{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:53:37Z","timestamp":1790564017945,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118894","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T08:30:07Z","timestamp":1755765007000},"page":"118894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Aflatoxin B1 disrupts intestinal barrier integrity: Insights into DAF-16\/SOD-3-mediated oxidative imbalance and autophagy in Caenorhabditis elegans"],"prefix":"10.1016","volume":"303","author":[{"given":"Yajiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-2946","authenticated-orcid":false,"given":"An","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ecoenv.2025.118894_bib1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0022-3565(24)35212-7","article-title":"Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms","volume":"291","author":"Banan","year":"1999","journal-title":"J. Pharm. Exp. Ther."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ibd.20821","article-title":"ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8","volume":"15","author":"Bhattacharyya","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ecoenv.2025.118894_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112754","article-title":"Aflatoxin B1 alters meat quality associated with oxidative stress, inflammation, and gut-microbiota in sheep","volume":"225","author":"Cao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrgastro.2010.39","article-title":"Hypoxia: an alarm signal during intestinal inflammation","volume":"7","author":"Colgan","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118894_bib5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/hmg\/9.6.869","article-title":"A role for caenorhabditis elegans in understanding the function and interactions of human disease genes","volume":"9","author":"Culetto","year":"2000","journal-title":"Hum. Mol. Genet"},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118894_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9010009","article-title":"Aflatoxin B1-induced developmental and DNA damage in caenorhabditis elegans","volume":"9","author":"Feng","year":"2016","journal-title":"Toxins"},{"issue":"10","key":"10.1016\/j.ecoenv.2025.118894_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14100665","article-title":"Effects of compound mycotoxin detoxifier on alleviating aflatoxin B1-induced inflammatory responses in intestine, liver and kidney of broilers","volume":"14","author":"Guo","year":"2022","journal-title":"Toxins"},{"issue":"Database","key":"10.1016\/j.ecoenv.2025.118894_bib8","article-title":"WormBase: a multi-species resource for nematode biology and genomics","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2025.118894_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1289\/ehp.939999","article-title":"Does aflatoxin exposure in the United Kingdom constitute a cancer risk?","volume":"99","author":"Harrison","year":"1993","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118894_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cjoc.202100456","article-title":"SPONGE: a GPU-accelerated molecular dynamics package with enhanced sampling and AI-driven algorithms","volume":"40","author":"Huang","year":"2022","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.ecoenv.2025.118894_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115161","article-title":"Porcine \u03b2-defensin-2 alleviates AFB1-induced intestinal mucosal injury by inhibiting oxidative stress and apoptosis","volume":"262","author":"Jin","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding function in novel targets: c. elegans as a model organism","volume":"5","author":"Kaletta","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.118894_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12866-022-02579-x","article-title":"caenorhabditis elegans DAF-16 regulates lifespan and immune responses to cryptococcus neoformans and cryptococcus gattii infections","volume":"22","author":"Kitisin","year":"2022","journal-title":"BMC Microbiol."},{"issue":"3","key":"10.1016\/j.ecoenv.2025.118894_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/wdev.93","article-title":"The caenorhabditis elegans intestine","volume":"2","author":"McGhee","year":"2013","journal-title":"Wiley Inter. Rev. Dev. Biol."},{"issue":"6946","key":"10.1016\/j.ecoenv.2025.118894_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature01789","article-title":"Genes that act downstream of DAF-16 to influence the lifespan of caenorhabditis elegans","volume":"424","author":"Murphy","year":"2003","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ecoenv.2025.118894_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10111824","article-title":"Mitochondrial management of reactive oxygen species","volume":"10","author":"Napolitano","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2025.118894_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.108647","article-title":"Betula utilis extract prolongs life expectancy, protects against amyloid-\u03b2 toxicity and reduces alpha synuclien in caenorhabditis elegans via DAF-16 and SKN-1","volume":"228","author":"Pandey","year":"2020","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharm."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.118894_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0006-2952(98)00333-5","article-title":"Inhibition of oxidant-induced barrier disruption and protein tyrosine phosphorylation in Caco-2 cell monolayers by epidermal growth factor","volume":"57","author":"Rao","year":"1999","journal-title":"Biochem. Pharm."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/pca.2931","article-title":"Immunochemical approaches for detection of aflatoxin B1 in herbal medicines","volume":"31","author":"Raysyan","year":"2020","journal-title":"Phytochem. Anal."},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020085","article-title":"OrthoList: a compendium of c. elegans genes with human orthologs","volume":"6","author":"Shaye","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.118894_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/toxics12050339","article-title":"Integrating epigenetics, proteomics, and metabolomics to reveal the involvement of Wnt\/\u03b2-Catenin signaling pathway in oridonin-induced reproductive toxicity","volume":"12","author":"Wu","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2025.118894_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111036","article-title":"Gelsenicine disrupted the intestinal barrier of caenorhabditis elegans","volume":"395","author":"Wu","year":"2024","journal-title":"Chem. Biol. Inter."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118894_bib23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.arcmed.2010.05.002","article-title":"Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis","volume":"41","author":"Yao","year":"2010","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ecoenv.2025.118894_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113640","article-title":"SeMet attenuates AFB1-induced intestinal injury in rabbits by activating the Nrf2 pathway","volume":"239","author":"Zhang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.118894_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11040705","article-title":"Oxidation and antioxidation of natural products in the model organism caenorhabditis elegans","volume":"11","author":"Zhu","year":"2022","journal-title":"Antioxidants"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325012394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325012394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:49:43Z","timestamp":1777124983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325012394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"alternative-id":["S0147651325012394"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118894","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aflatoxin B1 disrupts intestinal barrier integrity: Insights into DAF-16\/SOD-3-mediated oxidative imbalance and autophagy in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118894"}}