{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:24:41Z","timestamp":1781303081071,"version":"3.54.1"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171631"],"award-info":[{"award-number":["32171631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118678","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T03:50:54Z","timestamp":1752637854000},"page":"118678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Effect of paternal exposure to glyphosate and microcystin-LR on zebrafish (Danio rerio) fathers and progeny: An integrated investigation based on behavioral, histopathological, biochemical, and transcriptomic analysis"],"prefix":"10.1016","volume":"302","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junguo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118678_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.leu.2402417","article-title":"The proteasome: a novel target for cancer chemotherapy","volume":"16","author":"Almond","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.ecoenv.2025.118678_bib2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2009.07.006","article-title":"Recreational exposure to microcystins during algal blooms in two California lakes","volume":"55","author":"Backer","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2025.118678_bib3","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1021\/acs.est.1c04296","article-title":"Identification of novel microcystins using highresolution MS and MSn with Python code","volume":"56","author":"Baliu-Rodriguez","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115888","article-title":"From dysbiosis to neuropathologies: toxic effects of glyphosate in zebrafish","volume":"270","author":"Bellot","year":"2024","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118678_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.ecoenv.2025.118678_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036931","article-title":"Measures of anxiety in zebrafish (Danio rerio): dissociation of black\/white preference and novel tank test","volume":"7","author":"Blaser","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.ecoenv.2025.118678_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2017.10.007","article-title":"Glyphosate and Roundup\u00ae alter morphology and behavior in zebrafish","volume":"392","author":"Bridi","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118678_bib8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/life14050640","article-title":"Neurotoxicity of some environmental pollutants to zebrafish","volume":"14","author":"Buzenchi Proca","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.ecoenv.2025.118678_bib9","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/nprot.2010.140","article-title":"Measuring behavioral and endocrine responses to novelty stress in adult zebrafish","volume":"5","author":"Cachat","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ecoenv.2025.118678_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017597","article-title":"Three-dimensional neurophenotyping of adult zebrafish behavior","volume":"6","author":"Cachat","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ecoenv.2025.118678_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2004.11.015","article-title":"Toxicological awakenings: the rebirth ofhormesis as a central pillar of toxicology","volume":"204","author":"Calabrese","year":"2005","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118678_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115784","article-title":"Critical window of exposure of CMIT\/MIT with respect to developmental effects on zebrafish embryos: multi-level endpoint and proteomics analysis","volume":"268","author":"Chatterjee","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142319","article-title":"Challenges of using blooms of Microcystis spp. in animal feeds: a comprehensive review of nutritional, toxicological and microbial health evaluation","volume":"764","author":"Chen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jes.2022.03.043","article-title":"Risk assessment and identification of factors influencing the historical concentrations of microcystin in Lake Taihu, China","volume":"127","author":"Cheng","year":"2023","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib15","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1055\/s-0032-1315240","article-title":"Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors","volume":"78","author":"Del Valle-Mojica","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.ecoenv.2025.118678_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117685","article-title":"Negative impacts of microcystin-LR and glyphosate on zebrafish intestine: linked with gut microbiota and microRNAs?","volume":"286","author":"Ding","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ecoenv.2025.118678_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123669","article-title":"Toxicity of glyphosate to animals: a meta-analytical approach","volume":"347","author":"Evalen","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib19","series-title":"Determination of Glyphosate Content in Taihu Water Body by Ion Chromatography. Abstract Set of the 6th National Conference on Environmental Chemistry and Environmental Scientific Instrument and Analytical Instrument Exhibition","first-page":"222","author":"Fan","year":"2011"},{"key":"10.1016\/j.ecoenv.2025.118678_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106253","article-title":"Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety","volume":"146","author":"Faria","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118678_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.178838","article-title":"Effect of microcystin-LR on intestinal microbiota, metabolism, and health of zebrafish (Danio rerio)","volume":"967","author":"Feng","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib22","doi-asserted-by":"crossref","first-page":"12734","DOI":"10.1021\/acs.est.9b03393","article-title":"Paternal exposure to carbamazepine impacts zebrafish offspring reproduction over multiple generations","volume":"53","author":"Fraz","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/dxab036","article-title":"Nerve-macrophage interactions in cardiovascular disease","volume":"34","author":"Fujiu","year":"2022","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104978","article-title":"Zebrafish (Danio rerio): a newcomer with great promise in behavioral neuroscience","volume":"144","author":"Gerlai","year":"2023","journal-title":"Neurosci. Biobehav. R."},{"key":"10.1016\/j.ecoenv.2025.118678_bib25","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3390\/md9112164","article-title":"An acute case of intoxication with cyanobacteria and cyanotoxins in recreational water in Salto Grande Dam, Argentina","volume":"9","author":"Giannuzzi","year":"2011","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2025.118678_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jneumeth.2012.07.017","article-title":"Automated high-throughput neurophenotyping of zebrafish social behavior","volume":"210","author":"Green","year":"2012","journal-title":"J. Neurosci. Meth"},{"key":"10.1016\/j.ecoenv.2025.118678_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(01)00350-X","article-title":"Regulation of mRNA stability in mammalian cells","volume":"265","author":"Guhaniyogi","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.ecoenv.2025.118678_bib28","first-page":"93","article-title":"Determination of glyphosate resuidues in fish pond water using hydrophilic interaction chromatography-tandem mass spectrometry","volume":"32","author":"Guo","year":"2013","journal-title":"Chin. J. Anal. Lab."},{"key":"10.1016\/j.ecoenv.2025.118678_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106287","article-title":"Tributyltin exposure disrupted the locomotor activity rhythms in adult zebrafish (Danio rerio) and the mechanism involved","volume":"251","author":"Guo","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib30","article-title":"Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies","volume":"13","author":"Gupta","year":"2024","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ecoenv.2025.118678_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170914","article-title":"The impact of ammonia and microcystin-LR on neurobehavior and glutamate\/gamma-aminobutyric acid balance in female zebrafish (Danio rerio): ROS and inflammation as key pathways","volume":"920","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/fee.1985","article-title":"The overlooked impact of rising glyphosate use on phosphorus loading in agricultural watersheds","volume":"17","author":"H\u00e9bert","year":"2019","journal-title":"Front. Ecol. Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.33696\/Signaling.6.131","article-title":"Microcystin: from blooms to brain toxicity","volume":"6","author":"Hedrick","year":"2025","journal-title":"J. Cell. Signal"},{"key":"10.1016\/j.ecoenv.2025.118678_bib34","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1007\/s11356-016-6073-y","article-title":"A review of neurotoxicity of microcystins","volume":"23","author":"Hu","year":"2016","journal-title":"Environ. Sci. Pollut. R."},{"key":"10.1016\/j.ecoenv.2025.118678_bib35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fevo.2020.00086","article-title":"Effects of pollution on fish behavior, personality, and cognition: some research perspectives","volume":"8","author":"Jacquin","year":"2020","journal-title":"Front. Ecol. Evol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuroscience.2016.06.019","article-title":"Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2\/HO-1 pathway","volume":"331","author":"Liao","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.ecoenv.2025.118678_bib37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jes.2021.11.039","article-title":"The mechanism of different cyanobacterial responses to glyphosate","volume":"125","author":"Lin","year":"2023","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuro.2022.12.009","article-title":"Investigating the neurotoxicity of environmental pollutants using zebrafish as a model organism: A review and recommendations for future work","volume":"94","author":"Lin","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118678_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jes.2022.04.022","article-title":"Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): a combination of transcriptomic and metabolomics","volume":"127","author":"Liu","year":"2023","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113666","article-title":"Hydrogen sulfide-induced oxidative stress mediated apoptosis via mitochondria pathway in embryo-larval stages of zebrafish","volume":"239","author":"Liu","year":"2022","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118678_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113493","article-title":"Developmental toxicity of glyphosate on embryo-larval zebrafish (Danio rerio)","volume":"236","author":"Liu","year":"2022","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118678_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106281","article-title":"Effects of the herbicide glyphosate on fish from embryos to adults: A review addressing behavior patterns and mechanisms behind them","volume":"251","author":"Lopes","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168058","article-title":"Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis","volume":"908","author":"Luan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib44","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.envpol.2019.06.040","article-title":"Biochemical and molecular impacts of glyphosate-based herbicide on the gills of common carp","volume":"252","author":"Ma","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105644","article-title":"Fenpropathrin induces neurotoxic effects in common carp (Cyprinus carpio L.)","volume":"197","author":"Ma","year":"2023","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.ecoenv.2025.118678_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106262","article-title":"Developmental effects of fenpropathrin on zebrafish (Danio rerio) embryo-larvae: Toxic endpoints and potential mechanism","volume":"208","author":"Ma","year":"2025","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.ecoenv.2025.118678_bib47","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.4081\/ejh.2016.2639","article-title":"Histological and histochemical methods-theory and practice","volume":"60","author":"Malatesta","year":"2016","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.ecoenv.2025.118678_bib48","first-page":"275","article-title":"Retinal phototransduction","volume":"19","author":"Mannu","year":"2014","journal-title":"Neurosci. J."},{"key":"10.1016\/j.ecoenv.2025.118678_bib49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1139\/cjfas-2013-0558","article-title":"Fish behavioral types and their ecological consequences","volume":"71","author":"Mittelbach","year":"2014","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.envpol.2019.03.125","article-title":"Widespread occurrence and spatial distribution of glyphosate, atrazine, and neonicotinoids pesticides in the St. Lawrence and tributary rivers","volume":"250","author":"Montiel-Le\u00f3n","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib51","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.microc.2012.05.021","article-title":"Determination of glyphosate residues in Hungarian water samples by immunoassay","volume":"107","author":"M\u00f6rtl","year":"2013","journal-title":"Microchem. J."},{"key":"10.1016\/j.ecoenv.2025.118678_bib52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/brainsci6010006","article-title":"The effects of hypoxia and inflammation on synaptic signaling in the CNS","volume":"6","author":"Mukandala","year":"2016","journal-title":"Brain Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib53","article-title":"Cyanotoxins in groundwater; occurrence, potential sources, health impacts and knowledge gap for public health","volume":"226","author":"Mulalo","year":"2023","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2025.118678_bib54","first-page":"1","article-title":"Test No. 230: 21-Day fish assay: a short-term screening for estrogenic and androgenic activity, and aromatase inhibition","volume":"2","author":"OECD","year":"2009","journal-title":"OECD Guidel. Test. Chem."},{"key":"10.1016\/j.ecoenv.2025.118678_bib55","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.118678_bib56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envpol.2008.01.015","article-title":"Levels of glyphosate in surface waters, sediments and soils associated with directsowing soybean cultivation in north pampasic region of Argentina","volume":"156","author":"Peruzzo","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemosphere.2016.05.038","article-title":"Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response","volume":"157","author":"Qi","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118678_bib58","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S","article-title":"Time course of the development of motor behaviors in the zebrafish embryo","volume":"37","author":"Saint-Amant","year":"1998","journal-title":"J. Neurobiolo"},{"key":"10.1016\/j.ecoenv.2025.118678_bib59","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10661-017-6058-4","article-title":"Management of toxic cyanobacteria for drinking water production of Ain Zada Dam","volume":"189","author":"Saoudi","year":"2017","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2025.118678_bib60","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1089\/ars.2012.4720","article-title":"Severe life stress and oxidative stress in the brain: from animal models to human pathology","volume":"18","author":"Schiavone","year":"2013","journal-title":"Antioxid. Redox Sign"},{"key":"10.1016\/j.ecoenv.2025.118678_bib61","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2011.12.016","article-title":"Measuring thigmotaxis in larval zebrafish","volume":"228","author":"Schn\u00f6rr","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ecoenv.2025.118678_bib62","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.aquatox.2004.03.016","article-title":"The effects of environmental pollutants on complex fish behaviour: integrating behavioural and physiological indicators of toxicity","volume":"68","author":"Scott","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib63","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1037\/bne0000220","article-title":"Effect of social isolation on anxiety-related behaviors, cortisol, and monoamines in adult zebrafish","volume":"131","author":"Shams","year":"2017","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib64","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/antiox9080743","article-title":"ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease","volume":"9","author":"Simpson","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2025.118678_bib65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/ijnp\/pyx017","article-title":"Modulating oxidative stress relieves stress-induced behavioral and cognitive impairments in rats","volume":"20","author":"Solanki","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163136","article-title":"Microcystis spp. and phosphorus in aquatic environments: A comprehensive review on their physiological and ecological interactions","volume":"878","author":"Song","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib67","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/j.scitotenv.2010.02.038","article-title":"Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures","volume":"408","author":"Spurgeon","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib68","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00128-008-9373-1","article-title":"Occurrence of glyphosate in surface waters of southern Ontario","volume":"80","author":"Struger","year":"2008","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.envpol.2015.03.038","article-title":"Sources of aminomethylphosphonic acid (AMPA) in urban and rural catchments in Ontario, Canada: glyphosate or phosphonates in wastewater?","volume":"204","author":"Struger","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160086","article-title":"Global warming and glyphosate toxicity (I): adult zebrafish modelling with behavioural, immunohistochemical and metabolomic approaches","volume":"858","author":"Sulukan","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib71","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fenvs.2018.00078","article-title":"Re-registration challenges of glyphosate in the European Union","volume":"6","author":"Sz\u00e9k\u00e1cs","year":"2018","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2025.118678_bib72","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chemosphere.2007.10.059","article-title":"Environmental fate and non-target impact of glyphosatebased herbicide (Roundup) in a subtropical wetland","volume":"71","author":"Tsui","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118678_bib73","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.taap.2017.06.011","article-title":"Behavioral screening of the LOPAC1280 library in zebrafsh embryos","volume":"329","author":"Vliet","year":"2017","journal-title":"Toxicol. Appl. Phar"},{"key":"10.1016\/j.ecoenv.2025.118678_bib74","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chemosphere.2010.07.061","article-title":"Protein profiles in zebrafish (Danio rerio) brains exposed to chronic microcystin-LR","volume":"81","author":"Wang","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118678_bib75","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1100\/tsw.2010.172","article-title":"Factors affecting temporal and spatial variations of microcystins in Gonghu Bay of Lake Taihu, with potential risk of microcystin contamination to human health","volume":"10","author":"Wang","year":"2010","journal-title":"Sci. World J."},{"key":"10.1016\/j.ecoenv.2025.118678_bib76","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/etc.4942","article-title":"Glyphosate accelerates the proliferation of Microcystis aeruginosa, a dominant species in cyanobacterial blooms","volume":"40","author":"Wang","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2025.118678_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119791","article-title":"Microcystin pollution in lakes and reservoirs: a nationwide meta-analysis and assessment in China","volume":"309","author":"Wei","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib78","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.envpol.2017.08.038","article-title":"Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring","volume":"231","author":"Wu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118678_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.07.346","article-title":"Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish","volume":"693","author":"Wu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105799","article-title":"Adverse effects of fenpropathrin on the intestine of common carp (Cyprinus carpio L.) and the mechanism involved","volume":"199","author":"Xiu","year":"2024","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.ecoenv.2025.118678_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159032","article-title":"Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information","volume":"857","author":"Xu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib82","doi-asserted-by":"crossref","first-page":"19152","DOI":"10.1021\/acs.est.4c05793","article-title":"Long-term neurotoxic effects and Alzheimer\u2019s disease risk of early EHDPP exposure in zebrafish: insights from molecular mechanisms to adult pathology","volume":"58","author":"Yan","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib83","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/s12035-022-03134-5","article-title":"Chronic microcystin-LR-induced \u03b1-synuclein promotes neuroinflammation through activation of the NLRP3 inflammasome in microglia","volume":"60","author":"Yan","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2025.118678_bib84","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.1007\/s11356-014-2937-1","article-title":"Variation of microcystis and microcystins coupling nitrogen and phosphorus nutrients in Lake Erhai, a drinkingwater source in Southwest Plateau, China","volume":"21","author":"Yu","year":"2014","journal-title":"Environ. Sci. Pollut. R."},{"key":"10.1016\/j.ecoenv.2025.118678_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148865","article-title":"Proteomic analysis of zebrafish brain damage induced by Microcystis aeruginosa bloom","volume":"795","author":"Yu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167018","article-title":"The mechanisms of microcystin-LR-induced genotoxicity and neurotoxicity in fish and mammals: Bibliometric analysis and meta-analysis","volume":"905","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118678_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108689","article-title":"Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: a review","volume":"187","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118678_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109824","article-title":"Responses of the proteome in testis of mice exposed chronically to environmentally relevant concentrations of Microcystin-LR","volume":"187","author":"Zhou","year":"2020","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.ecoenv.2025.118678_bib89","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nurt.2009.10.016","article-title":"Involvement of pro-and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury","volume":"7","author":"Ziebe","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ecoenv.2025.118678_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116665","article-title":"Metabolomics reveals the reproductive abnormality in female zebrafish exposed to environmentally relevant levels of climbazole","volume":"275","author":"Zou","year":"2021","journal-title":"Environ. Pollut."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325010231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325010231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:09:35Z","timestamp":1777489775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325010231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":90,"alternative-id":["S0147651325010231"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118678","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of paternal exposure to glyphosate and microcystin-LR on zebrafish (Danio rerio) fathers and progeny: An integrated investigation based on behavioral, histopathological, biochemical, and transcriptomic analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118678"}}