{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:18:50Z","timestamp":1783520330968,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ecoenv.2024.116651","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T02:43:12Z","timestamp":1719888192000},"page":"116651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Assessment of environmental exposure to betamethasone on the reproductive function of female Japanese medaka (Oryzias latipes)"],"prefix":"10.1016","volume":"281","author":[{"given":"Maoliang","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youling","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujia","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116651_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1477-7827-2-62","article-title":"17beta-estradiol induced vitellogenesis is inhibited by cortisol at the post-transcriptional level in Arctic char (Salvelinus alpinus).","volume":"2","author":"Berg","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2023.114332","article-title":"Negative feedback regulation in the hypothalamic-pituitary-interrenal axis of rainbow trout subjected to chronic social stress.","volume":"341","author":"Best","year":"2023","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib3","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/raq.12563","article-title":"Testicular development and spermatogenesis in fish: insights into molecular aspects and regulation of gene expression by different exogenous factors","volume":"13","author":"Bhat","year":"2021","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.ecoenv.2024.116651_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tox.2016.04.005","article-title":"Long-term adverse effects on reproductive function in male rats exposed prenatally to the glucocorticoid betamethasone.","volume":"376","author":"Borges","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.116651_bib5","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1210\/en.2019-00034","article-title":"Transgenerational effects of endocrine-disrupting chemicals on male and female reproduction.","volume":"160","author":"Brehm","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2024.116651_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chemosphere.2015.06.031","article-title":"Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout.","volume":"139","author":"Burkina","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116651_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1095\/biolreprod66.1.106","article-title":"Corticosteroids affect the testicular androgen production in male common carp (Cyprinus carpio L.)","volume":"66","author":"Consten","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2024.116651_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ceb.2018.02.011","article-title":"Post-transcriptional regulation of gene expression and human disease.","volume":"52","author":"Corbett","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13148-021-01153-y","article-title":"Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation","volume":"13","author":"Czamara","year":"2021","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.ecoenv.2024.116651_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1008986522208","article-title":"Vitellogenin as a biomarker of exposure for estrogen or estrogen mimics","volume":"8","author":"Denslow","year":"1999","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2024.116651_bib11","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1021\/acsestwater.1c00059","article-title":"COVID-19 treatment agents: do they pose an environmental risk?","volume":"1","author":"Desgens-Martin","year":"2021","journal-title":"ACS EST Water"},{"key":"10.1016\/j.ecoenv.2024.116651_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105372","article-title":"Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish","volume":"218","author":"Faltermann","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.seppur.2018.11.018","article-title":"Rejection of pharmaceutical compounds from surface water by nanofiltration and reverse osmosis","volume":"212","author":"Foureaux","year":"2019","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107163","article-title":"Are synthetic glucocorticoids in the aquatic environment a risk to fish?","volume":"162","author":"Hamilton","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116651_bib15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1289\/ehp.1002555","article-title":"The consequences of feminization in breeding groups of wild fish","volume":"119","author":"Harris","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116651_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.theriogenology.2019.05.021","article-title":"Metabolic hormones and the regulation of spermatogenesis in fishes.","volume":"134","author":"Hatef","year":"2019","journal-title":"Theriogenology"},{"issue":"21","key":"10.1016\/j.ecoenv.2024.116651_bib17","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1007\/s00018-020-03532-9","article-title":"Activation of stress response axis as a key process in environment-induced sex plasticity in fish","volume":"77","author":"Hattori","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2024.116651_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ecoenv.2016.11.024","article-title":"Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations","volume":"138","author":"Hidasi","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116651_bib19","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/dvdy.23860","article-title":"Developmental tracing of luteinizing hormone \u03b2-subunit gene expression using green fluorescent protein transgenic medaka (Oryzias latipes) reveals a putative novel developmental function","volume":"241","author":"Hildahl","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2024.116651_bib20","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1038\/s41598-019-45373-y","article-title":"Gene knockout analysis reveals essentiality of estrogen receptor \u03b21 (Esr2a) for female reproduction in medaka","volume":"9","author":"Kayo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2024.116651_bib21","first-page":"1","article-title":"Determination of gender and sexual maturity stages of reared Great sturgeon (Huso huso) using blood plasma sex steroid ratios","volume":"19","author":"Kazemi","year":"2020","journal-title":"Iran. J. Fish. Sci."},{"issue":"3-5","key":"10.1016\/j.ecoenv.2024.116651_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jsbmb.2011.03.013","article-title":"Ovarian steroidogenesis and the role of sex steroid hormones on ovarian growth and maturation of the Japanese eel.","volume":"127","author":"Kazeto","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2022.107161","article-title":"Gonad recrudescence and annual sex steroid patterns in female goldspot mullet, Liza parsia reared in brackishwater pond","volume":"248","author":"Kumar","year":"2023","journal-title":"Anim. Reprod. Sci."},{"issue":"1-2","key":"10.1016\/j.ecoenv.2024.116651_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mce.2012.11.005","article-title":"Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics","volume":"371","author":"Lalli","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib25","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1158\/1078-0432.CCR-10-1113","article-title":"Expression of receptors for luteinizing hormone-releasing hormone (LH-RH) in prostate cancers following therapy with LH-RH agonists","volume":"16","author":"Liu","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ecoenv.2024.116651_bib26","doi-asserted-by":"crossref","first-page":"12902","DOI":"10.1021\/es502711c","article-title":"Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish","volume":"48","author":"Macikova","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/fishes4040052","article-title":"Changes in sex steroids and ovarian steroidogenic enzyme mRNA levels in artificially maturing Japanese eel (Anguilla japonica) and naturally maturing New Zealand longfin eel (Anguilla dieffenbachii) during vitellogenesis.","volume":"4","author":"Matsubara","year":"2019","journal-title":"Fishes"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116651_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1210\/en.2016-1340","article-title":"The steroidogenic acute regulatory protein (StAR) is regulated by the H19\/let-7 axis","volume":"158","author":"Men","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2024.116651_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cbpa.2009.02.027","article-title":"Corticosteroids: friends or foes of teleost fish reproduction?","volume":"153","author":"Milla","year":"2009","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41398-022-01828-x","article-title":"No long-term effects of antenatal synthetic glucocorticoid exposure on epigenetic regulation of stress-related genes","volume":"12","author":"M\u00fcller","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ecoenv.2024.116651_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1440-169X.2008.01019.x","article-title":"Regulation of oocyte maturation in fish","volume":"50","author":"Nagahama","year":"2008","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ecoenv.2024.116651_bib32","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/etc.3136","article-title":"Occurrence of glucocorticoids discharged from a sewage treatment plant in Japan and the effects of clobetasol propionate exposure on the immune responses of common carp (Cyprinus carpio) to bacterial infection","volume":"35","author":"Nakayama","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2024.116651_bib33","unstructured":"NIH. 2021. Drug record: corticosteroids. U.S. Department of Health & Human Services, Last Update 5\/7\/2021 Accessed 4\/21\/2022. \u3008https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548400\/\u3009."},{"key":"10.1016\/j.ecoenv.2024.116651_bib34","unstructured":"OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems. Test Guidelines No. 240: Medaka Extended One Generation Reproduction Test (MEOGRT) Organization for Economic Co-operation and Development (OECD): Paris, France; 2023."},{"key":"10.1016\/j.ecoenv.2024.116651_bib35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/annonc\/mdg290","article-title":"Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer","volume":"14","author":"Piccart","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib36","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1080\/07420528.2018.1498098","article-title":"Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis.","volume":"35","author":"Rao","year":"2018","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.ecoenv.2024.116651_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.112996","article-title":"A LC-MS\/MS method for the quantification of caffeine, betamethasone, clonidine and furosemide in cerebrospinal fluid of preterm infants","volume":"179","author":"Romantsik","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ecoenv.2024.116651_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141011","article-title":"Occurrence and risk assessment of pharmaceutically active compounds in water supply systems in Brazil","volume":"746","author":"Santos","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116651_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jmor.1052180209","article-title":"Stages of oocyte development in the zebrafish, BrachyDanio rerio","volume":"218","author":"Selman","year":"1993","journal-title":"J. Morphol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1525-1373.2000.22401.x","article-title":"Activity of environmentally relevant low doses of endocrine disruptors and the bisphenol A controversy: initial results confirmed","volume":"224","author":"Sheehan","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ecoenv.2024.116651_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105278","article-title":"Determination and occurrence of natural and synthetic glucocorticoids in surface waters","volume":"134","author":"Shen","year":"2020","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116651_bib42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10695-022-01061-9","article-title":"Chronic exposure to aquacultural stressors affects pituitary-testis axis in the Mozambique tilapia Oreochromis mossambicus","volume":"48","author":"Shinde","year":"2022","journal-title":"Fish. Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2024.116651_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131493","article-title":"Reproductive endocrine disruption and gonadal intersex induction in male Japanese medaka chronically exposed to betamethasone at environmentally relevant levels","volume":"455","author":"Su","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116651_bib44","article-title":"Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination.","volume":"582","author":"Torres-Mart\u00ednez","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jchromb.2004.12.006","article-title":"Detection of synthetic glucocorticoid residues in cattle tissue and hair samples after a single dose administration using LC-MS\/MS","volume":"817","author":"Van den","year":"2005","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ecoenv.2024.116651_bib46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2024.116651_bib47","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1021\/acs.est.6b02211","article-title":"Equol induces gonadal intersex in Japanese medaka (Oryzias latipes) at environmentally relevant concentrations: comparison with 17\u03b2-estradiol.","volume":"50","author":"Wang","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib48","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1289\/ehp.5494","article-title":"Large effects from small exposures: I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity","volume":"111","author":"Welshons","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116651_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.scitotenv.2019.03.426","article-title":"Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos","volume":"672","author":"Willi","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116651_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jhazmat.2019.04.023","article-title":"Glucocorticoid mixtures of fluticasone propionate, triamcinolone acetonide and clobetasol propionate induce additive effects in zebrafish embryos","volume":"374","author":"Willi","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.116651_bib51","article-title":"Occurrence, distribution, and environmental risk of 61 glucocorticoids in surface water of the Yellow River Delta, China","volume":"906","author":"Xiang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116651_bib52","doi-asserted-by":"crossref","first-page":"12202","DOI":"10.1021\/acs.est.0c03982","article-title":"Machine learning models for estrogen receptor bioactivity and endocrine disruption prediction","volume":"54","author":"Zorn","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2024.116651_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116665","article-title":"Metabolomics reveals the reproductive abnormality in female zebrafish exposed to environmentally relevant levels of climbazole.","volume":"275","author":"Zou","year":"2021","journal-title":"Environ. Pollut."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T23:18:10Z","timestamp":1720999090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324007279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":53,"alternative-id":["S0147651324007279"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116651","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of environmental exposure to betamethasone on the reproductive function of female Japanese medaka (Oryzias latipes)","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116651","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116651"}}