{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:42:03Z","timestamp":1784547723314,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ecoenv.2024.116686","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T02:34:21Z","timestamp":1720146861000},"page":"116686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The critical role of SETDB1-mediated CCND1\/PI3K\/AKT pathway via p53-RS di-methylation at K370 in the proliferation of WRL68 cells induced by nicotine"],"prefix":"10.1016","volume":"282","author":[{"given":"Zihan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ecoenv.2024.116686_bib1","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.3892\/mmr.2014.2456","article-title":"Expression and significance of Pin1, \u03b2-catenin and cyclin D1 in hepatocellular carcinoma","volume":"10","author":"Ao","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"2-3","key":"10.1016\/j.ecoenv.2024.116686_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2008.04.023","article-title":"Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein","volume":"588","author":"Bandyopadhyaya","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"20","key":"10.1016\/j.ecoenv.2024.116686_bib3","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1056\/NEJM198811173192005","article-title":"Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addiction","volume":"319","author":"Benowitz","year":"1988","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116686_bib4","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41401-018-0205-5","article-title":"Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells","volume":"40","author":"Cao","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116686_bib5","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.3390\/cancers14112798","article-title":"Emerging therapies for hepatocellular carcinoma (HCC)","volume":"14","author":"Chakraborty","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"27","key":"10.1016\/j.ecoenv.2024.116686_bib6","doi-asserted-by":"crossref","first-page":"41306","DOI":"10.18632\/oncotarget.9320","article-title":"microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K\/AKT pathway","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ecoenv.2024.116686_bib7","doi-asserted-by":"crossref","first-page":"8651","DOI":"10.1038\/ncomms9651","article-title":"Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53","volume":"6","author":"Fei","year":"2015","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116686_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/v12060596","article-title":"SETDB1-mediated silencing of retroelements","volume":"12","author":"Fukuda","year":"2020","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116686_bib9","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.5897\/AJB11.141","article-title":"Role of green tea on nicotine toxicity on liver and lung of mice: histological and morphometrical studies","volume":"11","author":"Gawish","year":"2012","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.ecoenv.2024.116686_bib10","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3892\/ijo.2014.2320","article-title":"Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro","volume":"44","author":"Gong","year":"2014","journal-title":"Int J. Oncol."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116686_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrc3725","article-title":"Connections of nicotine to cancer","volume":"14","author":"Grando","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116686_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF02634356","article-title":"Expression of some hepatocyte-like functional properties of WRL-68 cells in culture","author":"Guti\u00e9rrez-Ruiz","year":"1994","journal-title":"Vitr. Cell Dev. Biol. Anim. 30A"},{"key":"10.1016\/j.ecoenv.2024.116686_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169604","article-title":"The role of \u03b17-nAChR-mediated PI3K\/AKT pathway in lung cancer induced by nicotine","volume":"912","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"7158","key":"10.1016\/j.ecoenv.2024.116686_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature06092","article-title":"p53 is regulated by the lysine demethylase LSD1","volume":"449","author":"Huang","year":"2007","journal-title":"Nature"},{"issue":"3-4","key":"10.1016\/j.ecoenv.2024.116686_bib15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbrc.2017.10.116","article-title":"Overexpression of eEF1A1 regulates G1-phase progression to promote HCC proliferation through the STAT1-cyclin D1 pathway","volume":"494","author":"Huang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41420-020-00400-0","article-title":"Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis","volume":"7","author":"Ishiguro","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2024.116686_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5905357","article-title":"Tobacco smoking and liver cancer risk: potential avenues for carcinogenesis","volume":"2021","author":"Jain","year":"2021","journal-title":"J. Oncol."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116686_bib18","first-page":"1803","article-title":"SETDB1 in cancer: overexpression and its therapeutic implications","volume":"11","author":"Lazaro-Camp","year":"2021","journal-title":"Am. J. Cancer Res."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116686_bib19","doi-asserted-by":"crossref","first-page":"11959","DOI":"10.1007\/s13277-014-2489-5","article-title":"Genetic association between cyclin D1 polymorphism and breast cancer susceptibility","volume":"35","author":"Li","year":"2014","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3892\/or.2015.4362","article-title":"Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway","volume":"35","author":"Li","year":"2016","journal-title":"Oncol. Rep."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116686_bib21","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/jcm8091391","article-title":"Smoking as an independent risk factor for hepatocellular carcinoma due to the \u03b17-Nachr modulating the JAK2\/STAT3 signaling axis","volume":"8","author":"Li","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ecoenv.2024.116686_bib22","article-title":"The natural compound dehydrocrenatidine attenuates nicotine-induced stemness and epithelial-mesenchymal transition in hepatocellular carcinoma by regulating a7nAChR-Jak2 signaling pathways","volume":"2022","author":"Li","year":"2022","journal-title":"Dis. Markers"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jhep.2022.01.016","article-title":"Cigarette smoking and liver diseases","volume":"77","author":"Marti-Aguado","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/0971-5851.151771","article-title":"Harmful effects of nicotine","volume":"36","author":"Mishra","year":"2015","journal-title":"Indian J. Med. Paediatr. Oncol."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116686_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrc2012","article-title":"Regulating the p53 pathway: in vitro hypotheses, in vivo veritas","volume":"6","author":"oledo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116686_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/carcin\/21.4.701","article-title":"Arsenite induces DNA-protein crosslinks and cytokeratin expression in the WRL-68 human hepatic cell line","volume":"21","author":"Ram\u00edrez","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ecoenv.2024.116686_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10311-023-01668-1","article-title":"Carcinogenicity of nicotine and signal pathways in cancer progression: a review","volume":"22","author":"Rao","year":"2024","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.ecoenv.2024.116686_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1541-7786.MCR-13-0541","article-title":"Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers","volume":"12","author":"Schaal","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ecoenv.2024.116686_bib29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrc3725","article-title":"Connections of nicotine to cancer","volume":"14","author":"Sergei","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116686_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.taap.2008.08.012","article-title":"Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways","volume":"233","author":"Shin","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2024.116686_bib31","article-title":"Clinical biochemistry of hepatotoxicity","author":"Singh","year":"2011","journal-title":"J. Clin. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116686_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2024.116686_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.toxlet.2021.06.013","article-title":"Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-\u03baB, and AhR","volume":"349","author":"Ung","year":"2021","journal-title":"Toxicol. Lett."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116686_bib34","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1021\/acs.chemrestox.0c00119","article-title":"Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway","volume":"33","author":"Wang","year":"2020","journal-title":"Chem. Res Toxicol."},{"issue":"3-4","key":"10.1016\/j.ecoenv.2024.116686_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000516598","article-title":"p53 mutation at serine 249 and its gain of function are highly related to hepatocellular carcinoma after smoking exposure","volume":"24","author":"Wang","year":"2021","journal-title":"Public Health Genom."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116686_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/jmcb\/mjy086","article-title":"It takes a team: a gain-of-function story of p53-R249S","volume":"11","author":"Wang","year":"2019","journal-title":"J. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116686_bib37","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.28304","article-title":"Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis","volume":"63","author":"Wong","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.onc.1209763","article-title":"5-Aza-2\u2032-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation","volume":"26","author":"Wozniak","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ecoenv.2024.116686_bib39","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.2147\/CMAR.S263590","article-title":"Ultrasound-targeted microbubble destruction mediated si-CyclinD1 inhibits the development of hepatocellular carcinoma via suppression of PI3K\/AKT signaling pathway","volume":"12","author":"Yan","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116686_bib40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.toxicon.2004.01.017","article-title":"Nicotine, its metabolism and an overview of its biological effects","volume":"43","author":"Yildiz","year":"2004","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116686_bib41","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/carcin\/bgz131","article-title":"Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1\/CDK6 axis","volume":"41","author":"Yu","year":"2020","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116686_bib42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s12885-018-4464-9","article-title":"Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting with Tiam1 in hepatocellular carcinoma","volume":"18","author":"Zhang","year":"2018","journal-title":"BMC Cancer"},{"issue":"130","key":"10.1016\/j.ecoenv.2024.116686_bib43","first-page":"19","article-title":"STAT1 in cancer: friend or foe?","volume":"24","author":"Zhang","year":"2017","journal-title":"Discov. Med."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324007620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T01:03:12Z","timestamp":1723510992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324007620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":43,"alternative-id":["S0147651324007620"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116686","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The critical role of SETDB1-mediated CCND1\/PI3K\/AKT pathway via p53-RS di-methylation at K370 in the proliferation of WRL68 cells induced by nicotine","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116686"}}