{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:17:52Z","timestamp":1777738672513,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005356","name":"Zhejiang Shuren University","doi-asserted-by":"publisher","award":["2023R011"],"award-info":[{"award-number":["2023R011"]}],"id":[{"id":"10.13039\/501100005356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ecoenv.2025.118437","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:18:21Z","timestamp":1749449901000},"page":"118437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Stereoselective toxicity and metabolic impacts of difenoconazole-alcohol enantiomers in earthworms: Accumulation, degradation, and oxidative stress"],"prefix":"10.1016","volume":"300","author":[{"given":"Huizhen","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyang","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhexiong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingrong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118437_bib1","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.2174\/1386207326666230208094859","article-title":"Polysaccharide and cyclodextrin-based monolithic chiral stationary phases and its application to chiral separation","volume":"26","author":"Aboul","year":"2023","journal-title":"Comb. Chem. High. Throughput Screen"},{"key":"10.1016\/j.ecoenv.2025.118437_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.chemosphere.2023.137898","article-title":"Bioaccumulation, metabolism and toxicological effects of chiral insecticide malathion and its metabolites in zebrafish (Danio rerio)","volume":"318","author":"Cui","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118437_bib3","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1021\/es304982m","article-title":"Chiral triazole fungicide difenoconazole: Absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil","volume":"47","author":"Dong","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"13","key":"10.1016\/j.ecoenv.2025.118437_bib4","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.3390\/molecules27134323","article-title":"Pesticide-residue analysis in soils by the quechers method: a review","volume":"27","author":"Gonzalez-curbelo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.118437_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1071\/AP09090","article-title":"Effect of fungicide use strategies on the control of early blight (Alternaria solani) and potato yield","volume":"39","author":"Horsfield","year":"2010","journal-title":"Australas. Plant. Pathol."},{"key":"10.1016\/j.ecoenv.2025.118437_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128794","article-title":"Toxicity evaluation of pyraclostrobin exposure in farmland soils and co-exposure with nZnO to Eisenia fetida","volume":"433","author":"Hou","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.118437_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110934","article-title":"Comparative transcriptomics implicate mitochondrial and neurodevelopmental impairments in larval zebrafish (Danio rerio) exposed to two selective serotonin reuptake inhibitors (SSRIs)","volume":"203","author":"Huang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118437_bib8","first-page":"22","article-title":"Enantioselectivity in the toxicological effects of chiral pesticides: a review","volume":"857","author":"Ji","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118437_bib9","doi-asserted-by":"crossref","unstructured":"Jiang, W., Zhao, Z., Zhao, Q., 2024. Enantioselective toxicity of ibuprofen to earthworms: unraveling the effect and mechanism on enhanced toxicity of s-ibuprofen over r-ibuprofen. Environ. Sci. Technol. 0013-936x. \u3008https:\/\/doi.org\/10.1021\/acs.est.4c08655\u3009.","DOI":"10.1021\/acs.est.4c08655"},{"key":"10.1016\/j.ecoenv.2025.118437_bib10","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00216-012-6240-z","article-title":"Simultaneous enantioselective determination of triazole fungicide difenoconazole and its main chiral metabolite in vegetables and soil by normal-phase high-performance liquid chromatography","volume":"404","author":"Li","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2025.118437_bib11","first-page":"12598","article-title":"Ecotoxicity of herbicide carfentrazone-ethyl towards earthworm Eisenia fetida in soil","volume":"356","author":"Li","year":"2022","journal-title":"Comp. Biochem. Phys."},{"key":"10.1016\/j.ecoenv.2025.118437_bib12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.chemosphere.2015.04.058","article-title":"Toxicity and bioaccumulation of bromadiolone to earthworm Eisenia. fetida","volume":"135","author":"Liu","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118437_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ecoenv.2015.04.011","article-title":"Biomarker responses in the earthworm, dichogaster curgensis exposed to fly ash polluted soils","volume":"118","author":"Markad","year":"2015","journal-title":"Ecotoxiol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118437_bib14","unstructured":"OECD Guideline for Testing of Chemicals No 317, 2010. Bioaccumulation in Terrertrial Oligochaetes. OECD, Paris, France."},{"key":"10.1016\/j.ecoenv.2025.118437_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115989","article-title":"Oxidative stress and detoxification mechanisms of earthworms (Eisenia fetida) after exposure to flupyradifurone in a soil-earthworm system","volume":"322","author":"Qiao","year":"2022","journal-title":"J. Environ. Manag."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118437_bib16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ps.3841","article-title":"Enantioselective bioaccumulation and toxic effects of fipronil in the earthworm Eisenia foetida following soil exposure","volume":"71","author":"Qin","year":"2015","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.ecoenv.2025.118437_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116148","article-title":"Stereoselective bioaccumulation and degradation of chiral pesticide hexythiazox in earthworm-soil microcosm","volume":"273","author":"Song","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118437_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/chir.22796","article-title":"The influence of microbial communities for triadimefon enantiomerization in soils with different pH values","volume":"30","author":"Talab","year":"2018","journal-title":"Chirality"},{"key":"10.1016\/j.ecoenv.2025.118437_bib19","first-page":"1364","article-title":"8-Oxo-7,8-Dihydro-2\u2019-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2\u2019-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development","volume":"125","author":"Urbaniak","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.118437_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142404","article-title":"Enantioselective bioaccumulation, biotransformation and spatial distribution of chiral fungicide difenoconazole in earthworms (Eisenia fetida)","volume":"361","author":"Wang","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118437_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109491","article-title":"Enantioselective degradation of chiral fungicides triticonazole and prothioconazole in soils and their enantioselective accumulation in earthworms Eisenia fetida","volume":"183","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118437_bib22","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1021\/es2003793","article-title":"Enantioselectivity tuning of chiral herbicide dichlorprop by copper: roles of reactive oxygen species","volume":"45","author":"Wen","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118437_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105455","article-title":"Pathway-based assessment of single chemicals and mixtures by a high-throughput transcriptomics approach","volume":"136","author":"Xia","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118437_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106924","article-title":"Earthworms as candidates for remediation of potentially toxic elements contaminated soils and mitigating the environmental and human health risks: a review","volume":"158","author":"Xiao","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118437_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135199","article-title":"Systematic health risks assessment of chiral fungicide famoxadone: Stereoselectivities in ferroptosis-mediated cytotoxicity and metabolic behavior","volume":"477","author":"Xiao","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118437_bib26","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.envpol.2018.07.091","article-title":"Remediation effectiveness of Phyllostachys pubescens biochar in reducing the bioavailability and bioaccumulation of metals in sediments","volume":"242","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118437_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144347","article-title":"Combined toxic effects of dioxin-like PCB77 with Fe-based nanoparticles in earthworm Eisenia fetida","volume":"766","author":"Zhang","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2025.118437_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150454","article-title":"Stereoselective effects of fungicide difenoconazole and its four stereoisomers on gut barrier, microbiota, and glucolipid metabolism in male mice","volume":"805","author":"Zhang","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2025.118437_bib29","doi-asserted-by":"crossref","first-page":"8405","DOI":"10.1021\/es300049q","article-title":"Enantioselective damage of diclofop acid mediated by oxidative stress and acetyl-CoA carboxylase in nontarget plant Arabidopsis thaliana","volume":"46","author":"Zhang","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118437_bib30","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1021\/acs.est.1c05692","article-title":"Toxicological Effect and Molecular Mechanism of the Chiral Neonicotinoid Dinotefuran in Honeybees","volume":"56","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118437_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10646-010-0583-z","article-title":"Bioaccumulation and degradation of pesticide fluroxypyr are associated with toxic tolerance in green alga Chlamydomonas reinhardtii","volume":"20","author":"Zhang","year":"2011","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118437_bib32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/tx600281n","article-title":"Stereoisomeric separation and toxicity of a new organophosphorus insecticide chloramidophos","volume":"20","author":"Zhou","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118437_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112227","article-title":"Difenoconazole induces cardiovascular toxicity through oxidative stress-mediated apoptosis in early life stages of zebrafish (Danio rerio)","volume":"216","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325007778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325007778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:03:58Z","timestamp":1764641038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325007778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":33,"alternative-id":["S0147651325007778"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118437","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stereoselective toxicity and metabolic impacts of difenoconazole-alcohol enantiomers in earthworms: Accumulation, degradation, and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118437"}}