{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:15:02Z","timestamp":1786536902837,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903334"],"award-info":[{"award-number":["81903334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ecoenv.2024.116861","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T14:06:44Z","timestamp":1723471604000},"page":"116861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Prenatal ozone exposure and variations of the gut microbiome: Evidence from a Chinese mother-infant cohort"],"prefix":"10.1016","volume":"283","author":[{"given":"Qingbo","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlai","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116861_bib1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bbi.2019.05.035","article-title":"Gut microbiota composition is associated with temperament traits in infants","volume":"80","author":"Aatsinki","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ecoenv.2024.116861_bib2","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/alz.12471","article-title":"Recently decreased association of air pollution with cognitive impairment in a population-based aging cohort and in a mouse model","volume":"18","author":"Ailshire","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ecoenv.2024.116861_bib3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","article-title":"Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life","volume":"17","author":"B\u00e4ckhed","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ecoenv.2024.116861_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2105096","article-title":"Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age","volume":"14","author":"Bailey","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ecoenv.2024.116861_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108248","article-title":"Oxidative stress and inflammation induced by air pollution-derived PM(2.5) persist in the lungs of mice after cessation of their sub-chronic exposure.","volume":"181","author":"Barbier","year":"2023","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116861_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.chom.2023.01.009","article-title":"Gut microbiome lipid metabolism and its impact on host physiology","volume":"31","author":"Brown","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ecoenv.2024.116861_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116304","article-title":"Does PM(1) exposure during pregnancy impact the gut microbiota of mothers and neonates?","volume":"231","author":"Cao","year":"2023","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2024.116861_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric., Biol., Environ. Stat."},{"key":"10.1016\/j.ecoenv.2024.116861_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbi.2022.08.015","article-title":"Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism","volume":"106","author":"Chen","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ecoenv.2024.116861_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1038876","article-title":"The associations of maternal and children's gut microbiota with the development of atopic dermatitis for children aged 2 years","volume":"13","author":"Fan","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2024.116861_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jpsychires.2023.06.034","article-title":"Inflammatory cytokines and prenatal depression: Is there a mediating role of maternal gut microbiota?","volume":"164","author":"Fang","year":"2023","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.ecoenv.2024.116861_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111165","article-title":"Exposure to ambient air pollution during pregnancy and inflammatory biomarkers in maternal and umbilical cord blood: The Healthy Start study","volume":"197","author":"Friedman","year":"2021","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2024.116861_bib13","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1053\/j.gastro.2020.01.024","article-title":"Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood","volume":"158","author":"Galazzo","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2024.116861_bib14","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1289\/EHP212","article-title":"Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress","volume":"124","author":"Haberzettl","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2024.116861_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1475-6773.2009.01044.x","article-title":"Spatial implications associated with using Euclidean distance measurements and geographic centroid imputation in health care research","volume":"45","author":"Jones","year":"2010","journal-title":"Health Serv. Res"},{"key":"10.1016\/j.ecoenv.2024.116861_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2022.114047","article-title":"The mediating role of the gut microbiome in the association between ambient air pollution and autistic traits","volume":"246","author":"Kim","year":"2022","journal-title":"Int J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2024.116861_bib17","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1053\/j.gastro.2022.07.004","article-title":"Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease","volume":"163","author":"Leibovitzh","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2024.116861_bib18","doi-asserted-by":"crossref","first-page":"e958","DOI":"10.1016\/S2542-5196(22)00260-1","article-title":"Global trends in ozone concentration and attributable mortality for urban, peri-urban, and rural areas between 2000 and 2019: a modelling study","volume":"6","author":"Malashock","year":"2022","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.ecoenv.2024.116861_bib19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jaci.2015.12.1309","article-title":"Preterm birth and air pollution: Critical windows of exposure for women with asthma","volume":"138","author":"Mendola","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116861_bib20","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1053\/j.gastro.2017.09.055","article-title":"The Fragility of Probiotic Bifidobacterium longum NCC3001 Use for Depression in Patients With Irritable Bowel Syndrome","volume":"154","author":"Meyer","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2024.116861_bib21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2019.01.011","article-title":"Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors","volume":"25","author":"Moossavi","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ecoenv.2024.116861_bib22","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/s41467-018-04641-7","article-title":"Individuality and convergence of the infant gut microbiota during the first year of life","volume":"9","author":"de Muinck","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2024.116861_bib23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.apsb.2022.12.010","article-title":"Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota","volume":"13","author":"Pan","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ecoenv.2024.116861_bib24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamapediatrics.2017.0378","article-title":"Association between breast milk bacterial communities and establishment and development of the infant gut microbiome","volume":"171","author":"Pannaraj","year":"2017","journal-title":"JAMA Pedia"},{"key":"10.1016\/j.ecoenv.2024.116861_bib25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.gastro.2017.05.003","article-title":"Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome","volume":"153","author":"Pinto-Sanchez","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2024.116861_bib26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41588-021-00991-z","article-title":"Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort","volume":"54","author":"Qin","year":"2022","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ecoenv.2024.116861_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122389","article-title":"Cumulative and lagged effects of varying-sized particulate matter exposure associates with toddlers' gut microbiota","volume":"336","author":"Qiu","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.116861_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/s00787-024-02445-3","article-title":"Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia","author":"Qiu","year":"2024","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.ecoenv.2024.116861_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1053\/j.gastro.2020.08.065","article-title":"Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development","volume":"160","author":"Ronan","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2024.116861_bib30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.chom.2021.02.021","article-title":"Developmental trajectory of the healthy human gut microbiota during the first 5 years of life","volume":"29","author":"Roswall","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ecoenv.2024.116861_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238923","article-title":"Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol","volume":"15","author":"Terada-Ikeda","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.116861_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162769","article-title":"Ambient particulate air pollution and the intestinal microbiome; a systematic review of epidemiological, in vivo and, in vitro studies","volume":"878","author":"Van Pee","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116861_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13073-021-01007-5","article-title":"Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease","volume":"13","author":"Walker","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.ecoenv.2024.116861_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126750","article-title":"Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study","volume":"421","author":"Wang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2024.116861_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7110511","article-title":"The Effect of Maternal Postpartum Practices on Infant Gut Microbiota: A Chinese Cohort Study","volume":"7","author":"Wang","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2024.116861_bib36","article-title":"Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota","volume":"11","author":"Wang","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2024.116861_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106290","article-title":"The ChinaHighPM(10) dataset: generation, validation, and spatiotemporal variations from 2015 to 2019 across China.","volume":"146","author":"Wei","year":"2021","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116861_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.rse.2020.112136","article-title":"Reconstructing 1-km-resolution high-quality PM2.5 data records from 2000 to 2018 in China: spatiotemporal variations and policy implications","volume":"252","author":"Wei","year":"2021","journal-title":"Remote Sens. Environ."},{"key":"10.1016\/j.ecoenv.2024.116861_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.rse.2021.112775","article-title":"Full-coverage mapping and spatiotemporal variations of ground-level ozone (O3) pollution from 2013 to 2020 across China","volume":"270","author":"Wei","year":"2022","journal-title":"Remote Sens. Environ."},{"key":"10.1016\/j.ecoenv.2024.116861_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107216","article-title":"Association between residential greenness and gut microbiota in Chinese adults","volume":"163","author":"Wu","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2024.116861_bib41","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/gutjnl-2022-328970","article-title":"Microbial transmission, colonisation and succession: from pregnancy to infancy","volume":"72","author":"Xiao","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2024.116861_bib42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1099800420975129","article-title":"Environmental Tobacco Smoke Exposure and Breastfeeding Duration Influence the Composition and Dynamics of Gut Microbiota in Young Children Aged 0-2 Years","volume":"23","author":"Xie","year":"2021","journal-title":"Biol. Res Nurs."},{"key":"10.1016\/j.ecoenv.2024.116861_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2024.116861_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132945","article-title":"Individual ambient ozone exposure during pregnancy and adverse birth outcomes: Exploration of the potentially vulnerable windows","volume":"464","author":"Zhang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2024.116861_bib45","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1002\/jmv.27047","article-title":"The association between short-term exposure to air pollutants and rotavirus infection in Wuhan, China","volume":"93","author":"Zhang","year":"2021","journal-title":"J. Med Virol."},{"key":"10.1016\/j.ecoenv.2024.116861_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131539","article-title":"Ambient PM(2.5), ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005-2018)","volume":"454","author":"Zhang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2024.116861_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132562","article-title":"The adverse impact of maternal ozone exposure on fetal growth in utero and the interaction with residential greenness","volume":"461","author":"Zhu","year":"2024","journal-title":"J. Hazard Mater."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T08:51:42Z","timestamp":1726303902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324009370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"alternative-id":["S0147651324009370"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116861","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal ozone exposure and variations of the gut microbiome: Evidence from a Chinese mother-infant cohort","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116861"}}