{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:13:51Z","timestamp":1774743231879,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF21H260010"],"award-info":[{"award-number":["LGF21H260010"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273609"],"award-info":[{"award-number":["82273609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973011"],"award-info":[{"award-number":["81973011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ecoenv.2025.118357","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:57:07Z","timestamp":1747983427000},"page":"118357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A four-miRNA signature as a potential biomarker of malignant mesothelioma patients from hand-spinning asbestos exposed area in Eastern China"],"prefix":"10.1016","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-0570","authenticated-orcid":false,"given":"Lijin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-9383","authenticated-orcid":false,"given":"Shibo","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenke","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaiyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingfang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-7865","authenticated-orcid":false,"given":"Jianlin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118357_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbior.2014.09.013","article-title":"MicroRNA and cancer--a brief overview","volume":"57","author":"Acunzo","year":"2015","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.ecoenv.2025.118357_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s13277-012-0615-9","article-title":"PTEN protein expression in malignant pleural mesothelioma","volume":"34","author":"Agarwal","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ng.556","article-title":"Subtle variations in Pten dose determine cancer susceptibility","volume":"42","author":"Alimonti","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2025.118357_bib4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1164\/rccm.200310-1436ST","article-title":"Diagnosis and initial management of nonmalignant diseases related to asbestos","volume":"170","author":"American Thoracic","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2025.118357_bib5","doi-asserted-by":"crossref","first-page":"82700","DOI":"10.18632\/oncotarget.12408","article-title":"Circulating microRNAs found dysregulated in ex-exposed asbestos workers and pleural mesothelioma patients as potential new biomarkers","volume":"7","author":"Bononi","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ecoenv.2025.118357_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2025.118357_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cncy.21646","article-title":"Young investigator challenge: MicroRNA-21\/MicroRNA-126 profiling as a novel tool for the diagnosis of malignant mesothelioma in pleural effusion cytology","volume":"124","author":"Cappellesso","year":"2016","journal-title":"Cancer Cytopathol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1158\/0008-5472.CAN-10-2488","article-title":"PTEN level in tumor suppression: how much is too little?","volume":"71","author":"Carracedo","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.118357_bib9","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/modpathol.2011.123","article-title":"Quantitative image analysis in the assessment of diffuse large B-cell lymphoma","volume":"24","author":"Chabot-Richards","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib10","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1186\/s12889-022-14437-6","article-title":"A comparative study of the disease burden attributable to asbestos in Brazil, China, Kazakhstan, and Russia between 1990 and 2019","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ecoenv.2025.118357_bib11","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1038\/onc.2013.476","article-title":"Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma","volume":"33","author":"Cioce","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.ecoenv.2025.118357_bib12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","article-title":"Epithelial-mesenchymal transition in malignant mesothelioma","volume":"25","author":"Fassina","year":"2012","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1535-6108(03)00021-7","article-title":"PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms","volume":"3","author":"Freeman","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ecoenv.2025.118357_bib14","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/ajim.22494","article-title":"Asbestos textile production linked to malignant peritoneal and pleural mesothelioma in women: analysis of 28 cases in Southeast China","volume":"58","author":"Gao","year":"2015","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.ecoenv.2025.118357_bib15","series-title":"Asbestos","article-title":"Mesothelioma in 2024: what\u2019s new?","author":"Giannakou","year":"2024"},{"key":"10.1016\/j.ecoenv.2025.118357_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eururo.2018.11.045","article-title":"Compound genomic alterations of TP53, PTEN, and RB1 tumor suppressors in localized and metastatic prostate Cancer","volume":"76","author":"Hamid","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/1759-7714.13746","article-title":"Diagnostic value of microRNAs for malignant pleural mesothelioma: a mini-review","volume":"12","author":"Han","year":"2021","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.ecoenv.2025.118357_bib18","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative molecular characterization of malignant pleural mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ecoenv.2025.118357_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5858\/arpa.2017-0124-RA","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the international mesothelioma interest group","volume":"142","author":"Husain","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.ecoenv.2025.118357_bib20","doi-asserted-by":"crossref","first-page":"22809","DOI":"10.1074\/jbc.M110.100354","article-title":"Pro-tumorigenic effects of miR-31 loss in mesothelioma","volume":"285","author":"Ivanov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118357_bib21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2217\/epi-2018-0143","article-title":"Genome-wide profiling reveals novel microRNAs in hand-spinning-specific chrysotile exposure","volume":"11","author":"Jia","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.ecoenv.2025.118357_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1725354","article-title":"Plasma Fibulin-3 as a potential biomarker for patients with asbestos-related diseases in the han population","volume":"2017","author":"Jiang","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ecoenv.2025.118357_bib23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ijc.31077","article-title":"Hand-spinning chrysotile exposure and risk of malignant mesothelioma: a case-control study in Southeastern China","volume":"142","author":"Jiang","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ecoenv.2025.118357_bib24","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/2211-5463.12274","article-title":"miR-30d is related to asbestos exposure and inhibits migration and invasion in NCI-H2452 cells","volume":"7","author":"Ju","year":"2017","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.ecoenv.2025.118357_bib25","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/JTO.0b013e3182572e83","article-title":"Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma","volume":"7","author":"Kirschner","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135331","article-title":"Two different serum MiRNA signatures correlate with the clinical outcome and histological subtype in pleural malignant mesothelioma patients","volume":"10","author":"Lamberti","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.118357_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib28","article-title":"MicroRNAome of porcine pre- and postnatal development","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.118357_bib29","doi-asserted-by":"crossref","first-page":"E4504","DOI":"10.1073\/pnas.1408759111","article-title":"Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2025.118357_bib30","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jamaoncol.2016.5487","article-title":"Association of asbestos exposure with malignant mesothelioma incidence in Eastern China","volume":"3","author":"Mao","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7150\/ijbs.65763","article-title":"Common genomic aberrations in mouse and human breast cancers with concurrent P53 deficiency and activated PTEN-PI3K-AKT pathway","volume":"18","author":"Martinez","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118357_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020595","article-title":"Secreted and tissue miRNAs as diagnosis biomarkers of malignant pleural mesothelioma","volume":"19","author":"Martinez-Rivera","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118357_bib33","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1158\/1541-7786.MCR-12-0082","article-title":"Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways","volume":"10","author":"Menges","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.118357_bib34","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejcts.2007.09.045","article-title":"PTEN expression is a strong predictor of survival in mesothelioma patients","volume":"33","author":"Opitz","year":"2008","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ecoenv.2025.118357_bib35","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/onc.2010.555","article-title":"AXL regulates mesothelioma proliferation and invasiveness","volume":"30","author":"Ou","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.ecoenv.2025.118357_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1158\/1078-0432.CCR-17-1172","article-title":"Comprehensive pharmacogenomic profiling of malignant pleural mesothelioma identifies a subgroup sensitive to FGFR inhibition","volume":"24","author":"Quispel-Janssen","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.118357_bib37","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1093\/annonc\/mdt412","article-title":"Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma","volume":"24","author":"Reid","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2008.04.013","article-title":"Tenets of PTEN tumor suppression","volume":"133","author":"Salmena","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.118357_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018232","article-title":"Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma","volume":"6","author":"Santarelli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.118357_bib40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","author":"Song","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00401-021-02302-6","article-title":"Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1","volume":"142","author":"Suwala","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ecoenv.2025.118357_bib42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2012.02.009","article-title":"Clinical significance of circulating miR-126 quantification in malignant mesothelioma patients","volume":"45","author":"Tomasetti","year":"2012","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.ecoenv.2025.118357_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030221","article-title":"Identification of miRNA-103 in the cellular fraction of human peripheral blood as a potential biomarker for malignant mesothelioma--a pilot study","volume":"7","author":"Weber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.118357_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5756102","article-title":"Serum HMGB1 as a potential biomarker for patients with asbestos-related diseases","volume":"2017","author":"Ying","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ecoenv.2025.118357_bib45","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.20360","article-title":"Assessment of global trends in the diagnosis of mesothelioma from 1990 to 2017","volume":"4","author":"Zhai","year":"2021","journal-title":"JAMA Netw. Open"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325006931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325006931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:47:57Z","timestamp":1762246077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325006931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":45,"alternative-id":["S0147651325006931"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118357","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A four-miRNA signature as a potential biomarker of malignant mesothelioma patients from hand-spinning asbestos exposed area in Eastern China","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118357"}}