{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:41:38Z","timestamp":1788543698574,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971400"],"award-info":[{"award-number":["81971400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ecoenv.2025.117728","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T20:54:29Z","timestamp":1736974469000},"page":"117728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation"],"prefix":"10.1016","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7437-0085","authenticated-orcid":false,"given":"Pei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenshen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-8049","authenticated-orcid":false,"given":"Xiaomei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.117728_bib1","first-page":"325","article-title":"POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and\/or polyposis: review of reported cases and recommendations for genetic testing and surveillance","volume":"18","author":"Bellido","year":"2016"},{"key":"10.1016\/j.ecoenv.2025.117728_bib2","doi-asserted-by":"crossref","first-page":"12754","DOI":"10.1074\/jbc.R117.787101","article-title":"Iron-sulfur cluster biogenesis and trafficking in mitochondria","volume":"292","author":"Braymer","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.117728_bib3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/acs.biochem.6b00447","article-title":"Human mitochondrial ferredoxin 1 (FDX1) and ferredoxin 2 (FDX2) both bind cysteine desulfurase and donate electrons for iron-sulfur cluster biosynthesis","volume":"56","author":"Cai","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecoenv.2025.117728_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/biom12071009","article-title":"Molecular basis of rare diseases associated to the maturation of mitochondrial [4Fe-4S]-containing proteins","volume":"12","author":"Camponeschi","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2025.117728_bib5","article-title":"Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8","volume":"10","author":"Chang","year":"2021"},{"key":"10.1016\/j.ecoenv.2025.117728_bib6","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1152\/ajpendo.00457.2019","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2025.117728_bib7","article-title":"The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1\/S transition","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.117728_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1126\/science.1106391","article-title":"Aconitase couples metabolic regulation to mitochondrial DNA maintenance","volume":"307","author":"Chen","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.117728_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biom10030453","article-title":"The TGF\u03b2 family in human placental development at the fetal-maternal interface","volume":"10","author":"Chuva de Sousa Lopes","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2025.117728_bib10","series-title":"In Methods in enzymology","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/bs.mie.2017.07.004","article-title":"Chapter Six - Fe\u2013S Cluster Hsp70 Chaperones: The ATPase Cycle and Protein Interactions","author":"Dutkiewicz","year":"2017"},{"key":"10.1016\/j.ecoenv.2025.117728_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.yrtph.2015.01.006","article-title":"Variation in tobacco and mainstream smoke toxicant yields from selected commercial cigarette products","volume":"71","author":"Eldridge","year":"2015","journal-title":"Regul. Toxicol. Pharmacol.: RTP"},{"key":"10.1016\/j.ecoenv.2025.117728_bib12","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1873-3468.13995","article-title":"Mitochondrial disorders of the OXPHOS system","volume":"595","author":"Fernandez-Vizarra","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ecoenv.2025.117728_bib13","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1038\/s41467-019-11470-9","article-title":"Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin","volume":"10","author":"Gervason","year":"2019","journal-title":"Nat Commun."},{"key":"10.1016\/j.ecoenv.2025.117728_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114015","article-title":"Cigarette smoke-induced trophoblast cell ferroptosis in rat placenta and the effects of L-arginine intervention","volume":"243","author":"Guan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117728_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0026-895X(25)09964-X","article-title":"Benzo(a)pyrene inhibits epidermal growth factor binding and receptor autophosphorylation in human placental cell cultures","volume":"37","author":"Guyda","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib16","unstructured":"Huang, Z., Li, S., Fan, W., and Ma, Q. Transforming growth factor \u03b21 promotes invasion of human JEG-3 trophoblast cells via TGF-\u03b2\/Smad3 signaling pathway."},{"key":"10.1016\/j.ecoenv.2025.117728_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ecoenv.2025.117728_bib18","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.molcel.2010.07.029","article-title":"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation","volume":"39","author":"Ito","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2025.117728_bib19","doi-asserted-by":"crossref","first-page":"e2018012","DOI":"10.5620\/eht.e2018012","article-title":"Comparison of volatile organic compounds between cigarette smoke condensate (CSC) and extract (CSE) samples","volume":"33","author":"Kim","year":"2018","journal-title":"Environ. Anal. Health Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.molcel.2016.04.010","article-title":"Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion","volume":"62","author":"Kumar","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2025.117728_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/tox.22506","article-title":"Cigarette smoke extract and isoprene resulted in the induction of apoptosis and autophagy in human placenta choriocarcinoma JEG-3 cells","volume":"33","author":"Lee","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ejcb.2015.05.002","article-title":"The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins","volume":"94","author":"Lill","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib23","article-title":"Preliminary study on the function of the POLD1 (CDC2) EXON2c.56G>A mutation","volume":"8","author":"Liu","year":"2020","journal-title":"Mol. Genet Genom. Med."},{"key":"10.1016\/j.ecoenv.2025.117728_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104957","article-title":"Ercc2\/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress","volume":"25","author":"Ma","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ecoenv.2025.117728_bib25","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/ntr\/ntv292","article-title":"Cigarette smoking among working women of reproductive age\u2014United States, 2009\u20132013","volume":"18","author":"Mazurek","year":"2016","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.ecoenv.2025.117728_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.placenta.2011.01.015","article-title":"Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes","volume":"32","author":"Menon","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2025.117728_bib27","doi-asserted-by":"crossref","first-page":"31277","DOI":"10.1074\/jbc.M400641200","article-title":"Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells","volume":"279","author":"Munir","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.117728_bib28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2025.117728_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1476-4598-9-79","article-title":"HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0\/G1 in thiol-containing agents reversible way","volume":"9","author":"Peng","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ecoenv.2025.117728_bib30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/pro.3424","article-title":"The essential and multifunctional TFIIH complex","volume":"27","author":"Rimel","year":"2018","journal-title":"Protein Sci.: a Publ. Protein Soc."},{"key":"10.1016\/j.ecoenv.2025.117728_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm3909","article-title":"Mammalian iron-sulphur proteins: novel insights into biogenesis and function","volume":"16","author":"Rouault","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib32","article-title":"Sulfur administration in Fe-S cluster homeostasis","volume":"10","author":"Rydz","year":"2021"},{"key":"10.1016\/j.ecoenv.2025.117728_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.ecoenv.2025.117728_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0002-9378(00)70240-7","article-title":"A systematic review and meta-analysis of prospective studies on the association between maternal cigarette smoking and preterm delivery","volume":"182","author":"Shah","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib35","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.117728_bib36","first-page":"E9085","article-title":"Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins","volume":"115","author":"Stehling","year":"2018"},{"key":"10.1016\/j.ecoenv.2025.117728_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biochi.2014.01.010","article-title":"Mitochondrial iron-sulfur protein biogenesis and human disease","volume":"100","author":"Stehling","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.ecoenv.2025.117728_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.reprotox.2015.12.010","article-title":"Prenatal nicotine exposure induces poor articular cartilage quality in female adult offspring fed a high-fat diet and the intrauterine programming mechanisms","volume":"60","author":"Tie","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117728_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12971-017-0140-0","article-title":"Smoking in pregnancy: a cross-sectional study in China","volume":"15","author":"Xu","year":"2017","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.ecoenv.2025.117728_bib40","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.cellsig.2014.08.030","article-title":"Smad3\/Nox4-mediated mitochondrial dysfunction plays a crucial role in puromycin aminonucleoside-induced podocyte damage","volume":"26","author":"Yu","year":"2014","journal-title":"Cell Signal"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325000648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325000648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:42:59Z","timestamp":1762245779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325000648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"alternative-id":["S0147651325000648"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117728","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117728"}}