{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:45:11Z","timestamp":1773326711069,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ecoenv.2024.116871","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T10:02:08Z","timestamp":1723716128000},"page":"116871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system"],"prefix":"10.1016","volume":"284","author":[{"given":"Yueyao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banghan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ecoenv.2024.116871_bib1","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1073\/pnas.1914742117","article-title":"Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes","volume":"117","author":"Al Mamun","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"20","key":"10.1016\/j.ecoenv.2024.116871_bib2","doi-asserted-by":"crossref","first-page":"24815","DOI":"10.1007\/s11356-020-09042-2","article-title":"Ambient air pollution and its influence on human health and welfare: an overview","volume":"27","author":"Almetwally","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2024.116871_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2023.05.012","article-title":"Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport","volume":"375","author":"An","year":"2023","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116871_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/joim.13467","article-title":"Ambient air pollution and cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses","volume":"291","author":"de Bont","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ecoenv.2024.116871_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.800756","article-title":"Exploration of lung cancer-related genetic factors via mendelian randomization method based on genomic and transcriptomic summarized data","volume":"9","author":"Cheng","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.116871_bib6","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"Bmj"},{"key":"10.1016\/j.ecoenv.2024.116871_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135558","article-title":"The microplastics menace: an emerging link to environment and health","volume":"707","author":"Dmytriw","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116871_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1183\/09031936.00128712","article-title":"Air pollution and multiple acute respiratory outcomes","volume":"42","author":"Faustini","year":"2013","journal-title":"Eur. Respir. J."},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116871_bib9","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86460","article-title":"Protein methionine oxidation augments reperfusion injury in acute ischemic stroke","volume":"1","author":"Gu","year":"2016","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116871_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12989-023-00558-2","article-title":"Acute and continuous exposure of airborne fine particulate matter (PM(2.5)): diverse outer blood-retinal barrier damages and disease susceptibilities","volume":"20","author":"Gu","year":"2023","journal-title":"Part Fibre Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116871_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12012-017-9399-x","article-title":"In utero exposure of hyperlipidemic mice to diesel exhaust: lack of effects on atherosclerosis in adult offspring fed a regular chow diet","volume":"17","author":"Harrigan","year":"2017","journal-title":"Cardiovasc. Toxicol."},{"issue":"46","key":"10.1016\/j.ecoenv.2024.116871_bib12","doi-asserted-by":"crossref","first-page":"102438","DOI":"10.1007\/s11356-023-29544-z","article-title":"Effect of short-term exposure to air pollution on daily cardio- and cerebrovascular hospitalisations in areas with a low level of air pollution","volume":"30","author":"Hasnain","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"7","key":"10.1016\/j.ecoenv.2024.116871_bib13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/10715760290032601","article-title":"Differences in mRNA expression, protein content, and enzyme activity of superoxide dismutases in type II pneumocytes of acute and chronic lung injury","volume":"36","author":"Hochscheid","year":"2002","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116871_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-069X-12-43","article-title":"Long-term air pollution exposure and cardio- respiratory mortality: a review","volume":"12","author":"Hoek","year":"2013","journal-title":"Environ. Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116871_bib15","article-title":"Inflammatory factors mediated the effect of air pollution on ischemic stroke: a two-step","volume":"28","author":"Huang","year":"2024","journal-title":"Mediat. Mendel. Random Study"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116871_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2023-001236","article-title":"Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study","volume":"11","author":"Hujoel","year":"2024","journal-title":"BMJ Open Gastroenterol."},{"key":"10.1016\/j.ecoenv.2024.116871_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envint.2017.03.014","article-title":"European Union research in support of environment and health: Building scientific evidence base for policy","volume":"103","author":"Karjalainen","year":"2017","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116871_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40572-020-00268-3","article-title":"The impact of environmental factors on 5-hydroxymethylcytosine in the brain","volume":"7","author":"Kochmanski","year":"2020","journal-title":"Curr. Environ. Health Rep."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116871_bib19","doi-asserted-by":"crossref","first-page":"H1417","DOI":"10.1152\/ajpheart.00706.2020","article-title":"Cardiovascular effects of air pollution: current evidence from animal and human studies","volume":"320","author":"Lederer","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116871_bib20","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.chemosphere.2010.11.055","article-title":"Oxidative stress, endothelial dysfunction and inflammatory response in rat heart to NO\u2082 inhalation exposure.","volume":"82","author":"Li","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2024.116871_bib21","article-title":"Causal effects of exposure to ambient air pollution on cancer risk: insights from genetic evidence","volume":"912","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116871_bib22","article-title":"Causal effects of exposure to ambient air pollution on cancer risk: insights from genetic evidence","volume":"912","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116871_bib23","doi-asserted-by":"crossref","unstructured":"Long, Y., Tang, L., Zhou, Y., Zhao, S., Zhu, H.J.B., 2023. Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study. 21(1), 66..","DOI":"10.1186\/s12916-023-02761-6"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116871_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/STROKEAHA.123.044284","article-title":"Genetic susceptibility modifies relationships between air pollutants and stroke risk: a large cohort study","volume":"55","author":"Ma","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.ecoenv.2024.116871_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1294692","article-title":"Role of gut microbiota and inflammatory factors in acute respiratory distress syndrome: a Mendelian randomization analysis","volume":"14","author":"Ma","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2024.116871_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.967047","article-title":"Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases","volume":"11","author":"Mallah","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.ecoenv.2024.116871_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163802","article-title":"Long-term residential exposure to air pollution and risk of chronic respiratory diseases in Italy: the BIGEPI study","volume":"884","author":"Marchetti","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116871_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107041","article-title":"Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals","volume":"159","author":"Melbourne","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116871_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107996","article-title":"The cardiovascular effects of air pollution: prevention and reversal by pharmacological agents","volume":"232","author":"Miller","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116871_bib30","first-page":"279","article-title":"Air pollution and cardiovascular disease: car sick","volume":"116","author":"Miller","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116871_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pulmoe.2021.09.003","article-title":"Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with functional activity and oxidative modification of alpha-1-antitrypsin in COPD patients","volume":"30","author":"Milovanovic","year":"2024","journal-title":"Pulmonology"},{"issue":"59","key":"10.1016\/j.ecoenv.2024.116871_bib32","doi-asserted-by":"crossref","first-page":"123939","DOI":"10.1007\/s11356-023-31047-w","article-title":"Exploring the association between air pollution and Parkinson's disease or Alzheimer's disease: a Mendelian randomization study","volume":"30","author":"Ning","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"10419","key":"10.1016\/j.ecoenv.2024.116871_bib33","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1016\/S0140-6736(23)01859-7","article-title":"The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms","volume":"402","author":"Romanello","year":"2023","journal-title":"Lancet"},{"issue":"9897","key":"10.1016\/j.ecoenv.2024.116871_bib34","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(13)60898-3","article-title":"Global association of air pollution and heart failure: a systematic review and meta-analysis","volume":"382","author":"Shah","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2024.116871_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122623","article-title":"Assessing the effectiveness of artificial neural networks (ANN) and multiple linear regressions (MLR) in forcasting AQI and PM10 and evaluating health impacts through AirQ+ (case study: Tehran)","volume":"338","author":"Shams","year":"2023","journal-title":"Environ. Pollut."},{"issue":"16","key":"10.1016\/j.ecoenv.2024.116871_bib36","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.ecoenv.2024.116871_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1233086","article-title":"Genetic liability for diet-derived circulating antioxidants, oxidative stress, and risk of osteoarthritis: a Mendelian randomization study","volume":"10","author":"Tang","year":"2023","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116871_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116871_bib39","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1016\/S2542-5196(21)00145-5","article-title":"Ambient air pollution and the risk of ischaemic and haemorrhagic stroke","volume":"5","author":"Verhoeven","year":"2021","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.ecoenv.2024.116871_bib40","article-title":"Long-term exposure to ambient air pollution and inflammatory response in the KORA study","volume":"912","author":"Vogli","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116871_bib41","article-title":"Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study","volume":"384","author":"Wei","year":"2024","journal-title":"Bmj"},{"key":"10.1016\/j.ecoenv.2024.116871_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170621","article-title":"The relationship between cooking fuel use and sex hormone levels: a cross-sectional study and Mendelian randomization study","volume":"918","author":"Wu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116871_bib43","doi-asserted-by":"crossref","unstructured":"Xiao, H., Huang, S., Yang, W., Zhang, W., Xiao, H., Cai, S.J.F. i P.H., 2023. Causal association between air pollution and frailty: a Mendelian randomization study. 11, 1288293..","DOI":"10.3389\/fpubh.2023.1288293"},{"issue":"21","key":"10.1016\/j.ecoenv.2024.116871_bib44","doi-asserted-by":"crossref","first-page":"27299","DOI":"10.1007\/s11356-021-12474-z","article-title":"Ambient air pollution and cerebrovascular disease mortality: an ecological time-series study based on 7-year death records in central China","volume":"28","author":"Yan","year":"2021","journal-title":"Environ. Sci. Pollut. Res Int"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116871_bib45","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.0535","article-title":"Early-life exposure to air pollution and childhood asthma cumulative incidence in the ECHO CREW consortium","volume":"7","author":"Zanobetti","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ecoenv.2024.116871_bib46","article-title":"Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis","author":"Zhu","year":"2024","journal-title":"Neurol. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116871_bib47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-019-13870-3","article-title":"Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization","volume":"11","author":"Zuber","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:37:44Z","timestamp":1744072664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324009473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":47,"alternative-id":["S0147651324009473"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116871","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116871","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116871"}}