{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:13:37Z","timestamp":1777778017394,"version":"3.51.4"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["OPUS-19 UMO-2020\/37\/B\/NZ8\/03823"],"award-info":[{"award-number":["OPUS-19 UMO-2020\/37\/B\/NZ8\/03823"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118660","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:25:48Z","timestamp":1752578748000},"page":"118660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Seasonal anti-androgen activity in the brackish Baltic waters in relation to the gene expression profiles of the blue mussel Mytilus trossulus"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5129","authenticated-orcid":false,"given":"Paulina","family":"Go\u017adzik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Smolarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5862","authenticated-orcid":false,"given":"Magda","family":"Caban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3815-7073","authenticated-orcid":false,"given":"Anna","family":"Hallmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118660_bib1","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1242\/jeb.205.13.1831","article-title":"Temperature-dependence of mitochondrial function and production of reactive oxygen species in the intertidal mud clam Mya arenaria","volume":"205","author":"Abele","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib2","series-title":"Serotonin - A Chemical Messenger Between All Types of Living Cells","article-title":"Structure-Function of Serotonin in Bivalve Molluscs","author":"Alavi","year":"2017"},{"key":"10.1016\/j.ecoenv.2025.118660_bib3","first-page":"27","article-title":"Gene set enrichment analysis with topGO","author":"Alexa","year":"2007","journal-title":"Bioconductor Improv"},{"key":"10.1016\/j.ecoenv.2025.118660_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149006","article-title":"Bioaccumulation of emerging contaminants in mussel (Mytilus galloprovincialis): Influence of microplastics","volume":"796","author":"\u00c1lvarez-Ruiz","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118660_bib5","unstructured":"Andrews, K.F.S., Seconds-Pichon, A., Biggins, F., Wingett, S., 2010. FastQC: a quality control tool for high throughput sequence data [WWW Document]. URL http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc (accessed 10.19.24)."},{"key":"10.1016\/j.ecoenv.2025.118660_bib6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/etc.3339","article-title":"Pharmaceuticals in the environment-Global occurrences and perspectives","volume":"35","author":"aus der Beek","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118660_bib7","first-page":"454","article-title":"Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: New developments","author":"Baker","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118660_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbrc.2008.08.047","article-title":"Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: implications for estrogen receptor evolution","volume":"375","author":"Baker","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2025.118660_bib9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.envpol.2016.08.050","article-title":"Impact of bisphenol A (BPA) on early embryo development in the marine mussel Mytilus galloprovincialis: Effects on gene transcription","volume":"218","author":"Balbi","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cbpc.2019.05.004","article-title":"Estrogenic compounds as exogenous modulators of physiological functions in molluscs: signaling pathways and biological responses","volume":"222","author":"Balbi","year":"2019","journal-title":"Comp. Biochem. Physiol. Part C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118660_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.watres.2016.02.047","article-title":"Occurrence and removal of organic micropollutants: an overview of the watch list of EU Decision 2015\/495","volume":"94","author":"Barbosa","year":"2016","journal-title":"Water Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib12","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.1021\/acs.est.8b01604","article-title":"Transcriptomic and network analyses reveal mechanistic-based biomarkers of endocrine disruption in the Marine Mussel, Mytilus edulis","volume":"52","author":"Blalock","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib13","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2025.118660_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.marpolbul.2015.03.008","article-title":"Contamination of the southern Baltic Sea waters by the residues of selected pharmaceuticals: method development and field studies","volume":"94","author":"Borecka","year":"2015","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.118660_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.marpolbul.2013.06.040","article-title":"NOAA\u2019s mussel watch program: incorporating contaminants of emerging concern (CECs) into a long-term monitoring program","volume":"81","author":"Bricker","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.118660_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.celrep.2016.12.063","article-title":"A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors","volume":"18","author":"Bryant","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2025.118660_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chroma.2014.04.054","article-title":"A new silylating reagent - dimethyl(3,3,3-trifluoropropyl)silyldiethylamine - for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas chromatography-mass spectrometry analysis","volume":"1346","author":"Caban","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ecoenv.2025.118660_bib18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1515\/ohs-2016-0050","article-title":"Screening of 17\u03b1-ethynylestradiol and non-steroidal anti-inflammatory pharmaceuticals accumulation in Mytilus edulis trossulus (Gould, 1890) collected from the Gulf of Gda\u0144sk","volume":"45","author":"Caban","year":"2016","journal-title":"Oceanol. Hydrobiol. Stud."},{"key":"10.1016\/j.ecoenv.2025.118660_bib19","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/etc.1825","article-title":"Predicted-no-effect concentrations for the steroid estrogens estrone, 17\u03b2-estradiol, estriol, and 17\u03b1-ethinylestradiol","volume":"31","author":"Caldwell","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118660_bib20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1152\/ajpregu.00139.2006","article-title":"Immunomodulation by 17\u03b2-estradiol in bivalve hemocytes","volume":"291","author":"Canesi","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2007.06.002","article-title":"Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas","volume":"276","author":"Canesi","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2022.792589","article-title":"Physiological roles of serotonin in bivalves: possible interference by environmental chemicals resulting in neuroendocrine disruption","volume":"13","author":"Canesi","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.ecoenv.2025.118660_bib23","article-title":"Characterization of the GABAergic system in Asian clam Corbicula fluminea: phylogenetic analysis, tissue distribution, and response to the aquatic contaminant carbamazepine","volume":"239","author":"Chen","year":"2021","journal-title":"Comp. Biochem. Physiol. Part C."},{"key":"10.1016\/j.ecoenv.2025.118660_bib24","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.envpol.2010.05.025","article-title":"Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis","volume":"158","author":"Ciocan","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquatox.2015.01.013","article-title":"Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study","volume":"160","author":"Coimbra","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jat.860","article-title":"Oestrogenic activity of isobutylparaben in vitro and in vivo","volume":"22","author":"Darbre","year":"2002","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib27","article-title":"Patterns of estrogenic activity in the Baltic Sea","volume":"2019","author":"Deich","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118660_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105421","article-title":"Environmental exposure of northern pike to a primary wastewater effluent: impact on the lipidomic profile and lipid metabolism","volume":"221","author":"D\u00e9patie","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2025.118660_bib30","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.3390\/w14223772","article-title":"The Baltic sea under anthropopressure\u2014the sea of paradoxes","volume":"14","author":"Dobrzycka-Krahel","year":"2022","journal-title":"Water (Switz. )"},{"key":"10.1016\/j.ecoenv.2025.118660_bib31","first-page":"2127","article-title":"Some chemical contaminant of surface sediments at the Baltic Sea coastal region with special emphasis on androgenic and anti-androgenic compounds","volume":"41","author":"Falandysz","year":"2006","journal-title":"J. Environ. Sci. Heal. Part A Toxic. \/Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.ecoenv.2025.118660_bib32","first-page":"264","article-title":"Correlation between intermediary metabolism, Hsp gene expression, and oxidative stress-related proteins in long-term thermal-stressed Mytilus galloprovincialis","volume":"319","author":"Feidantsis","year":"2020","journal-title":"Transl. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01742-19","article-title":"Interspecies and intraspecies signals synergistically regulate lysobacter enzymogenes twitching motility","volume":"85","author":"Feng","year":"2019","journal-title":"Appl. Environ. Microbiol"},{"key":"10.1016\/j.ecoenv.2025.118660_bib34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2533\/chimia.2008.368","article-title":"UV filters in the aquatic environment induce hormonal effects and affect fertility and reproduction in fish","volume":"62","author":"Fent","year":"2008","journal-title":"Chimia (Aarau)"},{"key":"10.1016\/j.ecoenv.2025.118660_bib35","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1242\/jeb.062273","article-title":"Proteomic responses of blue mussel (Mytilus) congeners to temperature acclimation","volume":"215","author":"Fields","year":"2012","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib36","doi-asserted-by":"crossref","first-page":"13864","DOI":"10.1007\/s11356-016-6524-5","article-title":"Endocrine disruptors in blue mussels and sediments from the Gulf of Gda\u0144sk (Southern Baltic)","volume":"23","author":"Filipkowska","year":"2016","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.marpolbul.2017.07.057","article-title":"Occurrence of pharmaceuticals and UV-filters in riverine run-offs and waters of the German Baltic Sea","volume":"124","author":"Fisch","year":"2017","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.118660_bib38","doi-asserted-by":"crossref","first-page":"39296","DOI":"10.1007\/s11356-021-13254-5","article-title":"Seasonal variability, long-term distribution (2001\u20132014), and risk assessment of polar organic micropollutants in the Baltic Sea","volume":"28","author":"Fisch","year":"2021","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib39","doi-asserted-by":"crossref","first-page":"13365","DOI":"10.1021\/acs.est.0c04226","article-title":"Endocrine disruption in invertebrates: a survey of research progress","volume":"54","author":"Ford","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-38816-0","article-title":"Multiyear analysis uncovers coordinated seasonality in stocks and composition of the planktonic food web in the Baltic Sea proper","volume":"13","author":"Fridolfsson","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.118660_bib41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ecoenv.2006.11.015","article-title":"A multispecies approach for monitoring persistent toxic substances in the Gulf of Gda\u0144sk (Baltic Sea)","volume":"69","author":"Galassi","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118660_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jembe.2004.10.011","article-title":"Effects of GABA and epinephrine on the settlement and metamorphosis of the larvae of four species of bivalve molluscs","volume":"316","author":"Garcia-Lavandeira","year":"2005","journal-title":"J. Exp. Mar. Bio. Ecol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib43","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s10646-019-02090-6","article-title":"Biochemical responses of freshwater mussel Unio tumidus to titanium oxide nanoparticles, Bisphenol A, and their combination","volume":"28","author":"Gnatyshyna","year":"2019","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118660_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2011.12.017","article-title":"Does non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis?","volume":"33","author":"Gonzalez-Rey","year":"2012","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118660_bib45","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jpba.2015.09.013","article-title":"LC-MS measurment of free steroids in mussels (Mytilus trossulus) from the southern Baltic Sea","volume":"117","author":"Hallmann","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ecoenv.2025.118660_bib47","first-page":"123","article-title":"The presence of histamine and a histamine receptor in the Bivalve Mollusc, Crassostrea virginica","volume":"36","author":"Harrison","year":"2015","journal-title":"Vivo"},{"key":"10.1016\/j.ecoenv.2025.118660_bib48","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1289\/ehp.5932","article-title":"Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence","volume":"111","author":"Hayes","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118660_bib49","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00128-021-03285-6","article-title":"Effects of polychlorinated biphenyls on animal reproductive systems and epigenetic modifications","volume":"107","author":"He","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib50","unstructured":"HELCOM, 2022."},{"key":"10.1016\/j.ecoenv.2025.118660_bib51","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0166-445X(93)90064-8","article-title":"Detergent components in sewage effluent are weakly oestrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes","volume":"27","author":"Jobling","year":"1993","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib52","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1039\/c2em30519d","article-title":"The influence of climate change on the global distribution and fate processes of anthropogenic persistent organic pollutants","volume":"14","author":"Kallenborn","year":"2012","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.ecoenv.2025.118660_bib53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF01993142","article-title":"Histamine in the nervous system of Macoma balthica (Bivalvia)","volume":"33","author":"Karhunen","year":"1991","journal-title":"Agents Actions"},{"key":"10.1016\/j.ecoenv.2025.118660_bib54","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/en.2008-1338","article-title":"Hormone-activated estrogen receptors in annelid invertebrates: implications for evolution and endocrine disruption","volume":"150","author":"Keay","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2025.118660_bib55","unstructured":"Kimbrough, K.L., Johnson, W.E., Lauenstein, G.G., Christensen, J.D., Apeti, D.A., 2008. An Assessment of Two Decades of Contaminant Monitoring in the Nation\u2019s Coastal Zone. NOAA Technical Memorandum NOS NCCOS 74., Silver Spring, Maryland."},{"key":"10.1016\/j.ecoenv.2025.118660_bib56","doi-asserted-by":"crossref","first-page":"48823","DOI":"10.1007\/s11356-021-14136-6","article-title":"Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?","volume":"28","author":"Koagouw","year":"2021","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.marenvres.2016.02.010","article-title":"Mussels of a marginal population affect the patterns of ambient macrofauna: a case study from the Baltic Sea","volume":"116","author":"Lauringson","year":"2016","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118660_bib58","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.envpol.2018.08.076","article-title":"Combined toxicity of organophosphate flame retardants and cadmium to Corbicula fluminea in aquatic sediments","volume":"243","author":"Li","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fsi.2016.03.015","article-title":"The inhibitory role of g-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas","volume":"52","author":"Li","year":"2016","journal-title":"Fish. FShellfish Immunol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib60","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"FeatureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ecoenv.2025.118660_bib61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jsbmb.2014.01.008","article-title":"Characteristics of 17\u03b2-hydroxysteroid dehydrogenase 8 and its potential role in gonad of Zhikong scallop Chlamys farreri","volume":"141","author":"Liu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108855","article-title":"High-efficiency effect-directed analysis (EDA) advancing toxicant identification in aquatic environments: Latest progress and application status","volume":"190","author":"Luo","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118660_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2023.106277","article-title":"Combined toxic effects of nanoplastics and norfloxacin on antioxidant and immune genes in mussels","volume":"193","author":"Ma","year":"2024","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118660_bib65","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.marpolbul.2007.09.010","article-title":"First evidence of altered vitellogenin-like protein levels in clam Tapes philippinarum and in cockle Cerastoderma glaucum from the Lagoon of Venice","volume":"55","author":"Matozzo","year":"2007","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.118660_bib66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.envint.2007.09.008","article-title":"Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates: a review","volume":"34","author":"Matozzo","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118660_bib67","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.fsi.2015.07.017","article-title":"How important are glutathione and thiol reductases to oyster hemocyte function?","volume":"46","author":"Mello","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1152\/physiolgenomics.90263.2008","article-title":"Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus)","volume":"35","author":"Mennigen","year":"2008","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.ecoenv.2025.118660_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112658","article-title":"An introduction to the sources, fate, occurrence and effects of endocrine disrupting chemicals released into the environment","volume":"207","author":"Metcalfe","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118660_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2020.105137","article-title":"Human pharmaceuticals in marine mussels: evidence of sneaky environmental hazard along Italian coasts","volume":"162","author":"Mezzelani","year":"2020","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118660_bib71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jat.3014","article-title":"Endocrine disruption effects of p,p\u2019-DDE on juvenile zebrafish","volume":"35","author":"Monteiro","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.gene.2015.03.073","article-title":"Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species","volume":"564","author":"Nagasawa","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.ecoenv.2025.118660_bib73","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1515\/reveh-2016-0040","article-title":"Effects of 17\u03b2-estradiol (E2) on aqueous organisms and its treatment problem: A review","volume":"31","author":"Nazari","year":"2016","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118660_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140346","article-title":"Presence and risk assessment of herbicides in the marine environment of Camps Bay (Cape Town, South Africa)","volume":"738","author":"Ojemaye","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118660_bib75","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00244-005-1082-8","article-title":"Biomarkers of exposure and reproduction-related effects in mussels exposed to endocrine disrupters","volume":"50","author":"Ortiz-Zarragoitia","year":"2006","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib76","unstructured":"OSPAR Commission, 2018. CEMP Guidelines for Monitoring Contaminants in Biota.."},{"key":"10.1016\/j.ecoenv.2025.118660_bib77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cbpb.2004.10.016","article-title":"Physiological measurements from native and transplanted mussel (Mytilus galloprovincialis) in the canals of Venice. Survival in air and condition index","volume":"140","author":"Pampanin","year":"2005","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib78","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acs.chemrev.8b00299","article-title":"Pharmaceuticals of emerging concern in aquatic systems: chemistry, occurrence, effects, and removal methods","volume":"119","author":"Patel","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ecoenv.2025.118660_bib79","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tiv.2003.08.006","article-title":"Estrogenicity of solid phase-extracted water samples from two municipal sewage treatment plant effluents and river Rhine water using the yeast estrogen screen","volume":"18","author":"Pawlowski","year":"2004","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2025.118660_bib80","doi-asserted-by":"crossref","unstructured":"Peinado, F.M., Iribarn, L.M., Oc\u00f3n-Hern\u00e1ndez, O., Olea, N., Artacho-Cord\u00f3n, F., 2021. Endocrine Disrupting Chemicals in Cosmetics and Personal Care Products and Risk of Endometriosis, in: Endometriosis. p. 13. https:\/\/doi.org\/10.5772\/intechopen.93091.","DOI":"10.5772\/intechopen.93091"},{"key":"10.1016\/j.ecoenv.2025.118660_bib81","doi-asserted-by":"crossref","first-page":"9051","DOI":"10.1007\/s11356-017-1100-1","article-title":"Diurnal variations in personal care products in seawater and mussels at three Mediterranean coastal sites","volume":"25","author":"Picot-Groz","year":"2018","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib82","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/ar.23626","article-title":"Spermatogenic cycle and steroidogenic control of spermatogenesis in mytilus galloprovincialis collected in the bay of Naples","volume":"300","author":"Prisco","year":"2017","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ecoenv.2025.118660_bib83","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10152-013-0347-2","article-title":"Effect of salinity on filtration rates of mussels Mytilus edulis with special emphasis on dwarfed mussels from the low-saline Central Baltic Sea","volume":"67","author":"Riisg\u00e5rd","year":"2013","journal-title":"Helgol. Mar. Res."},{"key":"10.1016\/j.ecoenv.2025.118660_bib84","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ar.24075","article-title":"The Mussel Mytilus galloprovincialis in the Bay of Naples: new insights on oogenic cycle and its hormonal control","volume":"302","author":"Rosati","year":"2019","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ecoenv.2025.118660_bib85","first-page":"484","article-title":"Cocaine effects on reproductive behavior and fertility: an overview","volume":"10","author":"Rosati","year":"2023","journal-title":"Vet. Sci."},{"key":"10.1016\/j.ecoenv.2025.118660_bib86","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/10937400306476","article-title":"Molecular markers of endocrine disruption in aquatic organisms","volume":"6","author":"Rotchell","year":"2003","journal-title":"J. Toxicol. Environ. Heal. Part B Crit. Rev."},{"key":"10.1016\/j.ecoenv.2025.118660_bib87","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1039\/C6EM00193A","article-title":"The occurrence of endocrine disrupting compounds in off-shore sediments from the southern Baltic Sea","volume":"18","author":"Ruczynska","year":"2016","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.ecoenv.2025.118660_bib88","first-page":"631","article-title":"Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review","author":"Sehonova","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118660_bib89","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1532-0456(03)00085-1","article-title":"Delayed gametogenesis and progesterone levels in soft-shell clams (Mya arenaria) in relation to in situ contamination to organotins and heavy metals in the St. Lawrence River (Canada)","volume":"135","author":"Siah","year":"2003","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118660_bib90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jat.2550010302","article-title":"Tributyltin compounds induce male characteristics on female mud snails Nassarius obsoletus = Ilyanassa obsoleta","volume":"1","author":"Smith","year":"1981","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib91","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00244-014-0023-9","article-title":"Bisphenol A, 4-tert-Octylphenol, and 4-Nonylphenol in The Gulf of Gda\u0144sk (Southern Baltic)","volume":"67","author":"Staniszewska","year":"2014","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib92","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.envpol.2015.09.031","article-title":"The role of phytoplankton composition, biomass and cell volume in accumulation and transfer of endocrine disrupting compounds in the Southern Baltic Sea (The Gulf of Gdansk)","volume":"207","author":"Staniszewska","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib93","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.mad.2009.09.005","article-title":"Aging reduces reproductive success in mussels Mytilus edulis","volume":"130","author":"Sukhotin","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ecoenv.2025.118660_bib94","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib95","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.chemosphere.2015.12.015","article-title":"Endocrine disrupting compounds in gaseous and particulate outdoor air phases according to environmental factors","volume":"146","author":"Teil","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118660_bib96","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.envpol.2019.02.056","article-title":"The utility of vitellogenin as a biomarker of estrogenic endocrine disrupting chemicals in molluscs","volume":"248","author":"Tran","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib97","unstructured":"Vieno, N., Hallgren, P., Wallberg, P., Pyh\u00e4l\u00e4, M., Zandaryaa, S., 2017. Pharmaceuticals in the aquatic environment of the Baltic Sea region A status report International Initiative on Water Quality-IIWQ, Report."},{"key":"10.1016\/j.ecoenv.2025.118660_bib98","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.envpol.2017.12.098","article-title":"Water contamination by endocrine disruptors: Impacts, microbiological aspects and trends for environmental protection","volume":"235","author":"Vilela","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118660_bib99","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/er.2009-0009","article-title":"The effects of opioids and opioid analogs on animal and human endocrine systems","volume":"31","author":"Vuong","year":"2010","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2025.118660_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142032","article-title":"Temporal transcriptome analysis in female scallop Chlamys farreri: First molecular insights into the disturbing mechanism on lipid metabolism of reproductive-stage dependence under benzo[a]pyrene exposure","volume":"746","author":"Xu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118660_bib101","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1021\/acs.est.7b06476","article-title":"Environmentally Relevant Concentrations of Carbamazepine Caused Endocrine-Disrupting Effects on Nontarget Organisms, Chinese Rare Minnows (Gobiocypris rarus)","volume":"52","author":"Yan","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118660_bib102","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/etc.2511","article-title":"Effects of triclocarban, N,N-diethyl-meta-toluamide, and a mixture of pharmaceuticals and personal care products on fathead minnows (Pimephales promelas)","volume":"33","author":"Zenobio","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118660_bib103","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","article-title":"The oyster genome reveals stress adaptation and complexity of shell formation","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.118660_bib104","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.etap.2014.04.027","article-title":"Identification and mRNA expression of two 17\u03b2-hydroxysteroid dehydrogenase genes in the marine mussel Mytilus galloprovincialis following exposure to endocrine disrupting chemicals","volume":"37","author":"Zhang","year":"2014","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118660_bib105","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1007\/s11356-013-2265-x","article-title":"Application of canonical correspondence analysis to determine the ecological contribution of phytoplankton to PCBs bioaccumulation in Qinhuai River, Nanjing, China","volume":"21","author":"Zhao","year":"2014","journal-title":"Environ. Sci. Pollut. Res"},{"key":"10.1016\/j.ecoenv.2025.118660_bib106","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-011-0811-8","article-title":"Identification and functional characterization of a putative 17\u03b2-hydroxysteroid dehydrogenase 12 in abalone (Haliotis diversicolor supertexta)","volume":"354","author":"Zhou","year":"2011","journal-title":"Mol. Cell. Biochem"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132501005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132501005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:17:06Z","timestamp":1777490226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132501005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":106,"alternative-id":["S014765132501005X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118660","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seasonal anti-androgen activity in the brackish Baltic waters in relation to the gene expression profiles of the blue mussel Mytilus trossulus","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118660"}}