{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:26:44Z","timestamp":1772616404666,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313390"],"award-info":[{"award-number":["2018A030313390"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014214","name":"Xiamen University of Technology Key Laboratory of Functional Materials and Applications of Fujian Province","doi-asserted-by":"publisher","award":["XMMC-FCTM202102"],"award-info":[{"award-number":["XMMC-FCTM202102"]}],"id":[{"id":"10.13039\/501100014214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ecoenv.2024.117241","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T21:27:06Z","timestamp":1729805226000},"page":"117241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Impact of fluoride and aluminum co-exposure on bone growth and quality in juvenile rats: dose and duration effects"],"prefix":"10.1016","volume":"286","author":[{"given":"Shi-Ying","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Gui","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Guo","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.117241_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jtemb.2012.03.017","article-title":"Osteoporosis and trace elements--an overview","volume":"26","author":"Aaseth","year":"2012","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2024.117241_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pathophys.2014.12.001","article-title":"Interplay of glia activation and oxidative stress formation in fluoride and aluminium exposure","volume":"22","author":"Akinrinade","year":"2015","journal-title":"Pathophysiology"},{"key":"10.1016\/j.ecoenv.2024.117241_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110106","article-title":"Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis","volume":"365","author":"Babu","year":"2022","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2024.117241_bib4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bbamem.2018.05.014","article-title":"Aluminum inhibits the plasma membrane and sarcoplasmic reticulum Ca2+-ATPases by different mechanisms","volume":"1860","author":"de Sautu","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.ecoenv.2024.117241_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.ecoenv.2024.117241_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0185(199609)246:1<39::AID-AR5>3.0.CO;2-A","article-title":"Trabecular and endocortical bone surfaces in the rat: modeling or remodeling?","volume":"246","author":"Erben","year":"1996","journal-title":"Anat. Re"},{"key":"10.1016\/j.ecoenv.2024.117241_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103275","article-title":"Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh\/PTHrP feedback loop during endochondral ossification","volume":"73","author":"Gao","year":"2020","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2024.117241_bib8","first-page":"164","article-title":"Combined effect of fluoride and aluminum on the expression of Runx2 and osterix mRNA in MC3T3-E1 cells","volume":"40","author":"Guo","year":"2011","journal-title":"Wei Sheng Yan Jiu"},{"key":"10.1016\/j.ecoenv.2024.117241_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152429","article-title":"Effect of fluoride on osteocyte-driven osteoclastic differentiation","volume":"436","author":"Jiang","year":"2020","journal-title":"Toxicology"},{"issue":"436","key":"10.1016\/j.ecoenv.2024.117241_bib10","article-title":"Effect of fluoride on osteocyte-driven osteoclastic differentiation","volume":"30","author":"Jiang","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.117241_bib11","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00204-020-02687-5","article-title":"Principles of fluoride toxicity and the cellular response: a review","volume":"94","author":"Johnston","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117241_bib12","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2024.117241_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12011-010-8847-2","article-title":"Serum parathyroid hormone levels in chronic endemic fluorosis","volume":"143","author":"Koroglu","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2024.117241_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1759720X16670154","article-title":"Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis","volume":"8","author":"Langdahl","year":"2016","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.ecoenv.2024.117241_bib15","first-page":"197","article-title":"Investigation and analysis of trace elements levels in children with osteomalacia malformation from endemic fluorosis area in Shuicheng, Guizhou","volume":"30","author":"Li","year":"2011","journal-title":"Chin. J. Endem."},{"key":"10.1016\/j.ecoenv.2024.117241_bib16","first-page":"561","article-title":"Analysis of bone micro-CT results of patients with bone deformation exposed to high aluminum high fluoride","volume":"33","author":"Li","year":"2014","journal-title":"Chin. J. Endem."},{"key":"10.1016\/j.ecoenv.2024.117241_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109659","article-title":"Fluoride regulates chondrocyte proliferation and autophagy via PI3K\/AKT\/mTOR signaling pathway","volume":"349","author":"Ma","year":"2021","journal-title":"Chem. - Biol. Interact."},{"key":"10.1016\/j.ecoenv.2024.117241_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.126962","article-title":"Aluminum intake in the neonatal phase disrupts endochondral ossification in rodents","volume":"72","author":"Marques","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2024.117241_bib19","volume":"9","author":"Mustafy","year":"2019","journal-title":"High Impact Exercise Improves Bone Microstructure and Strength in Growing Rats"},{"key":"10.1016\/j.ecoenv.2024.117241_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-13-1370-7_1","article-title":"Overview of the relationship between aluminum exposure and health of human being","volume":"1091","author":"Niu","year":"2018","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.ecoenv.2024.117241_bib21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00774-007-0832-2","article-title":"Sodium fluoride modulates caprine osteoblast proliferation and differentiation","volume":"26","author":"Qu","year":"2008","journal-title":"J. Bone Min. Metab."},{"key":"10.1016\/j.ecoenv.2024.117241_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jbm.a.35917","article-title":"The incorporation of fluoride and strontium in hydroxyapatite affects the composition, structure, and mechanical properties of human cortical bone","volume":"105","author":"Riedel","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.ecoenv.2024.117241_bib23","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jhazmat.2008.01.086","article-title":"An exposure and risk assessment for fluoride and trace metals in black tea","volume":"158","author":"Sofuoglu","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2024.117241_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s12011-020-02089-9","article-title":"Ginsenoside Rg3 attenuates aluminum-induced osteoporosis through regulation of oxidative stress and bone metabolism in rats","volume":"198","author":"Song","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2024.117241_bib25","doi-asserted-by":"crossref","first-page":"45879","DOI":"10.1007\/s11356-021-13937-z","article-title":"Long-term exposure to low doses of aluminum affects mineral content and microarchitecture of rats alveolar bone","volume":"28","author":"Souza-Monteiro","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2024.117241_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2014.06.020","article-title":"The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth","volume":"393","author":"Touaitahuata","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.117241_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00198-007-0437-6","article-title":"Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis","volume":"19","author":"Vestergaard","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ecoenv.2024.117241_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02648725.2023.2184961","article-title":"The influence of interventional measures on metabolic factors in fluoride and aluminum combined poisoning bones","volume":"2","author":"Wang","year":"2023","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"10.1016\/j.ecoenv.2024.117241_bib29","first-page":"1967","article-title":"Effects of fluoride on biomechanical parameters of the femur in young rats","volume":"14","author":"Wu","year":"2010","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"10.1016\/j.ecoenv.2024.117241_bib30","first-page":"500","article-title":"Assessment of dietary aluminum intake among primary and middle school students in Shanghai","volume":"35","author":"Wu","year":"2018","journal-title":"J. Environ. Occup. Med."},{"key":"10.1016\/j.ecoenv.2024.117241_bib31","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12011-018-1624-3","article-title":"The inverted U-Curve association of fluoride and osteoclast formation in mice","volume":"191","author":"Yao","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2024.117241_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112796","article-title":"Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure","volume":"225","author":"Yu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.117241_bib33","first-page":"426","article-title":"Experimental study on the relationship between fluorosis and different dosage proportion of fluorine to aluminum","volume":"20","author":"Zhang","year":"2001","journal-title":"Chin. J. Endem."},{"key":"10.1016\/j.ecoenv.2024.117241_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10534-016-9982-9","article-title":"Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats","volume":"30","author":"Zhang","year":"2017","journal-title":"Biometals"},{"key":"10.1016\/j.ecoenv.2024.117241_bib35","first-page":"373","article-title":"Effects of aluminum on serum, bone and urinary fluoride content of rats with fluorosis","volume":"31","author":"Zhu","year":"2012","journal-title":"Chin. J. Endem."},{"key":"10.1016\/j.ecoenv.2024.117241_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.etap.2016.10.009","article-title":"The suppressive effects of aluminum chloride on the osteoblasts function","volume":"48","author":"Zhu","year":"2016","journal-title":"Environ. Toxicol. Pharm."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324013174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324013174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:35:17Z","timestamp":1772084117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324013174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":36,"alternative-id":["S0147651324013174"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117241","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of fluoride and aluminum co-exposure on bone growth and quality in juvenile rats: dose and duration effects","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117241"}}