{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:25:28Z","timestamp":1790882728928,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ecoenv.2024.117217","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T03:59:34Z","timestamp":1729569574000},"page":"117217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Microplastics exacerbate tissue damage and promote carcinogenesis following liver infection in mice"],"prefix":"10.1016","volume":"286","author":[{"given":"Haipeng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengze","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beidou","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.ecoenv.2024.117217_bib1","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.3390\/cancers13246292","article-title":"SALL proteins; common and antagonistic roles in cancer","volume":"13","author":"\u00c1lvarez","year":"2021","journal-title":"Cancers"},{"issue":"24","key":"10.1016\/j.ecoenv.2024.117217_bib2","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1002\/1873-3468.13696","article-title":"Innate immunity to adenovirus: lessons from mice","volume":"593","author":"Atasheva","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ecoenv.2024.117217_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envint.2017.02.013","article-title":"Distribution and importance of microplastics in the marine environment: A review of the sources, fate, effects, and potential solutions","volume":"102","author":"Auta","year":"2017","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117217_bib4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/v14020278","article-title":"The human virome: viral metagenomics, relations with human diseases, and therapeutic applications","volume":"14","author":"Bai","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.ecoenv.2024.117217_bib5","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1039\/C6AY02674E","article-title":"First detection of seven phthalate esters (PAEs) as plastic traces in super\ufb01cial\/planktonic samples and cetacean blubbler","volume":"9","author":"Baini","year":"2017","journal-title":"Anal. Methods"},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2024.117217_bib6","article-title":"Micro- and nanoplastic induced cellular toxicity in mammals: a review","volume":"755","author":"Banerjee","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.117217_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-024-07715-3","article-title":"In vivo interaction screening reveals liver-derived constraints to metastasis","author":"Borrelli","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2024.117217_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106921","article-title":"Tiered testing of micro- and nanoplastics using intestinal in vitro models to support hazard assessments","volume":"158","author":"Bredeck","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.117217_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.envpol.2018.02.069","article-title":"Low levels of microplastics (MP) in wild mussels indicate that MP ingestion by humans is minimal compared to exposure via household \ufb01bres fallout during a meal","volume":"237","author":"Catarino","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.117217_bib10","unstructured":"[CDC]. Centers for Disease Control and Prevention Fourth National Report on Human Exposure to Environmental Chemicals. Updated tables, march 2013. Retrieved from. \u3008http:\/\/www.cdc.gov\/exposurereport\/pdf\/FourthReport_UpdatedTables_Mar2013.pdf\u3009."},{"key":"10.1016\/j.ecoenv.2024.117217_bib11","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117217_bib12","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/gcb.14020","article-title":"Microplastics as an emerging threat to terrestrial ecosystems","volume":"24","author":"de Souza Machado","year":"2018","journal-title":"Glob. Change Biol."},{"key":"10.1016\/j.ecoenv.2024.117217_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s43018-024-00796-z","article-title":"p53 at the crossroads of tumor immunity","author":"Efe","year":"2024","journal-title":"Nat. Cancer"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.117217_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Science advances"},{"issue":"7","key":"10.1016\/j.ecoenv.2024.117217_bib15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/carcin\/bgx036","article-title":"Developmental SALL2 transcription factor: a new player in cancer","volume":"38","author":"Hermosilla","year":"2017","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117217_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107390","article-title":"Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction","volume":"26","author":"Huang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ecoenv.2024.117217_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124187","article-title":"Microplastics and associated contaminants in the aquatic environment: A review on their ecotoxicological effects, trophic transfer, and potential impacts to human health","volume":"405","author":"Huang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.117217_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164297","article-title":"Polystyrene microplastics trigger adiposity in mice by remodeling gut microbiota and boosting fatty acid synthesis","volume":"890","author":"Huang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.ecoenv.2024.117217_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41579-019-0205-6","article-title":"Origin of viruses: primordial replicators recruiting capsids from hosts","volume":"17","author":"Krupovic","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ecoenv.2024.117217_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2024.117217_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ecoenv.2024.117217_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envpol.2016.04.012","article-title":"Microplastics in mussels along the coastal waters of China","volume":"214","author":"Li","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.117217_bib23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.scitotenv.2019.04.110","article-title":"Source and potential risk assessment of suspended atmospheric microplastics in Shanghai","volume":"675","author":"Liu","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117217_bib24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2024.117217_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.scitotenv.2019.02.380","article-title":"Interaction between microplastics and microorganism as well as gut microbiota: A consideration on environmental animal and human health","volume":"667","author":"Lu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.117217_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631-632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.117217_bib27","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s43018-024-00777-2","article-title":"Pharmacological targeting of the cancer epigenome","volume":"5","author":"Mabe","year":"2024","journal-title":"Nat. Cancer"},{"issue":"4 Pt 1","key":"10.1016\/j.ecoenv.2024.117217_bib28","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/ajrccm.159.4.9712012","article-title":"LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock","volume":"159","author":"Mignon","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117217_bib29","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1021\/acs.est.0c07384","article-title":"Lifetime Accumulation of Microplastic in Children and Adults","volume":"55","author":"Mohamed Nor","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.ecoenv.2024.117217_bib30","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s43018-023-00595-y","article-title":"Cancer cell plasticity during tumor progression, metastasis and response to therapy","volume":"4","author":"P\u00e9rez-Gonz\u00e1lez","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ecoenv.2024.117217_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146094","article-title":"A One Health perspective of the impacts of microplastics on animal, human and environmental health","volume":"777","author":"Prata","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117217_bib32","first-page":"139","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinforma. (Oxf., Engl. )"},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2024.117217_bib33","article-title":"Estimation of the mass of microplastics ingested - A pivotal first step towards human health risk assessment","volume":"404","author":"Senathirajah","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"Pt 3","key":"10.1016\/j.ecoenv.2024.117217_bib34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.semcancer.2021.11.002","article-title":"The oral microbiota and its role in carcinogenesis","volume":"86","author":"Stasiewicz","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117217_bib35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s12272-016-0874-x","article-title":"Roles of SALL2 in tumorigenesis","volume":"40","author":"Sung","year":"2017","journal-title":"Arch. Pharmacal Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117217_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/bioinformatics\/btp612","article-title":"DEGseq: an R package for identifying differentially expressed genes from RNA-seq data","volume":"26","author":"Wang","year":"2010","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117217_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188454","article-title":"Technologies for targeting DNA methylation modifications: Basic mechanism and potential application in cancer","volume":"1875","author":"Wang","year":"2021","journal-title":"Biochim. Et. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.ecoenv.2024.117217_bib38","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1016\/j.watres.2020.116731","article-title":"The entering of polyethylene terephthalate microplastics into biological wastewater treatment system affects aerobic sludge digestion differently from their direct entering into sludge treatment system","volume":"190","author":"Wei","year":"2021","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117217_bib39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12989-024-00581-x","article-title":"Micro- and nanoplastics concepts for particle and fibre toxicologists","volume":"21","author":"Wright","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117217_bib40","doi-asserted-by":"crossref","unstructured":"Xie, C., Mao, X., Huang, J., et al. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic acids research, 39(Web Server issue) (2011), W316\u2013W322. https:\/\/doi.org\/10.1093\/nar\/gkr483.","DOI":"10.1093\/nar\/gkr483"},{"key":"10.1016\/j.ecoenv.2024.117217_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149338","article-title":"Recent advances on ecological effects of microplastics on soil environment","volume":"798","author":"Ya","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2024.117217_bib42","article-title":"Impact of microplastics on the foraging, photosynthesis and digestive systems of submerged carnivorous macrophytes under low and high nutrient concentrations","volume":"292","author":"Yu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.117217_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115328","article-title":"Air pollution exposure and bladder, kidney and urinary tract cancer risk: a systematic review","volume":"267","author":"Zare Sakhvidi","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.117217_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144010","article-title":"A review of data for quantifying human exposures to micro and nanoplastics and potential health risks","volume":"756","author":"Zarus","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.117217_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.earscirev.2020.103118","article-title":"Atmospheric microplastics: a review on current status and perspectives","volume":"203","author":"Zhang","year":"2020","journal-title":"Earth-Sci. Rev."},{"key":"10.1016\/j.ecoenv.2024.117217_bib46","article-title":"Human adenovirus associated hepatic injury","volume":"10","author":"Zheng","year":"2022","journal-title":"Front. Public Health"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324012934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324012934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:39:46Z","timestamp":1772084386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324012934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":46,"alternative-id":["S0147651324012934"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117217","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microplastics exacerbate tissue damage and promote carcinogenesis following liver infection in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117217"}}