{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:28:00Z","timestamp":1793237280589,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research Project of Zhejiang Chinese Medical University","award":["2023JKZDZC02"],"award-info":[{"award-number":["2023JKZDZC02"]}]},{"name":"Ding Zhishan Expert Workstation in Yunnan Province","award":["202305AF150117"],"award-info":[{"award-number":["202305AF150117"]}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22106143"],"award-info":[{"award-number":["22106143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ecoenv.2025.118516","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T03:36:45Z","timestamp":1750045005000},"page":"118516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Triclosan inhibits testosterone synthesis in male offspring by activating mitophagy"],"prefix":"10.1016","volume":"301","author":[{"given":"Huili","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118516_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117518","article-title":"Chronic low-level perfluorooctane sulfonate (PFOS) exposure promotes testicular steroidogenesis through enhanced histone acetylation","volume":"284","author":"Alam","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118516_bib2","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.1700558114","article-title":"Discovery of a widespread metabolic pathway within and among phenolic xenobiotics","volume":"114","author":"Ashrap","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2025.118516_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpc.2016.08.009","article-title":"Utilization of Mytilus digestive gland cells for the in vitro screening of potential metabolic disruptors in aquatic invertebrates","volume":"191","author":"Balbi","year":"2017","journal-title":"Comp. Biochem Physiol. C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118516_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.chemosphere.2018.03.186","article-title":"Effects of triclosan in breast milk on the infant fecal microbiome","volume":"203","author":"Bever","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118516_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41580-019-0129-z","article-title":"PI3K isoforms in cell signalling and vesicle trafficking","volume":"20","author":"Bilanges","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tox.2017.07.013","article-title":"Mitochondria targeting by environmental stressors: Implications for redox cellular signaling","volume":"391","author":"Blajszczak","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118516_bib7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bulcan.2020.11.004","article-title":"An overview of autophagy: Mechanism, regulation and research progress","volume":"108","author":"Cao","year":"2021","journal-title":"Bull. Cancer"},{"key":"10.1016\/j.ecoenv.2025.118516_bib8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s40572-021-00317-5","article-title":"Racial\/Ethnic Disparities in Pregnancy and Prenatal Exposure to Endocrine-Disrupting Chemicals Commonly Used in Personal Care Products","volume":"8","author":"Chan","year":"2021","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2025.118516_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113880","article-title":"Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K\/AKT pathway","volume":"242","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118516_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12958-024-01316-5","article-title":"Age-related testosterone decline: mechanisms and intervention strategies","volume":"22","author":"Cheng","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/07482337241242510","article-title":"Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)","volume":"40","author":"Chokki","year":"2024","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ecoenv.2025.118516_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2015.02.019","article-title":"Cholesterol transport through lysosome-peroxisome membrane contacts","volume":"161","author":"Chu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.118516_bib13","article-title":"Lipoproteins and Their Effects on the Cardiovascular System","volume":"15","author":"Das","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.ecoenv.2025.118516_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112040","article-title":"Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals","volume":"204","author":"Delbes","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.ecoenv.2025.118516_bib15","first-page":"539","article-title":"The Role of the PI3K\/AKT\/mTOR Signalling Pathway in Male Reproduction","volume":"21","author":"Deng","year":"2021","journal-title":"Curr. Mol. Med"},{"key":"10.1016\/j.ecoenv.2025.118516_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137280","article-title":"miR-142-5p\/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression","volume":"717","author":"Duan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118516_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/15287394.2018.1451188","article-title":"Evaluation of subchronic exposure to triclosan on hepatorenal and reproductive toxicities in prepubertal male rats","volume":"81","author":"Ena","year":"2018","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ecoenv.2025.118516_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042021","article-title":"Role of Constitutive STAR in Leydig Cells","volume":"22","author":"Galano","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118516_bib19","first-page":"1","article-title":"PM2.5 induces autophagy-mediated cell apoptosis via PI3K\/AKT\/mTOR signaling pathway in mice bronchial epithelium cells","volume":"21","author":"Han","year":"2021","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.ecoenv.2025.118516_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12885-024-11903-9","article-title":"Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy","volume":"24","author":"He","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ecoenv.2025.118516_bib21","doi-asserted-by":"crossref","DOI":"10.4172\/2153-2435.1000516","article-title":"Effect of Antimicrobial Triclosan on Reproductive System of Male Rat","volume":"7","author":"Ibtisham","year":"2016","journal-title":"Pharm. Anal. Acta"},{"key":"10.1016\/j.ecoenv.2025.118516_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173013","article-title":"Critical review on the environmental behaviors and toxicity of triclosan and its removal technologies","volume":"932","author":"Jiang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118516_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s12020-016-1019-1","article-title":"Testosterone differentially regulates targets of lipid and glucose metabolism in liver, muscle and adipose tissues of the testicular feminised mouse","volume":"54","author":"Kelly","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.ecoenv.2025.118516_bib24","doi-asserted-by":"crossref","DOI":"10.58292\/ct.v15.9271","article-title":"Pathophysiology, diagnosis, and management of testicular degeneration in the bull","volume":"15","author":"Koziol","year":"2023","journal-title":"Clin. Theriogenology"},{"key":"10.1016\/j.ecoenv.2025.118516_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.reprotox.2008.12.002","article-title":"Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan","volume":"27","author":"Kumar","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yrtph.2014.02.002","article-title":"Critical comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals - 2012","volume":"69","author":"Lamb","year":"2014","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118516_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/tox.21897","article-title":"Triclosan exhibits a tendency to accumulate in the epididymis and shows sperm toxicity in male Sprague-Dawley rats","volume":"30","author":"Lan","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s43856-022-00226-0","article-title":"Genetic analyses implicate complex links between adult testosterone levels and health and disease","volume":"3","author":"Leinonen","year":"2023","journal-title":"Commun. Med (Lond. )"},{"key":"10.1016\/j.ecoenv.2025.118516_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2025.118516_bib30","article-title":"Hormone Regulation in Testicular Development and Function","volume":"25","author":"Li","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118516_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133217","article-title":"Hollow fiber membrane-protected amino\/hydroxyl bifunctional microporous organic network fiber for solid-phase microextraction of bisphenols A, F, S, and triclosan in breast milk and infant formula","volume":"390","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.ecoenv.2025.118516_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131532","article-title":"Long-term percutaneous triclosan exposure induces thyroid damage in mice: Interpretation of toxicity mechanism from metabolic and proteomic perspectives","volume":"454","author":"Liang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.118516_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.745621","article-title":"Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis","volume":"9","author":"Lin","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib34","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1016\/j.cell.2024.08.004","article-title":"Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake","volume":"187","author":"Long","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.118516_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/tox.23663","article-title":"Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN\/PI3K\/AKT\/mTOR","volume":"38","author":"Lu","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120314","article-title":"Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells","volume":"314","author":"Lu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118516_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152290","article-title":"Insights into the spatiotemporal occurrence and mixture risk assessment of household and personal care products in the waters from rivers to Laizhou Bay, southern Bohai Sea","volume":"810","author":"Lu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118516_bib38","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3389\/fendo.2018.00654","article-title":"Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview","volume":"9","author":"Maradonna","year":"2018","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2025.118516_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15102158","article-title":"Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL\/6 Male Mice","volume":"15","author":"Meng","year":"2018","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118516_bib40","doi-asserted-by":"crossref","first-page":"25119","DOI":"10.1007\/s11356-021-17273-0","article-title":"Comprehensive insight into triclosan-from widespread occurrence to health outcomes","volume":"30","author":"Milanovic","year":"2023","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2025.118516_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147653","article-title":"A Step Forward in Understanding the Expression of Classical Aquaporins in the Male Reproductive Tract: Study Findings in Cattle (Bos taurus)","volume":"25","author":"Oberska","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118516_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.ecoenv.2025.118516_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.reprotox.2017.11.004","article-title":"Male rat exposure to low dose of di(2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: Impact on sperm count, gonad histology and testosterone secretion","volume":"75","author":"Oudir","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.beem.2012.05.002","article-title":"Role of mitochondria in steroidogenesis","volume":"26","author":"Papadopoulos","year":"2012","journal-title":"Best. Pr. Res Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2025.118516_bib45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.reprotox.2017.11.010","article-title":"Evaluation of reproductive toxicity in rats treated with triclosan","volume":"75","author":"Pernoncini","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106229","article-title":"Associations among urinary triclosan and bisphenol A concentrations and serum sex steroid hormone measures in the Canadian and U.S. Populations","volume":"146","author":"Pollock","year":"2021","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118516_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113617","article-title":"Gestational and lactational exposure to triclosan causes impaired fertility of F1 male offspring and developmental defects in F2 generation","volume":"257","author":"Priyanka","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118516_bib48","first-page":"47","article-title":"Triclosan Influences on Reproductive Physiology of Climbing Perch in the Spawning Phase","volume":"80","author":"Priyatha","year":"2022","journal-title":"Ribarstvo"},{"key":"10.1016\/j.ecoenv.2025.118516_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22037","article-title":"Reproductive toxic impact of subchronic treatment with combined butylparaben and triclosan in weanling male rats","volume":"32","author":"Riad","year":"2018","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib50","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/15287390600631706","article-title":"Pharmacokinetics of triclosan following oral ingestion in humans","volume":"69","author":"Sandborgh-Englund","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ecoenv.2025.118516_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108827","article-title":"Triclosan inhibits testosterone biosynthesis in adult rats via inducing m6A methylation-mediated autophagy","volume":"190","author":"Sang","year":"2024","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118516_bib52","article-title":"Maternal Exposure to T-2 Toxin Induces Changes in Antioxidant System and Testosterone Synthesis in the Testes of Mice Offspring","volume":"10","author":"Shen","year":"2019","journal-title":"Anim. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118516_bib53","article-title":"Impacts of Oxidative Stress and PI3K\/AKT\/mTOR on Metabolism and the Future Direction of Investigating Fucoidan-Modulated Metabolism","volume":"11","author":"Shiau","year":"2022","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.ecoenv.2025.118516_bib54","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2164\/jandrol.05140","article-title":"Feedback inhibition of gonadotropins by testosterone in men with hypogonadotropic hypogonadism: comparison to the intact pituitary-testicular axis in primary hypogonadism","volume":"27","author":"Shimon","year":"2006","journal-title":"J. Androl."},{"key":"10.1016\/j.ecoenv.2025.118516_bib55","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1002\/jcp.26539","article-title":"Targeting the phosphatidylinositol 3-kinase\/Akt\/mechanistic target of rapamycin signaling pathway in B-lineage acute lymphoblastic leukemia: An update","volume":"233","author":"Simioni","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161885","article-title":"Triclosan and related compounds in the environment: Recent updates on sources, fates, distribution, analytical extraction, analysis, and removal techniques","volume":"870","author":"Sun","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118516_bib57","unstructured":"US EPA, 2007. Dietary Risk Assessment for Triclosan for the RED Process. Antimicrobials Division (7510P), Office of Pesticide Programs, Environmental Protection Agency, Washington, DC, EPA-HQ-OPP-2007-0513-0007."},{"key":"10.1016\/j.ecoenv.2025.118516_bib58","unstructured":"US EPA, 2008. Reregistration Eligibility Decision for Triclosan. Antimicrobials Division (7510P), Office of Pesticide Programs, Environmental Protection Agency, Washington, DC, EPA-HQ-OPP-2007-0513-0033."},{"key":"10.1016\/j.ecoenv.2025.118516_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136285","article-title":"Occurrence of emerging organic contaminants and endocrine disruptors in different water compartments in Mexico - A review","volume":"308","author":"Vazquez-Tapia","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118516_bib60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2017.09.020","article-title":"mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis","volume":"68","author":"Wan","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2025.118516_bib61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2017.11.007","article-title":"Impacts of prenatal triclosan exposure on fetal reproductive hormones and its potential mechanism","volume":"111","author":"Wang","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2025.118516_bib62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.envpol.2015.07.001","article-title":"Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms","volume":"206","author":"Wang","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118516_bib63","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2025.118516_bib64","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1038\/s41467-023-38290-2","article-title":"Structural basis for catalysis of human choline\/ethanolamine phosphotransferase 1","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.118516_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105624","article-title":"Baicalein inhibits apoptosis and autophagy induced by chlorpyrifos exposure to kidney of Cyprinus carpio through activation of PI3K\/AKT pathway","volume":"196","author":"Wu","year":"2023","journal-title":"Pest. Biochem Physiol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101776","article-title":"Mono-2-ethylhexyl phthalate drives progression of PINK1-parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity","volume":"38","author":"Xu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17207412","article-title":"Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011-2012","volume":"17","author":"Yan","year":"2020","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118516_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114075","article-title":"Benzo[a]pyrene inhibits testosterone biosynthesis via NDUFA10-mediated mitochondrial compromise in mouse Leydig cells: Integrating experimental and in silico toxicological approaches","volume":"244","author":"Yang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118516_bib69","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.3390\/molecules16129983","article-title":"Inhibitors of testosterone biosynthetic and metabolic activation enzymes","volume":"16","author":"Ye","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.118516_bib70","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.reprotox.2018.02.011","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin can alter the sex ratio of embryos with decreased viability of Y spermatozoa in mice","volume":"77","author":"You","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib71","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12974-021-02334-5","article-title":"Mitophagy in neurological disorders","volume":"18","author":"Zhang","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ecoenv.2025.118516_bib72","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1210\/en.2006-1497","article-title":"Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse","volume":"148","author":"Zhang","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2025.118516_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129689","article-title":"Phthalate-induced testosterone\/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene","volume":"439","author":"Zhao","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.118516_bib74","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1515\/reveh-2023-0064","article-title":"Impacts and potential mechanisms of fine particulate matter (PM(2.5)) on male testosterone biosynthesis disruption","volume":"39","author":"Zheng","year":"2024","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118516_bib75","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fgene.2020.00527","article-title":"Toxicological Effects of Cadmium on Mammalian Testis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.ecoenv.2025.118516_bib76","doi-asserted-by":"crossref","first-page":"11333","DOI":"10.1021\/acs.est.0c04299","article-title":"Occurrence, Distribution, and Human Exposure of Several Endocrine-Disrupting Chemicals in Indoor Dust: A Nationwide Study","volume":"54","author":"Zhu","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118516_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113282","article-title":"Methyl tert-butyl ether inhibits pubertal development of Leydig cells in male rats by inducing mitophagy and apoptosis","volume":"232","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118516_bib78","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/ijerph13020224","article-title":"Environmental Exposure to Triclosan and Semen Quality","volume":"13","author":"Zhu","year":"2016","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.ecoenv.2025.118516_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115866","article-title":"Effects of chronic triclosan exposure on nephrotoxicity and gut microbiota dysbiosis in adult mice","volume":"271","author":"Zhuang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118516_bib80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325008619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325008619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T07:51:23Z","timestamp":1750837883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325008619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":80,"alternative-id":["S0147651325008619"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118516","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triclosan inhibits testosterone synthesis in male offspring by activating mitophagy","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118516"}}