{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:53:01Z","timestamp":1789800781796,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82361138566"],"award-info":[{"award-number":["82361138566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JCW-08"],"award-info":[{"award-number":["2021JCW-08"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFC2503100"],"award-info":[{"award-number":["2022YFC2503100"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-45-00073"],"award-info":[{"award-number":["24-45-00073"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ecoenv.2024.117148","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T13:11:22Z","timestamp":1728133882000},"page":"117148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease"],"prefix":"10.1016","volume":"285","author":[{"given":"Xuena","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoge","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Tinkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Skalny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.ecoenv.2024.117148_bib1","article-title":"Green synthesis of chitosan\/polyacrylic acid\/graphitic carbon nitride nanocarrier as a potential pH-sensitive system for curcumin delivery to MCF-7 breast cancer cells","volume":"242","author":"Abdouss","year":"2023","journal-title":"Int J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7150\/ntno.78611","article-title":"Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective","volume":"7","author":"Ahmadian","year":"2023","journal-title":"Nanotheranostics"},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117148_bib3","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.joca.2022.08.018","article-title":"Association of oxidative stress and Kashin-Beck disease integrated Meta and Bioinformatics analysis","volume":"30","author":"Ba","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117148_bib4","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1039\/d0pp00032a","article-title":"Curcumin encapsulated colloidal amphiphilic block co-polymeric nanocapsules: colloidal nanocapsules enhance photodynamic and anticancer activities of curcumin","volume":"19","author":"Bechnak","year":"2020","journal-title":"Photochem. Photobio. Sci."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.117148_bib5","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/art.21795","article-title":"Connective tissue growth factor\/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage","volume":"54","author":"Blaney Davidson","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117148_bib6","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/15384101.2020.1750813","article-title":"miR-296-5p inhibits IL-1\u03b2-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-\u03b21\/CTGF\/p38MAPK pathway","volume":"19","author":"Cao","year":"2020","journal-title":"Cell Cycle"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.117148_bib7","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ptr.4639","article-title":"A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis","volume":"26","author":"Chandran","year":"2012","journal-title":"Phytother. Res"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.117148_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1631\/jzus.B0820013","article-title":"T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes","volume":"9","author":"Chen","year":"2008","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/03009742.2015.1092581","article-title":"CTGF promotes articular damage by increased proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"45","author":"Ding","year":"2016","journal-title":"Scand. J. Rheuma"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117148_bib10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s12013-024-01248-2","article-title":"Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer's Disease","volume":"82","author":"Ekundayo","year":"2024","journal-title":"Cell Biochem Biophys."},{"issue":"28","key":"10.1016\/j.ecoenv.2024.117148_bib11","doi-asserted-by":"crossref","first-page":"18022","DOI":"10.1039\/D2RA00231K","article-title":"Curcumin assisted green synthesis of silver and zinc oxide nanostructures and their antibacterial activity against some clinical pathogenic multi-drug resistant bacteria","volume":"12","author":"El-Kattan","year":"2022","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12906-022-03740-9","article-title":"Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials","volume":"22","author":"Feng","year":"2022","journal-title":"BMC Complement Med Ther."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib13","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.apsb.2022.01.007","article-title":"Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases","volume":"12","author":"Fu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.117148_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.joca.2007.11.001","article-title":"CCN family 2\/connective tissue growth factor (CCN2\/CTGF) stimulates proliferation and differentiation of auricular chondrocytes","volume":"16","author":"Fujisawa","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ecoenv.2024.117148_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2023.107193","article-title":"T-2 toxin-induced chondrocyte apoptosis contributes to growth plate damage through Smad2 and Smad3 signaling","volume":"232","author":"He","year":"2023","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/1354750X.2012.666676","article-title":"Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis","volume":"17","author":"Honsawek","year":"2012","journal-title":"Biomarkers"},{"key":"10.1016\/j.ecoenv.2024.117148_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.935112","article-title":"Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity","volume":"9","author":"Jia","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.ecoenv.2024.117148_bib18","article-title":"Recent advances in green synthesized nanoparticles: from production to application","volume":"24","author":"kazemi","year":"2023","journal-title":"Mater. Today Sustain."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117148_bib19","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.joca.2012.08.009","article-title":"Icariin: a potential promoting compound for cartilage tissue engineering","volume":"20","author":"Li","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117148_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/C5TX00377F","article-title":"The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review","volume":"5","author":"Li","year":"2016","journal-title":"Toxicol. Res (Camb. )"},{"key":"10.1016\/j.ecoenv.2024.117148_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104154","article-title":"Role of epigenetics in mycotoxin toxicity: A review","volume":"100","author":"Li","year":"2023","journal-title":"Environ. Toxicol. Pharm."},{"issue":"18","key":"10.1016\/j.ecoenv.2024.117148_bib22","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1080\/15384101.2020.1807665","article-title":"The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease","volume":"19","author":"Li","year":"2020","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3390\/nu9040414","article-title":"Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1\/2 Signaling Pathways Induced Autophagy","volume":"9","author":"Li","year":"2017","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.117148_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/toxins9110359","article-title":"TGF-\u03b21\/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes","volume":"9","author":"Li","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2024.117148_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110661","article-title":"DNA methylation is involved in pro-inflammatory cytokines expression in T-2 toxin-induced liver injury","volume":"132","author":"Liu","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib26","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.3390\/ijms15046925","article-title":"Protective effect of resveratrol against IL-1\u03b2-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4\/MyD88\/NF-\u03baB signaling pathway: an \"in vitro study\"","volume":"15","author":"Liu","year":"2014","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2015.08.020","article-title":"Berberine attenuates CCN2-induced IL-1\u03b2 expression and prevents cartilage degradation in a rat model of osteoarthritis","volume":"289","author":"Liu","year":"2015","journal-title":"Toxicol. Appl. Pharm."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.117148_bib28","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00264-010-1062-0","article-title":"Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients","volume":"35","author":"Luo","year":"2011","journal-title":"Int Orthop."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.62476\/abes9196","article-title":"THE SAFFRON EFFECTS ON THE DYNAMICS OF EXPERIMENTAL EPILEPSY","volume":"9","author":"Miryusifova","year":"2024","journal-title":"Adv. Biol. Earth Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117148_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/08916934.2015.1113405","article-title":"Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis","volume":"49","author":"Miyashita","year":"2016","journal-title":"Autoimmunity"},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117148_bib31","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1359\/JBMR.040322","article-title":"Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)","volume":"19","author":"Nishida","year":"2004","journal-title":"J. Bone Min. Res"},{"issue":"6","key":"10.1016\/j.ecoenv.2024.117148_bib32","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1186\/ar2863","article-title":"Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis","volume":"11","author":"Nozawa","year":"2009","journal-title":"Arthritis Res Ther."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.117148_bib33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.joca.2004.06.009","article-title":"Expression and localization of connective tissue growth factor (CTGF\/Hcs24\/CCN2) in osteoarthritic cartilage","volume":"12","author":"Omoto","year":"2004","journal-title":"Osteoarthr. Cartil."},{"issue":"18","key":"10.1016\/j.ecoenv.2024.117148_bib34","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3390\/ijms20184331","article-title":"Molecular Docking: Shifting Paradigms in Drug Discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117148_bib35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/biom14020154","article-title":"Curcumin and Resveratrol: Nutraceuticals with so Much Potential for Pseudoachondroplasia and Other ER-Stress Conditions","volume":"14","author":"Posey","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13018-023-03633-8","article-title":"A study on atypical Kashin-Beck disease: an endemic ankle arthritis","volume":"18","author":"Qi","year":"2023","journal-title":"J. Orthop. Surg. Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41413-024-00332-w","article-title":"Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections","volume":"12","author":"Qin","year":"2024","journal-title":"Bone Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117148_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102340","article-title":"Effect of gelatinous spongy scaffold containing nano-hydroxyapatite on the induction of odontogenic activity of dental pulp stem cells","volume":"34","author":"Shahi","year":"2022","journal-title":"J. King Saud. Univ. - Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117148_bib39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12263-010-0179-5","article-title":"Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro","volume":"6","author":"Shakibaei","year":"2011","journal-title":"Genes Nutr."},{"key":"10.1016\/j.ecoenv.2024.117148_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8148510","article-title":"Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF","volume":"2019","author":"Shao","year":"2019","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.ecoenv.2024.117148_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxicon.2021.11.003","article-title":"The WNT\/\u03b2-catenin signalling pathway induces chondrocyte apoptosis in the cartilage injury caused by T-2 toxin in rats","volume":"204","author":"Shi","year":"2021","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117148_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2008.01.002","article-title":"Regulation and function of connective tissue growth factor\/CCN2 in tissue repair, scarring and fibrosis","volume":"19","author":"Shi-Wen","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.117148_bib43","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.3390\/pharmaceutics14102239","article-title":"Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review","volume":"14","author":"Sun","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1-3","key":"10.1016\/j.ecoenv.2024.117148_bib44","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12011-012-9469-7","article-title":"T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province","volume":"150","author":"Sun","year":"2012","journal-title":"Biol. Trace Elem. Res"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.117148_bib45","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20191374","article-title":"The pathogenic role of connective tissue growth factor in osteoarthritis","volume":"39","author":"Tu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ecoenv.2024.117148_bib46","unstructured":"W.T. 207-2010, Diagnosis of Kashin-Beck Disease, National Health and Family Planning Commission of People\u2019s Republic of China: Beijing, China, 2010."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.117148_bib47","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.joca.2014.08.010","article-title":"Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis","volume":"22","author":"Wu","year":"2014","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib48","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41598-017-00522-z","article-title":"Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib49","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.bbrc.2017.11.190","article-title":"Effects of connective tissue growth factor (CTGF\/CCN2) on condylar chondrocyte proliferation, migration, maturation, differentiation and signalling pathway","volume":"495","author":"Xing","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"issue":"5","key":"10.1016\/j.ecoenv.2024.117148_bib50","first-page":"351","article-title":"Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency","volume":"30","author":"Yang","year":"2017","journal-title":"Biomed. Environ. Sci."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117148_bib51","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1007\/s12011-021-02772-5","article-title":"Dysregulation of Transcription Profile of Selenoprotein in Patients with Kashin-Beck Disease and Its Effect on Se Deficiency-Induced Chondrocyte Apoptosis","volume":"200","author":"Yang","year":"2022","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.ecoenv.2024.117148_bib52","article-title":"CTGF as a multifunctional molecule for cartilage and a potential drug for osteoarthritis","volume":"13","author":"Yang","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2024.117148_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12891-015-0599-x","article-title":"Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-\u03b21","volume":"16","author":"Yoon","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ecoenv.2024.117148_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133090","article-title":"T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway","volume":"465","author":"Yu","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2024.117148_bib55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gene.2018.01.083","article-title":"Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF","volume":"651","author":"Zeng","year":"2018","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.ecoenv.2024.117148_bib56","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s10067-017-3667-9","article-title":"Genome-wide DNA methylation analysis of articular chondrocytes identifies TRAF1, CTGF, and CX3CL1 genes as hypomethylated in osteoarthritis","volume":"36","author":"Zhao","year":"2017","journal-title":"Clin. Rheuma"},{"key":"10.1016\/j.ecoenv.2024.117148_bib57","article-title":"The Combination of Bioactive Herbal Compounds with Biomaterials for Regenerative Medicine","author":"Zhou","year":"2024","journal-title":"Tissue Eng. Part B Rev."},{"issue":"10","key":"10.1016\/j.ecoenv.2024.117148_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20163","article-title":"Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2","volume":"9","author":"Zhou","year":"2023","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117148_bib59","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1007\/s10067-019-04704-0","article-title":"The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis","volume":"38","author":"Zou","year":"2019","journal-title":"Clin. Rheuma"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117148_bib60","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13018-019-1307-6","article-title":"Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis","volume":"14","author":"Zu","year":"2019","journal-title":"J. Orthop. Surg. Res"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324012247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324012247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T08:17:30Z","timestamp":1729671450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324012247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":60,"alternative-id":["S0147651324012247"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117148","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117148"}}