{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:11:51Z","timestamp":1790140311068,"version":"4.0.1"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR061341"],"award-info":[{"award-number":["RS-2021-NR061341"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011705","name":"Korea Institute of Marine Science and Technology promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Korea Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2022-KS221655"],"award-info":[{"award-number":["RS-2022-KS221655"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Korea Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2024-00417889"],"award-info":[{"award-number":["RS-2024-00417889"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118579","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T21:05:48Z","timestamp":1750885548000},"page":"118579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Characterization of known and unknown AhR-active substances in freshwater fish from the Gapcheon River, South Korea: Application of effect-directed analysis and nontarget screening"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-0604","authenticated-orcid":false,"given":"Jihyun","family":"Cha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Gwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-569X","authenticated-orcid":false,"given":"Dokyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6766-6307","authenticated-orcid":false,"given":"Eun-Ji","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hoon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Bang","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-0929","authenticated-orcid":false,"given":"Jong Seong","family":"Khim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-8731","authenticated-orcid":false,"given":"Seongjin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118579_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115160","article-title":"Trophic transfer of persistent toxic substances through a coastal food web in Ulsan Bay, South Korea: application of compound-specific isotope analysis of nitrogen in amino acids","volume":"266","author":"An","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118579_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/atmos9100381","article-title":"Emission and cytotoxicity of surgical smoke: cholesta-3,5-diene released from pyrolysis of prostate tissue","volume":"9","author":"Bae","year":"2018","journal-title":"Atmosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ecoenv.2019.06.008","article-title":"In vitro and in silico AHR assays for assessing the risk of heavy oil-derived polycyclic aromatic hydrocarbons in fish","volume":"181","author":"Bak","year":"2019","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118579_bib4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0025-326X(98)00088-5","article-title":"Concentrations of PAHs (polycyclic aromatic hydrocarbons) in various marine organisms in relation to those in sediments and to trophic level","volume":"36","author":"Baumard","year":"1998","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.118579_bib5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/molecules25040817","article-title":"Lipid Droplet composition varies based on medaka fish eggs development as revealed by NIR-, MIR-, and Raman imaging","volume":"25","author":"Bik","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2025.118579_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134547","article-title":"Metalloproteomic approach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma macropomum (tambaqui) from Amazon region: possible identification of mercury contamination biomarkers","volume":"711","author":"Bittarello","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib7","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1021\/acs.est.0c07846","article-title":"Using estrogenic activity and nontargeted chemical analysis to identify contaminants in sewage sludge","volume":"55","author":"Black","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1139\/cjfas-2016-0420","article-title":"Comparing compound-specific and bulk stable nitrogen isotope trophic discrimination factors across multiple freshwater fish species and diets","volume":"74","author":"Blanke","year":"2017","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.ecoenv.2025.118579_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.envint.2006.09.005","article-title":"Concentrations of PCDD\/PCDFs and PCBs in fish and seafood from the Catalan (Spain) market: estimated human intake","volume":"33","author":"Bocio","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118579_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00216-003-2139-z","article-title":"Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures?","volume":"377","author":"Brack","year":"2003","journal-title":"Anal. Bional. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib11","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.scitotenv.2015.11.102","article-title":"Effect-directed analysis supporting monitoring of aquatic environments \u2014 an in-depth overview","volume":"544","author":"Brack","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib12","first-page":"498","article-title":"Analysis of metabolomic data: tools, current strategies and future challenges for omics data integration","volume":"18","author":"Cambiaghi","year":"2017","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.ecoenv.2025.118579_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128305","article-title":"Identification of novel polar aryl hydrocarbon receptor agonists accumulated in liver of black-tailed gulls in Korea using advanced effect-directed analysis","volume":"429","author":"Cha","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118579_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105199","article-title":"Major AhR-active chemicals in sediments of Lake Sihwa, South Korea: application of effect-directed analysis combined with full-scan screening analysis","volume":"133","author":"Cha","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118579_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146566","article-title":"Novel polar AhR-active chemicals detected in sediments of an industrial area using effect-directed analysis based on in vitro bioassays with full-scan high resolution mass spectrometric screening","volume":"779","author":"Cha","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib16","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1021\/acs.est.3c04311","article-title":"Identification of mid-polar and polar AhR agonists in cetaceans from Korean Coastal waters: application of effect-directed analysis with full-scan screening","volume":"57","author":"Cha","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib17","doi-asserted-by":"crossref","first-page":"15415","DOI":"10.1021\/acs.est.3c10814","article-title":"Deep learning bridged bioactivity, structure, and GC-HRMS-readable evidence to decipher nontarget toxicants in sediments","volume":"58","author":"Cheng","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib18","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.chemosphere.2006.06.008","article-title":"Residual levels of DDTs and PAHs in freshwater and marine fish from Hong Kong markets and their health risk assessment","volume":"66","author":"Cheung","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.4319\/lom.2009.7.740","article-title":"Determination of aquatic food-web structure based on compound-specific nitrogen isotopic composition of amino acids","volume":"7","author":"Chikaraishi","year":"2009","journal-title":"Limnol. Oceanogr. Methods"},{"key":"10.1016\/j.ecoenv.2025.118579_bib20","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.3390\/s120912741","article-title":"Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment","volume":"12","author":"Connon","year":"2012","journal-title":"Sensors"},{"key":"10.1016\/j.ecoenv.2025.118579_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: a review","volume":"13","author":"van der Oost","year":"2003","journal-title":"Environ. Toxicol. Phar"},{"key":"10.1016\/j.ecoenv.2025.118579_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aquatox.2012.02.015","article-title":"Tissue specificity of aryl hydrocarbon receptor (AhR) mediated responses and relative sensitivity of white sturgeon (Acipenser transmontanus) to an AhR agonist","volume":"114\u2013115","author":"Doering","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib23","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1021\/es305071v","article-title":"Mercury as a global pollutant: sources, pathways, and effects","volume":"47","author":"Driscoll","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150691","article-title":"Identification of organic pollutants with potential ecological and health risks in aquatic environments: progress and challenges","volume":"806","author":"Du","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib25","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.aay6636","article-title":"Tracking complex mixtures of chemicals in our changing environment","volume":"367","author":"Escher","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118579_bib26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.aay6636","article-title":"Tracking complex mixtures of chemicals in our changing environment","volume":"367","author":"Escher","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118579_bib27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/ijms18010147","article-title":"New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii","volume":"18","author":"Fan","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118579_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/15376516.2015.1135223","article-title":"Structure, function and carcinogenicity of metabolites of methylated and non-methylated polycyclic aromatic hydrocarbons: a comprehensive review","volume":"26","author":"Flesher","year":"2016","journal-title":"Toxicol. Mech. Method"},{"key":"10.1016\/j.ecoenv.2025.118579_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149969","article-title":"Effect-directed identification of novel aryl hydrocarbon receptor-active aromatic compounds in coastal sediments collected from a highly industrialized area","volume":"803","author":"Gwak","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143771","article-title":"Characterization of AhR-mediated potency in sediments from Kongsfjorden, Svalbard: application of effect-directed analysis and nontarget screening","volume":"368","author":"Gwak","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib31","doi-asserted-by":"crossref","first-page":"13085","DOI":"10.1021\/acs.est.2c03428","article-title":"Molecular characterization of estrogen receptor agonists during sewage treatment processes using effect-directed analysis combined with high-resolution full-scan screening","volume":"56","author":"Gwak","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114074","article-title":"Monitoring ocean water quality by deployment of lumpfish (Cyclopterus lumpus) eggs: in situ bioaccumulation and toxicity in embryos","volume":"245","author":"Hansen","year":"2022","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2025.118579_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/etc.4609","article-title":"Effect-directed analysis of progestogens and glucocorticoids at trace concentrations in river water","volume":"39","author":"Hashmi","year":"2020","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib34","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.watres.2008.11.027","article-title":"Fluorescence as a potential monitoring tool for recycled water systems: a review","volume":"43","author":"Henderson","year":"2009","journal-title":"Water Res"},{"key":"10.1016\/j.ecoenv.2025.118579_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12601-016-0038-4","article-title":"Effect-directed analysis: current status and future challenges","volume":"51","author":"Hong","year":"2016","journal-title":"Ocean Sci. J."},{"key":"10.1016\/j.ecoenv.2025.118579_bib36","doi-asserted-by":"crossref","first-page":"19148","DOI":"10.1021\/acs.est.3c05035","article-title":"Effect-directed analysis combined with nontarget screening to identify unmonitored toxic substances in the environment","volume":"57","author":"Hong","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib37","doi-asserted-by":"crossref","first-page":"17439","DOI":"10.1021\/acs.est.3c05008","article-title":"Suspect and nontarget screening reveal the underestimated risks of antibiotic transformation products in wastewater treatment plant effluents","volume":"57","author":"Hu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib38","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1021\/acs.chemrestox.7b00232","article-title":"Potential metabolic activation of representative alkylated polycyclic aromatic hydrocarbons 1-methylphenanthrene and 9-ethylphenanthrene associated with the deepwater horizon oil spill in human hepatoma (HepG2) cells","volume":"30","author":"Huang","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.talanta.2018.10.050","article-title":"Evaluation of a data-processing method for target and non-target screening using comprehensive two-dimensional gas chromatography coupled with high-resolution time-of-flight mass spectrometry for environmental samples","volume":"194","author":"Ieda","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2025.118579_bib40","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/polb.10151","article-title":"Temperature dependence of the fluorescence quantum yields of diphenylsiloxane-based copolymers in dilute solutions","volume":"40","author":"Itoh","year":"2002","journal-title":"J. Polym. Sci. Pol. Phys."},{"key":"10.1016\/j.ecoenv.2025.118579_bib41","first-page":"399","article-title":"Characteristics and management plan of water quality at the water pollution deterioration area of the upper stream of Gapcheon. J","volume":"35","author":"Jang","year":"2019","journal-title":"Korean Soc. Water Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154067","article-title":"Elevated mercury and PCB concentrations in Dolly Varden (Salvelinus malma) collected near a formerly used defense site on Sivuqaq, Alaska","volume":"826","author":"Jordan-Ward","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.1138275","article-title":"Food web\u2013specific biomagnification of persistent organic pollutants","volume":"317","author":"Kelly","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118579_bib44","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0380-1330(03)70553-X","article-title":"Mercury concentrations in the food web of Lake Malawi, East Africa","volume":"29","author":"Kidd","year":"2003","journal-title":"J. Gt. Lakes Res"},{"key":"10.1016\/j.ecoenv.2025.118579_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107123","article-title":"Environmental fate and trophic transfer of synthetic musk compounds and siloxanes in Geum River, Korea: compound-specific nitrogen isotope analysis of amino acids for accurate trophic position estimation","volume":"161","author":"Kim","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118579_bib46","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.est.9b02166","article-title":"Newly identified AhR-active compounds in the sediments of an industrial area using effect-directed analysis","volume":"53","author":"Kim","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib47","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.chemosphere.2012.05.093","article-title":"Nationwide monitoring of mercury in wild and farmed fish from fresh and coastal waters of Korea","volume":"89","author":"Kim","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib48","doi-asserted-by":"crossref","unstructured":"Kim, D., Won, E.-J., Cho, H.-E., Jo, H.-W., Choi, K.-Y., Kim, C.-J., Shin, K.-H., 2025. Probabilistic Trophic Magnification Analysis for Assessing the Bioaccumulation Potential of Organophosphate Flame Retardants in Freshwater Ecosystems of South Korea. Ecotox. Environ. Safe. (In revision).","DOI":"10.1016\/j.ecoenv.2025.118657"},{"key":"10.1016\/j.ecoenv.2025.118579_bib49","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1365-2427.2004.01232.x","article-title":"Carp (Cyprinus carpio) as a powerful invader in Australian waterways","volume":"49","author":"Koehn","year":"2004","journal-title":"Freshw. Biol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2004.05.001","article-title":"Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-TCDD equivalents (TEQs) in sediment from the Hyeongsan River, Korea","author":"Koh","year":"2004","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118579_bib51","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0045-6535(98)00041-1","article-title":"Identification of lipophilic pollutants discharged from a finnish pulp and paper mill","volume":"37","author":"Koistinen","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib52","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/etc.2517","article-title":"Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay","volume":"33","author":"Larsson","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128908","article-title":"Identification of AhR agonists in sediments of the Bohai and Yellow Seas using advanced effect-directed analysis and in silico prediction","volume":"435","author":"Lee","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118579_bib54","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1007\/s11356-013-1770-2","article-title":"Revised relative potency values for PCDDs, PCDFs, and non-ortho-substituted PCBs for the optimized H4IIE-luc in vitro bioassay","volume":"20","author":"Lee","year":"2013","journal-title":"Environ. Sci. Pollut. R."},{"key":"10.1016\/j.ecoenv.2025.118579_bib55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/obr.12481","article-title":"Persistent organic pollutants in adipose tissue should be considered in obesity research","volume":"18","author":"Lee","year":"2017","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ecoenv.2025.118579_bib56","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1021\/ef502558a","article-title":"Qualitative and quantitative analysis of dibenzofuran, alkyldibenzofurans, and benzo[b]naphthofurans in crude oils and source rock Extracts","volume":"29","author":"Li","year":"2015","journal-title":"Energ. Fuel"},{"key":"10.1016\/j.ecoenv.2025.118579_bib57","doi-asserted-by":"crossref","first-page":"15123","DOI":"10.1021\/acs.est.1c02946","article-title":"Substituted two- to five-ring polycyclic aromatic compounds are potent agonists of atlantic cod (Gadus morhua) aryl hydrocarbon receptors Ahr1a and Ahr2a","volume":"55","author":"Lille-Lang\u00f8y","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib58","doi-asserted-by":"crossref","first-page":"3182746","DOI":"10.1155\/2016\/3182746","article-title":"How muscle structure and composition influence meat and flesh quality","volume":"2016","author":"Listrat","year":"2016","journal-title":"Sci. World J."},{"key":"10.1016\/j.ecoenv.2025.118579_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167967","article-title":"Assessment for the data processing performance of non-target screening analysis based on high-resolution mass spectrometry","volume":"908","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib60","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0003-2670(03)00815-8","article-title":"Decarbonation and preservation method for the analysis of organic C and N contents and stable isotope ratios of low-carbonated suspended particulate material","volume":"491","author":"Lorrain","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ecoenv.2025.118579_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnucene.2021.103900","article-title":"High temperature stability of a commercial terphenyl-based thermal oil","volume":"140","author":"Mansi","year":"2021","journal-title":"Prog. Nucl. Energ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tox.2016.09.015","article-title":"Integrating in silico models to enhance predictivity for developmental toxicity","volume":"370","author":"Marzo","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118579_bib63","first-page":"623","article-title":"Effect of exposure duration on the aryl hydrocarbon receptor-mediated activity of polycyclic aromatic hydrocarbons measured by in vitro reporter gene assay","volume":"66","author":"Masunaga","year":"2004","journal-title":"Organomet. Compd."},{"key":"10.1016\/j.ecoenv.2025.118579_bib64","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1289\/ehp.961041302","article-title":"A QSAR evaluation of Ah receptor binding of halogenated aromatic xenobiotics","volume":"104","author":"Mekenyan","year":"1996","journal-title":"Environ. Health Persp"},{"key":"10.1016\/j.ecoenv.2025.118579_bib65","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0016-7037(84)90204-7","article-title":"Stepwise enrichment of 15N along food chains: Further evidence and the relation between \u03b415N and animal age","volume":"48","author":"Minagawa","year":"1984","journal-title":"Geochim. Cosmochim. Acta"},{"key":"10.1016\/j.ecoenv.2025.118579_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108311","article-title":"Target and non-target analyses of neutral per- and polyfluoroalkyl substances from fluorochemical industries using GC-MS\/MS and GC-TOF: insights on their environmental fate","volume":"182","author":"Mok","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118579_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143814","article-title":"Nationwide human biomonitoring strategy in Korea: prioritization of novel contaminants using GC\/TOF-MS with suspect and non-target screening","volume":"369","author":"Mok","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib68","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.chemosphere.2005.04.063","article-title":"Distribution characteristics of polychlorinated biphenyls in crucian carp (Carassius auratus) from major rivers in Korea","volume":"62","author":"Moon","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib69","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1021\/acs.est.6b05468","article-title":"Mutagenicity in surface waters: synergistic effects of carboline alkaloids and aromatic amines","volume":"51","author":"Muz","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib70","article-title":"Ambient water quality criteria for polycyclic aromatic hydrocarbons (PAHs), BC","author":"Nagpal","year":"1993","journal-title":"Environ. Water Qual. Branch"},{"key":"10.1016\/j.ecoenv.2025.118579_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143160","article-title":"Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration","volume":"762","author":"Ndabambi","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib72","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1021\/acs.est.2c06365","article-title":"Application of effect-based methods to water quality monitoring: answering frequently asked questions by water quality managers, regulators, and policy makers","volume":"57","author":"Neale","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib73","series-title":"Polycyclic Aromatic Hydrocarbons Sources Fates and Biological Effects","first-page":"262","author":"Neff","year":"1979"},{"key":"10.1016\/j.ecoenv.2025.118579_bib74","first-page":"3","article-title":"Occurrence and distribution of pyrene and its derivatives in crude oils and source rock extracts from Niger Delta","volume":"9","author":"Ogbesejana","year":"2019","journal-title":"Niger. J. Pet. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/etc.5620210118","article-title":"Bioavailability to juvenile rainbow trout (Oncorynchus mykiss) of retene and other mixed-function oxygenase-active compounds from sediments","volume":"21","author":"Oikari","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib76","article-title":"Polycyclic aromatic hydrocarbons (PAHs) in fish (Clarias gariepinus) of southwestern rivers","volume":"77","author":"Ololade","year":"2024"},{"key":"10.1016\/j.ecoenv.2025.118579_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112647","article-title":"Occurrence and characteristics of microplastics in fish of the Han River, South Korea: Factors affecting microplastic abundance in fish","volume":"206","author":"Park","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118579_bib78","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/etc.5196","article-title":"A framework for utilizing high-resolution mass spectrometry and nontargeted analysis in rapid response and emergency situations","volume":"41","author":"Phillips","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib79","article-title":"The effects of exposure to crude oil or PAHs on fish swim bladder development and function","volume":"238","author":"Price","year":"2020","journal-title":"Comp. Biochem. Phys. C."},{"key":"10.1016\/j.ecoenv.2025.118579_bib80","first-page":"700","article-title":"Identification of some adhesives and wood pyrolysis products of archaeological origin by direct inlet mass spectrometry","volume":"52","author":"Prokes","year":"2007","journal-title":"Chem. Anal."},{"key":"10.1016\/j.ecoenv.2025.118579_bib81","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ecoenv.2019.04.003","article-title":"Trophodynamics and parabolic behaviors of polycyclic aromatic hydrocarbons in an urbanized lake food web, Shanghai","volume":"178","author":"Qadeer","year":"2019","journal-title":"Ecotoxicol. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118579_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141577","article-title":"Tissue distribution, bioaccumulation, and carcinogenic risk of polycyclic aromatic hydrocarbons in aquatic organisms from Lake Chaohu, China","volume":"749","author":"Qin","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib83","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/306580a0","article-title":"Retene\u2014a molecular marker of wood combustion in ambient air","volume":"306","author":"Ramdahl","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.118579_bib84","doi-asserted-by":"crossref","first-page":"10584","DOI":"10.1021\/acs.chemrev.3c00056","article-title":"Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective","volume":"123","author":"Ruan","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ecoenv.2025.118579_bib85","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/toxsci\/kfae098","article-title":"Aryl hydrocarbon receptor-dependent toxicity by retene requires metabolic competence","volume":"202","author":"Rude","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118579_bib86","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/es9800737","article-title":"Maternal transfer and in ovo exposure of organochlorines in oviparous organisms: a model and field verification","volume":"33","author":"Russell","year":"1999","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib87","first-page":"52","article-title":"Suspect screening of chemicals in food packaging plastic film by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry","volume":"37","author":"Sapozhnikova","year":"2019","journal-title":"LC GC N. Am."},{"key":"10.1016\/j.ecoenv.2025.118579_bib88","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/toxsci\/kfad072","article-title":"Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment","volume":"195","author":"Schaupp","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118579_bib89","doi-asserted-by":"crossref","first-page":"9460","DOI":"10.3390\/ijms22179460","article-title":"Immunotoxicity of xenobiotics in fish: a role for the aryl hydrocarbon receptor (AhR)","volume":"22","author":"Segner","year":"2021","journal-title":"? Int. Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118579_bib90","doi-asserted-by":"crossref","first-page":"8902","DOI":"10.1021\/es401696u","article-title":"Effect-directed analysis to explore the polar bear exposome: identification of thyroid hormone disrupting compounds in plasma","volume":"47","author":"Simon","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib91","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1021\/acs.est.5b01870","article-title":"PAH exposure in Gulf of Mexico demersal fishes, post-deepwater horizon","volume":"49","author":"Snyder","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib92","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/etc.2687","article-title":"Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling","volume":"33","author":"Sun","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib93","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.chemosphere.2005.09.032","article-title":"Bioaccumulation, depuration and oxidative stress in fish Carassius auratus under phenanthrene exposure","volume":"63","author":"Sun","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib94","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.toxlet.2005.09.004","article-title":"Time-course changes of mixture effects on AhR binding-dependent luciferase activity in a crude extract from a compost sample","volume":"161","author":"Suzuki","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.118579_bib95","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.118579_bib96","doi-asserted-by":"crossref","DOI":"10.1080\/10934529.2014.854586","article-title":"The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles","author":"Totlandsdal","year":"2014","journal-title":"J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.ecoenv.2025.118579_bib97","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5004\/dwt.2023.29270","article-title":"An evaluation of decolorization mechanism of synthetic dyes belonging to the azo, anthraquinone, and triphenylmethane group, as a sustainable approach, by immobilized CB8 strain (Trametes versicolor","volume":"284","author":"Upadhyay","year":"2023","journal-title":"Desalin. Water Treat."},{"key":"10.1016\/j.ecoenv.2025.118579_bib98","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.toxlet.2014.09.004","article-title":"OpenVirtualToxLab\u2014a platform for generating and exchanging in silico toxicity data","volume":"232","author":"Vedani","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.118579_bib99","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1897\/07-161R.1","article-title":"Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines","volume":"26","author":"Vondr\u00e1\u0109ek","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118579_bib100","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.scitotenv.2015.10.134","article-title":"PAHs and PCBs accumulated by SPMD-based virtual organisms and feral fish in Three Gorges Reservoir, China","volume":"542","author":"Wang","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib101","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ecoenv.2012.05.010","article-title":"Polycyclic aromatic hydrocarbons and organochlorine pesticides in fish from Taihu Lake: their levels, sources, and biomagnification","volume":"82","author":"Wang","year":"2012","journal-title":"Ecotoxicol. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118579_bib102","series-title":"Detoxification mechanisms in fish","author":"Wassur","year":"2012"},{"key":"10.1016\/j.ecoenv.2025.118579_bib103","article-title":"Halogenation of common phenolic household and personal care product ingredients enhances their AhR-modulating capacity. Chemosphere 350, 141116","volume":"2024","author":"Weiss","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118579_bib104","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1289\/ehp.1408437","article-title":"Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells","volume":"123","author":"Whirledge","year":"2015","journal-title":"Environ. Health Persp"},{"key":"10.1016\/j.ecoenv.2025.118579_bib105","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/019262339802600510","article-title":"Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses","volume":"26","author":"Wilson","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib106","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1080\/10643389.2011.556546","article-title":"Sources and fate of PAHs and PCBs in the marine environment","volume":"42","author":"Wolska","year":"2012","journal-title":"Crit. Rev. Env. Sci. Tec."},{"key":"10.1016\/j.ecoenv.2025.118579_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105361","article-title":"Variability of trophic magnification factors as an effect of estimated trophic position: application of compound-specific nitrogen isotope analysis of amino acids","volume":"135","author":"Won","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118579_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121652","article-title":"Effect-directed analysis of androgenic compounds from sewage sludges in China","volume":"256","author":"Xiang","year":"2024","journal-title":"Water Res"},{"key":"10.1016\/j.ecoenv.2025.118579_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156816","article-title":"An integrated screening strategy for novel AhR agonist candidate identification and toxicity confirmation in sediments","volume":"842","author":"Xie","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118579_bib110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.marpetgeo.2019.01.004","article-title":"Algal-derived polycyclic aromatic hydrocarbons in Paleogene lacustrine sediments from the Dongying Depression, Bohai Bay Basin, China","volume":"102","author":"Xu","year":"2019","journal-title":"Mar. Petrol. Geol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib111","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1021\/es1004158","article-title":"Partitioning of persistent organic pollutants between blubber and blood of wild bottlenose dolphins: implications for biomonitoring and health","volume":"44","author":"Yordy","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118579_bib112","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/clen.201400305","article-title":"Polycyclic aromatic hydrocarbons in the food web of coastal wetlands: distribution, sources and potential toxicity","volume":"43","author":"Zhang","year":"2015","journal-title":"Clean Soil Air Water"},{"key":"10.1016\/j.ecoenv.2025.118579_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128084","article-title":"The aryl hydrocarbon receptor: a predominant mediator for the toxicity of emerging dioxin-like compounds","volume":"426","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.118579_bib114","doi-asserted-by":"crossref","first-page":"16768","DOI":"10.1021\/acs.est.2c04183","article-title":"Identification of glucocorticoid receptor antagonistic activities and responsible compounds in house dust: bioaccessibility should not be ignored","volume":"56","author":"Zhou","year":"2022","journal-title":"Environ. Sci. Technol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325009248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325009248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T14:53:40Z","timestamp":1755615220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325009248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":114,"alternative-id":["S0147651325009248"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118579","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of known and unknown AhR-active substances in freshwater fish from the Gapcheon River, South Korea: Application of effect-directed analysis and nontarget screening","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118579","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118579"}}