{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:36Z","timestamp":1792120416122,"version":"4.4.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017963","name":"Department of Education of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["STAQZX202314"],"award-info":[{"award-number":["STAQZX202314"]}],"id":[{"id":"10.13039\/100017963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","award":["ZY20242107"],"award-info":[{"award-number":["ZY20242107"]}],"id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024QN03035"],"award-info":[{"award-number":["2024QN03035"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2021LHBS03005"],"award-info":[{"award-number":["2021LHBS03005"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024SHZR2106"],"award-info":[{"award-number":["2024SHZR2106"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024QN03068"],"award-info":[{"award-number":["2024QN03068"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ecoenv.2025.117816","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T20:03:57Z","timestamp":1738267437000},"page":"117816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Prenatal Perfluorooctanoic Acid (PFOA) exposure causes reproductive toxicity by disrupting the formation of transzonal projections (TZPs) and down-regulating Wnt4\/\u03b2-catenin signaling pathway in progeny"],"prefix":"10.1016","volume":"291","author":[{"given":"Hua","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-248X","authenticated-orcid":false,"given":"Shengtao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9191-8954","authenticated-orcid":false,"given":"Jiapeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.117816_bib1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41467-021-21644-z","article-title":"Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation","volume":"12","author":"Abbassi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.117816_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/cam.22826","article-title":"The laminin family","volume":"7","author":"Aumailley","year":"2013","journal-title":"Cell Adh Migr."},{"key":"10.1016\/j.ecoenv.2025.117816_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2015.10.021","article-title":"Ovarian development and disease: The known and the unexpected","volume":"45","author":"Biason-Lauber","year":"2015","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib4","doi-asserted-by":"crossref","first-page":"27006","DOI":"10.1289\/EHP6233","article-title":"Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.117816_bib5","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9091","article-title":"Maternal levels of perfluoroalkyl substances (PFAS) during early pregnancy in relation to preeclampsia subtypes and biomarkers of preeclampsia risk","volume":"129","author":"Bommarito","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.117816_bib6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib7","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1096\/fj.09-145789","article-title":"WNT4 is required for normal ovarian follicle development and female fertility","volume":"24","author":"Boyer","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2025.117816_bib8","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1242\/dev.078972","article-title":"WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad","volume":"139","author":"Chassot","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2025.117816_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113857","article-title":"Arsenic exposure during juvenile and puberty significantly affected reproductive system development of female SD rats","volume":"242","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117816_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.reprotox.2017.02.010","article-title":"Maternal exposure to perfluorooctanoic acid inhibits luteal function via oxidative stress and apoptosis in pregnant mice","volume":"69","author":"Chen","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/mrd.23645","article-title":"Transzonal projections: essential structures mediating intercellular communication in the mammalian ovarian follicle","volume":"89","author":"Clarke","year":"2022","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ecoenv.2025.117816_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biology11010052","article-title":"Dynamics of the actin cytoskeleton at adhesion complexes","volume":"11","author":"Cronin","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ecoenv.2025.117816_bib13","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301963","article-title":"Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes","volume":"6","author":"Crozet","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.ecoenv.2025.117816_bib14","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1038\/s41418-020-0547-7","article-title":"R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth","volume":"27","author":"De Cian","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2025.117816_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/etc.4935","article-title":"PFAS Exposure pathways for humans and wildlife: a synthesis of current knowledge and key gaps in understanding","volume":"40","author":"De Silva","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.117816_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2025.117816_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tiv.2016.05.011","article-title":"Effect of perfluorooctane sulfonate on viability, maturation and gap junctional intercellular communication of porcine oocytes in vitro","volume":"35","author":"Dominguez","year":"2016","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2025.117816_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11050425","article-title":"Multigenerational effects of a complex human-relevant exposure during folliculogenesis and preimplantation embryo development: the FEDEXPO Study","volume":"11","author":"El Fouikar","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.117816_bib19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cub.2018.02.039","article-title":"Mammalian oocytes locally remodel follicular architecture to provide the foundation for germline-soma communication","volume":"28","author":"El-Hayek","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.055","article-title":"Insights into Gonadal Sex Differentiation Provided by Single-Cell Transcriptomics in the Chicken Embryo","volume":"31","author":"Estermann","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2025.117816_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfv197","article-title":"Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation","volume":"148","author":"Feng","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.117816_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007488","article-title":"Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries","volume":"14","author":"Fu","year":"2018","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ecoenv.2025.117816_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep38039","article-title":"Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.117816_bib24","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.7150\/thno.94943","article-title":"Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling","volume":"14","author":"Fu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.ecoenv.2025.117816_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/cdd.2013.34","article-title":"Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis","volume":"20","author":"Gozo","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2025.117816_bib26","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1016\/j.scitotenv.2010.04.040","article-title":"Low serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) in children and adults from Afghanistan","volume":"408","author":"Hemat","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117816_bib27","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1530\/REP-14-0685","article-title":"The role of WNT signaling in adult ovarian folliculogenesis","volume":"150","author":"Hernandez Gifford","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.ecoenv.2025.117816_bib28","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1210\/me.2005-0420","article-title":"Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process?","volume":"20","author":"Hernandez-Gonzalez","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib29","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1021\/acs.est.2c07185","article-title":"Systematic evidence mapping of potential exposure pathways for per- and polyfluoroalkyl substances based on measured occurrence in multiple media","volume":"57","author":"Holder","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib30","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/endo.143.3.8684","article-title":"Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary","volume":"143","author":"Hsieh","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2025.117816_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.matbio.2004.05.008","article-title":"A novel basal lamina matrix of the stratified epithelium of the ovarian follicle","volume":"23","author":"Irving-Rodgers","year":"2004","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2006-948549","article-title":"Extracellular matrix of the developing ovarian follicle","volume":"24","author":"Irving-Rodgers","year":"2006","journal-title":"Semin Reprod. Med"},{"key":"10.1016\/j.ecoenv.2025.117816_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-physiol-022516-034102","article-title":"Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle","volume":"79","author":"Jaffe","year":"2017","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.envres.2016.02.037","article-title":"Perfluoroalkyl substances in serum from South Korean infants with congenital hypothyroidism and healthy infants--Its relationship with thyroid hormones","volume":"147","author":"Kim","year":"2016","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.117816_bib35","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1289\/ehp.1307923","article-title":"The Navigation Guide - evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth","volume":"122","author":"Lam","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.117816_bib36","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.273.5279.1219","article-title":"Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)","volume":"273","author":"Lee","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.117816_bib37","doi-asserted-by":"crossref","first-page":"10126","DOI":"10.1096\/fj.201900093RR","article-title":"Wnt4 signaling mediates protective effects of melatonin on new bone formation in an inflammatory environment","volume":"33","author":"Li","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2025.117816_bib38","doi-asserted-by":"crossref","first-page":"23534","DOI":"10.1074\/jbc.M114.588897","article-title":"Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4","volume":"289","author":"Liang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.117816_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/d41586-019-00441-1","article-title":"Tainted water: the scientists tracing thousands of fluorinated chemicals in our environment","volume":"566","author":"Lim","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.117816_bib40","article-title":"WNT4\/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary","volume":"5","author":"Liu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.117816_bib41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/tox.22661","article-title":"Perfluorooctanoic acid disrupts gap junction intercellular communication and induces reactive oxygen species formation and apoptosis in mouse ovaries","volume":"34","author":"Lopez-Arellano","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib42","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cclet.2014.03.023","article-title":"Perfluorinated compounds in blood of textile workers and barbers","volume":"25","author":"Lu","year":"2014","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ecoenv.2025.117816_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103377","article-title":"beta-Catenin regulates ovarian granulosa cell cycle and proliferation in laying hens by interacting with TCF4","volume":"103","author":"Ma","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2025.117816_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1095\/biolreprod.114.119867","article-title":"The gametic synapse: RNA transfer to the bovine oocyte","volume":"91","author":"Macaulay","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117816_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1095\/biolreprod.114.127571","article-title":"Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation","volume":"94","author":"Macaulay","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117816_bib46","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s42003-024-06418-9","article-title":"Dorsomorphin inhibits AMPK, upregulates Wnt and Foxo genes and promotes the activation of dormant follicles","volume":"7","author":"Madsen","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1095\/biolreprod63.3.913","article-title":"Identification and immunolocalization of decorin, versican, perlecan, nidogen, and chondroitin sulfate proteoglycans in bovine small-antral ovarian follicles","volume":"63","author":"McArthur","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117816_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116762","article-title":"Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice","volume":"282","author":"Meng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117816_bib49","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envres.2008.06.001","article-title":"Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples","volume":"108","author":"Monroy","year":"2008","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.117816_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/acs.est.3c06499","article-title":"Occurrence of major perfluorinated alkylate substances in human blood and target organs","volume":"58","author":"Nielsen","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121610","article-title":"N-cadherin is critical for the survival of germ cells, the formation of steroidogenic cells, and the architecture of developing mouse gonads","volume":"8","author":"Piprek","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2025.117816_bib52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0303-7207(99)00087-8","article-title":"Development of the ovarian follicular epithelium","volume":"151","author":"Rodgers","year":"1999","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib53","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac047","article-title":"Jumonji domain-containing protein-3 (JMJD3\/Kdm6b) Is critical for normal ovarian function and female fertility","volume":"163","author":"Roy","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2025.117816_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12020-024-03940-y","article-title":"Environmental factors affecting female fertility","volume":"86","author":"Sakali","year":"2024","journal-title":"Endocrine"},{"key":"10.1016\/j.ecoenv.2025.117816_bib55","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1073\/pnas.1423598112","article-title":"Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles","volume":"112","author":"Shuhaibar","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2025.117816_bib56","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.reprotox.2012.05.039","article-title":"Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: a pilot study","volume":"34","author":"Stein","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1095\/biolreprod.113.109801","article-title":"The canonical WNT2 pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells","volume":"89","author":"Wang","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117816_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171742","article-title":"Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin","volume":"925","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117816_bib59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/B978-0-12-416024-8.00009-X","article-title":"Biogenesis of the mouse egg's extracellular coat, the zona pellucida","volume":"102","author":"Wassarman","year":"2013","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/toxsci\/kfl177","article-title":"Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring","volume":"96","author":"White","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.117816_bib61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.theriogenology.2024.05.013","article-title":"Role of secreted frizzled-related protein 5 in granulosa cells of hu sheep ovaries","volume":"225","author":"Yang","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2025.117816_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105926","article-title":"Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae","volume":"238","author":"Yu","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib63","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1021\/es401905e","article-title":"Biomonitoring of perfluoroalkyl acids in human urine and estimates of biological half-life","volume":"47","author":"Zhang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.117816_bib64","article-title":"Association of early pregnancy perfluoroalkyl and polyfluoroalkyl substance exposure with birth outcomes","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ecoenv.2025.117816_bib65","doi-asserted-by":"crossref","first-page":"13799","DOI":"10.1002\/jcp.28060","article-title":"H19 and Foxc2 synergistically promotes osteogenic differentiation of BMSCs via Wnt-beta-catenin pathway","volume":"234","author":"Zhou","year":"2019","journal-title":"J. Cell Physiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325001526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325001526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:41:48Z","timestamp":1762245708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325001526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":65,"alternative-id":["S0147651325001526"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117816","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal Perfluorooctanoic Acid (PFOA) exposure causes reproductive toxicity by disrupting the formation of transzonal projections (TZPs) and down-regulating Wnt4\/\u03b2-catenin signaling pathway in progeny","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117816"}}