{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:30:28Z","timestamp":1768087828395,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ecoenv.2024.116949","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T07:21:55Z","timestamp":1724829715000},"page":"116949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Association between maternal antibiotic exposure and emotional and behavioural problems in children at four years of age: A biomonitoring-based prospective study"],"prefix":"10.1016","volume":"284","author":[{"given":"Wanhong","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglong","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangbiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ecoenv.2024.116949_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0093906","article-title":"The classification of children's psychiatric symptoms: a factor-analytic study","volume":"80","author":"Achenbach","year":"1966","journal-title":"Psychol. Monogr."},{"issue":"27","key":"10.1016\/j.ecoenv.2024.116949_bib2","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1021\/acs.jafc.9b01334","article-title":"Antibiotic residues in food: extraction, analysis, and human health concerns","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116949_bib3","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.3390\/nu13103469","article-title":"The complementary roles for plant-source and animal-source foods in sustainable healthy diets","volume":"13","author":"Comerford","year":"2021","journal-title":"Nutrients"},{"issue":"10064","key":"10.1016\/j.ecoenv.2024.116949_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(16)31659-2","article-title":"Early childhood development: the foundation of sustainable development","volume":"389","author":"Daelmans","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2024.116949_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jpsychires.2020.11.003","article-title":"Early life exposure to antibiotics and the risk of mood and anxiety disorders in children and adolescents: a population-based cohort study","volume":"137","author":"Delara","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116949_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/neu.2021.23","article-title":"Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes","volume":"33","author":"Di Lorenzo","year":"2021","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.ecoenv.2024.116949_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.envint.2017.03.021","article-title":"Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: repeated measures analysis","volume":"104","author":"Gao","year":"2017","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116949_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148732","article-title":"Maternal snoring may predict adverse pregnancy outcomes: a cohort study in China","volume":"11","author":"Ge","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.116949_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106164","article-title":"Urinary antibiotic exposure across pregnancy from Chinese pregnant women and health risk assessment: repeated measures analysis","volume":"145","author":"Geng","year":"2020","journal-title":"Environ. Int."},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2024.116949_bib10","article-title":"Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: a repeated measures study","volume":"838","author":"Geng","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116949_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170891","article-title":"Prenatal antibiotics exposure and preschoolers' internalizing and externalizing problems: a biomonitoring-based prospective birth cohort study","volume":"919","author":"Geng","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.116949_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s007870050008","article-title":"Predicting type of psychiatric disorder from Strengths and Difficulties Questionnaire (SDQ) scores in child mental health clinics in London and Dhaka","volume":"9","author":"Goodman","year":"2000","journal-title":"Eur. Child Adolesc. Psych."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116949_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","article-title":"Causal diagrams for epidemiologic research","volume":"10","author":"Greenland","year":"1999","journal-title":"Epidemiology"},{"issue":"20","key":"10.1016\/j.ecoenv.2024.116949_bib14","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1503\/cmaj.190883","article-title":"Prenatal antibiotic exposure and risk of attention-deficit\/hyperactivity disorder: a population-based cohort study","volume":"192","author":"Hamad","year":"2020","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.ecoenv.2024.116949_bib15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ypmed.2014.07.030","article-title":"The health consequences of child mental health problems and parenting styles: unintentional injuries among European schoolchildren","volume":"67","author":"Keyes","year":"2014","journal-title":"Prev. Med."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.116949_bib16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s41590-024-01797-x","article-title":"Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders","volume":"25","author":"Kim","year":"2024","journal-title":"Nat. Immunol."},{"issue":"7673","key":"10.1016\/j.ecoenv.2024.116949_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature23910","article-title":"Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring","volume":"549","author":"Kim","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116949_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/microorganisms7060180","article-title":"Antibiotic pollution in the environment: from microbial ecology to public policy","volume":"7","author":"Kraemer","year":"2019","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116949_bib19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4049\/jimmunol.1701755","article-title":"Cutting edge: critical roles for microbiota-mediated regulation of the immune system in a prenatal immune activation model of autism","volume":"201","author":"Lammert","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116949_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41398-019-0653-9","article-title":"Early exposure to antibiotic drugs and risk for psychiatric disorders: a population-based study","volume":"9","author":"Lavebratt","year":"2019","journal-title":"Transl. Psychiatr."},{"key":"10.1016\/j.ecoenv.2024.116949_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114041","article-title":"Association between prenatal antibiotics exposure and measures of fetal growth: a repeated-measure study","volume":"244","author":"Lin","year":"2022","journal-title":"Ecotox. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.116949_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fendo.2016.00016","article-title":"Preliminary findings show maternal hypothyroidism may contribute to abnormal cortical morphology in offspring","volume":"7","author":"Lischinsky","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2024.116949_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10337-020-03866-3","article-title":"A stable isotope dilution assay for multi-class antibiotics in pregnant urines by LC\u2013MS\/MS","volume":"83","author":"Liu","year":"2020","journal-title":"Chromatographia"},{"key":"10.1016\/j.ecoenv.2024.116949_bib24","article-title":"Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2024.116949_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbi.2022.12.008","article-title":"Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment","volume":"108","author":"Lynch","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116949_bib26","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3390\/biomedicines10051042","article-title":"Antibiotic treatment during pregnancy alters offspring gut microbiota in a sex-dependent manner","volume":"10","author":"Madany","year":"2022","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116949_bib27","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1093\/cercor\/bhy332","article-title":"Connectivity of frontoparietal regions reveals executive attention and consciousness interactions","volume":"29","author":"Mart\u00edn-Signes","year":"2019","journal-title":"Cereb. Cortex."},{"issue":"20","key":"10.1016\/j.ecoenv.2024.116949_bib28","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/bdr2.1416","article-title":"Maternal immune activation, central nervous system development and behavioral phenotypes","volume":"110","author":"Minakova","year":"2018","journal-title":"Birth Defects Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116949_bib29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1192\/bjp.2023.23","article-title":"Impact of anxiety and depression across childhood and adolescence on adverse outcomes in young adulthood: a UK birth cohort study","volume":"222","author":"Morales-Mu\u00f1oz","year":"2023","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ecoenv.2024.116949_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109479","article-title":"Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring","volume":"229","author":"Morel","year":"2023","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.116949_bib31","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-057346","article-title":"Autism risk and perinatal antibiotic use","volume":"150","author":"Nitschke","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.ecoenv.2024.116949_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103995","article-title":"Antibiotic resistance in the aquatic environment: analytical techniques and interactive impact of emerging contaminants","volume":"96","author":"Okoye","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.116949_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/mcn.13264","article-title":"Animal source foods, rich in essential amino acids, are important for linear growth and development of young children in low- and middle-income countries","volume":"18","author":"Parikh","year":"2022","journal-title":"Matern. Child Nutr."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.116949_bib34","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00787-022-02040-4","article-title":"Alarming changes in the global burden of mental disorders in children and adolescents from 1990 to 2019: a systematic analysis for the Global Burden of Disease study","volume":"31","author":"Piao","year":"2022","journal-title":"Eur. Child Adolesc. Psych."},{"key":"10.1016\/j.ecoenv.2024.116949_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jpsychires.2023.03.014","article-title":"Association between screen time and developmental and behavioral problems among children in the United States: evidence from 2018 to 2020 NSCH","volume":"161","author":"Qu","year":"2023","journal-title":"J. Psychiatr. Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.116949_bib36","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ajcn\/49.5.765","article-title":"Body fat mass and basal metabolic rate in Dutch women before, during, and after pregnancy: a reappraisal of energy cost of pregnancy","volume":"49","author":"van Raaij","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116949_bib37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/acps.13426","article-title":"Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study","volume":"145","author":"Schuurmans","year":"2022","journal-title":"Acta Psychiatr. Scand."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.116949_bib38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jpc.14182","article-title":"The aggressive child","volume":"54","author":"Scott","year":"2018","journal-title":"J. Paediatr. Child Health"},{"issue":"12","key":"10.1016\/j.ecoenv.2024.116949_bib39","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1042\/CS20200475","article-title":"Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis","volume":"134","author":"Su","year":"2020","journal-title":"Clin. Sci."},{"issue":"7828","key":"10.1016\/j.ecoenv.2024.116949_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2745-3","article-title":"The maternal microbiome modulates fetal neurodevelopment in mice","volume":"586","author":"Vuong","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.116949_bib41","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1021\/acs.est.6b06474","article-title":"Urinary antibiotics of pregnant women in eastern China and cumulative health risk assessment","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2024.116949_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.envint.2018.09.032","article-title":"Predictors of urinary antibiotics in children of Shanghai and health risk assessment","volume":"121","author":"Wang","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116949_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.119940","article-title":"Antibiotic residues of drinking-water and its human exposure risk assessment in rural Eastern China","volume":"236","author":"Wang","year":"2023","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2024.116949_bib44","unstructured":"World Health Organization, ICD-10 Version: 2019. \u3008https:\/\/icd.who.int\/browse10\/2019\/en#\/F90-F98\u3009, 2024 (accessed 19 January 2024)."},{"key":"10.1016\/j.ecoenv.2024.116949_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105638","article-title":"Maternal antibiotic concentrations in pregnant women in Shanghai and their determinants: a biomonitoring-based prospective study","volume":"138","author":"Zeng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116949_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110237","article-title":"Antibiotic exposure across three generations from Chinese families and cumulative health risk","volume":"191","author":"Zhang","year":"2020","journal-title":"Ecotox. Environ. Saf."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.116949_bib47","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1007\/s10653-021-00840-2","article-title":"Exposure to antibiotics and mental disorders in children: a community-based cross-sectional study","volume":"43","author":"Zhang","year":"2021","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.ecoenv.2024.116949_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.envint.2018.11.053","article-title":"Determination of antibiotic concentration in meconium and its association with fetal growth and development","volume":"123","author":"Zhao","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.116949_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157070","article-title":"Antibiotics in urine from general adults in Shenzhen, China: demographic-related difference in exposure levels","volume":"843","author":"Zhong","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.116949_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110945","article-title":"Detection of antibiotics in the urine of children and pregnant women in Jiangsu, China","volume":"196","author":"Zhou","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2024.116949_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113311","article-title":"Antibiotic body burden of elderly Chinese population and health risk assessment: a human biomonitoring-based study","volume":"256","author":"Zhu","year":"2020","journal-title":"Environ. Pollut."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132401025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132401025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T01:05:40Z","timestamp":1744074340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132401025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":51,"alternative-id":["S014765132401025X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116949","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between maternal antibiotic exposure and emotional and behavioural problems in children at four years of age: A biomonitoring-based prospective study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116949"}}