{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:25:47Z","timestamp":1787934347325,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017590","name":"Hubei University of Science and Technology","doi-asserted-by":"publisher","award":["2020-21\\u00D729"],"award-info":[{"award-number":["2020-21\\u00D729"]}],"id":[{"id":"10.13039\/501100017590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ecoenv.2024.116674","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T18:39:52Z","timestamp":1720031992000},"page":"116674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1\/2-FOS pathway"],"prefix":"10.1016","volume":"281","author":[{"given":"Zhenkun","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116674_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejphar.2016.02.062","article-title":"Astaxanthin ameliorates aluminum chloride-induced spatial memory impairment and neuronal oxidative stress in mice","volume":"777","author":"Al-Amin","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116674_bib2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.chemosphere.2011.02.078","article-title":"Novel\" brominated flame retardants in Belgian and UK indoor dust: implications for human exposure","volume":"83","author":"Ali","year":"2011","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116674_bib3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.biochi.2003.09.006","article-title":"A role for AP-1 in apoptosis: the case for and against","volume":"85","author":"Ameyar","year":"2003","journal-title":"Biochimie"},{"issue":"21","key":"10.1016\/j.ecoenv.2024.116674_bib4","doi-asserted-by":"crossref","first-page":"7167","DOI":"10.3390\/molecules27217167","article-title":"The role of astaxanthin as a nutraceutical in health and age-related conditions","volume":"27","author":"Bj\u00f8rklund","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116674_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ecoenv.2024.116674_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.envint.2017.08.008","article-title":"Legacy and alternative halogenated flame retardants in human milk in Europe: implications for children's health","volume":"108","author":"\u010cechov\u00e1","year":"2017","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116674_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10571-014-0132-z","article-title":"Up-regulation of c-Fos associated with neuronal apoptosis following intracerebral hemorrhage","volume":"35","author":"Chen","year":"2015","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2024.116674_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105479","article-title":"Therapeutic uses of natural astaxanthin: an evidence-based review focused on human clinical trials","volume":"166","author":"Donoso","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ecoenv.2024.116674_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2018.08.012","article-title":"Astaxanthin: a mechanistic review on its biological activities and health benefits","volume":"136","author":"Fakhri","year":"2018","journal-title":"Pharmaocol. Res."},{"issue":"14","key":"10.1016\/j.ecoenv.2024.116674_bib10","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.3390\/molecules24142640","article-title":"The Neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective","volume":"24","author":"Fakhri","year":"2019","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116674_bib11","first-page":"114","article-title":"Effects of minocycline on learning and memory of mice following ischemic-hypoxic cerebral injuries","volume":"7","author":"Fan","year":"2012","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ecoenv.2024.116674_bib12","article-title":"RRx-001 exerts neuroprotection against LPS-induced microglia activation and neuroinflammation through disturbing the TLR4 pathway","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116674_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119356","article-title":"Mechanisms of ERK phosphorylation triggered via mouse formyl peptide receptor 2","volume":"1869","author":"Filina","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116674_bib14","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s41467-020-14762-7","article-title":"Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery","volume":"11","author":"Forbes","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116674_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/acs.est.3c07129","article-title":"Integrated studies on male reproductive toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo","volume":"58","author":"Fu","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2024.116674_bib16","article-title":"Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region","volume":"254","author":"Guo","year":"2019","journal-title":"Environ. Pollut."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116674_bib17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-020-0255-7","article-title":"ERK signalling: a master regulator of cell behaviour, life and fate. Nature reviews","volume":"21","author":"Lavoie","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.116674_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.133970","article-title":"Distribution characteristics and risks assessment of brominated flame retardants in surface soil from both a legacy and a new e-waste dismantling site","volume":"373","author":"Ling","year":"2022","journal-title":"J. Clean. Prod."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2024.116674_bib19","article-title":"Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: evidences from in vitro and in vivo studies","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116674_bib20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4103\/1673-5374.300460","article-title":"Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins","volume":"16","author":"Liu","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ecoenv.2024.116674_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainresbull.2019.03.009","article-title":"Neuroprotective effect of astaxanthin on newborn rats exposed to prenatal maternal seizures","volume":"148","author":"Lu","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116674_bib22","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/etc.4180","article-title":"Bioaccumulation and effects of dietary exposure to the alternative flame retardant, bis(2-ethylhexyl) tetrabromophthalate (TBPH), in the Atlantic killifish, Fundulus heteroclitus","volume":"37","author":"Nacci","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116674_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3892\/mmr.2022.12816","article-title":"Biological and neurological activities of astaxanthin (Review)","volume":"26","author":"Si","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116674_bib24","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3892\/ijmm.2017.2962","article-title":"The extracellular signal-regulated kinase 1\/2 pathway in neurological diseases: a potential therapeutic target","volume":"39","author":"Sun","year":"2017","journal-title":"Int. J. Mol. Med"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116674_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.ecoenv.2024.116674_bib26","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.3390\/ijms20194844","article-title":"Mitogen-activated protein kinases: functions in signal transduction and human diseases","volume":"20","author":"Tikkanen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116674_bib27","article-title":"The neuroprotective effects of carvacrol on ethanol-induced hippocampal neurons impairment via the antioxidative and antiapoptotic pathways","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ecoenv.2024.116674_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2010.08.100","article-title":"Astaxanthin upregulates heme oxygenase-1 expression through ERK1\/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells","volume":"1360","author":"Wang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ecoenv.2024.116674_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172411","article-title":"Prenatal co-exposure to diisodecyl phthalate and ozone contribute to depressive behavior in offspring mice through oxidative stress and TWIST1 participation","volume":"928","author":"Xie","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"7844)","key":"10.1016\/j.ecoenv.2024.116674_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-020-3031-0","article-title":"Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network","volume":"590","author":"Yap","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116674_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/mnfr.201500634","article-title":"Astaxanthin supplementation enhances adult hippocampal neurogenesis and spatial memory in mice","volume":"60","author":"Yook","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"Pt 3","key":"10.1016\/j.ecoenv.2024.116674_bib32","article-title":"Metabolomic analysis and oxidative stress response reveals the toxicity in Escherichia coli induced by organophosphate flame retardants tris(2-chloroethyl) phosphate and triphenyl phosphate","volume":"291","author":"Yu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116674_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2022.114887","article-title":"Metabolic perturbations in human hepatocytes induced by bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate exposure: insights from high-coverage quantitative metabolomics","volume":"657","author":"Zhang","year":"2022","journal-title":"Anal. Biochem."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116674_bib34","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/bph.15346","article-title":"Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1\/NRF2\/Prx2\/ASK1\/p38 after traumatic brain injury in mice","volume":"178","author":"Zhang","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116674_bib35","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41401-019-0314-9","article-title":"Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK\/Bim pathway","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ecoenv.2024.116674_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174575","article-title":"Astaxanthin alleviates neuropathic pain by inhibiting the MAPKs and NF-\u03baB pathways","volume":"912","author":"Zhao","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"24","key":"10.1016\/j.ecoenv.2024.116674_bib37","doi-asserted-by":"crossref","first-page":"12381","DOI":"10.1039\/D1FO02326H","article-title":"Astaxanthin alleviates inflammatory pain by regulating the p38 mitogen-activated protein kinase and nuclear factor-erythroid factor 2-related factor\/heme oxygenase-1 pathways in mice","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2024.116674_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.02.006","article-title":"Flame retardants and organochlorines in indoor dust from several e-waste recycling sites in South China: composition variations and implications for human exposure","volume":"78","author":"Zheng","year":"2015","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116674_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118127","article-title":"Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition","volume":"290","author":"Zhou","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116674_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171133","article-title":"Aggravated visual toxicity in zebrafish larvae upon co-exposure to titanium dioxide nanoparticles and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate","volume":"921","author":"Zhou","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116674_bib41","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/acs.est.4c00421","article-title":"Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate enhances foxo1-mediated lipophagy to remodel lipid metabolism in Zebrafish liver","volume":"58","author":"Zhou","year":"2024","journal-title":"Environ. Sci. Technol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:05:03Z","timestamp":1777489503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324007504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"alternative-id":["S0147651324007504"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116674","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1\/2-FOS pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116674"}}