed extract on improving water quality, health benefits, and disease resistance in Nile tilapia"],"prefix":"10.1016","volume":"280","author":[{"given":"Mahmoud","family":"Radwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa A.","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Manaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"El-Sharkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem F.","family":"Darweesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said M.A.","family":"Elraey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad A.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaal","family":"Mohammadein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa Mohammed","family":"Al-Otaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadeer M.","family":"Albadrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muath Q.","family":"Al-Ghadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lobna A.","family":"Badawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa O.","family":"Abd El-Halim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Abdel-Daim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsayed E.","family":"Mekky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116522_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fsi.2021.09.043","article-title":"\"Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection\"","volume":"119","author":"Abdelhamid","year":"2021","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738155","article-title":"Elucidating the ameliorative effects of the cyanobacterium Spirulina (Arthrospira platensis) and several microalgal species against the negative impacts of contaminants in freshwater fish: a review","volume":"554","author":"Abdel-Latif","year":"2022","journal-title":"Aquaculture"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116522_bib3","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1021\/acsomega.2c01450","article-title":"Magnesium oxide nanoparticles: effective ant larvicidal and antibacterial agents","volume":"8","author":"Abinaya","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ecoenv.2024.116522_bib4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fsi.2016.08.003","article-title":"Effects of dietary Spirulina platensis on growth performance, humoral and mucosal immune responses and disease resistance in juvenile great sturgeon (Huso huso Linnaeus, 1754)","volume":"56","author":"Adel","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib5","first-page":"121","article-title":"[13] Catalase in vitro","volume":"Vol. 105","author":"Aebi","year":"1984"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1080\/23308249.2020.1818689","article-title":"Benefits of dietary polyphenols and polyphenol-rich additives to aquatic animal health: an overview","volume":"29","author":"Ahmadifar","year":"2021","journal-title":"Rev. Fish. Sci. Aquac."},{"key":"10.1016\/j.ecoenv.2024.116522_bib7","first-page":"1","article-title":"Exploring the aspects of the application of nanotechnology system in aquaculture: a systematic review","author":"Ahmed","year":"2024","journal-title":"Aquac. Int."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib8","first-page":"59","article-title":"Effect of dietary supplementation of Ulva rigida C. Agardh extract on several of physiological parameters of grey mullet, Mugil cephalus (Linnaeus)","volume":"4","author":"Akbary","year":"2018","journal-title":"Sustain. Aquac. Health Manag. J."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib9","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/s41598-022-06412-3","article-title":"Anticancer and antimicrobial activity of biosynthesized Red Sea marine algal silver nanoparticles","volume":"12","author":"Algotiml","year":"2022","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116522_bib10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3390\/catal13050888","article-title":"Advances in green synthesis of metal oxide nanoparticles by marine algae for wastewater treatment by adsorption and photocatalysis techniques","volume":"13","author":"Alprol","year":"2023","journal-title":"Catalysts"},{"key":"10.1016\/j.ecoenv.2024.116522_bib11","article-title":"Potency testing of fish vaccines","author":"Amend","year":"1981","journal-title":"Fish. Biol.: Serodiagn. Vaccines"},{"key":"10.1016\/j.ecoenv.2024.116522_bib12","series-title":"Official Methods of Analysis of the Association of Official Analytical Chemists","author":"AOAC","year":"2003"},{"key":"10.1016\/j.ecoenv.2024.116522_bib13","series-title":"Standard Methods for the Examination of Water and Wastewater","author":"APHA","year":"2005"},{"key":"10.1016\/j.ecoenv.2024.116522_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.736915","article-title":"A liquid seaweed extract (TAM\u00ae) improves aqueous rearing environment, diversity of zooplankton community, whilst enhancing growth and immune response of Nile tilapia, Oreochromis niloticus, challenged by Aeromonas hydrophila","volume":"543","author":"Ashour","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib15","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1007\/s10811-020-02178-1","article-title":"Effect of dietary seaweed extract supplementation on growth, feed utilization, hematological indices, and non-specific immunity of Nile Tilapia, Oreochromis niloticus challenged with Aeromonas hydrophila","volume":"32","author":"Ashour","year":"2020","journal-title":"J. Appl. Phycol."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116522_bib16","first-page":"1319","article-title":"Application of iron oxide nanoparticles in the reactor for treatment of effluent from fish farms","volume":"19","author":"Askari Hesni","year":"2020","journal-title":"Iran. J. Fish. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116522_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/biology10030233","article-title":"Efficacy assessment of biosynthesized copper oxide nanoparticles (CuO-NPs) on stored grain insects and their impacts on morphological and physiological traits of wheat (Triticum aestivum L.) plant","volume":"10","author":"Badawy","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ecoenv.2024.116522_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/raq.12792","article-title":"Microalgae with immunomodulatory effects on fish","author":"Bahi","year":"2023","journal-title":"Rev. Aquac."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116522_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/md19110637","article-title":"Antiparasitic effects of sulfated polysaccharides from marine hydrobionts","volume":"19","author":"Besednova","year":"2021","journal-title":"Mar. Drugs"},{"issue":"3-4","key":"10.1016\/j.ecoenv.2024.116522_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0044-8486(90)90135-A","article-title":"Studies on the digestive lipases of milkfish, Chanos chanos","volume":"89","author":"Borlongan","year":"1990","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib21","series-title":"Water quality in ponds for aquaculture","author":"Boyd","year":"1990"},{"issue":"1-4","key":"10.1016\/j.ecoenv.2024.116522_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0044-8486(03)00357-0","article-title":"Diseases resistance of Nile tilapia (Oreochromis niloticus), blue tilapia (Oreochromis aureus) and their hybrid (female Nile tilapia\u00d7 male blue tilapia) to Aeromonas sobria","volume":"229","author":"Cai","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib23","series-title":"Identification of Unusual Pathogenic Gram negative Aerobic and Facultatively Anaerobic Bacteria","author":"Clark","year":"1984"},{"key":"10.1016\/j.ecoenv.2024.116522_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109377","article-title":"Chicken egg lysozyme enhanced the growth performance, feed utilization, upregulated immune-related genes, and mitigated the impacts of Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus)","volume":"146","author":"Dawood","year":"2024","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739620","article-title":"Interactive effects of cyclical fasting, refeeding, and dietary protein regimes on the growth performance, blood health, and intestinal histology of Nile tilapia (Oreochromis niloticus)","volume":"573","author":"Dawood","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2019.734669","article-title":"Probiotic effects of Aspergillus oryzae on the oxidative status, heat shock protein, and immune related gene expression of Nile tilapia (Oreochromis niloticus) under hypoxia challenge","volume":"520","author":"Dawood","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736287","article-title":"The regulatory roles of yucca extract on the growth rate, hepato-renal function, histopathological alterations, and immune-related genes in common carp exposed with acute ammonia stress","volume":"534","author":"Dawood","year":"2021","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0145-305X(97)00009-8","article-title":"The immediate effects of stress on hormones and plasma lysozyme in rainbow trout","volume":"21","author":"Demers","year":"1997","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116522_bib29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/md20060342","article-title":"Phytochemical and potential properties of seaweeds and their recent applications: a review","volume":"20","author":"El-Beltagi","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2024.116522_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1254300","article-title":"Algae as a potential source of protein meat alternatives","volume":"10","author":"Espinosa-Ram\u00edrez","year":"2023","journal-title":"Front. Nutr."},{"issue":"477","key":"10.1016\/j.ecoenv.2024.116522_bib31","first-page":"2","article-title":"Sulfated polysaccharides in diets for Nile tilapia (Oreochromis niloticus) in the initial growth phase","volume":"8","author":"Fabrini","year":"2017","journal-title":"J. Aquac. Res Dev."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib32","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1166\/jbn.2020.2918","article-title":"In vitro biomedical and photo-catalytic application of bio-inspired Zingiber officinale mediated silver nanoparticles","volume":"16","author":"Faisal","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib33","first-page":"114","article-title":"[12] Assays of glutathione peroxidase","volume":"Vol. 105","author":"Flohe","year":"1984"},{"issue":"21","key":"10.1016\/j.ecoenv.2024.116522_bib34","doi-asserted-by":"crossref","first-page":"12311","DOI":"10.3390\/su132112311","article-title":"Removal of toxic heavy metals from contaminated aqueous solutions using seaweeds: a review","volume":"13","author":"Foday","year":"2021","journal-title":"Sustainability"},{"issue":"16","key":"10.1016\/j.ecoenv.2024.116522_bib35","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1021\/acsomega.9b03687","article-title":"Polyphenols from brown seaweeds as a potential antimicrobial agent in animal feeds","volume":"5","author":"Ford","year":"2020","journal-title":"Acs Omega"},{"key":"10.1016\/j.ecoenv.2024.116522_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.849921","article-title":"Enhanced antimicrobial, cytotoxicity, larvicidal, and repellence activities of brown algae, Cystoseira crinita-mediated green synthesis of magnesium oxide nanoparticles","volume":"10","author":"Fouda","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib37","series-title":"Fish Nutrition","first-page":"745","article-title":"Nutritional supplements and fish health","author":"Gatlin","year":"2022"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/bmc-2022-0003","article-title":"Seaweeds' pigments and phenolic compounds with antimicrobial potential","volume":"13","author":"Gomes","year":"2022","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.ecoenv.2024.116522_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ultsonch.2017.09.006","article-title":"Ultrasound-assisted biosynthesis of CuO-NPs using brown alga Cystoseira trinodis: characterization, photocatalytic AOP, DPPH scavenging and antibacterial investigations","volume":"41","author":"Gu","year":"2018","journal-title":"Ultrason. Sonochem."},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116522_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/md20070445","article-title":"Seaweed phenolics as natural antioxidants, aquafeed additives, veterinary treatments and cross-linkers for microencapsulation","volume":"20","author":"Gunathilake","year":"2022","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jhazmat.2007.07.028","article-title":"Biosorption of lead from aqueous solutions by green algae Spirogyra species: kinetics and equilibrium studies","volume":"152","author":"Gupta","year":"2008","journal-title":"J. Hazard. Mater."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116522_bib42","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.3390\/ma14092189","article-title":"Synthesis of eco-friendly biopolymer, alginate-chitosan composite to adsorb the heavy metals, Cd (II) and Pb (II) from contaminated effluents","volume":"14","author":"Hamza","year":"2021","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116522_bib43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0009-8981(73)90466-X","article-title":"Determination of serum creatinine by a direct colorimetric method","volume":"43","author":"Heinegard","year":"1973","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ecoenv.2024.116522_bib44","series-title":"Clinical Chemistry, Principles and Techniques","author":"Henry","year":"1964"},{"key":"10.1016\/j.ecoenv.2024.116522_bib45","first-page":"415","article-title":"Blood and circulation","author":"Houston","year":"1990","journal-title":"Methods Fish. Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib46","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3390\/microorganisms11041002","article-title":"The effect of the microalgae Chlorella vulgaris on the gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) is feeding-time dependent","volume":"11","author":"Huang","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2024.116522_bib47","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/BF02897474","article-title":"Influence of nano-MgO particle size on bactericidal action against Bacillus subtilis var. niger","volume":"50","author":"Huang","year":"2005","journal-title":"Chin. Sci. Bull."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116522_bib48","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.parint.2018.06.009","article-title":"Antiprotozoal activity of magnesium oxide (MgO) nanoparticles against Cyclospora cayetanensis oocysts","volume":"67","author":"Hussein","year":"2018","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.ecoenv.2024.116522_bib49","series-title":"Activity measuring for implemental enzyme","author":"Jiang","year":"1982"},{"key":"10.1016\/j.ecoenv.2024.116522_bib50","series-title":"The evaluation principle and method of functional food","author":"Jin","year":"1995"},{"key":"10.1016\/j.ecoenv.2024.116522_bib51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.22214\/ijraset.2018.3115","article-title":"Synthesis, characterization and applications of biogenic iron oxide nanoparticles","volume":"3","author":"Kanchana","year":"2018","journal-title":"Int. J. Res. Appl. Sci. Eng. Technol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jphotobiol.2018.11.001","article-title":"Fabrication of MgO nanostructures and its efficient photocatalytic, antibacterial and anticancer performance","volume":"190","author":"Karthik","year":"2019","journal-title":"J. Photochem. Photobiol. B: Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116522_bib53","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/17435390.2019.1621401","article-title":"Toxicity of differently sized and charged silver nanoparticles to yeast Saccharomyces cerevisiae BY4741: a nano-biointeraction perspective","volume":"13","author":"Kasemets","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2024.116522_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/8882736","article-title":"The Effects of Laurencia caspica Algae Extract on Hemato-Immunological Parameters, Antioxidant Defense, and Resistance against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus)","volume":"2023","author":"Khanzadeh","year":"2023","journal-title":"Aquac. Nutr."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib55","first-page":"97","article-title":"Effect of Extract and Fucoidan of Sargassum sp. on Growth, biochemical, Immunity and antioxidant Parameters of Nile Tilapia (Oreochromis niloticus)","volume":"29","author":"Khanzadeh","year":"2020","journal-title":"Iran. Sci. Fish. J."},{"key":"10.1016\/j.ecoenv.2024.116522_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735361","article-title":"Effects of feeding with red algae (Laurencia caspica) hydroalcoholic extract on antioxidant defense, immune responses, and immune gene expression of kidney in rainbow trout (Oncorhynchus mykiss) infected with Aeromonas hydrophila","volume":"526","author":"Kiadaliri","year":"2020","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib57","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3390\/nano10040766","article-title":"Flower-based green synthesis of metallic nanoparticles: applications beyond fragrance","volume":"10","author":"Kumar","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ecoenv.2024.116522_bib58","first-page":"1554","article-title":"Reduction of toxic elements in marine environment using nano adsorbent materials","volume":"37","author":"Kumar","year":"2021","journal-title":"Mater. Today.: Proc."},{"key":"10.1016\/j.ecoenv.2024.116522_bib59","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using realtime quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib60","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2024.116522_bib61","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.envpol.2016.09.044","article-title":"Infectious bacterial pathogens, parasites and pathological correlations of sewage pollution as an important threat to farmed fishes in Egypt","volume":"219","author":"Mahmoud","year":"2016","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116522_bib62","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3390\/foods10030516","article-title":"Advances in extraction methods to recover added-value compounds from seaweeds: sustainability and functionality","volume":"10","author":"Matos","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib63","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2478\/aoas-2020-0049","article-title":"Extract of grape seed enhances the growth performance, humoral and mucosal immunity, and resistance of common carp (Cyprinus carpio) against Aeromonas hydrophila","volume":"21","author":"Mehrinakhi","year":"2021","journal-title":"Ann. Anim. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40260-z","article-title":"Antimicrobial activity of Spirulina platensis extract on total mesophilic and psychrophilic bacteria of fresh tilapia fillet","volume":"13","author":"Metekia","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116522_bib65","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/clinchem\/29.3.538","article-title":"A peroxidasecoupled method for colorimetric determination of serum triglycerides","volume":"29","author":"MGowan","year":"1983","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/01652176.2022.2061744","article-title":"Antioxidant effects of seaweeds and their active compounds on animal health and production\u2013a review","volume":"42","author":"Michalak","year":"2022","journal-title":"Vet. Q."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116522_bib67","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/jmse8080559","article-title":"Seaweed potential in the animal feed: a review","volume":"8","author":"Morais","year":"2020","journal-title":"J. Mar. Sci. Eng."},{"key":"10.1016\/j.ecoenv.2024.116522_bib68","first-page":"48","article-title":"Investigation of the effect of diet containing Red algae (Laurencia caspica) on blood parameters and activity of digestive enzymes of goldfish (Carassius auratus)","author":"Nahavandi","year":"2023","journal-title":"J. Surv. Fish. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116522_bib69","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116522_bib70","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4315\/0362-028X.JFP-18-078","article-title":"Microbiological safety of fresh tilapia (Oreochromis niloticus) from Kenyan fresh water fish value chains","volume":"81","author":"Onjong","year":"2018","journal-title":"J. Food Prot."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib71","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/01971528808053210","article-title":"Production of polyclonal antibodies in ascitic fluid of mice: technique and applications","volume":"9","author":"Overkamp","year":"1988","journal-title":"J. Immunoass."},{"key":"10.1016\/j.ecoenv.2024.116522_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.06.001","article-title":"Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides","volume":"222","author":"Pandeirada","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib73","first-page":"203","article-title":"Efficacy of aqueous and methanol extracts of some medicinal plants for potential antibacterial activity","volume":"29","author":"Parekh","year":"2005","journal-title":"Turk. J. Biol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib74","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jphotobiol.2018.11.014","article-title":"Anticancer, antimicrobial and photocatalytic activities of green synthesized magnesium oxide nanoparticles (MgONPs) using aqueous extract of Sargassum wightii","volume":"190","author":"Pugazhendhi","year":"2019","journal-title":"J. Photochem. Photobiol. B: Biol."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116522_bib75","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s10499-023-01093-9","article-title":"The synergy between serious parasitic pathogens and bacterial infestation in the cultured Nile tilapia (Oreochromis niloticus): a severe threat to fish immunity, causing mass mortality and significant economic losses","volume":"31","author":"Radwan","year":"2023","journal-title":"Aquac. Int."},{"key":"10.1016\/j.ecoenv.2024.116522_bib76","volume":"9","author":"Radwan","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.ecoenv.2024.116522_bib77","first-page":"1","article-title":"Elucidating the protective influence of dietary Juniperus communis extracts on Nile tilapia (Oreochromis niloticus) growth, intestinal health, immune-antioxidant, gene expression responses, and resistance to infection","author":"Radwan","year":"2024","journal-title":"Aquac. Int."},{"key":"10.1016\/j.ecoenv.2024.116522_bib78","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aquaculture.2006.03.020","article-title":"Growth, production and food preference of rohu Labeo rohita (H.) in monoculture and in polyculture with common carp Cyprinus carpio (L.) under fed and non-fed ponds","volume":"257","author":"Rahman","year":"2006","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib79","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"issue":"17","key":"10.1016\/j.ecoenv.2024.116522_bib80","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.biortech.2006.09.026","article-title":"Comparative study of biosorption of heavy metals using different types of algae","volume":"98","author":"Romera","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib81","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9072958","article-title":"Microscopic techniques in materials science: current trends in the area of blends, composites, and hybrid materials","volume":"2019","author":"Rydz","year":"2019","journal-title":"Adv. Mater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib82","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jwas.12750","article-title":"Lemon, Citrus aurantifolia, peel and Bacillus licheniformis protected common carp, Cyprinus carpio, from Aeromonas hydrophila infection by improving the humoral and skin mucosal immunity, and antioxidative responses","volume":"52","author":"Sadeghi","year":"2021","journal-title":"J. World Aquac. Soc."},{"key":"10.1016\/j.ecoenv.2024.116522_bib83","article-title":"The putative effect of a SOD-rich melon pulp-concentrate on growth performance and antioxidant status of Nile tilapia (Oreochromis niloticus) under heat\/dissolved oxygen-induced stress","volume":"529","author":"dos Santos Xavier","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e14088","article-title":"A review on pathogenicity of Aeromonas hydrophila and their mitigation through medicinal herbs in aquaculture","volume":"9","author":"Semwal","year":"2023","journal-title":"Heliyon"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116522_bib85","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1111\/are.14566","article-title":"Effects of dietary marine microalgae, Tetraselmis suecica on production, gene expression, protein markers and bacterial count of Pacific white shrimp Litopenaeus vannamei","volume":"51","author":"Sharawy","year":"2020","journal-title":"Aquac. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0043933915000112","article-title":"A review of the role of magnesium in poultry nutrition","volume":"71","author":"Shastak","year":"2015","journal-title":"World'S. Poult. Sci. J."},{"issue":"23","key":"10.1016\/j.ecoenv.2024.116522_bib87","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.3390\/ani12233389","article-title":"Brown Seaweed (Padina australis) Extract can Promote Performance, Innate Immune Responses, Digestive Enzyme Activities, Intestinal Gene Expression and Resistance against Aeromonas hydrophila in Common Carp (Cyprinus carpio)","volume":"12","author":"Sheikhzadeh","year":"2022","journal-title":"Animals"},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116522_bib88","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.3390\/antiox12122066","article-title":"Seaweed and seaweed-based functional metabolites as potential modulators of growth, immune and antioxidant responses, and gut microbiota in fish","volume":"12","author":"Siddik","year":"2023","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116522_bib89","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1577\/1548-8667(1999)011<0183:EOPETT>2.0.CO;2","article-title":"Effect of previous exposure to tricaine methanesulfonate on time to anesthesia in hybrid tilapias","volume":"11","author":"Smith","year":"1999","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.ecoenv.2024.116522_bib90","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s12011-020-02188-7","article-title":"Green approach to overcome the resistance pattern of Candida spp. using biosynthesized silver nanoparticles fabricated by Penicillium chrysogenum F9","volume":"199","author":"Soliman","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2024.116522_bib91","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12011-016-0855-4","article-title":"Dietary supplementation of magnesium oxide (MgO) nanoparticles for better survival and growth of the freshwater prawn Macrobrachium rosenbergii post-larvae","volume":"177","author":"Srinivasan","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2024.116522_bib92","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0165-2427(94)05430-Z","article-title":"Natural hemolytic and bactericidal activities of sea bream Sparus aurata serum are effected by the alternative complement pathway","volume":"45","author":"Sunyer","year":"1995","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737589","article-title":"Cichlids endemic to India are not susceptible to Tilapia Lake virus infection","volume":"548","author":"Thangaraj","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib94","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fsi.2021.03.018","article-title":"Seaweed dietary supplements enhance the innate immune response of the mottled rabbitfish, Siganus fuscescens","volume":"113","author":"Thepot","year":"2021","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib95","article-title":"Antioxidant capacity of five microalgae species and their effect on heat shock protein 70 expression in the brine shrimp Artemia","volume":"18","author":"Tiong","year":"2020","journal-title":"Aquac. Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib96","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ecoenv.2024.116522_bib97","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.fsi.2020.07.010","article-title":"Dietary inclusion of chestnut (Castanea sativa) polyphenols to Nile tilapia reared in biofloc technology: Impacts on growth, immunity, and disease resistance against Streptococcus agalactiae","volume":"105","author":"Van Doan","year":"2020","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2024.116522_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-013-1595-4","article-title":"Selective antibacterial effects of mixed ZnMgO nanoparticles","volume":"15","author":"Vidic","year":"2013","journal-title":"J. Nanopart. Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116522_bib99","first-page":"2","article-title":"Impact of Magnesium Oxide Nanoparticles on Hematological, Biochemical and Antioxidant Levels of Mrigal Cirrhinus mrigala","volume":"152","author":"Vyshnav","year":"2023","journal-title":"J. Mater. Sci. Manuf. Res. SRC\/JMSMR-171"},{"key":"10.1016\/j.ecoenv.2024.116522_bib100","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00436-010-2010-z","article-title":"Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis CH Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)","volume":"107","author":"Wang","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ecoenv.2024.116522_bib101","first-page":"399","article-title":"Worthington enzyme manual","author":"Worthington","year":"1993","journal-title":"Enzym. Relat. Biochem."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116522_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-023-03618-z","article-title":"Nutritional and immunological evaluation of Nannochloropsis oculata as a potential Nile tilapia-aquafeed supplement","volume":"19","author":"Zahran","year":"2023","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.ecoenv.2024.116522_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1173225","article-title":"Beneficial effects of seaweed-derived components on metabolic syndrome via gut microbiota modulation","volume":"10","author":"Zang","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2024.116522_bib104","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.aquaculture.2013.09.022","article-title":"The efficacy of four common anthelmintic drugs and traditional Chinese medicinal plant extracts to control Dactylogyrus vastator (Monogenea)","volume":"420","author":"Zhang","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2024.116522_bib105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fsi.2022.05.036","article-title":"The effective components of herbal medicines used for prevention and control of fish diseases","volume":"126","author":"Zhang","year":"2022","journal-title":"Fish. Shellfish Immunol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324005980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324005980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T10:58:42Z","timestamp":1722509922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324005980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":105,"alternative-id":["S0147651324005980"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116522","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effect of green synthesis magnesium oxide nanoparticles and seaweed extract on improving water quality, health benefits, and disease resistance in Nile tilapia","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116522"}}