{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:20:20Z","timestamp":1794288020372,"version":"4.9.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ecoenv.2025.117868","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:10:46Z","timestamp":1739362246000},"page":"117868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":144,"special_numbering":"C","title":["First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility"],"prefix":"10.1016","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-9439","authenticated-orcid":false,"given":"Luigi","family":"Montano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-6952","authenticated-orcid":false,"given":"Marina","family":"Piscopo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-2380","authenticated-orcid":false,"given":"Maria","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Guglielmino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-1923","authenticated-orcid":false,"given":"Sandrine","family":"Chamayou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacira","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2203-2785","authenticated-orcid":false,"given":"Paola","family":"Rapisarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-8612","authenticated-orcid":false,"given":"Gea","family":"Oliveri Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-6741","authenticated-orcid":false,"given":"Oriana","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.117868_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/humrep\/deac011","article-title":"The changing tide of human fertility","volume":"37","author":"Aitken","year":"2022","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117868_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.117868_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.117868_bib4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/IJPSYM.IJPSYM_193_19","article-title":"The P Value and Statistical Significance: Misunderstandings, Explanations, Challenges, and Alternatives","volume":"41","author":"Andrade","year":"2019","journal-title":"Indian J. Psychol. Med."},{"key":"10.1016\/j.ecoenv.2025.117868_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2311253120","article-title":"Are microplastics spreading infectious disease?","volume":"120","author":"Beans","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.117868_bib6","series-title":"International Encyclopedia of Education (Fourth Edition","first-page":"575","article-title":"Categorical data analysis","author":"Chen","year":"2023"},{"key":"10.1016\/j.ecoenv.2025.117868_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s43591-022-00030-6","article-title":"Development and application of a health-based framework for informing regulatory action in relation to exposure of microplastic particles in California drinking water","volume":"2","author":"Coffin","year":"2022","journal-title":"Micro Nanoplastics"},{"key":"10.1016\/j.ecoenv.2025.117868_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119269","article-title":"Endocrine disrupting chemicals impact on ovarian aging: Evidence from epidemiological and experimental evidence","volume":"305","author":"Ding","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.117868_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106904","article-title":"Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid","volume":"158","author":"Dusza","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117868_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113966","article-title":"Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK\/eIF2\u03b1 signaling pathway","volume":"243","author":"Feng","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117868_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112247","article-title":"Microplastics in fillets of Mediterranean seafood. A risk assessment study","volume":"204","author":"Ferrante","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.117868_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105627","article-title":"Gamete quality in a multistressor environment","volume":"138","author":"Gallo","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117868_bib13","series-title":"Microplastics in food commodities: A food safety review on human exposure through dietary sources, Food Safety and Quality Series","author":"Garrido Gamarro","year":"2022"},{"key":"10.1016\/j.ecoenv.2025.117868_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1254886","article-title":"Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health","volume":"14","author":"Geng","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1210\/er.2015-1093","article-title":"Executive Summary to EDC-2: The Endocrine Society\u2019s Second Scientific Statement on Endocrine-Disrupting Chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2025.117868_bib16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1530\/jrf.0.0820813","article-title":"Physiological factors underlying the formation of ovarian follicular fluid","volume":"82","author":"Gosden","year":"1988","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.ecoenv.2025.117868_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110997","article-title":"The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis","volume":"518","author":"Graceli","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib18","doi-asserted-by":"crossref","first-page":"34594","DOI":"10.1007\/s11356-021-18218-3","article-title":"Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat","volume":"29","author":"Haddadi","year":"2022","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.117868_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117868_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147365","article-title":"Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment","volume":"785","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114371","article-title":"Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells","volume":"249","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117868_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108522","article-title":"Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota","volume":"185","author":"Jeong","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117868_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.724989","article-title":"A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens","volume":"12","author":"Kannan","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159164","article-title":"Microplastic diagnostics in humans: \u201cThe 3Ps\u201d Progress, problems, and prospects","volume":"856","author":"Kutralam-Muniasamy","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117868_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2025.117868_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113238","article-title":"Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt\/\u03b2-catenin signaling pathway in mice","volume":"232","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117868_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/d41586-021-01143-3","article-title":"Microplastics are everywhere \u2014 but are they harmful?","volume":"593","author":"Lim","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.117868_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.166045","article-title":"Uptake, transport and accumulation of micro- and nano-plastics in terrestrial plants and health risk associated with their transfer to food chain - A mini review","volume":"902","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.theriogenology.2019.03.023","article-title":"PKC\u03b4 contributes to oxidative stress-induced apoptosis in porcine ovarian granulosa cells via activating JNK","volume":"131","author":"Liu","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2025.117868_bib32","unstructured":"Microsoft Corporation. (2024). Excel (Microsoft 365 Subscription). [Computer Software]. Microsoft Corporation. https:\/\/www.microsoft.com\/en-us\/microsoft-365\/excel#:~:text=Microsoft%20Excel%20with%20a%20Microsoft,Excel%202007%2C%20and%20Excel%202003."},{"key":"10.1016\/j.ecoenv.2025.117868_bib33","first-page":"113","article-title":"Reproductive Biomarkers as Early Indicators for Assessing Environmental Health Risk","volume":"33","author":"Montano","year":"2020"},{"key":"10.1016\/j.ecoenv.2025.117868_bib34","doi-asserted-by":"crossref","unstructured":"Montano, L., Bergamo, P., Lorenzetti, M.G.A. and S., Montano, L., Bergamo, P., Lorenzetti, M.G.A. and S, 2018. The Role of Human Semen as an Early and Reliable Tool of Environmental Impact Assessment on Human Health, in: Spermatozoa - Facts and Perspectives. IntechOpen. \u3008https:\/\/doi.org\/10.5772\/intechopen.73231\u3009.","DOI":"10.5772\/intechopen.73231"},{"key":"10.1016\/j.ecoenv.2025.117868_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165922","article-title":"Raman Microspectroscopy evidence of microplastics in human semen","volume":"901","author":"Montano","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114088","article-title":"Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells","volume":"214","author":"Najahi","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.117868_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109677","article-title":"Micro- and nano-plastics in edible fruit and vegetables. The first diet risks assessment for the general population","volume":"187","author":"Oliveri Conti","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.117868_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1324993","article-title":"The adverse role of endocrine disrupting chemicals in the reproductive system","volume":"14","author":"Pan","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.toxlet.2020.01.008","article-title":"Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation","volume":"324","author":"Park","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.117868_bib40","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/humrep\/der448","article-title":"Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence","volume":"27","author":"Petro","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2025.117868_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/toxics11010040","article-title":"First Evidence of Microplastics in Human Urine, a Preliminary Study of Intake in the Human Body","volume":"11","author":"Pironti","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.117868_bib42","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/toxics9090224","article-title":"Microplastics in the Environment: Intake through the Food Web, Human Exposure and Toxicological Effects","volume":"9","author":"Pironti","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.117868_bib43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12989-020-00358-y","article-title":"The plastic brain: neurotoxicity of micro- and nanoplastics","volume":"17","author":"Pr\u00fcst","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib44","first-page":"287","article-title":"Effects of Nano and Microplastics on the Inflammatory Process: In Vitro and In Vivo Studies Systematic Review","volume":"27","author":"Pulvirenti","year":"2022","journal-title":"FBL"},{"key":"10.1016\/j.ecoenv.2025.117868_bib45","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2300582121","article-title":"Rapid single-particle chemical imaging of nanoplastics by SRS microscopy","volume":"121","author":"Qian","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.117868_bib46","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.3390\/ijerph191811593","article-title":"Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas","volume":"19","author":"Ragusa","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2025.117868_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117868_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164867","article-title":"A geological perspective of plastic pollution","volume":"893","author":"Rangel-Buitrago","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib49","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3390\/w13070973","article-title":"Microplastics in the Aquatic Environment: Occurrence, Persistence, Analysis, and Human Exposure","volume":"13","author":"Ricciardi","year":"2021","journal-title":"Water"},{"key":"10.1016\/j.ecoenv.2025.117868_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119473","article-title":"Influence of microplastics on the bioconcentration of organic contaminants in fish: Is the \u201cTrojan horse\u201d effect a matter of concern?","volume":"306","author":"Schell","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.117868_bib51","doi-asserted-by":"crossref","first-page":"25727","DOI":"10.1074\/jbc.M112.349902","article-title":"Involvement of the Up-regulated FoxO1 Expression in Follicular Granulosa Cell Apoptosis Induced by Oxidative Stress","volume":"287","author":"Shen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.117868_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1084236","article-title":"A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals","volume":"13","author":"Ullah","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib53","unstructured":"UNEP, 2021. United Nations Environment Programme (2021). Drowning in Plastics \u2013 Marine Litter and Plastic WasteVital Graphics."},{"key":"10.1016\/j.ecoenv.2025.117868_bib54","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/toxics11030225","article-title":"Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2\u03b1-ATF4-CHOP Signaling Pathway","volume":"11","author":"Wang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.117868_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112904","article-title":"Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine","volume":"162","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.117868_bib57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13048-017-0375-7","article-title":"DHEA-induced ovarian hyperfibrosis is mediated by TGF-\u03b2 signaling pathway","volume":"11","author":"Wang","year":"2018","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.ecoenv.2025.117868_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153059","article-title":"Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice","volume":"465","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.117868_bib59","unstructured":"WHO, 2023. Infertility Prevalence Estimates, 1990\u20132021 [WWW Document]. URL \u3008https:\/\/www.who.int\/publications-detail-redirect\/978920068315\u3009 (accessed 3.28.24)."},{"key":"10.1016\/j.ecoenv.2025.117868_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161962","article-title":"Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production","volume":"871","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117868_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.956885","article-title":"Impacts of microplastics on immunity","volume":"4","author":"Yang","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.117868_bib62","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s40726-023-00273-8","article-title":"Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review","volume":"9","author":"Yang","year":"2023","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.ecoenv.2025.117868_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121482","article-title":"Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress","volume":"327","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.117868_bib64","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/toxsci\/kfae013","article-title":"Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis","volume":"198","author":"Zhao","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.117868_bib65","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.watres.2019.03.091","article-title":"Exposure to microplastics (<10\u00a0\u03bcm) associated to plastic bottles mineral water consumption: The first quantitative study","volume":"157","author":"Zuccarello","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2025.117868_bib66","doi-asserted-by":"crossref","unstructured":"Zuccarello, P., Ferrante, M., Cristaldi, A., Copat, C., Grasso, A., Sangregorio, D., Fiore, M., Oliveri Conti, G., 2019b. Reply for comment on \u201cExposure to microplastics (<10 \u03bcm) associated to plastic bottles mineral water consumption: The first quantitative study by Zuccarello et al. [Water Research 157 (2019) 365\u2013371].\u201d Water Research 166, 115077. https:\/\/doi.org\/10.1016\/j.watres.2019.115077.","DOI":"10.1016\/j.watres.2019.115077"},{"key":"10.1016\/j.ecoenv.2025.117868_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1330396","article-title":"Microplastics exposure: implications for human fertility, pregnancy and child health","volume":"14","author":"Zurub","year":"2024","journal-title":"Front. Endocrinol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325002040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325002040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:15:32Z","timestamp":1745453732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325002040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":67,"alternative-id":["S0147651325002040"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117868","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.04.24305264","asserted-by":"object"}]},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117868"}}