{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:28:41Z","timestamp":1790645321534,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085MC074"],"award-info":[{"award-number":["2408085MC074"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971521"],"award-info":[{"award-number":["31971521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3246306"],"award-info":[{"award-number":["3246306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ecoenv.2025.118377","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T15:17:53Z","timestamp":1748272673000},"page":"118377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Synergistic reproductive toxicity of microcystin-LR and polystyrene micro\/nano-plastics in male zebrafish"],"prefix":"10.1016","volume":"299","author":[{"given":"Jiayao","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beicun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Tuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118377_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104901","article-title":"The potential impacts of micro-and-nano plastics on various organ systems in humans","volume":"99","author":"Ali","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ecoenv.2025.118377_bib2","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/REP-13-0178","article-title":"Mitochondria functionality and sperm quality","volume":"146","author":"Amaral","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.ecoenv.2025.118377_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.ecoenv.2025.118377_bib4","article-title":"Sublethal microcystin exposure and biochemical outcomes among hemodialysis patients","volume":"8","author":"Androulakis","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ecoenv.2025.118377_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120618","article-title":"Microplastics and nanoplastics: Source, behavior, remediation, and multi-level environmental impact","volume":"356","author":"Arif","year":"2024","journal-title":"J. Environ. Manag."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118377_bib6","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1021\/acs.est.1c04296","article-title":"Identification of novel microcystins using high-resolution MS and MSn with Python Code","volume":"56","author":"Baliu-Rodriguez","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105971","article-title":"Toxic effects of cyanotoxins in teleost fish: A comprehensive review","volume":"240","author":"Banerjee","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118377_bib9","doi-asserted-by":"crossref","DOI":"10.1071\/RD17533","article-title":"Negative effects of oxidative stress in bovine spermatozoa on in vitro development and DNA integrity of embryos","volume":"30","author":"Bittner","year":"2018","journal-title":"Reprod., Fertil. Dev."},{"key":"10.1016\/j.ecoenv.2025.118377_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137795","article-title":"Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models","volume":"490","author":"Bridgeman","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.118377_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1474-4422(13)70176-5","article-title":"A long shot? Could neurodegenerative disease be caused by a cyanobacterial toxin?","volume":"12","author":"Burton","year":"2013","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118377_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/ars.2007.1845","article-title":"Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia\u2013reperfusion injury","volume":"10","author":"Burwell","year":"2008","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.118377_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090482","article-title":"Effects of microcystin-LR on the microstructure and inflammation-related factors of jejunum in mice","volume":"11","author":"Cao","year":"2019","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.ecoenv.2025.118377_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090507","article-title":"A review of cardiovascular toxicity of microcystins","volume":"11","author":"Cao","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2025.118377_bib15","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2017.07.081","article-title":"Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis","volume":"229","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.118377_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11090530","article-title":"The diversity of cyanobacterial toxins on structural characterization, distribution and identification: a systematic review","volume":"11","author":"Du","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2025.118377_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113899","article-title":"Ameliorative effect of Spirulina and Saccharomyces cerevisiae against fipronil toxicity in Oreochromis niloticus","volume":"242","author":"Fadl","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118377_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146730","article-title":"microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2\/eIF2\u03b1 pathway in mouse testes","volume":"781","author":"Gao","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118377_bib19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/MCB.25.4.1354-1366.2005","article-title":"Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators","volume":"25","author":"Gleyzer","year":"2023","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfae060","article-title":"Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis","author":"Hu","year":"2024","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118377_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2184.2011.00753.x","article-title":"Cdc2: a monopotent or pluripotent CDK?","volume":"44","author":"Hu","year":"2011","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ecoenv.2025.118377_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135077","article-title":"Mitochondrial damage are involved in aflatoxin B1-induced testicular damage and spermatogenesis disorder in mice","volume":"701","author":"Huang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118377_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118377_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abb.2018.05.002","article-title":"Testosterone alleviates mitochondrial ROS accumulation and mitochondria-mediated apoptosis in the gastric mucosa of orchiectomized rats","volume":"649","author":"Kang","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ecoenv.2025.118377_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121445","article-title":"On the probability of ecological risks from microplastics in the Laurentian Great lakes","volume":"325","author":"Koelmans","year":"2023","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118377_bib26","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1021\/acsnano.1c02407","article-title":"Nanoplastic-induced genotoxicity and intestinal damage in freshwater benthic clams (Corbicula fluminea): comparison with microplastics","volume":"15","author":"Li","year":"2021","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118377_bib27","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1021\/acs.est.6b01062","article-title":"Determination of environmental exposure to microcystin and aflatoxin as a risk for renal function based on 5493 rural people in southwest China","volume":"50","author":"Lin","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chemosphere.2017.05.079","article-title":"Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish","volume":"183","author":"Lin","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118377_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123789","article-title":"Microcystin-LR and polystyrene microplastics jointly lead to hepatic histopathological damage and antioxidant dysfunction in male zebrafish","volume":"347","author":"Lin","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118377_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117855","article-title":"Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish","volume":"291","author":"Lin","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118377_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconhyd.2022.104028","article-title":"Spatial and temporal distributions of microplastics and their macroscopic relationship with algal blooms in Chaohu Lake, China","volume":"248","author":"Liu","year":"2022","journal-title":"J. Contam. Hydrol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114104","article-title":"Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice","volume":"181","author":"Liu","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121895","article-title":"Differences of microplastics and nanoplastics in urban waters: Environmental behaviors, hazards, and removal","volume":"260","author":"Liu","year":"2024","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118377_bib34","article-title":"Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"35","key":"10.1016\/j.ecoenv.2025.118377_bib35","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.1021\/acs.jafc.2c05207","article-title":"Chronic exposure to environmentally relevant concentrations of microcystin-leucine arginine causes lung barrier damage through PP2A activity inhibition and claudin1 ubiquitination","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2025.118377_bib36","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.envpol.2017.05.047","article-title":"Interactions between polystyrene microplastics and marine phytoplankton lead to species-specific hetero-aggregation","volume":"228","author":"Long","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118377_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168058","article-title":"Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis","volume":"908","author":"Luan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118377_bib38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chemosphere.2017.11.037","article-title":"Ecological risk assessment of microcystin-LR in the upstream section of the Haihe River based on a species sensitivity distribution model","volume":"193","author":"Niu","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118377_bib39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1589\/jpts.35.659","article-title":"Effectiveness of an educational approach between adolescents and adults with patellofemoral pain syndrome: a scoping review with meta-analysis","volume":"35","author":"Otsudo","year":"2023","journal-title":"J. Phys. Ther. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118377_bib40","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1007\/s12011-023-03848-0","article-title":"Reactive oxygen species-mediated mitophagy and cell apoptosis are involved in the toxicity of aluminum chloride exposure in GC-2spd","volume":"202","author":"Peng","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118377_bib41","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib42","doi-asserted-by":"crossref","first-page":"15940","DOI":"10.1021\/acs.est.1c05796","article-title":"Potentially Poisonous Plastic Particles: Microplastics as a Vector for Cyanobacterial Toxins Microcystin-LR and Microcystin-LF","volume":"55","author":"Pestana","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib43","article-title":"Impact of Oxidative Stress on Male Reproduction in Domestic and Wild Animals","volume":"10","author":"Pintus","year":"2021","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118377_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128161","article-title":"Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio)","volume":"263","author":"Qiang","year":"2021","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.ecoenv.2025.118377_bib45","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.celrep.2016.04.041","article-title":"The SAGA deubiquitination module promotes DNA repair and class switch recombination through ATM and DNAPK-mediated \u03b3H2AX formation","volume":"15","author":"Ramachandran","year":"2016","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.ecoenv.2025.118377_bib46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tibs.2020.03.009","article-title":"Reciprocal regulation of mitochondrial fission and fusion","volume":"45","author":"Sabouny","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ecoenv.2025.118377_bib47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fertnstert.2018.11.048","article-title":"Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging","volume":"111","author":"Seli","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2025.118377_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121117","article-title":"Microcystin-LR induced transgenerational effects of thyroid disruption in zebra\ufb01sh offspring by endoplasmic reticulum stress-mediated thyroglobulin accumulation and apoptosis","volume":"322","author":"Si","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118377_bib49","first-page":"73","author":"Smith","year":"2010","journal-title":"ATM\u2013Chk2 ATR\u2013Chk1 Pathw. DNA Damage Signal. Cancer"},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118377_bib50","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12185-017-2226-0","article-title":"DNA damage response and hematological malignancy","volume":"106","author":"Takagi","year":"2017","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112919","article-title":"The activated ATM\/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells","volume":"227","author":"Tian","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118377_bib52","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.20342","article-title":"CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATMdeficient cell growth in vitro","volume":"8","author":"Tsuji","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118377_bib53","doi-asserted-by":"crossref","first-page":"a011072","DOI":"10.1101\/cshperspect.a011072","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"van der Bliek","year":"2013","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118377_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14010061","article-title":"A summer of cyanobacterial blooms in belgian waterbodies: Microcystin quantification and Molecular characterizations","volume":"14","author":"Van Hassel","year":"2022","journal-title":"Toxins"},{"issue":"36","key":"10.1016\/j.ecoenv.2025.118377_bib55","doi-asserted-by":"crossref","first-page":"45095","DOI":"10.1007\/s11356-020-10384-0","article-title":"Occurrence and risk assessment of microcystin and its relationship with environmental factors in lakes of the eastern plain ecoregion, China","volume":"27","author":"Wan","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2025.118377_bib56","article-title":"Mechanisms of oxidative stress-induced sperm dysfunction","volume":"16","author":"Wang","year":"2025","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"12","key":"10.1016\/j.ecoenv.2025.118377_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11120729","article-title":"Measurement of microcystin and nodularin activity in human urine by immunocapture-protein phosphatase 2A Assay","volume":"11","author":"Wharton","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2025.118377_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159306","article-title":"Assessment of cancer-related signaling pathways in responses to polystyrene nanoplastics via a kidney-testis microfluidic platform (KTP)","volume":"857","author":"Xiao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118377_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124022","article-title":"Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos","volume":"352","author":"Xiao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118377_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.118377_bib61","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9736","article-title":"Association between semen microcystin levels and reproductive quality: A cross-sectional study in Jiangsu and Anhui Provinces, China","volume":"129","author":"Xu","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118377_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159032","article-title":"Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information","volume":"857","author":"Xu","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118377_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15060404","article-title":"Microcystin-LR-exposure-induced kidney damage by inhibiting MKK6-mediated mitophagy in mice","volume":"15","author":"Yao","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2025.118377_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121084","article-title":"SIRT1\/PGC-1\u03b1 is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc","volume":"320","author":"Ye","year":"2023","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.118377_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05364-w","article-title":"Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.118377_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170011","article-title":"Toxic effects of nanoplastics and microcystin-LR coexposure on the liver-gut axis of Hypophthalmichthys molitrix","volume":"916","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118377_bib67","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-022-01890-x","article-title":"Sensitization of cervical cancer cells to radiation by the cyclin-dependent kinase inhibitor dinaciclib","volume":"40","author":"Zhang","year":"2022","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ecoenv.2025.118377_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110254","article-title":"The latest advances in the reproductive toxicity of microcystin-LR","volume":"192","author":"Zhang","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118377_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162713","article-title":"Detection and characterization of microplastics in the human testis and semen","volume":"877","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118377_bib70","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chemosphere.2018.04.020","article-title":"N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes","volume":"204","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118377_bib71","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/acs.est.5b03369","article-title":"First identification of the toxicity of microcystins on pancreatic islet function in humans and the involved potential biomarkers","volume":"50","author":"Zhao","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118377_bib72","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/hep.29310","article-title":"Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case-control study in southwest China","volume":"66","author":"Zheng","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2025.118377_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161838","article-title":"Chronic nanoplastic exposure induced oxidative and immune stress in medaka gonad","volume":"869","author":"Zhou","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118377_bib74","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325007134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325007134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:51:45Z","timestamp":1762246305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325007134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":74,"alternative-id":["S0147651325007134"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118377","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic reproductive toxicity of microcystin-LR and polystyrene micro\/nano-plastics in male zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118377"}}