{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:43:51Z","timestamp":1762245831486,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Korea Ministry of Trade Industry and Energy","doi-asserted-by":"publisher","award":["20008861"],"award-info":[{"award-number":["20008861"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007845","name":"Ministry of Communication and Information Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ecoenv.2025.118214","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:04:38Z","timestamp":1745204678000},"page":"118214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy"],"prefix":"10.1016","volume":"296","author":[{"given":"Sae Woong","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunbi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"See-Hyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejun","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4322-8932","authenticated-orcid":false,"given":"Gyeonghyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Seon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokhyeon","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minkyung","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongsung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118214_bib1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/15376516.2013.770109","article-title":"Sildenafil citrate attenuates the deleterious effects of elevated ammonia","volume":"23","author":"Arafa","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ecoenv.2025.118214_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.1.01594","article-title":"Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins","volume":"34","author":"Bailey","year":"2005","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobio."},{"key":"10.1016\/j.ecoenv.2025.118214_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/md21020121","article-title":"Anti-pollutant activity of porphyra yezoensis water extract and its active compound, porphyra 334, against urban particulate matter-induced keratinocyte cell damage","volume":"21","author":"Choi","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2025.118214_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.clindermatol.2019.07.006","article-title":"The color of skin: blue diseases of the skin, nails, and mucosa","volume":"37","author":"Cohen","year":"2019","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib6","first-page":"886","article-title":"Air quality in alternative housing systems may have an impact on laying hen welfare","volume":"5","author":"David","year":"2015","journal-title":"Part II-Ammon. Anim. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118214_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/pcmr.12239","article-title":"Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression","volume":"27","author":"Falletta","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.ecoenv.2025.118214_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jcu.22135","article-title":"Doppler assessment of splanchnic arterial flow in patients with liver cirrhosis: correlation with ammonia plasma levels and MELD score","volume":"42","author":"Gli\u0161i\u0107","year":"2014","journal-title":"J. Clin. Ultrasound"},{"key":"10.1016\/j.ecoenv.2025.118214_bib9","first-page":"87","article-title":"Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity","volume":"13","author":"H\u00e4ussinger","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.ecoenv.2025.118214_bib10","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","article-title":"The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration","volume":"26","author":"Heras-Sandoval","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.ecoenv.2025.118214_bib11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1755-148X.2011.00845.x","article-title":"How are proliferation and differentiation of melanocytes regulated?","volume":"24","author":"Hirobe","year":"2011","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.ecoenv.2025.118214_bib12","doi-asserted-by":"crossref","first-page":"12509","DOI":"10.1074\/jbc.M110.200543","article-title":"WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition","volume":"286","author":"Ho","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118214_bib13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1755-148X.2011.00889.x","article-title":"The pleiotropic roles of autophagy regulators in melanogenesis","volume":"24","author":"Ho","year":"2011","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.ecoenv.2025.118214_bib14","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00403-010-1059-y","article-title":"Mechanisms of melanogenesis inhibition by propafenone","volume":"302","author":"Huh","year":"2010","journal-title":"Arch. Dermatol. Res"},{"key":"10.1016\/j.ecoenv.2025.118214_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9827519","article-title":"Melanogenic effects of maclurin are mediated through the activation of cAMP\/PKA\/CREB and p38 MAPK\/CREB signaling pathways","volume":"2019","author":"Hwang","year":"2019","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.ecoenv.2025.118214_bib16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1080\/15548627.2017.1287653","article-title":"Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation","volume":"13","author":"Jacquin","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.118214_bib17","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jid.2019.11.023","article-title":"The role of autophagy in skin fibroblasts, keratinocytes, melanocytes, and epidermal stem cells","volume":"140","author":"Jeong","year":"2020","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib18","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/15548627.2019.1709766","article-title":"Regulation of LC3B levels by ubiquitination and proteasomal degradation","volume":"16","author":"Jia","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.118214_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10132773","article-title":"The cerebral effect of ammonia in brain aging: blood-brain barrier breakdown, mitochondrial dysfunction, and neuroinflammation","volume":"10","author":"Jo","year":"2021","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.ecoenv.2025.118214_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00277-003-0731-0","article-title":"TNF-alpha induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin's lymphomas","volume":"83","author":"Jurisic","year":"2004","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152877","article-title":"p44\/42 MAPK signaling is a prime target activated by phenylethyl resorcinol in its anti-melanogenic action","volume":"58","author":"Kang","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ecoenv.2025.118214_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/biom9100596","article-title":"Flumequine-mediated upregulation of p38 MAPK and JNK results in melanogenesis in B16F10 cells and zebrafish larvae","volume":"9","author":"Karunarathne","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ecoenv.2025.118214_bib23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib24","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/jid.2013.510","article-title":"FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation","volume":"134","author":"Kim","year":"2014","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/pcmr.12838","article-title":"Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes","volume":"33","author":"Kim","year":"2020","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.ecoenv.2025.118214_bib26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cyto.2018.04.034","article-title":"TNFSF14 inhibits melanogenesis via NF-kB signaling in melanocytes","volume":"110","author":"Kim","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.ecoenv.2025.118214_bib27","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118214_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bpj.2015.11.3524","article-title":"Lipid geometry and bilayer curvature modulate LC3\/GABARAP-mediated model autophagosomal elongation","volume":"110","author":"Landajuela","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.ecoenv.2025.118214_bib29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00018-022-04241-1","article-title":"MDC1 is essential for G2\/M transition and spindle assembly in mouse oocytes","volume":"79","author":"Leem","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2025.118214_bib30","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s11064-014-1406-z","article-title":"Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain","volume":"39","author":"Liang","year":"2014","journal-title":"Neurochem. Res"},{"key":"10.1016\/j.ecoenv.2025.118214_bib31","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.jmb.2019.10.028","article-title":"Autophagosome-lysosome fusion","volume":"432","author":"L\u0151rincz","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib32","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1034\/j.1600-0749.2001.140508.x","article-title":"Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1","volume":"14","author":"Manga","year":"2001","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.ecoenv.2025.118214_bib33","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.118214_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010312","article-title":"GSK-3\u03b2-targeting fisetin promotes melanogenesis in B16F10 melanoma cells and zebrafish larvae through \u03b2-catenin activation","volume":"21","author":"Molagoda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118214_bib35","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1080\/15548627.2015.1106668","article-title":"MTOR, PIK3C3, and autophagy: signaling the beginning from the end","volume":"11","author":"Munson","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.118214_bib36","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/jid.2013.165","article-title":"Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes","volume":"133","author":"Murase","year":"2013","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10545-005-0303-7","article-title":"Urea cycle defects: management and outcome","volume":"28","author":"Nassogne","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ecoenv.2025.118214_bib38","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1016\/0004-6981(87)90203-4","article-title":"Vapour pressure of ammonium chloride aerosol: effect of temperature and humidity","volume":"21","author":"Pio","year":"1987","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.ecoenv.2025.118214_bib39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118214_bib40","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1080\/15548627.2017.1327509","article-title":"Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks","volume":"13","author":"Ramkumar","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2025.118214_bib41","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.152.4.809","article-title":"Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells","volume":"152","author":"Raposo","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0377-1237(17)30750-5","article-title":"Study of cutaneous manifestations in chronic liver disorders","volume":"53","author":"Sayal","year":"1997","journal-title":"Med J. Armed Forces India"},{"key":"10.1016\/j.ecoenv.2025.118214_bib43","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin pigmentation in mammalian skin and its hormonal regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2025.118214_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/ijpd.ijpd_100_22","article-title":"Skin as a window to diagnose inborn errors of metabolism","volume":"24","author":"Somasundaram","year":"2023","journal-title":"Indian J. Paediatr. Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib45","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ajim.4700170409","article-title":"Health effects of exposure to ammonia: scant information","volume":"17","author":"Swotinsky","year":"1990","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.ecoenv.2025.118214_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1600-0625.2009.01053.x","article-title":"\u201cTranscription physiology\u201d of pigment formation in melanocytes: central role of MITF","volume":"19","author":"Vachtenheim","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib47","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.bbadis.2018.02.003","article-title":"PI3K\/AKT\/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis","volume":"1864","author":"Varshney","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ecoenv.2025.118214_bib48","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1463-1326.2009.01054.x","article-title":"Ammonia toxicity and its prevention in inherited defects of the urea cycle","volume":"11","author":"Walker","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ecoenv.2025.118214_bib49","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1038\/s41467-018-05449-1","article-title":"Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.118214_bib50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pneurobio.2010.01.012","article-title":"Ammonia metabolism, the brain and fatigue; revisiting the link","volume":"91","author":"Wilkinson","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ecoenv.2025.118214_bib51","article-title":"Antioxidant activities and mechanisms of tomentosin in human keratinocytes","volume":"11","author":"Yang","year":"2022","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118214_bib52","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325005500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325005500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:40:58Z","timestamp":1762245658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325005500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":52,"alternative-id":["S0147651325005500"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118214","relation":{},"ISSN":["0147-6513"],"issn-type":[{"type":"print","value":"0147-6513"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118214"}}