{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:10:03Z","timestamp":1777777803182,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016308","name":"Wuxi Health Commission","doi-asserted-by":"publisher","award":["HB2023097"],"award-info":[{"award-number":["HB2023097"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017837","name":"Wuxi Science and Technology Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["WMCC202318"],"award-info":[{"award-number":["WMCC202318"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["WMCJ202302"],"award-info":[{"award-number":["WMCJ202302"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705700"],"award-info":[{"award-number":["2023YFC2705700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","award":["K20231040"],"award-info":[{"award-number":["K20231040"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118805","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T19:07:43Z","timestamp":1754593663000},"page":"118805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo\u2013larvae: A multiomics approach and comparison of biomarker responsiveness"],"prefix":"10.1016","volume":"303","author":[{"given":"Jingying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinliang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoqiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianchao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuncheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118805_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163344","article-title":"Impacts of hydraulic fracturing wastewater from oil and gas industries on drinking water: quantification of 69 disinfection by-products and calculated toxicity","volume":"882","author":"Abraham","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118805_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118316","article-title":"Microseira wollei and phormidium algae more than doubles DBP concentrations and calculated toxicity in drinking water","volume":"216","author":"Aziz","year":"2022","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118805_bib3","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/etc.5620210629","article-title":"Integrated biomarker response: a useful tool for ecological risk assessment","volume":"21","author":"Beliaeff","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"15","key":"10.1016\/j.ecoenv.2025.118805_bib4","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1016\/j.watres.2011.05.034","article-title":"Occurrence and control of nitrogenous disinfection by-products in drinking water--a review","volume":"45","author":"Bond","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2025.118805_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.watres.2015.08.015","article-title":"Nitrogenous disinfection byproducts in English drinking water supply systems: occurrence, bromine substitution and correlation analysis","volume":"85","author":"Bond","year":"2015","journal-title":"Water Res."},{"issue":"1-3","key":"10.1016\/j.ecoenv.2025.118805_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2011.05.004","article-title":"Potential carcinogenic hazards of non-regulated disinfection by-products: haloquinones, halo-cyclopentene and cyclohexene derivatives, N-halamines, halonitriles, and heterocyclic amines","volume":"286","author":"Bull","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.118805_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1270951","article-title":"Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases","volume":"10","author":"Cao","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ecoenv.2025.118805_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.118049","article-title":"Integrative biomarker response - threshold (IBR-T): refinement of IBRv2 to consider the reference and threshold values of biomarkers","volume":"341","author":"Catteau","year":"2023","journal-title":"J. Environ. Manag."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118805_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/zeb.2013.0875","article-title":"Impaired cardiovascular function caused by different stressors elicits a common pathological and transcriptional response in zebrafish embryos","volume":"10","author":"Chen","year":"2013","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/cvr\/cvn073","article-title":"Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms","volume":"79","author":"Chen","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib11","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0003-9861(91)90318-D","article-title":"Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: a role for lipid peroxidation in alkylation induced cytotoxicity","volume":"284","author":"Chen","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ecoenv.2025.118805_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chroma.2012.02.074","article-title":"Trace determination of 13 haloacetamides in drinking water using liquid chromatography triple quadrupole mass spectrometry with atmospheric pressure chemical ionization","volume":"1235","author":"Chu","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ecoenv.2025.118805_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.scitotenv.2015.06.099","article-title":"Ecological relevance of biomarkers in monitoring studies of macro-invertebrates and fish in Mediterranean rivers","volume":"540","author":"Colin","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib14","article-title":"Multimodal AI\/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases","volume":"14","author":"DeGroat","year":"2024","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.ecoenv.2025.118805_bib15","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1021\/es502010v","article-title":"Mice in vivo toxicity studies for monohaloacetamides emerging disinfection byproducts based on metabolomic methods","volume":"48","author":"Deng","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17435390.2016.1269374","article-title":"The integrated biomarker response: a suitable tool to evaluate toxicity of metal-based nanoparticles","volume":"11","author":"Devin","year":"2017","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118805_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.watres.2019.05.024","article-title":"Disinfection byproduct formation during drinking water treatment and distribution: a review of unintended effects of engineering agents and materials","volume":"160","author":"Ding","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2025.118805_bib18","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.scitotenv.2019.07.279","article-title":"Different cytotoxicity of disinfection by-product haloacetamides on two exposure pathway-related cell lines: human gastric epithelial cell line GES-1 and immortalized human keratinocyte cell line HaCaT","volume":"692","author":"Ding","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118805_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110037","article-title":"Developmental toxicity of disinfection by-product monohaloacetamides in embryo-larval stage of zebrafish","volume":"189","author":"Ding","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118805_bib20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/17435390.2015.1102981","article-title":"Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos","volume":"10","author":"Duan","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118805_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquatox.2011.12.012","article-title":"Effect of cadmium on glutathione S-transferase and metallothionein gene expression in coho salmon liver, gill and olfactory tissues","volume":"110-111","author":"Espinoza","year":"2012","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijcard.2015.07.089","article-title":"Cardiomyocyte-specific deletion of ferroportin using MCK-Cre has no apparent effect on cardiac iron homeostasis","volume":"201","author":"Fang","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130958","article-title":"Prediction of zebrafish embryonic developmental toxicity by integrating omics with adverse outcome pathway","volume":"448","author":"Gou","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118805_bib25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/oemed-2012-101093","article-title":"Risk of congenital anomalies in relation to the uptake of trihalomethane from drinking water during pregnancy","volume":"70","author":"Grazuleviciene","year":"2013","journal-title":"Occup. Environ. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118805_bib26","doi-asserted-by":"crossref","first-page":"R265","DOI":"10.1152\/ajpregu.00223.2016","article-title":"Nkx2.5 is essential to establish normal heart rate variability in the zebrafish embryo","volume":"313","author":"Harrington","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107135","article-title":"A computational system for Bayesian benchmark dose estimation of genomic data in BBMD","volume":"161","author":"Ji","year":"2022","journal-title":"Environ. Int."},{"issue":"D1","key":"10.1016\/j.ecoenv.2025.118805_bib28","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic diagramming platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2025.118805_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122008","article-title":"Haloacetamides disinfection by-products, a potential risk factor for nonalcoholic fatty liver disease","volume":"261","author":"Jiang","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2025.118805_bib30","article-title":"Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL\/6J mice","author":"Jiang","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118805_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125198","article-title":"Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays","volume":"242","author":"Kim","year":"2020","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.ecoenv.2025.118805_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144145","article-title":"Nuclear Receptor-Like structure and interaction of congenital heart Disease-Associated factors GATA4 and NKX2-5","volume":"10","author":"Kinnunen","year":"2015","journal-title":"PLOS One"},{"issue":"11","key":"10.1016\/j.ecoenv.2025.118805_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148671","article-title":"Ironing out mechanisms of iron homeostasis and disorders of iron deficiency","volume":"131","author":"Koleini","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ecoenv.2025.118805_bib34","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.watres.2016.10.029","article-title":"Occurrence and formation of haloacetamides from chlorination at water purification plants across Japan","volume":"106","author":"Kosaka","year":"2016","journal-title":"Water Res."},{"issue":"23","key":"10.1016\/j.ecoenv.2025.118805_bib35","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection byproducts","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib36","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N. 2024 Tricarboxylic Acid Cycle Intermediates and Individual Ageing.","DOI":"10.3390\/biom14030260"},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118805_bib37","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1073\/pnas.1422373112","article-title":"Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function","volume":"112","author":"Lakhal-Littleton","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0025-326X(02)00449-6","article-title":"The use of biomarkers in environmental monitoring programmes","volume":"46","author":"Lam","year":"2003","journal-title":"Mar. Pollut. Bull."},{"issue":"19","key":"10.1016\/j.ecoenv.2025.118805_bib39","article-title":"Are disinfection byproducts (DBPs) formed in my cup of tea? Regulated, priority, and unknown DBPs","volume":"55","author":"Li","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127818","article-title":"Metabolomic and transcriptomic investigation of the mechanism involved in enantioselective toxicity of imazamox in lemna minor","volume":"425","author":"Li","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118805_bib41","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/acs.est.7b05440","article-title":"Drinking water disinfection byproducts (DBPs) and human health effects: multidisciplinary challenges and opportunities","volume":"52","author":"Li","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"22","key":"10.1016\/j.ecoenv.2025.118805_bib42","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"Febs J."},{"key":"10.1016\/j.ecoenv.2025.118805_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107977","article-title":"Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae","volume":"176","author":"Liu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.118805_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116976","article-title":"Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio)","volume":"283","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118805_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using Real-Time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib46","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41420-022-01212-0","article-title":"GPX4-independent ferroptosis-a new strategy in disease's therapy","volume":"8","author":"Ma","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12859-020-03947-y","article-title":"Predicting chemosensitivity using drug perturbed gene dynamics","volume":"22","author":"Mannheimer","year":"2021","journal-title":"BMC Bioinforma."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.118805_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.2391","article-title":"Maternal exposure to tap water disinfection By-Products and risk of selected congenital heart defects","volume":"116","author":"Michalski","year":"2024","journal-title":"Birth Defects Res."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118805_bib49","article-title":"Guidance on the use of the benchmark dose approach in risk assessment","volume":"20","author":"More","year":"2022","journal-title":"Efsa J."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118805_bib50","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1289\/ehp.0900677","article-title":"Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses","volume":"117","author":"Nieuwenhuijsen","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib51","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/acs.est.9b04879","article-title":"Early life stage bioactivity assessment of Short-Chain chlorinated paraffins at environmentally relevant concentrations by Concentration-Dependent transcriptomic analysis of zebrafish embryos","volume":"54","author":"Peng","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118805_bib52","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/es071754h","article-title":"Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproducts","volume":"42","author":"Plewa","year":"2008","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118805_bib53","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1021\/acs.est.9b06213","article-title":"Transcriptomic responses of bisphenol s predict involvement of immune function in the cardiotoxicity of early Life-Stage zebrafish (Danio rerio)","volume":"54","author":"Qiu","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/ece3.10864","article-title":"IBRtools: an r package for calculating integrated biomarker indexes","volume":"14","author":"Resende","year":"2024","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.envres.2012.04.014","article-title":"Trihalomethanes, chlorite, chlorate in drinking water and risk of congenital anomalies: a population-based case-control study in Northern Italy","volume":"116","author":"Righi","year":"2012","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118805_bib56","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s11356-012-1359-1","article-title":"A novel \u201cIntegrated biomarker Response\u201d calculation based on reference deviation concept","volume":"20","author":"Sanchez","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"9","key":"10.1016\/j.ecoenv.2025.118805_bib57","doi-asserted-by":"crossref","first-page":"97012","DOI":"10.1289\/EHP9122","article-title":"Drinking water disinfection by-Products and congenital malformations: a nationwide register-based prospective study","volume":"129","author":"S\u00e4ve-S\u00f6derbergh","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118805_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.14.001.2009","article-title":"Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes","volume":"1","author":"Schmidt","year":"2009","journal-title":"Front. Neuroenerg."},{"issue":"8","key":"10.1016\/j.ecoenv.2025.118805_bib59","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/hrt.2005.068270","article-title":"Oxidative stress and redox signalling in cardiac hypertrophy and heart failure","volume":"93","author":"Seddon","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.ecoenv.2025.118805_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib61","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1289","article-title":"A Web-Based system for Bayesian benchmark dose estimation","volume":"126","author":"Shao","year":"2018","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.118805_bib62","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib63","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118805_bib64","first-page":"1217","article-title":"Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish","volume":"10","author":"Sun","year":"2017","journal-title":"Dis. Model Mech."},{"issue":"37","key":"10.1016\/j.ecoenv.2025.118805_bib65","doi-asserted-by":"crossref","first-page":"13744","DOI":"10.1021\/acs.est.3c03282","article-title":"Are new phthalate ester substitutes safer than traditional DBP and DiBP? comparative Endocrine-Disrupting analyses on zebrafish using in vivo, transcriptome, and in silico approaches","volume":"57","author":"Tan","year":"2023","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.118805_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLOS One"},{"issue":"15","key":"10.1016\/j.ecoenv.2025.118805_bib67","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1021\/es405118y","article-title":"A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States","volume":"48","author":"Vengosh","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib68","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00001648-199803000-00006","article-title":"Trihalomethanes in drinking water and spontaneous abortion","volume":"9","author":"Waller","year":"1998","journal-title":"Epidemiology"},{"key":"10.1016\/j.ecoenv.2025.118805_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160078","article-title":"Ferroptosis contributes to nickel-induced developmental neurotoxicity in zebrafish","volume":"858","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118805_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113334","article-title":"Developmental toxicity of bromoacetamide via the thyroid hormone receptors-mediated disruption of thyroid hormone homeostasis in zebrafish embryos","volume":"233","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib71","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/acs.est.7b04073","article-title":"A reduced transcriptome approach to assess environmental toxicants using zebrafish embryo test","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130682","article-title":"Effect of florasulam on oxidative damage and apoptosis in larvae and adult zebrafish (Danio rerio)","volume":"446","author":"Wang","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118805_bib73","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.est.3c06127","article-title":"Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118805_bib74","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.envint.2018.10.024","article-title":"Regulation, formation, exposure, and treatment of disinfection by-products (DBPs) in swimming pool waters: a critical review","volume":"121","author":"Yang","year":"2018","journal-title":"Environ. Int."},{"issue":"34","key":"10.1016\/j.ecoenv.2025.118805_bib75","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"49","key":"10.1016\/j.ecoenv.2025.118805_bib76","doi-asserted-by":"crossref","first-page":"45642","DOI":"10.1021\/acsomega.2c06296","article-title":"Emerging disinfection byproduct 2,6-Dichlorobenzoquinone-Induced cardiovascular developmental toxicity of embryonic zebrafish and larvae: imaging and transcriptome analysis","volume":"7","author":"Yang","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.ecoenv.2025.118805_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116443","article-title":"Global characterization of dose-dependent effects of cadmium in clam ruditapes philippinarum","volume":"273","author":"Zhan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118805_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116512","article-title":"GPX4, ferroptosis, and diseases","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2025.118805_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122191","article-title":"Determination of 10 haloacetamides in drinking water by gas chromatography with automated solid phase extraction","volume":"1150","author":"Zhou","year":"2020","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.118805_bib80","first-page":"284","article-title":"Discussion on disinfection byproducts of halogenoacetonitrile, halonitromethane and haloacetamide in urban wastewater","volume":"43","author":"Zhu","year":"2024","journal-title":"Water Purif. Technol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118805_bib81","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal. Transduct. Target Ther."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325011509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325011509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:08:10Z","timestamp":1777489690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325011509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"alternative-id":["S0147651325011509"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118805","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo\u2013larvae: A multiomics approach and comparison of biomarker responsiveness","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118805"}}