{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:31:14Z","timestamp":1786987874042,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ecoenv.2025.117937","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T03:41:04Z","timestamp":1740022864000},"page":"117937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway"],"prefix":"10.1016","volume":"292","author":[{"given":"Zhuo-nan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-hang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-he","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-ge","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-min","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-yu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-mei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-bao","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-mei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-xia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.117937_bib1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.physbeh.2015.06.040","article-title":"Melatonin ameliorates oxidative damage induced by maternal lead exposure in rat pups","volume":"151","author":"Bazrgar","year":"2015","journal-title":"Physiol. Behav."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.117937_bib2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tem.2008.08.002","article-title":"Anti-M\u00fcllerian hormone and ovarian dysfunction","volume":"19","author":"Broekmans","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.117937_bib3","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1096\/fj.201901761R","article-title":"Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells","volume":"34","author":"Carvalho","year":"2020","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.117937_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tins.2022.12.001","article-title":"Mitochondrial signalling and homeostasis: from cell biology to neurological disease","volume":"46","author":"Collier","year":"2023","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.117937_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12871","article-title":"Melatonin protects against developmental PBDE-47 neurotoxicity by targeting the AMPK\/mitophagy axis","volume":"75","author":"Dong","year":"2023","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41419-021-04374-4","article-title":"CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency","volume":"13","author":"E","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.117937_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113966","article-title":"Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK\/eIF2\u03b1 signaling pathway","volume":"243","author":"Feng","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12924","article-title":"Melatonin rescues the mitochondrial function of bone marrow-derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats","volume":"76","author":"Gu","year":"2024","journal-title":"J. Pineal Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.117937_bib11","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11309","article-title":"Synthetic phenolic antioxidants and their metabolites in follicular fluid and association with diminished ovarian reserve: a case\u2013control study","volume":"131","author":"Hao","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.117937_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118237","article-title":"Association of exposure to multiple heavy metals during pregnancy with the risk of gestational diabetes mellitus and insulin secretion phase after glucose stimulation","volume":"248","author":"He","year":"2024","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.117937_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.toxlet.2015.01.009","article-title":"Melatonin reduces lead levels in blood, brain and bone and increases lead excretion in rats subjected to subacute lead treatment","volume":"233","author":"Hern\u00e1ndez-Plata","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.117937_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102990","article-title":"Lead aggravates Alzheimer\u2019s disease pathology via mitochondrial copper accumulation regulated by COX17","volume":"69","author":"Huang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.117937_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111231","article-title":"Lead exposure activates the Nrf2\/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice","volume":"207","author":"Jiang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.117937_bib16","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/s41556-023-01244-3","article-title":"Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression","volume":"25","author":"Kramer","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.ecoenv.2025.117937_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112309","article-title":"MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol","volume":"42","author":"Kr\u00e4mer","year":"2023","journal-title":"EMBO J."},{"issue":"7844","key":"10.1016\/j.ecoenv.2025.117937_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41586-021-03214-x","article-title":"Function and regulation of the divisome for mitochondrial fission","volume":"590","author":"Kraus","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12874","article-title":"Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota","volume":"75","author":"Li","year":"2023","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2025.117937_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158665","article-title":"Lead exposure represses mitochondrial metabolism by activation of heme-binding protein BACH1 in differentiated SH-SY5Y cell","volume":"853","author":"Li","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.117937_bib21","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.ymthe.2024.01.031","article-title":"SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation","volume":"32","author":"Li","year":"2024","journal-title":"Mol. Ther."},{"issue":"43","key":"10.1016\/j.ecoenv.2025.117937_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo5600","article-title":"LC3-Associated endocytosis and the functions of rubicon and ATG16L1","volume":"8","author":"Magn\u00e9","year":"2022","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.117937_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/humupd\/dmw028","article-title":"Ovarian ageing: the role of mitochondria in oocytes and follicles","volume":"22","author":"May-Panloup","year":"2016","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.ecoenv.2025.117937_bib24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.molcel.2020.03.010","article-title":"Cdk1 controls global epigenetic landscape in embryonic stem cells","volume":"78","author":"Michowski","year":"2020","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.117937_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/009841097160582","article-title":"Lead-induced changes in ovarian follicular development and maturation in mice","volume":"50","author":"Mohammad Junaid, D. K. Chowdhuri, R","year":"1997","journal-title":"J. Toxicol. Environ. Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.117937_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/152873901300018093","article-title":"Lead accumulation in human ovarian follicular fluid, and in vitro effect of lead on progesterone production by cultured human ovarian granulosa cells","volume":"62","author":"Paksy","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"8","key":"10.1016\/j.ecoenv.2025.117937_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1218020110","article-title":"Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions","volume":"110","author":"Peng","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.117937_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152810","article-title":"Potential mechanism of lead poisoning to the growth and development of ovarian follicle","volume":"457","author":"Qu","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.117937_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114919","article-title":"Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1\u03b1-JNK signaling pathway in rat","volume":"257","author":"Shan","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.ecoenv.2025.117937_bib30","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1080\/15548627.2021.2005415","article-title":"Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1","volume":"18","author":"Shao","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.117937_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105559","article-title":"Toxicity evaluation of E-waste plastics and potential repercussions for human health","volume":"137","author":"Singh","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.117937_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.115932","article-title":"Elevated levels of Zn, Cu and Co are associated with an increased risk of endometriosis: results from a case control study","volume":"271","author":"Su","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117937_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165514","article-title":"Are High-Risk Heavy Metal(Loid)s contaminated vegetables detrimental to human health? A study of incorporating bioaccessibility and toxicity into accurate health risk assessment","volume":"897","author":"Tian","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.117937_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101378","article-title":"Mitochondria: their relevance during Oocyte ageing","volume":"70","author":"Van Der Reest","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.117937_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12899","article-title":"Melatonin in food allergy: mechanism and potential therapy","volume":"75","author":"Wang","year":"2023","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2025.117937_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109556","article-title":"Kaempferol improves Pb-induced cognitive impairments via inhibiting autophagy","volume":"125","author":"Wang","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ecoenv.2025.117937_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104231","article-title":"AIFM1 beyond cell death: an overview of this OXPHOS-inducing factor in mitochondrial diseases","volume":"83","author":"Wischhof","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ecoenv.2025.117937_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109759","article-title":"Blood lead levels and aberrant DNA methylation of the ALAD and P16 gene promoters in children exposed to environmental-lead","volume":"188","author":"Yohannes","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.117937_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117144","article-title":"The associations of the concentrations of toxic metals (including metalloid) in blood and follicular fluid with the risk of diminished ovarian reserve","volume":"286","author":"Yue","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.117937_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102215","article-title":"Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply","volume":"49","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.117937_bib41","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.18632\/aging.102024","article-title":"Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging","volume":"11","author":"Zhang","year":"2019","journal-title":"Aging"},{"issue":"6","key":"10.1016\/j.ecoenv.2025.117937_bib42","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.molcel.2018.10.029","article-title":"Transcriptome landscape of human folliculogenesis reveals oocyte and granulosa cell interactions","volume":"72","author":"Zhang","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2025.117937_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112091","article-title":"MAPK, AKT\/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells","volume":"214","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325002738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325002738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:52:51Z","timestamp":1741866771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325002738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":43,"alternative-id":["S0147651325002738"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117937","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117937"}}