{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:30:40Z","timestamp":1786987840787,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ecoenv.2024.116906","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T12:10:04Z","timestamp":1724501404000},"page":"116906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Calcitriol alleviates noise-induced hearing loss by regulating the ATF3\/DUSP1 signalling pathway"],"prefix":"10.1016","volume":"284","author":[{"given":"Rui","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkai","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.116906_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ebiom.2018.03.016","article-title":"Apoptosis-Inducing Factor (AIF) in physiology and disease: the tale of a repented natural born killer","volume":"30","author":"Bano","year":"2018","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15252\/emmm.201606230","article-title":"Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy","volume":"9","author":"Benkafadar","year":"2017","journal-title":"Embo Mol. Med."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116906_bib3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/antiox10091351","article-title":"Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea","volume":"10","author":"Berm\u00fadez-Mu\u00f1oz","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib4","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/s41467-020-15221-z","article-title":"Chromatin accessibility promotes hematopoietic and leukemia stem cell activity","volume":"11","author":"Cabal-Hierro","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2024.116906_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.semcancer.2020.05.018","article-title":"An update on vitamin D signaling and cancer","volume":"79","author":"Carlberg","year":"2022","journal-title":"Semin Cancer Biol."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116906_bib6","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.3390\/ijms18112482","article-title":"Vitamin D and Neurological Diseases: An Endocrine View","volume":"18","author":"Carolina","year":"2017","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116906_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39159","article-title":"Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss","volume":"8","author":"Celaya","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ecoenv.2024.116906_bib8","article-title":"mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis","volume":"16","author":"Chen","year":"2022","journal-title":"Front Cell Neurosci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12199-020-00906-0","article-title":"An overview of occupational noise-induced hearing loss among workers: epidemiology, pathogenesis, and preventive measures","volume":"25","author":"Chen","year":"2020","journal-title":"Environ. Health Prev. Med"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s10020-021-00377-1","article-title":"Vitamin D confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism","volume":"27","author":"Cui","year":"2021","journal-title":"Mol. Med."},{"key":"10.1016\/j.ecoenv.2024.116906_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2017.05.035","article-title":"Vitamin D and the brain: Genomic and non-genomic actions","volume":"453","author":"Cui","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"issue":"25","key":"10.1016\/j.ecoenv.2024.116906_bib12","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1056\/NEJMra1616601","article-title":"Hearing Loss in Adults","volume":"377","author":"Cunningham","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ecoenv.2024.116906_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101093","article-title":"Calcitriol inhibits ROS-NLRP3-IL-1\u03b2 signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.","volume":"21","author":"Dai","year":"2019","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116906_bib14","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3390\/nu14061291","article-title":"Rapid Nontranscriptional Effects of Calcifediol and Calcitriol","volume":"14","author":"Donati","year":"2022","journal-title":"Nutrients"},{"issue":"23","key":"10.1016\/j.ecoenv.2024.116906_bib15","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1093\/eurheartj\/ehr459","article-title":"Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress","volume":"33","author":"Dong","year":"2012","journal-title":"Eur. Heart J. Dec."},{"issue":"60","key":"10.1016\/j.ecoenv.2024.116906_bib16","doi-asserted-by":"crossref","first-page":"90230","DOI":"10.1007\/s11356-022-22427-9","article-title":"Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes","volume":"29","author":"Fathi","year":"2022","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2024.116906_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2019.02.022","article-title":"Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling","volume":"135","author":"Fetoni","year":"2019","journal-title":"Free Radic. Biol. Med"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s11658-021-00271-y","article-title":"Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2\/Keap1\/xCT signaling","volume":"26","author":"Fu","year":"2021","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.ecoenv.2024.116906_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104883","article-title":"Calcitriol attenuates the cytotoxicity induced by aluminium phosphide via inhibiting mitochondrial dysfunction and oxidative stress in rat isolated cardiomyocytes - ScienceDirect","volume":"176","author":"Hafez","year":"2021","journal-title":"Pest. Biochem Physiol."},{"issue":"4-6","key":"10.1016\/j.ecoenv.2024.116906_bib20","first-page":"321","article-title":"ATF3 and stress responses","volume":"7","author":"Hai T","year":"1999","journal-title":"Gene Expr."},{"key":"10.1016\/j.ecoenv.2024.116906_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.07.002","article-title":"ATM in DNA repair in cancer","volume":"203","author":"Jin","year":"2019","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.ecoenv.2024.116906_bib22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fncel.2017.00192","article-title":"Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss","volume":"11","author":"Kalinec","year":"2017","journal-title":"Front Cell Neurosci."},{"issue":"13","key":"10.1016\/j.ecoenv.2024.116906_bib23","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.4161\/cc.29018","article-title":"Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth","volume":"13","author":"Koch","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ecoenv.2024.116906_bib24","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fendo.2020.00556","article-title":"Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer","volume":"11","author":"Ku","year":"2020","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2024.116906_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108898","article-title":"Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and \u03b3-H2A.X phosphorylation","volume":"315","author":"Kumar","year":"2020","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2024.116906_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2016.11.013","article-title":"Cellular mechanisms of noise-induced hearing loss","volume":"349","author":"Kurabi","year":"2017","journal-title":"Hear Res."},{"key":"10.1016\/j.ecoenv.2024.116906_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115962","article-title":"Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload","volume":"220","author":"Lin","year":"2024","journal-title":"Biochem Pharm."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116906_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110665","article-title":"Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells","volume":"39","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2024.116906_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.freeradbiomed.2022.07.006","article-title":"A novel function of ATF3 in suppression of ferroptosis in mouse heart suffered ischemia\/reperfusion","volume":"189","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med"},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116906_bib30","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41401-021-00700-w","article-title":"ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron","volume":"42","author":"Lu","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.ecoenv.2024.116906_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108210","article-title":"Calcitriol inhibits apoptosis via activation of autophagy in hyperosmotic stress stimulated corneal epithelial cells in vivo and in vitro","volume":"200","author":"Lyu","year":"2020","journal-title":"Exp. Eye Res"},{"issue":"33","key":"10.1016\/j.ecoenv.2024.116906_bib32","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.2174\/09298673113209990195","article-title":"The Mechanism of Calcitriol in Cancer Prevention and Treatment","volume":"20","author":"Ma","year":"2013","journal-title":"Curr. Med Chem."},{"key":"10.1016\/j.ecoenv.2024.116906_bib33","doi-asserted-by":"crossref","first-page":"3373828","DOI":"10.1155\/2022\/3373828","article-title":"Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis","volume":"2022","author":"Ma","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.ecoenv.2024.116906_bib34","doi-asserted-by":"crossref","first-page":"4784385","DOI":"10.1155\/2021\/4784385","article-title":"Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions","volume":"2021","author":"Mao","year":"2021","journal-title":"Neural Plast."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116906_bib35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ajim.22565","article-title":"Hearing difficulty and tinnitus among U.S. workers and non-workers in 2007","volume":"59","author":"Masterson","year":"2016","journal-title":"Am. J. Ind. Med. Apr"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116906_bib36","first-page":"98","article-title":"Hearing Loss in Adults: Differential Diagnosis and Treatment","volume":"100","author":"Michels","year":"2019","journal-title":"Am. Fam. Physician"},{"issue":"24","key":"10.1016\/j.ecoenv.2024.116906_bib37","doi-asserted-by":"crossref","first-page":"15877","DOI":"10.3390\/ijms232415877","article-title":"Calcitriol Reduces the Inflammation, Endothelial Damage and Oxidative Stress in AKI Caused by Cisplatin","volume":"23","author":"Oliveira","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.116906_bib38","series-title":"Addressing the Rising Prevalence of Hearing Loss","author":"Organization","year":"2018"},{"key":"10.1016\/j.ecoenv.2024.116906_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2023.108706","article-title":"Music as a unique source of noise-induced hearing loss","volume":"430","author":"Reynolds","year":"2023","journal-title":"Hear Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116906_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/13543784.2017.1269171","article-title":"Emerging therapeutic interventions against noise-induced hearing loss","volume":"26","author":"Sha","year":"2017","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.ecoenv.2024.116906_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jsbmb.2012.11.003","article-title":"1\u03b1,25-Dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection.","volume":"136","author":"Song","year":"2013","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2024.116906_bib42","article-title":"ROS and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2018","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.ecoenv.2024.116906_bib43","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.4161\/cc.8.24.10109","article-title":"DDB2 (Damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response","volume":"8","author":"Stoyanova","year":"2009","journal-title":"Cell Cycle"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116906_bib44","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00109-022-02263-7","article-title":"ATF3 in atherosclerosis: a controversial transcription factor","volume":"100","author":"Wang","year":"2022","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.ecoenv.2024.116906_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105354","article-title":"N-acetylcysteine protect inner hair cells from cisplatin by alleviated celluar oxidative stress and apoptosis","volume":"81","author":"Wang","year":"2022","journal-title":"Toxicol. Vitr."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116906_bib46","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.3390\/nu7105392","article-title":"Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D","volume":"7","author":"Wei","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2024.116906_bib47","article-title":"CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress","volume":"166","author":"Wu","year":"2023","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2024.116906_bib48","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2021.12.010","article-title":"Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency","volume":"178","author":"Yang","year":"2022","journal-title":"Free Radic. Biol. Med"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116906_bib49","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/jpen.2313","article-title":"Intravenous calcitriol administration modulates mesenteric lymph node CD4+ T-cell polarization and attenuates intestinal inflammation in obese mice complicated with polymicrobial sepsis.","volume":"46","author":"Yeh","year":"2022","journal-title":"JPEN J. Parent. Enter. Nutr."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116906_bib50","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.drudis.2018.05.001","article-title":"Cochlear hair cell regeneration: an emerging opportunity to cure noise-induced sensorineural hearing loss","volume":"23","author":"Youm I","year":"2018","journal-title":"Drug Discov. Today"},{"issue":"9","key":"10.1016\/j.ecoenv.2024.116906_bib51","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-039576","article-title":"Occupational noise-induced hearing loss in China: a systematic review and meta-analysis","volume":"10","author":"Zhou","year":"2020","journal-title":"BMJ Open"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324009825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T20:52:08Z","timestamp":1744059128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324009825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":51,"alternative-id":["S0147651324009825"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116906","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcitriol alleviates noise-induced hearing loss by regulating the ATF3\/DUSP1 signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116906"}}