{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:42:01Z","timestamp":1793814121538,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202312233"],"award-info":[{"award-number":["tsqn202312233"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2022CXGC020515"],"award-info":[{"award-number":["2022CXGC020515"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ecoenv.2025.118154","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:53:47Z","timestamp":1744008827000},"page":"118154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2\u202f+ inward flow and microglial activation"],"prefix":"10.1016","volume":"295","author":[{"given":"Xinjia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-0876","authenticated-orcid":false,"given":"Meng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118154_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WCO.0000000000001045","article-title":"Microglia in multiple sclerosis - pathogenesis and imaging","volume":"35","author":"Airas","year":"2022","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib2","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1089\/scd.2017.0085","article-title":"Bicistronic CACNA1A gene expression in neurons derived from spinocerebellar ataxia type 6 patient-induced pluripotent stem cells","volume":"26","author":"Bavassano","year":"2017","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ecoenv.2025.118154_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00109-021-02080-4","article-title":"Multiple sclerosis is linked to MAPK(ERK) overactivity in microglia","volume":"99","author":"Bosch","year":"2021","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2025.118154_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2019.102130","article-title":"The Na(+)\/Ca(2+) exchangers in demyelinating diseases","volume":"85","author":"Boscia","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ecoenv.2025.118154_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.2040-4603.2017.tb00748.x","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Bravo-Sagua","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420981206","article-title":"Regulation of GFAP expression","volume":"13","author":"Brenner","year":"2021","journal-title":"ASN Neuro"},{"key":"10.1016\/j.ecoenv.2025.118154_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12640-019-0011-y","article-title":"Benzophenone-2 concentration and its effect on oxidative stress and apoptosis markers in rat brain","volume":"36","author":"Broniowska","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ecoenv.2025.118154_bib8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neuro.2016.03.003","article-title":"The effect of UV-filters on the viability of neuroblastoma (SH-SY5Y) cell line","volume":"54","author":"Broniowska","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118154_bib9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1897\/07-541.1","article-title":"Hormesis: why it is important to toxicology and toxicologists","volume":"27","author":"Calabrese","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118154_bib10","first-page":"527","article-title":"Progressive multiple sclerosis: from pathogenic mechanisms to treatment","volume":"140","author":"Correale","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.ecoenv.2025.118154_bib11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.aquatox.2010.02.019","article-title":"Assessment of uptake and toxicity of fluorescent silica nanoparticles in zebrafish (Danio rerio) early life stages","volume":"100","author":"Fent","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s40263-022-00951-z","article-title":"Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression?","volume":"36","author":"Geladaris","year":"2022","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ecoenv.2025.118154_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ncl.2023.07.006","article-title":"Bruton's tyrosine kinase inhibitors for multiple sclerosis treatment: a new frontier","volume":"42","author":"Greenberg","year":"2024","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ecoenv.2025.118154_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.expneurol.2012.07.010","article-title":"TNF-\u03b1-mediated anxiety in a mouse model of multiple sclerosis","volume":"237","author":"Haji","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.21307\/ane-2018-027","article-title":"c-Fos and neuronal plasticity: the aftermath of Kaczmarek's theory","volume":"78","author":"Jaworski","year":"2018","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.ecoenv.2025.118154_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41577-023-00907-4","article-title":"Microglia regulation of central nervous system myelin health and regeneration","volume":"24","author":"Kent","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib17","doi-asserted-by":"crossref","unstructured":"E. Lammer, G. Carr, K. Wendler, J. Rawlings, S. Belanger, T.J.C.B. Braunbeck, P.P.C. Toxicology, Pharmacology, Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?, 149 (2009) 196-209.","DOI":"10.1016\/j.cbpc.2008.11.006"},{"key":"10.1016\/j.ecoenv.2025.118154_bib18","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ecoenv.2025.118154_bib19","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3724\/SP.J.1123.2014.05040","article-title":"Determination of ultraviolet filters in environmental aqueous samlies by dispersive liquid-liquird microextraction with online derivatization-gas-chromatography-mass spectromety","volume":"32","author":"LI","year":"2014","journal-title":"Chin. J. Chromatogr."},{"key":"10.1016\/j.ecoenv.2025.118154_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.178664","article-title":"Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish","volume":"965","author":"Liu","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118154_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107405","article-title":"Assessment of human exposure to benzophenone-type UV filters: a review","volume":"167","author":"Mao","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118154_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.248534","article-title":"Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases","volume":"135","author":"Markovinovic","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ecoenv.2025.118154_bib23","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/glia.23980","article-title":"Activated microglia drive demyelination via CSF1R signaling","volume":"69","author":"Marzan","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.ecoenv.2025.118154_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nrl.2016.05.001","article-title":"U. Gomez-Pinedo, Vitamin D and remyelination in multiple sclerosis","volume":"33","author":"Mat\u00edas-Gu\u00edu","year":"2018","journal-title":"Neurologia"},{"key":"10.1016\/j.ecoenv.2025.118154_bib25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and treatment of multiple sclerosis: a review","volume":"325","author":"McGinley","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.ecoenv.2025.118154_bib26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s10661-021-09626-6","article-title":"UV-filter pollution: current concerns and future prospects","volume":"193","author":"de Miranda","year":"2021","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2025.118154_bib27","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1093\/brain\/awac019","article-title":"Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis","volume":"145","author":"Nishihara","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.ecoenv.2025.118154_bib28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/bs.apcsb.2019.08.007","article-title":"Microglial NLRP3 inflammasome activation in multiple sclerosis","volume":"119","author":"Olcum","year":"2020","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.envpol.2017.03.035","article-title":"Bioaccumulation and biomagnification of ultraviolet absorbents in marine wildlife of the Pearl River Estuarine, South China Sea","volume":"225","author":"Peng","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118154_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/toxsci\/kfz160","article-title":"Benzophenone-3 passes through the blood-brain barrier, increases the level of extracellular glutamate, and induces apoptotic processes in the hippocampus and frontal cortex of rats","volume":"171","author":"Pomierny","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118154_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12984-024-01383-0","article-title":"Effects of multidisciplinary inpatient rehabilitation on everyday life physical activity and gait in patients with multiple sclerosis","volume":"21","author":"Prigent","year":"2024","journal-title":"J. Neuroeng. Rehabil."},{"key":"10.1016\/j.ecoenv.2025.118154_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128930","article-title":"Triclosan affects motor function in zebrafish larva by inhibiting ache and syn2a genes","volume":"266","author":"Pullaguri","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118154_bib33","first-page":"21433","volume":"58","author":"Qi","year":"2024","journal-title":"Technol., Genet. Evid. Estrogenic Eff. Benzophenone-2 Zebra Neurodev. Its Signal. Mech."},{"key":"10.1016\/j.ecoenv.2025.118154_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160966","article-title":"Environmental impacts of the ultraviolet filter oxybenzone","volume":"863","author":"Scheele","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118154_bib35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/pharmrev.120.000025","article-title":"ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery","volume":"75","author":"Schulz","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ecoenv.2025.118154_bib36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s12640-020-00163-7","article-title":"Effect of combined prenatal and adult benzophenone-3 dermal exposure on factors regulating neurodegenerative processes, blood hormone levels, and hematological parameters in female rats","volume":"37","author":"Sk\u00f3rkowska","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ecoenv.2025.118154_bib37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.1432-18.2018","article-title":"Claudin-1-dependent destabilization of the blood-brain barrier in chronic stroke","volume":"39","author":"Sladojevic","year":"2019","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.118154_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155268","article-title":"Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish","volume":"834","author":"Song","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118154_bib39","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.118154_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib41","first-page":"90","article-title":"A review of the CACNA gene family: its role in neurological disorders","volume":"12","author":"Szymanowicz","year":"2024"},{"key":"10.1016\/j.ecoenv.2025.118154_bib42","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202213104","article-title":"ORAI3 is dispensable for store-operated Ca2+\u2009entry and immune responses by lymphocytes and macrophages","volume":"154","author":"Wang","year":"2022","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2007.11.012","article-title":"Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish","volume":"314","author":"Wen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib44","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1007\/s12035-018-1401-5","article-title":"Prenatal exposure to Benzophenone-3 impairs autophagy, disrupts RXRs\/PPAR\u03b3 signaling, and alters epigenetic and post-translational statuses in brain neurons","volume":"56","author":"Wnuk","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib45","unstructured":"Xiong, S., 2017.Bioaccumulation of organic ultraviolet absorbents in freshwater aquatic organisms from the Peral River basin."},{"key":"10.1016\/j.ecoenv.2025.118154_bib46","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","article-title":"Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ecoenv.2025.118154_bib47","doi-asserted-by":"crossref","unstructured":"R. Yang, M. Zhan, M. Guo, H. Yuan, Y. Wang, Y. Zhang, W. Zhang, S. Chen, H. de The, Z.J.C.D. Chen, Differentiation, Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-\u03baB-Tgf\u03b21 pathway, 28 (2021) 170-183.","DOI":"10.1038\/s41418-020-0591-3"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325004907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325004907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:43:48Z","timestamp":1762245828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325004907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":47,"alternative-id":["S0147651325004907"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118154","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2\u202f+ inward flow and microglial activation","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118154"}}