{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:36:05Z","timestamp":1789608965587,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YJS20230154"],"award-info":[{"award-number":["YJS20230154"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304190"],"award-info":[{"award-number":["82304190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2022AH050643"],"award-info":[{"award-number":["2022AH050643"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ecoenv.2025.117851","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T20:54:07Z","timestamp":1738788847000},"page":"117851","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Oxidative stress caused by 3-monochloro-1,2-propanediol provokes intestinal stem cell hyperproliferation and the protective role of quercetin"],"prefix":"10.1016","volume":"291","author":[{"given":"Zongzhong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-0979","authenticated-orcid":false,"given":"Tian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.117851_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3390\/biom9110735","article-title":"Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements","volume":"9","author":"Aggarwal","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2025.117851_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s42255-021-00458-9","article-title":"Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice","volume":"3","author":"Aliluev","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.ecoenv.2025.117851_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.stem.2008.10.016","article-title":"Tissue damage-induced intestinal stem cell division in Drosophila","volume":"4","author":"Amcheslavsky","year":"2009","journal-title":"Cell stem Cell"},{"key":"10.1016\/j.ecoenv.2025.117851_bib4","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1080\/19440049.2016.1223353","article-title":"2-and 3-Monochloropropanediols in paper products and their transfer to foods","volume":"33","author":"Becalski","year":"2016","journal-title":"Food Addit. Contam.: Part A"},{"key":"10.1016\/j.ecoenv.2025.117851_bib5","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1242\/dev.107086","article-title":"Stem cells and the impact of ROS signaling","volume":"141","author":"Bigarella","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2025.117851_bib6","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00204-011-0657-6","article-title":"Absorption and metabolism of the food contaminant 3-chloro-1, 2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells","volume":"85","author":"Buhrke","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162474","article-title":"Newly discovered developmental and ovarian toxicity of 3-monochloro-1, 2-propanediol in Drosophila melanogaster and cyanidin-3-O-glucoside's protective effect","volume":"874","author":"Cai","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117851_bib8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3390\/microorganisms7090336","article-title":"The intestine of Drosophila melanogaster: an emerging versatile model system to study intestinal epithelial homeostasis and host-microbial interactions in humans","volume":"7","author":"Capo","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.ecoenv.2025.117851_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/0008-5472.CAN-11-1982","article-title":"JNK-induced apoptosis, compensatory growth, and cancer stem cells","volume":"72","author":"Chen","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.117851_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101835","article-title":"Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species","volume":"39","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110767","article-title":"Effects of cyanidin-3-O-glucoside on 3-chloro-1, 2-propanediol induced intestinal microbiota dysbiosis in rats","volume":"133","author":"Chen","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114285","article-title":"Exposure to bisphenol A induced oxidative stress, cell death and impaired epithelial homeostasis in the adult Drosophila melanogaster midgut","volume":"248","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117851_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114555","article-title":"Chronic exposure to zearalenone induces intestinal inflammation and oxidative injury in adult Drosophila melanogaster midgut","volume":"251","author":"Chen","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117851_bib14","first-page":"751","article-title":"Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress","volume":"11","author":"Dorier","year":"2017","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2025.117851_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00204-023-03467-7","article-title":"Toxicology of 3-monochloropropane-1, 2-diol and its esters: a narrative review","volume":"97","author":"Fattore","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1017\/S0954422416000159","article-title":"Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity","volume":"29","author":"Gil-Cardoso","year":"2016","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.ecoenv.2025.117851_bib17","doi-asserted-by":"crossref","first-page":"12675","DOI":"10.1021\/acs.jafc.8b04229","article-title":"Cyanidin-3-O-glucoside at low doses protected against 3-Chloro-1, 2-propanediol induced testis injury and improved spermatogenesis in male rats","volume":"66","author":"Jiang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2025.117851_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature17039","article-title":"Reparative inflammation takes charge of tissue regeneration","volume":"529","author":"Karin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.117851_bib19","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1039\/C4FO01178C","article-title":"Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability","volume":"6","author":"Kawabata","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.117851_bib20","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.3390\/molecules26134021","article-title":"Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns","volume":"26","author":"Khan","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.117851_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/jrf.0.0210275","article-title":"Male antifertility compounds: efficacy of U-5897 in primates (Macacamulatta)","volume":"21","author":"Kirton","year":"1970","journal-title":"Reproduction"},{"key":"10.1016\/j.ecoenv.2025.117851_bib22","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1016\/j.fct.2012.07.038","article-title":"Acute oral toxicity of 3-MCPD mono-and di-palmitic esters in Swiss mice and their cytotoxicity in NRK-52E rat kidney cells","volume":"50","author":"Liu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5665778","article-title":"Biological activities underlying the therapeutic effect of quercetin on inflammatory bowel disease","volume":"2022","author":"Lyu","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ecoenv.2025.117851_bib24","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1080\/19440049.2013.840805","article-title":"Occurrence of 3-MCPD and glycidyl esters in edible oils in the United States","volume":"30","author":"MacMahon","year":"2013","journal-title":"Food Addit. Contam.: Part A"},{"key":"10.1016\/j.ecoenv.2025.117851_bib25","first-page":"1202","article-title":"The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress","volume":"19","author":"Raghu","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib26","doi-asserted-by":"crossref","first-page":"21064","DOI":"10.1073\/pnas.1012759107","article-title":"Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways","volume":"107","author":"Ren","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.117851_bib27","doi-asserted-by":"crossref","first-page":"21528","DOI":"10.1073\/pnas.1215849110","article-title":"Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila","volume":"109","author":"Rera","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.117851_bib28","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.tcb.2018.08.001","article-title":"The intestinal stem cell niche: homeostasis and adaptations","volume":"28","author":"Santos","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110957","article-title":"Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice","volume":"136","author":"Schultrich","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tox.2007.01.013","article-title":"The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation","volume":"232","author":"Skamarauskas","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.117851_bib31","article-title":"Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches","volume":"6","author":"Smith","year":"2017","journal-title":"Wiley Interdiscip. Rev.: Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/19336934.2017.1384104","article-title":"Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal","volume":"11","author":"Tian","year":"2017","journal-title":"Fly"},{"key":"10.1016\/j.ecoenv.2025.117851_bib33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/antiox13070832","article-title":"N-acetyl cysteine overdose induced acute toxicity and hepatic microvesicular steatosis by disrupting GSH and interfering lipid metabolisms in normal mice","volume":"13","author":"Tsai","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2025.117851_bib34","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.3390\/molecules25225243","article-title":"Important flavonoids and their role as a therapeutic agent","volume":"25","author":"Ullah","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.117851_bib35","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.cell.2020.04.049","article-title":"Sleep loss can cause death through accumulation of reactive oxygen species in the gut","volume":"181","author":"Vaccaro","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.117851_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.115978","article-title":"Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention","volume":"271","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117851_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.126033","article-title":"Estimation of the dietary intake and risk assessment of food carcinogens (3-MCPD and 1, 3-DCP) in soy sauces by Monte Carlo simulation","volume":"311","author":"Wong","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.ecoenv.2025.117851_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22441","article-title":"Oxidative stress induces stem cell proliferation via TRPA1\/RyR-mediated Ca2+\u2009signaling in the Drosophila midgut","volume":"6","author":"Xu","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ecoenv.2025.117851_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2011.03.018","article-title":"EGFR, Wingless and JAK\/STAT signaling cooperatively maintain Drosophila intestinal stem cells","volume":"354","author":"Xu","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib40","doi-asserted-by":"crossref","DOI":"10.1039\/D4FO03025G","article-title":"Quercetin ameliorates celiac-related intestinal inflammation caused by wheat gluten through modulating oxidative stress, Th1\/Th2\/Treg balance, and intestinal microflora structure","author":"Yu","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.117851_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114522","article-title":"Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy","volume":"186","author":"Zhang","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117851_bib42","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1080\/19440049.2021.1970241","article-title":"Investigation of factors influencing the release of chloropropanols (3-MCPD and 1, 3-DCP) from food contact paper","volume":"38","author":"Zhong","year":"2021","journal-title":"Food Addit. Contam.: Part A"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325001873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325001873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:06:43Z","timestamp":1777489603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325001873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":42,"alternative-id":["S0147651325001873"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117851","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress caused by 3-monochloro-1,2-propanediol provokes intestinal stem cell hyperproliferation and the protective role of quercetin","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117851"}}