{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:35:28Z","timestamp":1777991728738,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ecoenv.2025.118380","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T15:48:54Z","timestamp":1748015334000},"page":"118380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sex-specific impact of polycyclic aromatic hydrocarbons and metals on renal function in U.S. adults: Mediating roles of inflammation, oxidative stress and aging"],"prefix":"10.1016","volume":"299","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118380_bib1","doi-asserted-by":"crossref","unstructured":"A, E.-M., B, B., I, B.-D., C, G.-R., A, G., V, R., 2014. Distribution of PAHs and trace metals in urban stormwater sediments: combination of density fractionation, mineralogy and microanalysis. Environmental science and pollution research international 21. https:\/\/doi.org\/10.1007\/s11356-014-2850-7.","DOI":"10.1007\/s11356-014-2850-7"},{"key":"10.1016\/j.ecoenv.2025.118380_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ckj\/sfy111","article-title":"Air pollution and kidney disease: review of current evidence","volume":"12","author":"Afsar","year":"2019","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.ecoenv.2025.118380_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118686","article-title":"Bioremediation of PAHs and heavy metals co-contaminated soils: Challenges and enhancement strategies","volume":"295","author":"Ali","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118380_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102576","article-title":"Attenuation of inflammation, oxidative stress and TGF-\u03b21\/Smad3 signaling and upregulation of Nrf2\/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity","volume":"91","author":"Alruhaimi","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.ecoenv.2025.118380_bib5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s40572-018-0219-7","article-title":"Metal-Induced Pulmonary Fibrosis","volume":"5","author":"Assad","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2025.118380_bib6","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1289\/ehp.941021058","article-title":"Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake","volume":"102","author":"Berglund","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118380_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jtemb.2018.09.002","article-title":"Mercury in dental amalgams: A great concern for clinical toxicology in developing countries?","volume":"51","author":"Bj\u00f8rklund","year":"2019","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.yrtph.2014.02.003","article-title":"Toxic metals contained in cosmetics: A status report","volume":"68","author":"Bocca","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrneph.2017.181","article-title":"Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease","volume":"14","author":"Carrero","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib10","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.3390\/ijerph17114016","article-title":"Temporal Evolution of PAHs Bioaccessibility in an Aged-Contaminated Soil during the Growth of Two Fabaceae","volume":"17","author":"Davin","year":"2020","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118380_bib11","doi-asserted-by":"crossref","unstructured":"Deng, Q., Dai, X., Feng, W., Huang, S., Yuan, Y., Xiao, Y., Zhang, Z., Deng, N., Deng, H., Zhang, Xiao, Kuang, D., Li, X., Zhang, W., Zhang, Xiaomin, Guo, H., Wu, T., 2019. Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers. Environ Int 122, 369\u2013380. https:\/\/doi.org\/10.1016\/j.envint.2018.11.056.","DOI":"10.1016\/j.envint.2018.11.056"},{"key":"10.1016\/j.ecoenv.2025.118380_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e07976","article-title":"Assessing effectiveness of air purifiers (HEPA) for controlling indoor particulate pollution","volume":"7","author":"Dubey","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.ecoenv.2025.118380_bib13","article-title":"Toxicological Profile for Cadmium, Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles. Agency for Toxic Substances and Disease Registry (US)","author":"Faroon","year":"2012","journal-title":"Atlanta"},{"key":"10.1016\/j.ecoenv.2025.118380_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.envres.2015.11.012","article-title":"Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003-2008","volume":"144","author":"Farzan","year":"2016","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.118380_bib15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jtemb.2018.03.001","article-title":"Dietary intake of cadmium, chromium, copper, manganese, selenium and zinc in a Northern Italy community","volume":"50","author":"Filippini","year":"2018","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","article-title":"Chronic kidney disease and the global public health agenda: an international consensus","volume":"20","author":"Francis","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1379252","article-title":"Association between single and mixed exposure to polycyclic aromatic hydrocarbons and biological aging","volume":"12","author":"Fu","year":"2024","journal-title":"Front Public Health"},{"key":"10.1016\/j.ecoenv.2025.118380_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120891","article-title":"Associations of co-exposure to polycyclic aromatic hydrocarbons and metals with hyperuricemia risk in Chinese coke oven workers: Mediating roles of oxidative damage","volume":"318","author":"Guo","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118380_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/em.21866","article-title":"Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure","volume":"55","author":"Guo","year":"2014","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.ecoenv.2025.118380_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/j.ajkd.2018.02.358","article-title":"Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort","volume":"72","author":"Harari","year":"2018","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.ecoenv.2025.118380_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s12964-024-01968-1","article-title":"Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors","volume":"22","author":"Hejazian","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.ecoenv.2025.118380_bib22","doi-asserted-by":"crossref","unstructured":"Hj, H., H, S., 2022. Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. Cells 12. https:\/\/doi.org\/10.3390\/cells12010088.","DOI":"10.3390\/cells12010088"},{"key":"10.1016\/j.ecoenv.2025.118380_bib23","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1039\/C6FO01580H","article-title":"Toxicity of cadmium and its health risks from leafy vegetable consumption","volume":"8","author":"Huang","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.118380_bib24","doi-asserted-by":"crossref","unstructured":"I, H., Gm, F.-B., B, R.-G., Rw, S., 2012. Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nature reviews. Nephrology 8. https:\/\/doi.org\/10.1038\/nrneph.2012.19.","DOI":"10.1038\/nrneph.2012.19"},{"key":"10.1016\/j.ecoenv.2025.118380_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1550-8579(07)80009-X","article-title":"Female protection in progressive renal disease is associated with estradiol attenuation of superoxide production","volume":"4","author":"Ji","year":"2007","journal-title":"Gend. Med"},{"key":"10.1016\/j.ecoenv.2025.118380_bib26","article-title":"Joint association of heavy metals and polycyclic aromatic hydrocarbons exposure with depression in adults","author":"Jiang","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118380_bib27","article-title":"Heavy metals: toxicity and human health effects","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00467-021-05215-4","article-title":"Environmental exposure to lead, mercury, and cadmium is not associated with abnormal kidney function in Korean adolescents","volume":"37","author":"Joo","year":"2022","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ecoenv.2025.118380_bib29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"issue":"2011","key":"10.1016\/j.ecoenv.2025.118380_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int Suppl."},{"key":"10.1016\/j.ecoenv.2025.118380_bib31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/antiox13010076","article-title":"Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies","volume":"13","author":"Koyama","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118380_bib32","article-title":"Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up","volume":"9","author":"Li","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.ecoenv.2025.118380_bib33","article-title":"Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach","author":"Liao","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118380_bib34","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00204-019-02544-0","article-title":"A nongenomic mechanism for \u201cmetalloestrogenic\u201d effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor","volume":"93","author":"Liu","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib35","article-title":"Systemic immune-inflammatory biomarkers (SII, NLR, PLR and LMR) linked to non-alcoholic fatty liver disease risk","volume":"15","author":"Liu","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biortech.2016.11.095","article-title":"Bioremediation mechanisms of combined pollution of PAHs and heavy metals by bacteria and fungi: A mini review","volume":"224","author":"Liu","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib37","doi-asserted-by":"crossref","unstructured":"Mh, J., Y, W., M, L., K, K., S, L., J, M., Ba, W., S, F., H, T., L, T., 2022. Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation? Kidney360 3. https:\/\/doi.org\/10.34067\/KID.0000892022.","DOI":"10.34067\/KID.0000892022"},{"key":"10.1016\/j.ecoenv.2025.118380_bib38","article-title":"Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts","volume":"380","author":"Ong","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2025.118380_bib39","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.kint.2021.06.041","article-title":"A Mendelian randomization study found causal linkage between telomere attrition and chronic kidney disease","volume":"100","author":"Park","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecoenv.2025.118380_bib40","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3390\/antiox9080752","article-title":"Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease","volume":"9","author":"Podkowi\u0144ska","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118380_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114029","article-title":"The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle","volume":"244","author":"Qu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118380_bib42","doi-asserted-by":"crossref","first-page":"24024","DOI":"10.1007\/s11356-021-17479-2","article-title":"Association of chronic kidney disease with exposure to polycyclic aromatic hydrocarbons in the US population","volume":"29","author":"Rahman","year":"2022","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118380_bib43","doi-asserted-by":"crossref","first-page":"101681","DOI":"10.1007\/s11356-023-29422-8","article-title":"Exposure to arsenic, polycyclic aromatic hydrocarbons, metals, and association with skin cancers in the US adults","volume":"30","author":"Rahman","year":"2023","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2025.118380_bib44","article-title":"Improving risk management by using the spatial interaction relationship of heavy metals and PAHs in urban soil","volume":"364","author":"S","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118380_bib45","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1289\/ehp.5840","article-title":"Impact of metals on the biodegradation of organic pollutants","volume":"111","author":"Sandrin","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118380_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cca.2018.10.021","article-title":"Association between PAHs biomarkers and kidney injury biomarkers among kitchen workers with microalbuminuria: A cross-sectional pilot study","volume":"487","author":"Singh","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ecoenv.2025.118380_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-069X-12-9","article-title":"End-stage renal disease and low level exposure to lead, cadmium and mercury; a population-based, prospective nested case-referent study in Sweden","volume":"12","author":"Sommar","year":"2013","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118380_bib48","doi-asserted-by":"crossref","unstructured":"Sp, K., M, S., M, M., K, M., R, R., 2023. The Role of Inflammation in CKD. Cells 12. https:\/\/doi.org\/10.3390\/cells12121581.","DOI":"10.3390\/cells12121581"},{"key":"10.1016\/j.ecoenv.2025.118380_bib49","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/nu12051374","article-title":"Gender Differences in Fat-Rich Meat Choice: Influence of Personality and Attitudes","volume":"12","author":"Spinelli","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2025.118380_bib50","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/S0140-6736(00)04822-4","article-title":"Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers","volume":"357","author":"Staessen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.118380_bib51","doi-asserted-by":"crossref","unstructured":"T, Y., Y, I., 2024. Pathological mechanisms of kidney disease in ageing. Nature reviews. Nephrology 20. https:\/\/doi.org\/10.1038\/s41581-024-00868-4.","DOI":"10.1038\/s41581-024-00868-4"},{"key":"10.1016\/j.ecoenv.2025.118380_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117097","article-title":"Independent and combined associations of urinary heavy metals exposure and serum sex hormones among adults in NHANES 2013\u20132016","volume":"281","author":"Tao","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118380_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/ijms26010003","article-title":"The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence","volume":"26","author":"Teh","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118380_bib54","first-page":"282","article-title":"Associations among Heavy Metals and Proteinuria and Chronic Kidney Disease","volume":"11","author":"Tsai","year":"2021","journal-title":"Diagn. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118380_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0000000000000463","article-title":"Sex hormones and their influence on chronic kidney disease","volume":"28","author":"Valdivielso","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.ecoenv.2025.118380_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127395","article-title":"Association between blood metals mixture and chronic kidney disease in adults: NHANES 2013-2016","volume":"83","author":"Wang","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1207\/s15324796abm2702_5","article-title":"Gender differences in food choice: the contribution of health beliefs and dieting","volume":"27","author":"Wardle","year":"2004","journal-title":"Ann. Behav. Med"},{"key":"10.1016\/j.ecoenv.2025.118380_bib58","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/oem.2010.056077","article-title":"Associations of low-level urine cadmium with kidney function in lead workers","volume":"68","author":"Weaver","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2025.118380_bib59","article-title":"Association of low cadmium and mercury exposure with chronic kidney disease among Chinese adults aged \u2265\u200980 years: A cross-sectional study","author":"Wei","year":"2022","journal-title":"Chin. Med J. (Engl. ) 135, 2976\u20132983"},{"key":"10.1016\/j.ecoenv.2025.118380_bib60","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/j.ackd.2010.05.002","article-title":"The aging kidney: physiological changes","volume":"17","author":"Weinstein","year":"2010","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.ecoenv.2025.118380_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105055","article-title":"Co-exposure to polycyclic aromatic hydrocarbons and metals, four common polymorphisms in microRNA genes, and their gene-environment interactions: Influences on oxidative damage levels in Chinese coke oven workers","volume":"132","author":"Xie","year":"2019","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118380_bib62","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrneph.2018.11","article-title":"Environmental pollution and kidney diseases","volume":"14","author":"Xu","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib63","doi-asserted-by":"crossref","unstructured":"Y, F., B, C., Z, L., Ay, G., Wt, G., Y, G., D, M., Af, G., Ld, D., R, G., 2022. Age-related GSK3\u03b2 overexpression drives podocyte senescence and glomerular aging. The Journal of clinical investigation 132. https:\/\/doi.org\/10.1172\/JCI141848.","DOI":"10.1172\/JCI141848"},{"key":"10.1016\/j.ecoenv.2025.118380_bib64","doi-asserted-by":"crossref","unstructured":"Y, Y., W, M., H, K., X, C., X, Z., L, W., H, T., Y, X., P, D., M, X., G, H., Y, Z., Gh, D., 2023. Association of urinary exposure to multiple metal(loid)s with kidney function from a national cross-sectional study. The Science of the total environment 882. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.163100.","DOI":"10.1016\/j.scitotenv.2023.163100"},{"key":"10.1016\/j.ecoenv.2025.118380_bib65","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41581-024-00868-4","article-title":"Pathological mechanisms of kidney disease in ageing","volume":"20","author":"Yamamoto","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2025.118380_bib66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40557-015-0086-8","article-title":"Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication","volume":"28","author":"Ye","year":"2016","journal-title":"Ann. Occup. Environ. Med"},{"key":"10.1016\/j.ecoenv.2025.118380_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113457","article-title":"Associations between renal functions and exposure of arsenic and polycyclic aromatic hydrocarbon in adults living near a petrochemical complex","volume":"256","author":"Yuan","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118380_bib68","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.envpol.2016.03.050","article-title":"Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors","volume":"213","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118380_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131400","article-title":"Associations between systemic immunity-inflammation index and heart failure: Evidence from the NHANES 1999-2018","volume":"395","author":"Zheng","year":"2024","journal-title":"Int J. Cardiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132500716X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132500716X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:00:27Z","timestamp":1749099627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132500716X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":69,"alternative-id":["S014765132500716X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118380","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific impact of polycyclic aromatic hydrocarbons and metals on renal function in U.S. adults: Mediating roles of inflammation, oxidative stress and aging","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118380"}}