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Pollut."},{"key":"10.1016\/j.ecoenv.2025.118078_bib78","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.ecoenv.2025.118078_bib79","series-title":"Perfluorobutane Sulfonate, Potassium Salt (PFBS): A 48-hour Static Acute Toxicity Test with the Cladoceran (Daphnia magna","author":"Wildlife International Ltd","year":"2001"},{"key":"10.1016\/j.ecoenv.2025.118078_bib80","unstructured":"Zeilmaker, M.J., Fragki, S., Verbruggen, E.M.J., Bokkers, B.G.H., & Lijzen, J.P.A. (2018). Mixture exposure to PFAS: a relative potency factor approach. In RIVM Report 2018-0070. RIVM. \u3008https:\/\/www.rivm.nl\/bibliotheek\/rapporten\/2018-0070.pdf\u3009."},{"key":"10.1016\/j.ecoenv.2025.118078_bib81","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jes.2022.10.042","article-title":"Toxic effects of three perfluorinated or polyfluorinated compounds (PFCs) on two strains of freshwater algae: Implications for ecological risk assessments","volume":"131","author":"Zhang","year":"2023","journal-title":"J. Environ. 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