{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:25:20Z","timestamp":1780349120071,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0303040001"],"award-info":[{"award-number":["2023B0303040001"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["C2024043"],"award-info":[{"award-number":["C2024043"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62471185"],"award-info":[{"award-number":["62471185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ecoenv.2025.118896","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T01:07:41Z","timestamp":1755738461000},"page":"118896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age"],"prefix":"10.1016","volume":"303","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-0423","authenticated-orcid":false,"given":"Jieling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.118896_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2024.104467","article-title":"Exploring novel insights into the molecular mechanisms underlying bisphenol A-induced toxicity: a persistent threat to human health","volume":"108","author":"Ahmad","year":"2024","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.118896_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuro.2017.10.005","article-title":"Prenatal bisphenol a (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study","volume":"65","author":"Arambula","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118896_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-069X-11-42","article-title":"Developmental origins of non-communicable disease: implications for research and public health","volume":"11","author":"Barouki","year":"2012","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1289\/ehp.0900979","article-title":"Prenatal bisphenol a exposure and early childhood behavior","volume":"117","author":"Braun","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118896_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1542\/peds.2011-1335","article-title":"Impact of early-life bisphenol a exposure on behavior and executive function in children","volume":"128","author":"Braun","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.ecoenv.2025.118896_bib6","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1289\/ehp.0900979","article-title":"Prenatal bisphenol a exposure and early childhood behavior","volume":"117","author":"Braun","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.118896_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.talanta.2019.01.045","article-title":"Excitation-emission fluorescence-kinetic third-order\/four-way data: determination of bisphenol a and nonylphenol in food-contact plastics","volume":"197","author":"Carabajal","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2025.118896_bib8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijheh.2012.05.009","article-title":"Exposure to brominated flame retardants, perfluorinated compounds, phthalates and phenols in european birth cohorts: ENRIECO evaluation, first human biomonitoring results, and recommendations","volume":"216","author":"Casas","year":"2013","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.envres.2015.07.024","article-title":"'Exposure to bisphenol a during pregnancy and child neuropsychological development in the INMA-Sabadell cohort'","volume":"142","author":"Casas, Maribel","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118896_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chemosphere.2015.06.061","article-title":"Identification of dopamine- and serotonin-related genes modulated by bisphenol a in the prefrontal cortex of Male rats","volume":"139","author":"Castro","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118896_bib11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/jat\/bks072","article-title":"Determination of nine environmental phenols in urine by ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"36","author":"Chen","year":"2012","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-023-03614-0","article-title":"Effect of bisphenol a on the neurological system: a review update","volume":"98","author":"Costa","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192434","article-title":"Preconception paternal bisphenol a exposure induces sex-specific anxiety and depression behaviors in adult rats","volume":"13","author":"Fan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2025.118896_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2020.113597","article-title":"'Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the environment and childhood (INMA) project'","volume":"230","author":"Freire","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1080\/19440049.2010.508183","article-title":"Intake of bisphenol a from canned beverages and foods on the Belgian market","volume":"27","author":"Geens","year":"2010","journal-title":"Food Addit. Contam. Part A"},{"key":"10.1016\/j.ecoenv.2025.118896_bib16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.envpol.2018.09.107","article-title":"'Concentrations of perfluoroalkyl substances and bisphenol a in newborn dried blood spots and the association with child behavior'","volume":"243","author":"Ghassabian","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118896_bib17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/andr.12176","article-title":"Low-dose effect of developmental bisphenol a exposure on sperm count and behaviour in rats","volume":"4","author":"Hass","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2025.118896_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.envres.2018.12.055","article-title":"Prenatal bisphenol a exposure is associated with language development but not with ADHD-related behavior in toddlers from the odense child cohort","volume":"170","author":"Jensen","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118896_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108543","article-title":"Maternal oral exposure to low-dose BPA accelerates the onset of puberty by promoting prepubertal Kiss1 expression in the AVPV nucleus of female offspring","volume":"124","author":"Jiang","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113500","article-title":"Estimation of multi-route exposures to various chemicals during children's clay toy use","volume":"212","author":"Kang","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118896_bib21","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/jat.3627","article-title":"'Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults'","volume":"38","author":"Karzi","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2131\/jts.38.485","article-title":"Effect of fetal exposure to bisphenol a on brain mediated by X-chromosome inactivation","volume":"38","author":"Kumamoto","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118896_bib23","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol a distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118896_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114474","article-title":"Temporal trends in risk of bisphenol A, benzophenone-3 and triclosan exposure among U.S. Children and adolescents aged 6-19 years: findings from The National health and nutrition examination survey 2005-2016","volume":"216","author":"Li","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118896_bib25","first-page":"846","article-title":"Simultaneous determination of nine phthalate esters and bisphenol a in cosmetics by ultra-high performance liquid chromatography","volume":"41","author":"Liu","year":"2012","journal-title":"Wei Sheng Yan Jiu"},{"key":"10.1016\/j.ecoenv.2025.118896_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfu085","article-title":"Maternal bisphenol a diet induces anxiety-like behavior in female juvenile with neuroimmune activation","volume":"140","author":"Luo","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2025.118896_bib27","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1039\/C6EM00472E","article-title":"Exposure of children to BPA through dust and the association of urinary BPA and triclosan with oxidative stress in guangzhou, China","volume":"18","author":"Lv","year":"2016","journal-title":"Environ. Sci. Process Impacts"},{"key":"10.1016\/j.ecoenv.2025.118896_bib28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.envres.2018.11.017","article-title":"Early-life intake of major trace elements, bisphenol A, tetrabromobisphenol a and fatty acids: comparing human milk and commercial infant formulas","volume":"169","author":"Mart\u00ednez","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.118896_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuro.2013.03.001","article-title":"Sex specific impact of perinatal bisphenol a (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation","volume":"36","author":"McCaffrey","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.118896_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chemosphere.2017.10.132","article-title":"Concentrations of trace metals, phthalates, bisphenol a and flame-retardants in toys and other children's products in Israel","volume":"192","author":"Negev","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118896_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170754","article-title":"Identifying critical Windows of prenatal phenol, paraben, and pesticide exposure and child neurodevelopment: findings from a prospective cohort study","volume":"920","author":"Oskar","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118896_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115008","article-title":"Maternal prenatal urinary bisphenol a level and child cardio-metabolic risk factors: a prospective cohort study","volume":"265","author":"Ouyang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.118896_bib33","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.ijheh.2019.03.002","article-title":"Prenatal bisphenol a exposure and early childhood neurodevelopment in shandong, China","volume":"222","author":"Pan","year":"2019","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2010.02.051","article-title":"Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol a","volume":"167","author":"Poimenova","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.ecoenv.2025.118896_bib35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"'Bisphenol a and human health: a review of the literature'","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2011.05.002","article-title":"'Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects'","volume":"127","author":"Rubin","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib37","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3716","article-title":"Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health","volume":"141","author":"Schwarzenberg","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.ecoenv.2025.118896_bib38","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1038\/s41467-024-48897-8","article-title":"Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype","volume":"15","author":"Symeonides","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.118896_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpeds.2022.02.051","article-title":"Use of cotton balls in diapers for collection of urine samples impacts the analysis of routine chemistry tests: an evaluation of cotton balls, diapers, and chemistry analyzers","volume":"245","author":"Thomas","year":"2022","journal-title":"J. Pedia"},{"key":"10.1016\/j.ecoenv.2025.118896_bib40","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/syn.20746","article-title":"Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice","volume":"64","author":"Tian","year":"2010","journal-title":"Synapse"},{"key":"10.1016\/j.ecoenv.2025.118896_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12940-021-00767-2","article-title":"Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study","volume":"20","author":"Vindenes","year":"2021","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136583","article-title":"Bisphenol analogues in Chinese bottled water: quantification and potential risk analysis","volume":"713","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.118896_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115413","article-title":"The association between maternal urinary bisphenol a levels and neurodevelopment at age 2 years in Chinese boys and girls: a prospective cohort study","volume":"264","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.118896_bib44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yhbeh.2010.10.001","article-title":"The role of bisphenol a in shaping the brain, epigenome and behavior","volume":"59","author":"Wolstenholme","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ecoenv.2025.118896_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139973","article-title":"Associations of exposure to bisphenol a and its substitutes with neurodevelopmental outcomes among infants at 12 months of age: a cross-sectional study","volume":"341","author":"Xia","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.118896_bib46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12888-023-04667-2","article-title":"Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey","volume":"23","author":"Xiang","year":"2023","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.ecoenv.2025.118896_bib47","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1021\/acs.est.7b00701","article-title":"Bisphenols, benzophenones, and bisphenol a diglycidyl ethers in textiles and infant clothing","volume":"51","author":"Xue","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.118896_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137731","article-title":"Bisphenol a exposure and neurodevelopmental disorders and problems in children under 12 years of age: a systematic review and meta-analysis","volume":"490","author":"Zhang","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.118896_bib49","doi-asserted-by":"crossref","first-page":"1196248","DOI":"10.3389\/fpubh.2024.1196248","article-title":"Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019","volume":"12","author":"Zhang","year":"2024","journal-title":"Front Public Health"},{"key":"10.1016\/j.ecoenv.2025.118896_bib50","first-page":"1028","article-title":"Differential diagnosis of autism spectrum disorder and global developmental delay based on machine learning and children neuropsychological and behavioral scale","volume":"25","author":"Zhou","year":"2023","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.ecoenv.2025.118896_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120325","article-title":"Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort","volume":"264","author":"Zhou","year":"2025","journal-title":"Environ. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325012412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325012412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:08:05Z","timestamp":1777126085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325012412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":51,"alternative-id":["S0147651325012412"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118896","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118896"}}