{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:39:33Z","timestamp":1768462773416,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473747"],"award-info":[{"award-number":["82473747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273749"],"award-info":[{"award-number":["82273749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503000"],"award-info":[{"award-number":["2022YFC2503000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["NHCKLEE20230908"],"award-info":[{"award-number":["NHCKLEE20230908"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ecoenv.2024.117644","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T19:15:52Z","timestamp":1736018152000},"page":"117644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The potential of urinary miR-200c-3p as a biomarker of fluorosis in rats"],"prefix":"10.1016","volume":"289","author":[{"given":"Ailin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Fiorella Chacon","family":"Campoverde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazala","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Que","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korto Fatti","family":"Tarnue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-9566","authenticated-orcid":false,"given":"Junrui","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ecoenv.2024.117644_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/00016357.2020.1786600","article-title":"Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis","volume":"78","author":"Abbasoglu","year":"2020","journal-title":"Acta Odontol. Scand."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0102-67202012000100011","article-title":"Rat's age versus human's age: what is the relationship?","volume":"25","author":"Andreollo","year":"2012","journal-title":"Arq. Bras. Cir. Dig."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13567-021-00912-2","article-title":"MicroRNA expression profile in bovine mammary gland parenchyma infected by coagulase-positive or coagulase-negative staphylococci","volume":"52","author":"Bagnicka","year":"2021","journal-title":"Vet. Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-023-00273-w","article-title":"A novel saliva-based miRNA profile to diagnose and predict oral cancer","volume":"16","author":"Balakittnen","year":"2024","journal-title":"Int J. Oral. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.117644_bib5","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12505","article-title":"MicroRNA\u2011200c\u20113p suppresses intervertebral disc degeneration by targeting RAP2C\/ERK signaling","volume":"24","author":"Cao","year":"2021","journal-title":"Mol. Med Rep."},{"issue":"4","key":"10.1016\/j.ecoenv.2024.117644_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3181\/00379727-92-22641","article-title":"Renal clearance of fluoride","volume":"92","author":"Chen","year":"1956","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1016\/j.ecoenv.2024.117644_bib7","article-title":"MiR-1a-3p inhibits apoptosis in fluoride-exposed LS8 cells by targeting Map3k1","author":"Chen","year":"2023","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.ecoenv.2024.117644_bib8","series-title":"Endemiology","first-page":"182","author":"D, S","year":"2023"},{"key":"10.1016\/j.ecoenv.2024.117644_bib9","unstructured":"QiuH. Ghrelin, IL-1 \u03b2 And TNF- \u03b1 Expression and significance of different Mankin pathological grades in cartilage and synovium of knee osteoarthritis. 2019. (In Chinese)."},{"key":"10.1016\/j.ecoenv.2024.117644_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153079","article-title":"miR-21-5p and canonical Wnt signaling pathway promote osteoblast function through a feed-forward loop induced by fluoride","volume":"466","author":"Guo","year":"2022","journal-title":"Toxicology"},{"issue":"11","key":"10.1016\/j.ecoenv.2024.117644_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1454","article-title":"Identification of 3\u2032-terminal 2\u2032-O-methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC","volume":"13","author":"Guo","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jnci\/djz112","article-title":"Temporal stability and prognostic biomarker potential of the prostate cancer urine miRNA transcriptome","volume":"112","author":"Jeon","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ecoenv.2024.117644_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.chemosphere.2018.01.095","article-title":"Identification of miR-200c-3p as a major regulator of SaoS2 cells activation induced by fluoride","volume":"199","author":"Jiang","year":"2018","journal-title":"Chemosphere"},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2024.117644_bib14","article-title":"Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway","volume":"266","author":"Jiang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2024.117644_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221080981","article-title":"Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p expression and their clinical relevance as biomarkers in lung cancer","volume":"21","author":"Kumar","year":"2022","journal-title":"Technol. Cancer Res Treat."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s12011-022-03227-1","article-title":"A systematic review and meta-analysis of the relationship between the severity of dental fluorosis and fluoride biomarkers in endemic areas","volume":"201","author":"Lavalle-Carrasco","year":"2023","journal-title":"Biol. Trace Elem. Res"},{"issue":"07","key":"10.1016\/j.ecoenv.2024.117644_bib17","first-page":"57","article-title":"Absorption and metabolism of different forms of fluorine in tea in rats","volume":"18","author":"Li","year":"2018","journal-title":"Chin. J. Food Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117644_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S0103-64402010000200001","article-title":"Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice","volume":"21","author":"Lima-Arsati","year":"2010","journal-title":"Braz. Dent. J."},{"key":"10.1016\/j.ecoenv.2024.117644_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103331","article-title":"The dose-time effects of fluoride on the expression and DNA methylation level of the promoter region of BMP-2 and BMP-7 in rats","volume":"75","author":"Ma","year":"2020","journal-title":"Environ. Toxicol. Pharm."},{"issue":"6","key":"10.1016\/j.ecoenv.2024.117644_bib20","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1007\/s12011-022-03394-1","article-title":"Effect of fluoride on the expression of 8-hydroxy-2\u2032-deoxyguanosine in the blood, kidney, liver, and brain of rats","volume":"201","author":"Ma","year":"2023","journal-title":"Biol. Trace Elem. Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000512483","article-title":"Epidemiology of erosive tooth wear, dental fluorosis and molar incisor hypomineralization in the American Continent","volume":"55","author":"Martignon","year":"2021","journal-title":"Caries Res"},{"issue":"9","key":"10.1016\/j.ecoenv.2024.117644_bib22","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/tox.23302","article-title":"miR-486-3p regulates CyclinD1 and promotes fluoride-induced osteoblast proliferation and activation","volume":"36","author":"Ouyang","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/0974-7753.125613","article-title":"Hair as biomarker of fluoride exposure in a fluoride endemic area and a low fluoridated area","volume":"5","author":"Parimi","year":"2013","journal-title":"Int. J. Trichol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib24","first-page":"29","article-title":"Identification of pathogenesis-related microRNA profiles in skeletal fluorosis","volume":"52","author":"Pei","year":"2019","journal-title":"Fluoride"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jop.12650","article-title":"MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma","volume":"47","author":"Pereira","year":"2018","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.ecoenv.2024.117644_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.scitotenv.2014.07.048","article-title":"Fluoride exposure from groundwater as reflected by urinary fluoride and children's dental fluorosis in the Main Ethiopian Rift Valley","volume":"496","author":"Rango","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2024.117644_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2017.04.021","article-title":"Biomarkers of chronic fluoride exposure in groundwater in a highly exposed population","volume":"596-597","author":"Rango","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.117644_bib28","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/00220345820610091401","article-title":"Fluoride pharmacokinetics in the domestic pig","volume":"61","author":"Richards","year":"1982","journal-title":"J. Dent. Res"},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/00220345850640030601","article-title":"Pharmacokinetics of chronic fluoride ingestion in growing pigs","volume":"64","author":"Richards","year":"1985","journal-title":"J. Dent. Res"},{"issue":"12","key":"10.1016\/j.ecoenv.2024.117644_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25126762","article-title":"Deciphering key microRNA regulated pathways in tissue-engineered blood vessels: implications for vascular scaffold production","volume":"25","author":"Rodrigues","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00256-019-03302-0","article-title":"Skeletal fluorosis: don't miss the diagnosis!","volume":"49","author":"Sellami","year":"2020","journal-title":"Skelet. Radio."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/15563657708989848","article-title":"Fluoride accumulation in bone and the effect on their physical properties in guinea pigs given different levels of fluoridated water","volume":"11","author":"Sharma","year":"1977","journal-title":"Clin. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41416-023-02488-4","article-title":"Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer","volume":"130","author":"Shi","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ecoenv.2024.117644_bib34","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.919309","article-title":"Zingerone promotes osteoblast differentiation via MiR-200c-3p\/smad7 regulatory axis in human bone mesenchymal stem cells","volume":"26","author":"Song","year":"2020","journal-title":"Med Sci. Monit."},{"issue":"3","key":"10.1016\/j.ecoenv.2024.117644_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4103\/jispcd.JISPCD_52_20","article-title":"Comparative evaluation of hair, fingernails, and toenails as biomarkers of fluoride exposure: a cross-sectional study","volume":"10","author":"Vidyadharan","year":"2020","journal-title":"J. Int Soc. Prev. Community Dent."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00128-019-02660-8","article-title":"Analysis of the microRNA profile of coal-burning endemic fluorosis using deep sequencing and bioinformatic approaches","volume":"103","author":"Wang","year":"2019","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"01","key":"10.1016\/j.ecoenv.2024.117644_bib37","first-page":"7","article-title":"24-hour metabolism of fluoride in brick tea in rats","author":"Wang","year":"2005","journal-title":"Chin. J. Endem."},{"issue":"2","key":"10.1016\/j.ecoenv.2024.117644_bib38","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/ajplegacy.1976.230.2.527","article-title":"Fluoride renal clearance: a pH-dependent event","volume":"230","author":"Whitford","year":"1976","journal-title":"Am. J. Physiol."},{"issue":"11","key":"10.1016\/j.ecoenv.2024.117644_bib39","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.archoralbio.2008.04.001","article-title":"Pharmacokinetics of ingested fluoride: lack of effect of chemical compound","volume":"53","author":"Whitford","year":"2008","journal-title":"Arch. Oral. Biol."},{"issue":"9","key":"10.1016\/j.ecoenv.2024.117644_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093094","article-title":"Human breast milk composition and function in human health: from nutritional components to microbiome and MicroRNAs","volume":"13","author":"Yi","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib41","first-page":"39","article-title":"Correlation between femoral head bone iron content, serum ferritin and bone mineral density of postmenopausal women with femoral neck fragility fracture","volume":"34","author":"Zhang","year":"2014","journal-title":"Chin. J. Orthop."},{"issue":"1","key":"10.1016\/j.ecoenv.2024.117644_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13048-022-00980-8","article-title":"A risk score system based on a six-microRNA signature predicts the overall survival of patients with ovarian cancer","volume":"15","author":"Zhou","year":"2022","journal-title":"J. Ovarian Res"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324017202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651324017202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:53:38Z","timestamp":1762246418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651324017202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"alternative-id":["S0147651324017202"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117644","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of urinary miR-200c-3p as a biomarker of fluorosis in rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117644"}}