{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:26:41Z","timestamp":1791919601840,"version":"4.3.4"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2023166"],"award-info":[{"award-number":["B2023166"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2022192"],"award-info":[{"award-number":["A2022192"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013153","name":"Shantou Science and Technology Project","doi-asserted-by":"publisher","award":["STYL2022021"],"award-info":[{"award-number":["STYL2022021"]}],"id":[{"id":"10.13039\/501100013153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515220246"],"award-info":[{"award-number":["2023A1515220246"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20232082"],"award-info":[{"award-number":["20232082"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272281"],"award-info":[{"award-number":["82272281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402944"],"award-info":[{"award-number":["82402944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ecoenv.2024.117343","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:53:00Z","timestamp":1731739980000},"page":"117343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis"],"prefix":"10.1016","volume":"288","author":[{"given":"Yuxin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2024.117343_bib1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1042\/BST20210828","article-title":"MicroRNAs in neural crest development and neurocristopathies","volume":"50","author":"Antonaci","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ecoenv.2024.117343_bib2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3390\/genes14081603","article-title":"Orofacial clefts: genetics of cleft lip and palate","volume":"14","author":"Babai","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.ecoenv.2024.117343_bib3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.6026\/97320630005278","article-title":"Epigenetic regulation of osteogenesis: human embryonic palatal mesenchymal cells","volume":"5","author":"Barkhordarian","year":"2011","journal-title":"Bioinformation"},{"key":"10.1016\/j.ecoenv.2024.117343_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ydbio.2020.08.004","article-title":"Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a\/beta-catenin pathway during chondrocranial cartilage development","volume":"466","author":"Bartoletti","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41580-023-00615-w","article-title":"The technological landscape and applications of single-cell multi-omics","volume":"24","author":"Baysoy","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jcp.20923","article-title":"Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation","volume":"211","author":"Bobick","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/toxics10100612","article-title":"Embryonic nicotine exposure disrupts adult social behavior and craniofacial development in Zebrafish","volume":"10","author":"Borrego-Soto","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2024.117343_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neubiorev.2014.07.014","article-title":"Whole tobacco smoke extracts to model tobacco dependence in animals","volume":"47","author":"Brennan","year":"2014","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ecoenv.2024.117343_bib9","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.005132","article-title":"Wnt signaling mediates regional specification in the vertebrate face","volume":"134","author":"Brugmann","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2024.117343_bib10","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/bdr2.2211","article-title":"Oxidative balance scores and neural crest cell-related congenital anomalies","volume":"115","author":"Carmichael","year":"2023","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.ecoenv.2024.117343_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12967-024-05050-9","article-title":"Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1186\/s12967-023-04478-9","article-title":"CBX3 promotes clear cell renal carcinoma through PI3K\/AKT activation and aberrant immunity","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib13","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.freeradbiomed.2010.02.026","article-title":"Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src\/NADPH oxidase\/MAPK\/Nrf2 signaling pathway","volume":"48","author":"Cheng","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12680","article-title":"Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway","volume":"52","author":"Cui","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ecoenv.2024.117343_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1164\/rccm.200204-298OC","article-title":"Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease","volume":"167","author":"Culpitt","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/etc.2406","article-title":"Zebrafish as a model system to study toxicology","volume":"33","author":"Dai","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2024.117343_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1601-6343.2004.00299.x","article-title":"Inhibition of human embryonic palatal mesenchymal cell cycle by secalonic acid D: a probable mechanism of its cleft palate induction","volume":"7","author":"Dhulipala","year":"2004","journal-title":"Orthod. Craniofac Res."},{"key":"10.1016\/j.ecoenv.2024.117343_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ecoenv.2024.117343_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/dvdy.24566","article-title":"Zebrafish models of orofacial clefts","volume":"246","author":"Duncan","year":"2017","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2024.117343_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ng.82","article-title":"MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis","volume":"40","author":"Eberhart","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2024.117343_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154884","article-title":"Pedunculoside inhibits epithelial-mesenchymal transition and overcomes Gefitinib-resistant non-small cell lung cancer through regulating MAPK and Nrf2 pathways","volume":"116","author":"Fan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2024.117343_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.addr.2009.02.005","article-title":"Therapeutic strategies by modulating oxygen stress in cancer and inflammation","volume":"61","author":"Fang","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ecoenv.2024.117343_bib23","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/cells11152277","article-title":"Antioxidant systems, lncRNAs, and tunneling nanotubes in cell death rescue from cigarette smoke exposure","volume":"11","author":"Ferrer","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2024.117343_bib24","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/tox.22761","article-title":"Fisetin activates Hippo pathway and JNK\/ERK\/AP-1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression","volume":"34","author":"Fu","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11154-006-9000-6","article-title":"Bone morphogenetic proteins and their antagonists","volume":"7","author":"Gazzerro","year":"2006","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ecoenv.2024.117343_bib26","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/iej.13959","article-title":"Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: an ex vivo study","volume":"56","author":"Guo","year":"2023","journal-title":"Int Endod. J."},{"key":"10.1016\/j.ecoenv.2024.117343_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.stemcr.2020.03.001","article-title":"C-KIT expression distinguishes fetal from postnatal skeletal progenitors","volume":"14","author":"He","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ecoenv.2024.117343_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115789","article-title":"MicroRNA function in craniofacial bone formation, regeneration and repair","volume":"144","author":"Hong","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2024.117343_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S8756-3282(00)00422-1","article-title":"Tie2 ligands angiopoietin-1 and angiopoietin-2 are coexpressed with vascular endothelial cell growth factor in growing human bone","volume":"28","author":"Horner","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2024.117343_bib31","doi-asserted-by":"crossref","first-page":"613.e1","DOI":"10.1016\/j.ajog.2016.07.022","article-title":"Associations between maternal periconceptional exposure to secondhand tobacco smoke and major birth defects","volume":"215","author":"Hoyt","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.111991","article-title":"Effect of bisphenol A on craniofacial cartilage development in zebrafish (Danio rerio) embryos: a morphological study","volume":"212","author":"Huang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2024.117343_bib33","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/0021-9290(96)84536-2","article-title":"Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow","volume":"29","author":"Hung","year":"1996","journal-title":"J. Biomech."},{"key":"10.1016\/j.ecoenv.2024.117343_bib34","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-\u03baB1 and NF-\u03baB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat. Med"},{"key":"10.1016\/j.ecoenv.2024.117343_bib35","doi-asserted-by":"crossref","first-page":"14637","DOI":"10.1074\/jbc.M807598200","article-title":"Bidirectional Signaling through EphrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis","volume":"284","author":"Irie","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2024.117343_bib36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1242\/dev.103093","article-title":"TGF\u03b2 regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate","volume":"141","author":"Iwata","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2024.117343_bib37","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.3390\/ijms24043552","article-title":"MicroRNAs and gene regulatory networks related to cleft lip and palate","volume":"24","author":"Iwaya","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.117343_bib38","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/acs.chemrestox.0c00027","article-title":"Metabolites of Tobacco- and E-cigarette-related nitrosamines can drive Cu2+-Mediated DNA oxidation","volume":"33","author":"Kankanamage","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib39","doi-asserted-by":"crossref","first-page":"9904","DOI":"10.3390\/ijms23179904","article-title":"Embryonic exposure to cigarette smoke extract impedes skeletal development and evokes craniofacial defects in Zebrafish","volume":"23","author":"Karmach","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.117343_bib40","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jnutbio.2015.07.021","article-title":"Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration","volume":"26","author":"Khan","year":"2015","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.ecoenv.2024.117343_bib41","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib42","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.3390\/ijms22073692","article-title":"Astragalin inhibits cigarette smoke-induced pulmonary thrombosis and alveolar inflammation and disrupts PAR activation and oxidative stress-responsive mapk-signaling","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.117343_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1597\/12-136","article-title":"MAPK\/ERK signaling pathway analysis in primary osteoblasts from patients with nonsyndromic sagittal craniosynostosis","volume":"51","author":"Kim","year":"2014","journal-title":"Cleft Palate Craniofac J."},{"key":"10.1016\/j.ecoenv.2024.117343_bib44","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1172\/JCI72688","article-title":"Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis","volume":"124","author":"Kurosaka","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ecoenv.2024.117343_bib45","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/SCS.0000000000008425","article-title":"Dexamethasone induces apoptosis of embryonic palatal mesenchymal cells through the GATA-6\/bone morphogenetic protein-2\/p38 MAPK pathway","volume":"33","author":"Lan","year":"2022","journal-title":"J. Craniofacial Surg."},{"key":"10.1016\/j.ecoenv.2024.117343_bib46","doi-asserted-by":"crossref","DOI":"10.1242\/dev.187369","article-title":"Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk","author":"Lee","year":"2020","journal-title":"Dev. 147, dev187369"},{"key":"10.1016\/j.ecoenv.2024.117343_bib47","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2020.07.060","article-title":"TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization","volume":"531","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2024.117343_bib48","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/0022034519851786","article-title":"Regulatory mechanisms of soft palate development and malformations","volume":"98","author":"Li","year":"2019","journal-title":"J. Dent. Res"},{"key":"10.1016\/j.ecoenv.2024.117343_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/dev.02701","article-title":"Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development","volume":"134","author":"Li","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2024.117343_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101306","article-title":"Advanced oxidation protein products increase TNF-\u03b1 and IL-1\u03b2 expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression","volume":"28","author":"Liao","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152353","article-title":"TCDD inhibited the osteogenic differentiation of human fetal palatal mesenchymal cells through AhR and BMP-2\/TGF-\u03b2\/Smad signaling","volume":"431","author":"Liu","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2024.117343_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s10020-024-00960-2","article-title":"Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate","volume":"30","author":"Luo","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4161\/epi.5.7.12762","article-title":"Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta","volume":"5","author":"Maccani","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2024.117343_bib54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2024.117343_bib55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/dvdy.22072","article-title":"Visualizing canonical Wnt signaling during mouse craniofacial development","volume":"239","author":"Mani","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2024.117343_bib56","doi-asserted-by":"crossref","DOI":"10.1242\/dev.157206","article-title":"Dusp6 attenuates Ras\/MAPK signaling to limit zebrafish heart regeneration","volume":"145","author":"Missinato","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2024.117343_bib57","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1165\/rcmb.2006-0047SF","article-title":"Oxidants and signaling by mitogen-activated protein kinases in lung epithelium","volume":"34","author":"Mossman","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib58","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1073\/pnas.97.3.1113","article-title":"Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway","volume":"97","author":"Murakami","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2024.117343_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2019.04.404","article-title":"Levels of polycyclic aromatic hydrocarbons in umbilical cord and risk of orofacial clefts","volume":"678","author":"Ni","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.117343_bib60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10735-005-9014-5","article-title":"Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice","volume":"36","author":"Nie","year":"2005","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib61","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/thx.2006.061630","article-title":"Association of maternal smoking with increased infant oxidative stress at 3 months of age","volume":"62","author":"Noakes","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.ecoenv.2024.117343_bib62","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1101\/gr.268482.120","article-title":"Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits","volume":"31","author":"Orchard","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.ecoenv.2024.117343_bib63","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ntr\/ntv227","article-title":"Nicotine exposure during pregnancy results in persistent midline epithelial seam with improper palatal fusion","volume":"18","author":"Ozturk","year":"2016","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.ecoenv.2024.117343_bib64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gendis.2020.04.006","article-title":"Notch signaling: Its essential roles in bone and craniofacial development","volume":"8","author":"Pakvasa","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.ecoenv.2024.117343_bib65","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1038\/s41467-023-41349-9","article-title":"Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis","volume":"14","author":"Pi\u00f1a","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2024.117343_bib66","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.3390\/ijms24086963","article-title":"A compilation of the diverse miRNA functions in caenorhabditis elegans and drosophila melanogaster development","volume":"24","author":"Quesnelle","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.117343_bib67","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12903-021-01675-0","article-title":"Depletion of EREG enhances the osteo\/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment","volume":"21","author":"Ran","year":"2021","journal-title":"BMC Oral. Health"},{"key":"10.1016\/j.ecoenv.2024.117343_bib68","first-page":"151","article-title":"MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance.\u00a0Current opinion in structural biology, multi-protein assemblies in signaling","volume":"41","author":"Rauch","year":"2016","journal-title":"Catal. Regul."},{"key":"10.1016\/j.ecoenv.2024.117343_bib69","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.037051","article-title":"Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models","volume":"12","author":"Reynolds","year":"2019","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.ecoenv.2024.117343_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116963","article-title":"Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis","volume":"10","author":"Sabbagh","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2024.117343_bib71","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biocel.2015.04.004","article-title":"Chromatin mechanisms in the developmental control of imprinted gene expression","volume":"67","author":"Sanli","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib72","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3390\/nu14122448","article-title":"Quercetin Reduces the Development of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced cleft palate in mice by suppressing CYP1A1 via the Aryl Hydrocarbon Receptor","volume":"14","author":"Satake","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2024.117343_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diff.2022.01.002","article-title":"MicroRNAs as epigenetic regulators of orofacial development","volume":"124","author":"Seelan","year":"2022","journal-title":"Differentiation"},{"key":"10.1016\/j.ecoenv.2024.117343_bib74","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000534292","article-title":"Targeting cartilage miR-195\/497 cluster for osteoarthritis treatment regulates the circadian clock","volume":"70","author":"Shi","year":"2024","journal-title":"Gerontology"},{"key":"10.1016\/j.ecoenv.2024.117343_bib75","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ng2096","article-title":"RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis","volume":"39","author":"Shukla","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ecoenv.2024.117343_bib76","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1093\/hmg\/ddv228","article-title":"New insights into craniofacial malformations","volume":"24","author":"Twigg","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ecoenv.2024.117343_bib77","doi-asserted-by":"crossref","first-page":"14432","DOI":"10.1073\/pnas.0905840106","article-title":"Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins","volume":"106","author":"Vanhoutteghem","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2024.117343_bib78","doi-asserted-by":"crossref","DOI":"10.1177\/1559325820946918","article-title":"miR-152 attenuates apoptosis in chondrocytes and degeneration of cartilages in osteoarthritis rats via TCF-4 Pathway","volume":"18","author":"Wan","year":"2020","journal-title":"Dose Response"},{"key":"10.1016\/j.ecoenv.2024.117343_bib79","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/nph.17295","article-title":"Cross species multi-omics reveals cell wall sequestration and elevated global transcript abundance as mechanisms of boron tolerance in plants","volume":"230","author":"Wang","year":"2021","journal-title":"N. Phytol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib80","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/bdr2.1043","article-title":"Prevalence of orofacial clefts among live births in China: a systematic review and meta-analysis","volume":"109","author":"Wang","year":"2017","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.ecoenv.2024.117343_bib81","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.taap.2005.01.061","article-title":"Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species","volume":"207","author":"Wells","year":"2005","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2024.117343_bib82","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/tcm.1770060505","article-title":"Karyotype, growth, and cell cycle analysis of human embryonic palatal mesenchymal cells: relevance to the use of these cells in an in vitro teratogenicity screening assay","volume":"6","author":"Welsch","year":"1986","journal-title":"Teratog. Carcinog. Mutagen"},{"key":"10.1016\/j.ecoenv.2024.117343_bib83","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.116.001678","article-title":"A MicroRNA signature of cigarette smoking and evidence for a putative causal role of MicroRNAs in smoking-related inflammation and target organ damage","volume":"10","author":"Willinger","year":"2017","journal-title":"Circ. Cardiovasc Genet"},{"key":"10.1016\/j.ecoenv.2024.117343_bib84","doi-asserted-by":"crossref","first-page":"R185","DOI":"10.1530\/REP-15-0295","article-title":"Adverse effects of perinatal nicotine exposure on reproductive outcomes","volume":"150","author":"Wong","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.ecoenv.2024.117343_bib85","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jbmr\/zjae010","article-title":"Deletion of the auxiliary \u03b12\u03b41 voltage sensitive calcium channel subunit in osteocytes and late-stage osteoblasts impairs femur strength and load-induced bone formation in male mice","volume":"39","author":"Wright","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ecoenv.2024.117343_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res"},{"key":"10.1016\/j.ecoenv.2024.117343_bib87","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s13577-020-00433-8","article-title":"LncRNA NEAT1 regulates chondrocyte proliferation and apoptosis via targeting miR-543\/PLA2G4A axis","volume":"34","author":"Xiao","year":"2021","journal-title":"Hum. Cell"},{"key":"10.1016\/j.ecoenv.2024.117343_bib88","first-page":"1921","article-title":"Identification of key microRNAs and target genes for the diagnosis of bone nonunion","volume":"21","author":"Xiong","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ecoenv.2024.117343_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.621045","article-title":"MicroRNA-124-3p plays a crucial role in cleft palate induced by retinoic acid","volume":"9","author":"Yoshioka","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib90","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s00204-023-03534-z","article-title":"The mechanisms governing mouse embryonic palate mesenchymal cells\u2019 proliferation associated with atRA-induced cleft palate in mice: insights from integrated transcriptomic and metabolomic analyses","volume":"97","author":"Yu","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.152","article-title":"MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes","volume":"46","author":"Zhang","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ecoenv.2024.117343_bib92","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12903-023-03011-0","article-title":"IRAK4 inhibition: an effective strategy for immunomodulating peri-implant osseointegration via reciprocally-shifted polarization in the monocyte-macrophage lineage cells","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Oral. Health"},{"key":"10.1016\/j.ecoenv.2024.117343_bib93","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/bdrb.20052","article-title":"Nicotine-induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stress","volume":"74","author":"Zhao","year":"2005","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2024.117343_bib94","doi-asserted-by":"crossref","first-page":"12740","DOI":"10.3390\/ijms241612740","article-title":"Inhibition of Cxcr4 disrupts mouse embryonic palatal mesenchymal cell migration and induces cleft palate occurrence","volume":"24","author":"Zheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2024.117343_bib95","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41374-021-00595-5","article-title":"Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2\u03b1 by miR-96-5p","volume":"101","author":"Zhou","year":"2021","journal-title":"Lab Invest"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324014192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324014192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T15:21:38Z","timestamp":1737300098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324014192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":95,"alternative-id":["S0147651324014192"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117343","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117343"}}