{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:31:43Z","timestamp":1793917903242,"version":"4.8.0"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018588","name":"Yibin Science and Technology Planning Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2023QN03047"],"award-info":[{"award-number":["2023QN03047"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960154"],"award-info":[{"award-number":["31960154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ecoenv.2025.118269","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T06:36:15Z","timestamp":1746858975000},"page":"118269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases"],"prefix":"10.1016","volume":"298","author":[{"given":"Hong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-3765","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118269_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154808","article-title":"Persistent organic pollutants in water resources: fate, occurrence, characterization and risk analysis","volume":"831","author":"Aravind Kumar","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00204-022-03317-y","article-title":"Ferroptosis as a mechanism of non-ferrous metal toxicity","volume":"96","author":"Aschner","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112909","article-title":"Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway","volume":"163","author":"Bao","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2023.02.034","article-title":"The exposome and liver disease - how environmental factors affect liver health","volume":"79","author":"Barouki","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bpobgyn.2022.09.003","article-title":"Environmental toxicants and placental function","volume":"85","author":"Bloom","year":"2022","journal-title":"Best. Pr. Res Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib6","doi-asserted-by":"crossref","first-page":"122165","DOI":"10.1007\/s11356-023-30962-2","article-title":"Curcumin strengthens a spontaneous self-protective mechanism-SP1\/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage","volume":"30","author":"Bu","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2025.118269_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105655","article-title":"Paraquat-induced ferroptosis suppression via NRF2 expression regulation","volume":"92","author":"Cai","year":"2023","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2025.118269_bib8","doi-asserted-by":"crossref","first-page":"1428920","DOI":"10.3389\/fimmu.2024.1428920","article-title":"Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation","volume":"15","author":"Cao","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib9","doi-asserted-by":"crossref","first-page":"1275154","DOI":"10.3389\/fgene.2023.1275154","article-title":"The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer","volume":"14","author":"Chen","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.ecoenv.2025.118269_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib11","doi-asserted-by":"crossref","first-page":"mfad014","DOI":"10.1093\/mtomcs\/mfad014","article-title":"Roles of glutathione peroxidase 4 on the mercury-triggered ferroptosis in renal cells: implications for the antagonism between selenium and mercury","volume":"15","author":"Chen","year":"2023","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2025.118269_bib12","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3390\/ijms24021607","article-title":"Prospects for anti-tumor mechanism and potential clinical application based on glutathione peroxidase 4 mediated ferroptosis","volume":"24","author":"Chen","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib13","article-title":"The application of approaches in detecting ferroptosis","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ecoenv.2025.118269_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2022.06.002","article-title":"Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy","volume":"188","author":"Chu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2025.118269_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbi.2018.08.023","article-title":"Role of glutathione S-transferases in detoxification of a polycyclic aromatic hydrocarbon, methylcholanthrene","volume":"294","author":"Dasari","year":"2018","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2025.118269_bib16","doi-asserted-by":"crossref","first-page":"1291686","DOI":"10.3389\/fcell.2023.1291686","article-title":"Hippo pathway in intestinal diseases: focusing on ferroptosis","volume":"11","author":"Deng","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00011-022-01672-1","article-title":"Molecular mechanisms of ferroptosis and relevance to inflammation","volume":"72","author":"Deng","year":"2023","journal-title":"Inflamm. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167039","article-title":"Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans","volume":"905","author":"Deng","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.molcel.2023.03.005","article-title":"Ferroptosis: a flexible constellation of related biochemical mechanisms","volume":"83","author":"Dixon","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2025.118269_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113331","article-title":"Nrf2 mitigates sepsis-associated encephalopathy-induced hippocampus ferroptosis via modulating mitochondrial dynamic homeostasis","volume":"143","author":"Duan","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib21","doi-asserted-by":"crossref","first-page":"1219840","DOI":"10.3389\/fcell.2023.1219840","article-title":"The role of ferroptosis in intervertebral disc degeneration","volume":"11","author":"Fan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10565-024-09853-w","article-title":"Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future","volume":"40","author":"Fang","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113060","article-title":"Nano-remediation technologies for the sustainable mitigation of persistent organic pollutants","volume":"211","author":"Fei","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.14336\/AD.2023.0717","article-title":"Mitochondria-mediated ferroptosis in diseases therapy: from molecular mechanisms to implications","volume":"15","author":"Feng","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.ecoenv.2025.118269_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104356","article-title":"Research update for ferroptosis and cholangiocarcinoma","volume":"198","author":"Fu","year":"2024","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114462","article-title":"Enhanced glutathione production protects against zearalenone-induced oxidative stress and ferroptosis in female reproductive system","volume":"185","author":"Fu","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib28","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.molmed.2023.08.011","article-title":"Airway microbiome: environmental exposure-respiratory health nexus","volume":"29","author":"Gangneux","year":"2023","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib29","first-page":"736","article-title":"Moxibustion improves motor function by down-regulating SNX5 and inhibiting ferroptosis in neurons of corpus striatum in mice with Parkinson's disease","volume":"49","author":"Gao","year":"2024","journal-title":"Zhen Ci Yan Jiu"},{"key":"10.1016\/j.ecoenv.2025.118269_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-024-01966-1","article-title":"FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications","author":"Gao","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.ecoenv.2025.118269_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10815-022-02708-5","article-title":"New frontiers in embryo selection","volume":"40","author":"Glatstein","year":"2023","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.ecoenv.2025.118269_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2174\/1871527321666220329103610","article-title":"Elucidations of molecular mechanism and mechanistic effects of environmental toxicants in neurological disorders","volume":"22","author":"Goel","year":"2023","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ecoenv.2025.118269_bib33","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1002\/tox.23615","article-title":"1,3-Dichloro-2-propanol induced ferroptosis through Nrf2\/ARE signaling pathway in hepatocytes","volume":"37","author":"Guan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.freeradbiomed.2024.01.045","article-title":"Ambient particulate matter exposure induces ferroptosis in hippocampal cells through the GSK3B\/Nrf2\/GPX4 pathway","volume":"213","author":"Gui","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2025.118269_bib35","doi-asserted-by":"crossref","first-page":"9020236","DOI":"10.1155\/2023\/9020236","article-title":"Establishment of ferroptosis-related key gene signature and its validation in compression-induced intervertebral disc degeneration rats","volume":"2023","author":"Guo","year":"2023","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ecoenv.2025.118269_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116246","article-title":"Environmental cadmium exposure perturbs systemic iron homeostasis via hemolysis and inflammation, leading to hepatic ferroptosis in common carp (Cyprinus carpio L.)","volume":"275","author":"Guo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112588","article-title":"Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner","volume":"223","author":"Guohua","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114938","article-title":"Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS","volume":"257","author":"Han","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114123","article-title":"Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis","volume":"245","author":"He","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00204-023-03665-3","article-title":"The role of ferroptosis in cardio-oncology","volume":"98","author":"Hou","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib41","doi-asserted-by":"crossref","first-page":"1136240","DOI":"10.3389\/fgene.2023.1136240","article-title":"Regulation of ncRNAs involved with ferroptosis in various cancers","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Genet"},{"key":"10.1016\/j.ecoenv.2025.118269_bib42","first-page":"11","article-title":"Ferroptosis and its role in chronic diseases","author":"Hu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2025.118269_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135429","article-title":"Mechanism of effects of nickel or nickel compounds on intestinal mucosal barrier","volume":"305","author":"Huang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118269_bib44","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.7150\/ijms.74569","article-title":"Rotenone, an environmental toxin, causes abnormal methylation of the mouse brain organoid's genome and ferroptosis","volume":"19","author":"Huang","year":"2022","journal-title":"Int J. Med Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib45","doi-asserted-by":"crossref","first-page":"1333845","DOI":"10.3389\/fcell.2024.1333845","article-title":"Redox mechanisms of environmental toxicants on male reproductive function","volume":"12","author":"Hussain","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuro.2021.08.005","article-title":"Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system","volume":"86","author":"Ijomone","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118269_bib47","first-page":"11","article-title":"Bioaccumulation and bioremediation of heavy metals in fishes-a review","author":"Jamil Emon","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.118269_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171774","article-title":"Environmental pollutants and exosomes: a new paradigm in environmental health and disease","volume":"925","author":"Javdani-Mallak","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib50","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.2147\/IJGM.S331291","article-title":"Ferroptosis patterns correlate with immune microenvironment characterization in gastric cancer","volume":"14","author":"Jiang","year":"2021","journal-title":"Int J. Gen. Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib51","first-page":"20","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib52","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s12640-021-00455-6","article-title":"Neuropathological Mechanisms of \u03b2-N-Methylamino-L-Alanine (BMAA) with a focus on iron overload and ferroptosis","volume":"40","author":"Kazemi Shariat Panahi","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ecoenv.2025.118269_bib53","first-page":"18","article-title":"What do childcare providers know about environmental influences on children's health? Implications for environmental health literacy efforts","author":"Koester","year":"2021","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118269_bib54","doi-asserted-by":"crossref","first-page":"1329147","DOI":"10.3389\/fcell.2023.1329147","article-title":"Understanding the unique mechanism of ferroptosis: a promising therapeutic target","volume":"11","author":"Kong","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2478\/jtim-2023-0137","article-title":"Ferroptosis in organ fibrosis: from mechanisms to therapeutic medicines","volume":"12","author":"Lai","year":"2024","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.ecoenv.2025.118269_bib56","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s13402-023-00840-7","article-title":"Epigenetic modulation of ferroptosis in cancer: identifying epigenetic targets for novel anticancer therapy","volume":"46","author":"Lee","year":"2023","journal-title":"Cell Oncol. (Dordr. )"},{"key":"10.1016\/j.ecoenv.2025.118269_bib57","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-023-05978-8","article-title":"Autophagy mediates an amplification loop during ferroptosis","volume":"14","author":"Lee","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharm. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib59","doi-asserted-by":"crossref","first-page":"F147","DOI":"10.1530\/REP-20-0592","article-title":"Reproductive toxicology: environmental exposures, fetal testis development and function: phthalates and beyond","volume":"162","author":"Li","year":"2021","journal-title":"Reproduction"},{"key":"10.1016\/j.ecoenv.2025.118269_bib60","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib61","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140009","article-title":"Associations of multiple air pollutants with kidney function in normal-weight and obese adults and effect modification by free fatty acids","volume":"341","author":"Li","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118269_bib63","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/aja202266","article-title":"Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis","volume":"25","author":"Li","year":"2023","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.ecoenv.2025.118269_bib64","article-title":"The role of ferroptosis in central nervous system damage diseases","volume":"12","author":"Li","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.ecoenv.2025.118269_bib65","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/CM9.0000000000003048","article-title":"Emerging mechanisms of ferroptosis and its implications in lung cancer","volume":"137","author":"Li","year":"2024","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.ecoenv.2025.118269_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114848","article-title":"Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice","volume":"256","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116412","article-title":"BPA promotes lung fibrosis in mice by regulating autophagy-dependent ferroptosis in alveolar epithelial cells","volume":"278","author":"Liang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103138","article-title":"Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis\/ferroptosis for neurological disorders","volume":"72","author":"Liang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160839","article-title":"Glyphosate-triggered hepatocyte ferroptosis via suppressing Nrf2\/GSH\/GPX4 axis exacerbates hepatotoxicity","volume":"862","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib70","doi-asserted-by":"crossref","first-page":"1079548","DOI":"10.3389\/fcell.2022.1079548","article-title":"Ferroptosis: Mechanism and connections with cutaneous diseases","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114378","article-title":"TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy","volume":"184","author":"Liu","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib72","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib74","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2022.10.270","article-title":"The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD","volume":"193","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib75","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/gerona\/glaa204","article-title":"Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness","volume":"76","author":"Llarena","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib76","first-page":"25","article-title":"Severe hypothermia induces ferroptosis in cerebral cortical nerve cells","author":"Lu","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112650","article-title":"Cadmium exposure promotes activation of cerebrum and cerebellum ferroptosis and necrosis in swine","volume":"224","author":"Luan","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib78","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2147\/JMDH.S382643","article-title":"The relationship between ferroptosis and diseases","volume":"15","author":"Lv","year":"2022","journal-title":"J. Multidiscip. Health"},{"key":"10.1016\/j.ecoenv.2025.118269_bib79","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/CM9.0000000000002642","article-title":"Ferroptosis in acute leukemia","volume":"136","author":"Lyu","year":"2023","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.ecoenv.2025.118269_bib80","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2131\/jts.47.519","article-title":"Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance","volume":"47","author":"Lyu","year":"2022","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120868","article-title":"Focus on ferroptosis regulation: exploring novel mechanisms and applications of ferroptosis regulator","volume":"307","author":"Ma","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib82","doi-asserted-by":"crossref","first-page":"1440147","DOI":"10.3389\/fphar.2024.1440147","article-title":"Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells","volume":"15","author":"Mao","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib83","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41420-024-02000-8","article-title":"Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease","volume":"10","author":"Mao","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2025.118269_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103886","article-title":"Registered human trials addressing environmental and occupational toxicant exposures: scoping review of immunological markers and protective strategies","volume":"93","author":"Marques-da-Silva","year":"2022","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib85","article-title":"Nutrition paves the way to environmental toxicants and influences fetal development during pregnancy","volume":"89","author":"Meyyazhagan","year":"2023","journal-title":"Best. Pr. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120730","article-title":"Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis","volume":"317","author":"Miao","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118269_bib87","article-title":"Air, water, soil and environmental signaling","volume":"50","author":"Mielke","year":"2020","journal-title":"Curr. Probl. Pedia Adolesc. Health Care"},{"key":"10.1016\/j.ecoenv.2025.118269_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117178","article-title":"Inhaled toxins: A threat to male reproductive health","volume":"286","author":"Mohammadzadeh","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.837579","article-title":"Role of environmental toxicants on neurodegenerative disorders","volume":"4","author":"Nabi","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib90","doi-asserted-by":"crossref","first-page":"1142959","DOI":"10.3389\/fnut.2023.1142959","article-title":"Editorial: role of toxicants, pollutants, and trace elements in health and nutrition","volume":"10","author":"Naser","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2025.118269_bib91","first-page":"25","article-title":"Environmental pollution and risk of childhood cancer: a scoping review of evidence from the last decade","author":"Navarrete-Meneses","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12935-021-02366-0","article-title":"Induction and application of ferroptosis in cancer therapy","volume":"22","author":"Nie","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ecoenv.2025.118269_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105885","article-title":"Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway","volume":"201","author":"Pang","year":"2024","journal-title":"Pest. Biochem Physiol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105088","article-title":"Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation","volume":"102","author":"Peleman","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ecoenv.2025.118269_bib95","doi-asserted-by":"crossref","first-page":"67925","DOI":"10.1007\/s11356-021-16489-4","article-title":"Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility","volume":"28","author":"Priya","year":"2021","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2025.118269_bib96","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s10620-021-07203-y","article-title":"Environmental toxicants and NAFLD: a neglected yet significant relationship","volume":"67","author":"Rajak","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib97","first-page":"11","article-title":"Multi- and transgenerational effects of environmental toxicants on mammalian reproduction","author":"Rebuzzini","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2025.118269_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.166039","article-title":"Aquaporins and (in)fertility: more than just water transport","volume":"1867","author":"Ribeiro","year":"2021","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib99","first-page":"24","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","author":"Rochette","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib100","article-title":"Environmental toxicants and male fertility","volume":"86","author":"Rodprasert","year":"2023","journal-title":"Best. Pr. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib101","first-page":"19","article-title":"Uncovering evidence: associations between environmental contaminants and disparities in women's health","author":"Rumph","year":"2022","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118269_bib102","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10495-022-01806-0","article-title":"Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases","volume":"28","author":"Sahoo","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.ecoenv.2025.118269_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153751","article-title":"Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants?","volume":"503","author":"Santiago","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118269_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152456","article-title":"A comprehensive review on sources, analysis and toxicity of environmental pollutants and its removal methods from water environment","volume":"812","author":"Saravanan","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116147","article-title":"Effects of dietary arsenic exposure on liver metabolism in mice","volume":"274","author":"Shao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib106","first-page":"15","article-title":"Vaping, environmental toxicants exposure, and lung cancer risk","author":"Shehata","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118269_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19496","article-title":"Environmental pollutants and their effects on human health","volume":"9","author":"Shetty","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.ecoenv.2025.118269_bib108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4251\/wjgo.v15.i2.225","article-title":"Role of ferroptosis in colorectal cancer","volume":"15","author":"Song","year":"2023","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102248","article-title":"The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy","volume":"96","author":"Su","year":"2024","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.ecoenv.2025.118269_bib110","doi-asserted-by":"crossref","first-page":"1146651","DOI":"10.3389\/fphar.2023.1146651","article-title":"Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib111","article-title":"Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy","volume":"12","author":"Sun","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib112","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuro.2018.04.012","article-title":"Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure","volume":"67","author":"Tang","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118269_bib113","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.dld.2023.12.007","article-title":"Exploring occupational toxicant exposures in patients with metabolic dysfunction-associated steatotic liver disease: a prospective pilot study","volume":"56","author":"Tovoli","year":"2024","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157961","article-title":"Recent advances in bioremediation of heavy metals and persistent organic pollutants: A review","volume":"850","author":"Tufail","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1515\/reveh-2020-0048","article-title":"Toxicity of carbon tetrachloride, free radicals and role of antioxidants","volume":"36","author":"Unsal","year":"2021","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118269_bib116","first-page":"19","article-title":"Environmental toxicants and preterm birth: a bibliometric analysis of research trends and output","author":"Vidal","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2025.118269_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109526","article-title":"Novel pathways of fluoride-induced hepatotoxicity: P53-dependent ferroptosis induced by the SIRT1\/FOXOs pathway and Nrf2\/HO-1 pathway","volume":"264","author":"Wang","year":"2023","journal-title":"Comp. Biochem Physiol. C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162089","article-title":"PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis","volume":"872","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib119","first-page":"10","article-title":"The role of ferroptosis in the damage of human proximal tubule epithelial cells caused by perfluorooctane sulfonate","author":"Wang","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.118269_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109236","article-title":"Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse","volume":"195","author":"Wang","year":"2025","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118269_bib121","first-page":"647","article-title":"[Ferroptosis: mechanism and role in malignant tumors]","volume":"45","author":"Wang","year":"2023","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"10.1016\/j.ecoenv.2025.118269_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121434","article-title":"Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice","volume":"325","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118269_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114771","article-title":"Ferroptosis mediates decabromodiphenyl ether-induced liver damage and inflammation","volume":"255","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib124","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.2147\/JIR.S420676","article-title":"The emerging roles of ferroptosis in pathophysiology and treatment of acute lung injury","volume":"16","author":"Wang","year":"2023","journal-title":"J. Inflamm. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160078","article-title":"Ferroptosis contributes to nickel-induced developmental neurotoxicity in zebrafish","volume":"858","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153068","article-title":"Mitochondria damage and ferroptosis involved in Ni-induced hepatotoxicity in mice","volume":"466","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118269_bib127","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib128","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s10571-013-9948-1","article-title":"Involvement of NF kappa B in potentiated effect of Mn-containing dithiocarbamates on MPP(+) induced cell death","volume":"33","author":"Williams","year":"2013","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127807","article-title":"Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1\u03b1\/HO-1 signaling pathway in mouse testes","volume":"426","author":"Wu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.118269_bib130","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.biopsych.2023.01.007","article-title":"Environmental toxicants and the developing brain","volume":"93","author":"Wylie","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ecoenv.2025.118269_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19799","article-title":"Ferroptosis, autophagy, tumor and immunity","volume":"9","author":"Xie","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.ecoenv.2025.118269_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113373","article-title":"Exposure to low-dose cadmium induces testicular ferroptosis","volume":"234","author":"Xiong","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib133","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12967-023-04734-y","article-title":"Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice","volume":"22","author":"Xiong","year":"2024","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114241","article-title":"Ferroptosis in life: to be or not to be","volume":"159","author":"Xu","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41419-021-03559-1","article-title":"The emerging role of ferroptosis in intestinal disease","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.118269_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102349","article-title":"Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation","volume":"53","author":"Xu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153784","article-title":"Environmental toxicants and nephrotoxicity: implications on mechanisms and therapeutic strategies","volume":"504","author":"Yadav","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118269_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168073","article-title":"Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2\u03b1\/DUOX1\/GPX4 and iron homeostasis","volume":"907","author":"Yang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib139","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000530882","article-title":"Novel insight into ferroptosis in kidney diseases","volume":"54","author":"Yang","year":"2023","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib140","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.est.3c06127","article-title":"Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib141","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s42003-024-07180-8","article-title":"Ferroptosis as a new tool for tumor suppression through lipid peroxidation","volume":"7","author":"Yang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135614","article-title":"Role of ferroptosis in neurological diseases","volume":"747","author":"Yao","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ecoenv.2025.118269_bib143","doi-asserted-by":"crossref","first-page":"1219045","DOI":"10.3389\/fphys.2023.1219045","article-title":"Fertility loss: negative effects of environmental toxicants on oogenesis","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib144","doi-asserted-by":"crossref","first-page":"1084289","DOI":"10.3389\/fonc.2023.1084289","article-title":"Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors","volume":"13","author":"Yao","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123231","article-title":"Toxicity mechanism of engineered nanomaterials: Focus on mitochondria","volume":"343","author":"Yao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118269_bib146","doi-asserted-by":"crossref","DOI":"10.1002\/1878-0261.13649","article-title":"A guide to ferroptosis in cancer","author":"Yapici","year":"2024","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib147","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1039\/D3FO03641C","article-title":"Astaxanthin alleviates fine particulate matter (PM(2.5))-induced lung injury in rats by suppressing ferroptosis and apoptosis","volume":"14","author":"Yin","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.118269_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164172","article-title":"Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers","volume":"890","author":"Yu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110812","article-title":"Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1\/ERK signaling pathway leading to fetal growth restriction","volume":"387","author":"Yu","year":"2024","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2025.118269_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114486","article-title":"Ferroptosis and its potential as a therapeutic target","volume":"186","author":"Yuan","year":"2021","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib151","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41420-023-01665-x","article-title":"Emerging roles of ferroptosis in male reproductive diseases","volume":"9","author":"Yuan","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2025.118269_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107706","article-title":"Diesel exhaust PM2.5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis","volume":"171","author":"Yue","year":"2023","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118269_bib153","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40164-024-00498-3","article-title":"Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects","volume":"13","author":"Zeng","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib154","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3892\/ol.2024.14437","article-title":"Ferroptosis in cancer (Review","volume":"28","author":"Zeng","year":"2024","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ecoenv.2025.118269_bib155","article-title":"Molecular mechanisms of ferroptosis in cardiovascular disease","author":"Zeng","year":"2024","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.ecoenv.2025.118269_bib156","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ecoenv.2025.118269_bib157","doi-asserted-by":"crossref","first-page":"1354859","DOI":"10.3389\/fonc.2024.1354859","article-title":"A deep insight into ferroptosis in lung disease: facts and perspectives","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib158","doi-asserted-by":"crossref","first-page":"1259219","DOI":"10.3389\/fcvm.2023.1259219","article-title":"Current progress of ferroptosis in cardiovascular diseases","volume":"10","author":"Zhang","year":"2023","journal-title":"Front. Cardiovasc Med"},{"key":"10.1016\/j.ecoenv.2025.118269_bib159","first-page":"25","article-title":"Cadmium induces kidney iron deficiency and chronic kidney injury by interfering with the iron metabolism in rats","author":"Zhang","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib160","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11064-023-04096-3","article-title":"A new perspective in the treatment of ischemic stroke: ferroptosis","volume":"49","author":"Zhang","year":"2024","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ecoenv.2025.118269_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122207","article-title":"Role of Caveolin-1 on the molybdenum and cadmium exposure induces pulmonary ferroptosis and fibrosis in the sheep","volume":"334","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118269_bib162","doi-asserted-by":"crossref","first-page":"1269451","DOI":"10.3389\/fimmu.2023.1269451","article-title":"Mechanisms and regulations of ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112610","article-title":"Microcystin-LR induces ferroptosis in intestine of common carp (Cyprinus carpio","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118269_bib164","first-page":"14","article-title":"Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp","author":"Zhang","year":"2022","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2025.118269_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172618","article-title":"Ferroptosis implication in environmental-induced neurotoxicity","volume":"934","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118269_bib166","doi-asserted-by":"crossref","first-page":"1330910","DOI":"10.3389\/fphar.2023.1330910","article-title":"Ferroptosis: a dual-edged sword in tumour growth","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118269_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102584","article-title":"Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib168","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.4103\/NRR.NRR-D-24-00112","article-title":"Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regen. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib169","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s40164-023-00427-w","article-title":"Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy","volume":"12","author":"Zheng","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118269_bib170","first-page":"24","article-title":"The regulation of ferroptosis by noncoding RNAs","author":"Zheng","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118269_bib171","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s12011-023-03773-2","article-title":"Copper exposure induced chicken hepatotoxicity: involvement of ferroptosis mediated by lipid peroxidation, ferritinophagy, and inhibition of FSP1-CoQ10 and Nrf2\/SLC7A11\/GPX4 axis","volume":"202","author":"Zhong","year":"2024","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.ecoenv.2025.118269_bib172","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2025.118269_bib173","article-title":"Effects of Aroclor 1254 on Intestinal Immunity, Metabolism, and Microflora in Zebrafish","volume":"9","author":"Zhu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2025.118269_bib174","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.2147\/JIR.S457092","article-title":"Unraveling the molecular regulation of ferroptosis in respiratory diseases","volume":"17","author":"Zhu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ecoenv.2025.118269_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170724","article-title":"Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica","volume":"919","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325006050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325006050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:46:47Z","timestamp":1762246007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325006050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":175,"alternative-id":["S0147651325006050"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118269","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118269"}}