{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:23:01Z","timestamp":1792459381415,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSCF-82173532"],"award-info":[{"award-number":["NSCF-82173532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSCF-82471896"],"award-info":[{"award-number":["NSCF-82471896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2707200"],"award-info":[{"award-number":["2024YFC2707200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ecoenv.2025.119106","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:07:04Z","timestamp":1758971224000},"page":"119106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Essential trace element profile in follicular fluid and recurrent pregnancy loss: The role of amino acids\u2014A case-control study"],"prefix":"10.1016","volume":"304","author":[{"given":"Xun","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119106_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","article-title":"Iron homeostasis","volume":"69","author":"Andrews","year":"2007","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128225","article-title":"Metabolite dynamics and phytochemistry of a soy whey-based beverage bio-transformed by water kefir consortium","volume":"342","author":"Azi","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.ecoenv.2025.119106_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155796","article-title":"Metabolic linkages between zinc exposure and lung cancer risk: a nested case-control study","volume":"837","author":"Bai","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119106_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B."},{"key":"10.1016\/j.ecoenv.2025.119106_bib5","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/diabetes.51.6.1714","article-title":"A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion","volume":"51","author":"Brennan","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.ecoenv.2025.119106_bib6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ajog.2019.08.059","article-title":"The impact of occupational activities during pregnancy on pregnancy outcomes: a systematic review and metaanalysis","volume":"222","author":"Cai","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/jog.13799","article-title":"Obesity and recurrent miscarriage: a systematic review and meta-analysis","volume":"45","author":"Cavalcante","year":"2019","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib8","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/jn\/133.7.2348","article-title":"Hemoglobin concentrations influence birth outcomes in pregnant African-American adolescents","volume":"133","author":"Chang","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2025.119106_bib9","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1113\/JP274883","article-title":"A systems perspective on placental amino acid transport","volume":"596","author":"Cleal","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib10","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nature19356","article-title":"High-throughput discovery of novel developmental phenotypes","volume":"537","author":"Dickinson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.119106_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ecoenv.2025.119106_bib12","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1053\/j.gastro.2021.11.015","article-title":"Integrative analysis of the inflammatory bowel disease serum metabolome improves our understanding of genetic etiology and points to novel putative therapeutic targets","volume":"162","author":"Di'Narzo","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2025.119106_bib13","doi-asserted-by":"crossref","first-page":"839S","DOI":"10.3945\/an.115.011817","article-title":"Protein and amino acid requirements during pregnancy","volume":"7","author":"Elango","year":"2016","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.ecoenv.2025.119106_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0026-0495(73)90269-2","article-title":"The glucose-alanine cycle","volume":"22","author":"Felig","year":"1973","journal-title":"Metabolism"},{"key":"10.1016\/j.ecoenv.2025.119106_bib15","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1146\/annurev.bi.44.070175.004441","article-title":"Amino acid metabolism in man","volume":"44","author":"Felig","year":"1975","journal-title":"Annu Rev. Biochem."},{"key":"10.1016\/j.ecoenv.2025.119106_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.yrtph.2012.08.022","article-title":"Derivation of a chronic oral reference dose for cobalt","volume":"64","author":"Finley","year":"2012","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119106_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.envres.2014.10.013","article-title":"Interdependence between urinary cobalt concentrations and hemoglobin levels in pregnant women","volume":"136","author":"Fort","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-nutr-082018-124213","article-title":"The benefits and risks of iron supplementation in pregnancy and childhood","volume":"39","author":"Georgieff","year":"2019","journal-title":"Annu Rev. Nutr."},{"key":"10.1016\/j.ecoenv.2025.119106_bib19","doi-asserted-by":"crossref","first-page":"617.e1","DOI":"10.1016\/j.ajog.2019.05.043","article-title":"The combined impact of maternal age and body mass index on cumulative live birth following in vitro fertilization","volume":"221","author":"Goldman","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ajh.25341","article-title":"Iron homeostasis in pregnancy and spontaneous abortion","volume":"94","author":"Guo","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cois.2017.07.005","article-title":"Amino acid modulation of lifespan and reproduction in drosophila","volume":"23","author":"Hoedjes","year":"2017","journal-title":"Curr. Opin. Insect Sci."},{"key":"10.1016\/j.ecoenv.2025.119106_bib22","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/humrep\/dead189","article-title":"Serum and follicular fluid metabolome and markers of ovarian stimulation","volume":"38","author":"Hood","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2025.119106_bib23","first-page":"1556","article-title":"Differential effects of glucose and N-acetylglucosamine on genome instability","volume":"12","author":"Hsu","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s42003-024-06547-1","article-title":"Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK","volume":"7","author":"Huang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s40572-020-00284-3","article-title":"Air pollution and adverse pregnancy and birth outcomes: mediation analysis using metabolomic profiles","volume":"7","author":"Inoue","year":"2020","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.ecoenv.2025.119106_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/jama.2020.25019","article-title":"Interventions for tobacco smoking cessation in adults, including pregnant persons: US preventive services task force recommendation statement","volume":"325","author":"Krist","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2025.119106_bib28","article-title":"Enhanced Branched-Chain amino acid metabolism improves Age-Related reproduction in C. Elegans","author":"Lesnik","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.ecoenv.2025.119106_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113309","article-title":"The associations of serum metals concentrations with the intermediate and pregnancy outcomes in women undergoing in vitro fertilization (IVF)","volume":"233","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119106_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-016-0853-6","article-title":"Determine multiple elements simultaneously in the sera of umbilical cord blood Samples-a very simple method","volume":"177","author":"Liang","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib31","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.cell.2020.05.002","article-title":"Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women","volume":"181","author":"Liang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2025.119106_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119106_bib33","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s00125-018-4809-6","article-title":"Maternal glucose levels during pregnancy and childhood adiposity in the hyperglycemia and adverse pregnancy outcome Follow-up study","volume":"62","author":"Lowe","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.ecoenv.2025.119106_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.envres.2018.10.007","article-title":"Associations of environmental exposures to methylmercury and selenium with female infertility: a case-control study","volume":"168","author":"Maeda","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib35","doi-asserted-by":"crossref","first-page":"l869","DOI":"10.1136\/bmj.l869","article-title":"Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study","volume":"364","author":"Magnus","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ecoenv.2025.119106_bib36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/14767058.2018.1489795","article-title":"The significant role of amino acids during pregnancy: nutritional support","volume":"33","author":"Manta-Vogli","year":"2020","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"10.1016\/j.ecoenv.2025.119106_bib37","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.7022654","article-title":"The essential trace elements","volume":"213","author":"Mertz","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.119106_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41419-022-05037-8","article-title":"Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.119106_bib39","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1001\/jama.2012.4061","article-title":"Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial","volume":"307","author":"Persson","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2025.119106_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109217","article-title":"Cobalt accumulation and iron-regulatory protein profile expression in immature mouse brain after perinatal exposure to cobalt chloride","volume":"329","author":"Petrova","year":"2020","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2025.119106_bib41","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/HJH.0000000000003472","article-title":"Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes","volume":"41","author":"Piani","year":"2023","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ecoenv.2025.119106_bib42","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.119106_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.119106_bib44","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.51166","article-title":"Mediating factors in the association of maternal educational level with pregnancy outcomes: a mendelian randomization study","volume":"7","author":"Rogne","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ecoenv.2025.119106_bib45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-nutr-061021-030404","article-title":"Iron homeostasis during pregnancy: maternal, placental, and fetal regulatory mechanisms","volume":"43","author":"Sangkhae","year":"2023","journal-title":"Annu Rev. Nutr."},{"key":"10.1016\/j.ecoenv.2025.119106_bib46","first-page":"741","article-title":"High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational age","volume":"96","author":"Scanlon","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/nu13114134","article-title":"Pronounced trace element variation in follicular fluids of subfertile women undergoing assisted reproduction","volume":"13","author":"Schmalbrock","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2025.119106_bib48","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(23)00396-3","article-title":"Anaemia in pregnancy: a major global health problem","volume":"401","author":"Shand","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2025.119106_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158882","article-title":"The association between exposure to multiple toxic metals and the risk of endometriosis: evidence from the results of blood and follicular fluid","volume":"855","author":"Shen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119106_bib50","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.fertnstert.2008.02.007","article-title":"Trace element concentrations in follicular fluid of small follicles differ from those in blood serum, and May represent long-term exposure","volume":"91","author":"Silberstein","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2025.119106_bib51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.scitotenv.2012.06.009","article-title":"Cobalt metabolism and toxicology--a brief update","volume":"432","author":"Simonsen","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119106_bib52","article-title":"Novel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization","volume":"9","author":"Song","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119106_bib53","article-title":"Decidual stromal cell ferroptosis associated with abnormal iron metabolism is implicated in the pathogenesis of recurrent pregnancy loss","volume":"24","author":"Sun","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119106_bib54","article-title":"Amino acids during pregnancy and offspring Cardiovascular-Kidney-Metabolic health","volume":"16","author":"Tain","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2025.119106_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092535","article-title":"Prenatal amino acid supplementation to improve fetal growth: a systematic review and Meta-Analysis","volume":"12","author":"Terstappen","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2025.119106_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111065","article-title":"Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress","volume":"40","author":"Tsai","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2025.119106_bib57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1753-4887.1975.tb06019.x","article-title":"Cobalt","volume":"33","author":"Underwood","year":"1975","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.ecoenv.2025.119106_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod64.1.1","article-title":"Amino acid transport regulation and early embryo development","volume":"64","author":"Van Winkle","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.119106_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2021.07.001","article-title":"The metabolic landscape of decidua in recurrent pregnancy loss using a global metabolomics approach","volume":"112","author":"Wang","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.ecoenv.2025.119106_bib60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-animal-022513-114113","article-title":"Amino acid nutrition in animals: protein synthesis and beyond","volume":"2","author":"Wu","year":"2014","journal-title":"Annu Rev. Anim. Biosci."},{"key":"10.1016\/j.ecoenv.2025.119106_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/nu15010115","article-title":"Association between plasma trace element concentrations in early pregnancy and gestational diabetes mellitus in shanghai, China","volume":"15","author":"Wu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2025.119106_bib62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.freeradbiomed.2025.07.029","article-title":"Untargeted metabolomics and transcriptomics study reveals an activated ferroptosis metabolic spectrum in recurrent spontaneous abortion","volume":"239","author":"Wu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2025.119106_bib63","first-page":"7220","article-title":"Metabolomic profiling of human follicular fluid from patients with repeated failure of in vitro fertilization using gas chromatography\/mass spectrometry","volume":"7","author":"Xia","year":"2014","journal-title":"Int J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12958-024-01313-8","article-title":"Effect of serum uric acid level on reproductive outcome in women without polycystic ovary syndrome undergoing in vitro fertilization","volume":"22","author":"Xia","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib65","doi-asserted-by":"crossref","first-page":"324.e1","DOI":"10.1016\/j.ajog.2022.11.1287","article-title":"Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study","volume":"228","author":"Yang","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1476774","article-title":"Metabolomic analysis reveals potential role of immunometabolism dysregulation in recurrent pregnancy loss","volume":"15","author":"Ye","year":"2024","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2025.119106_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117144","article-title":"The associations of the concentrations of toxic metals (including metalloid) in blood and follicular fluid with the risk of diminished ovarian reserve","volume":"286","author":"Yue","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119106_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114244","article-title":"Association between co-exposure to phenols and phthalates mixture and infertility risk in women","volume":"215","author":"Zhan","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2025.119106_bib69","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.envint.2018.11.076","article-title":"Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: comparison of three statistical models","volume":"123","author":"Zhang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119106_bib70","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/biolre\/ioac038","article-title":"Metabolomic markers of biological fluid in women with reproductive failure: a systematic review of current literatures","volume":"106","author":"Zhang","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2025.119106_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106976","article-title":"A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: findings from the Boston birth cohort","volume":"158","author":"Zhang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119106_bib72","doi-asserted-by":"crossref","first-page":"11779","DOI":"10.1021\/acs.est.3c02535","article-title":"Maternal exposure to trace elements, toxic metals, and longitudinal changes in infancy anthropometry and growth trajectories: a prospective cohort study","volume":"57","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib73","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1021\/acs.est.3c10904","article-title":"Using machine learning to construct the Blood-Follicle distribution models of various trace elements and explore the Transport-Related pathways with multiomics data","volume":"58","author":"Zhang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib74","article-title":"Correlation analysis between trace elements and colorectal cancer metabolism by integrated serum proteome and metabolome","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2025.119106_bib75","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1471-0528.2007.01325.x","article-title":"A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin > or = 13.2 g\/dl","volume":"114","author":"Ziaei","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.ecoenv.2025.119106_bib76","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","article-title":"The essential metals for humans: a brief overview","volume":"195","author":"Zoroddu","year":"2019","journal-title":"J. Inorg. Biochem."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325014514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325014514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:15:23Z","timestamp":1773130523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325014514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":76,"alternative-id":["S0147651325014514"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119106","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential trace element profile in follicular fluid and recurrent pregnancy loss: The role of amino acids\u2014A case-control study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119106"}}