{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:41:27Z","timestamp":1787503287572,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ecoenv.2024.116636","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:08:38Z","timestamp":1719241718000},"page":"116636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Bta-miR-149\u20133p suppresses inflammatory response in bovine Sertoli cells exposed to microcystin-leucine arginine (MC-LR) through TLR4\/NF-kB signaling pathway"],"prefix":"10.1016","volume":"281","author":[{"given":"Wang","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Tianrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Jiaqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Ruxue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116636_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.etap.2018.09.001","article-title":"Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4\/NF-kB signaling pathway","volume":"63","author":"Adegoke","year":"2018","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116636_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ecoenv.2018.09.073","article-title":"Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4\/NF-kB and mitochondrial signaling pathways blockage","volume":"166","author":"Adegoke","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116636_bib3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.reprotox.2011.02.006","article-title":"Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR","volume":"31","author":"Chen","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40104-020-00487-6","article-title":"Profiling of miRNAs in porcine Sertoli cells","volume":"11","author":"Chen","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2013.09.005","article-title":"Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro","volume":"76","author":"Chen","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2024.116636_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/srep39238","article-title":"Microcystin-leucine arginine causes cytotoxic effects in sertoli cells resulting in reproductive dysfunction in male mice","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116636_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1477-7827-9-126","article-title":"miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol","volume":"9","author":"Choi","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/en.2008-0848","article-title":"Effect of interleukin-1 receptor antagonist gene deletion on male mouse fertility","volume":"150","author":"Ganaiem","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2024.116636_bib10","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.3892\/mmr.2016.5205","article-title":"Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma","volume":"13","author":"Jin","year":"2016","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.ecoenv.2024.116636_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0960-9822(95)00151-5","article-title":"Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus","volume":"5","author":"Karin","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/spmg.19119","article-title":"Genetically engineered immune privileged Sertoli cells: A new road to cell based gene therapy","volume":"2","author":"Kaur","year":"2012","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.ecoenv.2024.116636_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcdb.2014.02.011","article-title":"Sertoli cells--immunological sentinels of spermatogenesis","volume":"30","author":"Kaur","year":"2014","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors.","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.ecoenv.2024.116636_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/resp.12149","article-title":"Interaction of cyclic mechanical stretch and toll-like receptor 4-mediated innate immunity in rat alveolar type II cells","volume":"19","author":"Kuhn","year":"2014","journal-title":"Respirology"},{"key":"10.1016\/j.ecoenv.2024.116636_bib16","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.etap.2011.12.015","article-title":"Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells","volume":"33","author":"Li","year":"2012","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116636_bib17","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1007\/s13277-016-5106-y","article-title":"The clinicopathological significance of miR-149 and PARP-2 in hepatocellular carcinoma and their roles in chemo\/radiotherapy","volume":"37","author":"Lin","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000445653","article-title":"MicroRNA-149 increases the sensitivity of colorectal cancer cells to 5-fluorouracil by targeting forkhead box transcription factor FOXM1","volume":"39","author":"Liu","year":"2016","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.ecoenv.2024.116636_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ecoenv.2024.116636_bib20","first-page":"851","article-title":"The blood-testis and blood-epididymis barriers are more than just their tight junctions. Biol Reprod","volume":"84","author":"Mital","year":"2011"},{"key":"10.1016\/j.ecoenv.2024.116636_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/physrev.00025.2011","article-title":"The germline stem cell niche unit in mammalian testes","volume":"92","author":"Oatley","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2024.116636_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2013.11.092","article-title":"TNFalpha induces the expression of genes associated with endothelial dysfunction through p38MAPK-mediated down-regulation of miR-149","volume":"443","author":"Palmieri","year":"2014","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.ecoenv.2024.116636_bib23","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1007\/s11356-013-1813-8","article-title":"Semen quality of environmentally exposed human population: the toxicological consequence","volume":"20","author":"Pant","year":"2013","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2024.116636_bib24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/spmg.1.4.18392","article-title":"Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility","volume":"1","author":"Pointis","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.ecoenv.2024.116636_bib25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00441-017-2667-z","article-title":"MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility","volume":"370","author":"Procopio","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ecoenv.2024.116636_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molimm.2013.11.003","article-title":"Jellyfish collagen stimulates production of TNF-alpha and IL-6 by J774.1 cells through activation of NF-kappaB and JNK via TLR4 signaling pathway","volume":"58","author":"Putra","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib27","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.4049\/jimmunol.177.10.7122","article-title":"Sertoli cells initiate testicular innate immune responses through TLR activation","volume":"177","author":"Riccioli","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116636_bib28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00296-013-2754-8","article-title":"The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis","volume":"34","author":"Santini","year":"2014","journal-title":"Rheuma Int"},{"key":"10.1016\/j.ecoenv.2024.116636_bib29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/COPD.S128031","article-title":"Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD","volume":"12","author":"Shen","year":"2017","journal-title":"Int J. Chron. Obstruct Pulmon Dis."},{"key":"10.1016\/j.ecoenv.2024.116636_bib30","first-page":"766","article-title":"Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells. Biol Reprod","volume":"79","author":"Starace","year":"2008"},{"key":"10.1016\/j.ecoenv.2024.116636_bib31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2174\/1389557516666160219130553","article-title":"New insights on the mode of action of microcystins in animal cells - a review","volume":"16","author":"Valerio","year":"2016","journal-title":"Mini Rev. Med Chem."},{"key":"10.1016\/j.ecoenv.2024.116636_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.theriogenology.2019.07.007","article-title":"Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway","volume":"138","author":"Wang","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2024.116636_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1753425909354764","article-title":"Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides","volume":"17","author":"Winnall","year":"2011","journal-title":"Innate Immun."},{"key":"10.1016\/j.ecoenv.2024.116636_bib34","article-title":"Altered molecular expression of the TLR4\/NF-kappaB signaling pathway in mammary tissue of Chinese Holstein cattle with mastitis","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.116636_bib35","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1210\/en.2007-1776","article-title":"Expression patterns and functions of toll-like receptors in mouse sertoli cells","volume":"149","author":"Wu","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2024.116636_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2009.01.035","article-title":"Involvement of Fas\/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins","volume":"54","author":"Xiong","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2024.116636_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1620\/tjem.224.235","article-title":"A cyanobacterial toxin, microcystin-LR, induces apoptosis of sertoli cells by changing the expression levels of apoptosis-related proteins","volume":"224","author":"Zhang","year":"2011","journal-title":"Tohoku J. Exp. Med"},{"key":"10.1016\/j.ecoenv.2024.116636_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.05.008","article-title":"Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity","volume":"287","author":"Zhou","year":"2015","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2024.116636_bib39","first-page":"753","article-title":"[The mechanism of microcystin leucine-arginine (MC-LR)-induced injury of Sertoli cell immune response and biological behavior]","volume":"39","author":"Zhu","year":"2023","journal-title":"Xi Bao Yu Fen. Zi Mian Yi Xue Za Zhi"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T19:16:35Z","timestamp":1720984595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324007127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":39,"alternative-id":["S0147651324007127"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116636","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bta-miR-149\u20133p suppresses inflammatory response in bovine Sertoli cells exposed to microcystin-leucine arginine (MC-LR) through TLR4\/NF-kB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116636"}}