{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:34:18Z","timestamp":1791545658826,"version":"4.3.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473597"],"award-info":[{"award-number":["82473597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073515"],"award-info":[{"award-number":["82073515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ecoenv.2025.119187","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:42:03Z","timestamp":1760136123000},"page":"119187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits"],"prefix":"10.1016","volume":"305","author":[{"given":"Wenhui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-6832","authenticated-orcid":false,"given":"Zhiyuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoshuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119187_bib1","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1038\/s41467-024-51109-y","article-title":"Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver","volume":"15","author":"Aich","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119187_bib2","article-title":"Prevalence of endemic fluorosis with gastro-intestinal manifestations in people living in some North-Indian villages","volume":"26","author":"Andezhath","year":"1993","journal-title":"Fluoride Q. Rep."},{"key":"10.1016\/j.ecoenv.2025.119187_bib3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10555-024-10216-4","article-title":"Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets","volume":"43","author":"Bacon","year":"2024","journal-title":"Cancer Metastas.. Rev."},{"key":"10.1016\/j.ecoenv.2025.119187_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cbi.2010.07.011","article-title":"Molecular mechanisms of fluoride toxicity","volume":"188","author":"Barbier","year":"2010","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.ecoenv.2025.119187_bib5","doi-asserted-by":"crossref","DOI":"10.1289\/EHP655","article-title":"Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico","volume":"125","author":"Bashash","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.119187_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biocel.2013.12.011","article-title":"Mitochondria: impaired mitochondrial translation in human disease","volume":"48","author":"Boczonadi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119187_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in parkinson's disease","volume":"139","author":"Bose","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ecoenv.2025.119187_bib8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.1258026","article-title":"Structure of the large ribosomal subunit from human mitochondria","volume":"346","author":"Brown","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.119187_bib9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s12011-019-01882-5","article-title":"Sodium fluoride and fluoride contaminated ground water induced altered reproductive performances in male rats","volume":"195","author":"Chaithra","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2025.119187_bib10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10753-017-0556-y","article-title":"Fluoride induces neuroinflammation and alters wnt signaling pathway in BV2 microglial cells","volume":"40","author":"Chen","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.ecoenv.2025.119187_bib11","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1289\/ehp.1104912","article-title":"Developmental fluoride neurotoxicity: a systematic review and meta-analysis","volume":"120","author":"Choi","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.119187_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.autrev.2016.07.022","article-title":"Parkinson's disease: autoimmunity and neuroinflammation","volume":"15","author":"De Virgilio","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ecoenv.2025.119187_bib14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1126\/science.abc7782","article-title":"Elongational stalling activates mitoribosome-associated quality control","volume":"370","author":"Desai","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2025.119187_bib15","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ecoenv.2025.119187_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91229","article-title":"Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice","volume":"2","author":"Feng","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ecoenv.2025.119187_bib17","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.18632\/aging.202862","article-title":"Methylation factor MRPL15 identified as a potential biological target in alzheimer's disease","volume":"13","author":"Gao","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.ecoenv.2025.119187_bib18","first-page":"525","article-title":"Toxic metal -Mediated neurodegradation: a focus on glutathione and GST gene variants","volume":"77","author":"Gasmi","year":"2022","journal-title":"Arch. Razi Inst."},{"key":"10.1016\/j.ecoenv.2025.119187_bib19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature12890","article-title":"Architecture of the large subunit of the mammalian mitochondrial ribosome","volume":"505","author":"Greber","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.119187_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-biochem-060815-014343","article-title":"Structure and function of the mitochondrial ribosome","volume":"85","author":"Greber","year":"2016","journal-title":"Annu Rev. Biochem."},{"key":"10.1016\/j.ecoenv.2025.119187_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molmed.2014.11.008","article-title":"Mitochondria: diversity in the regulation of the NLRP3 inflammasome","volume":"21","author":"Gurung","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ecoenv.2025.119187_bib22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2011226118","article-title":"NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of alzheimer's disease via cGAS-STING","volume":"118","author":"Hou","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.ecoenv.2025.119187_bib25","article-title":"Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis","volume":"15","author":"Huang","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.ecoenv.2025.119187_bib26","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1093\/hmg\/ddae020","article-title":"Illuminating mitochondrial translation through mouse models","volume":"33","author":"Hughes","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ecoenv.2025.119187_bib27","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/ncomms3958","article-title":"The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein","volume":"5","author":"Hwang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119187_bib28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.intimp.2018.12.028","article-title":"Role of pyroptosis in cardiovascular diseases","volume":"67","author":"Jia","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib29","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1542\/peds.2016-2828H","article-title":"Neurodevelopment: the impact of nutrition and inflammation during early to middle childhood in Low-Resource settings","volume":"139","author":"John","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.ecoenv.2025.119187_bib30","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1089\/ars.2012.4896","article-title":"Mitochondrial protein synthesis: efficiency and accuracy","volume":"19","author":"Kehrein","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.ecoenv.2025.119187_bib31","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/nar\/gkt1280","article-title":"Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ","volume":"42","author":"Kogure","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2025.119187_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: effectors of pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41580-021-00332-2","article-title":"Mechanisms and regulation of protein synthesis in mitochondria","volume":"22","author":"Kummer","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35789-3","article-title":"Systematic analysis and biomarker study for alzheimer's disease","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119187_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161738","article-title":"Fluoride impairs mitochondrial translation by targeting miR-221-3p\/c-Fos\/RMND1 axis contributing to neurodevelopment defects","volume":"869","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119187_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02791-0","article-title":"The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ecoenv.2025.119187_bib37","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/10715762.2018.1479063","article-title":"Mitochondrial translation factor EF4 regulates oxidative phosphorylation complexes and the production of ROS","volume":"52","author":"Li","year":"2018","journal-title":"Free Radic. Res"},{"key":"10.1016\/j.ecoenv.2025.119187_bib38","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1016\/j.febslet.2014.05.054","article-title":"Mitochondrial protein synthesis: figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation","volume":"588","author":"Lightowlers","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ecoenv.2025.119187_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.phrs.2011.01.004","article-title":"Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for parkinsonism","volume":"63","author":"Liu","year":"2011","journal-title":"Pharm. Res"},{"key":"10.1016\/j.ecoenv.2025.119187_bib40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13046-018-0959-0","article-title":"The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma","volume":"37","author":"Liu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ecoenv.2025.119187_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70014","article-title":"Parkin-TLR4-NLRP3 axis directs melatonin to alleviate Atrazine-Induced immune impairment in splenic macrophages","volume":"76","author":"Liu","year":"2024","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.ecoenv.2025.119187_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.ecoenv.2025.119187_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083827","article-title":"Human mitoribosome biogenesis and its emerging links to disease","volume":"22","author":"Lopez Sanchez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119187_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WNR.0b013e328341e141","article-title":"Tetrahydrocurcumin confers protection against amyloid \u03b2-induced toxicity","volume":"22","author":"Mishra","year":"2011","journal-title":"Neuroreport"},{"key":"10.1016\/j.ecoenv.2025.119187_bib45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbi.2024.02.001","article-title":"Role of pyroptosis in the pathogenesis of various neurological diseases","volume":"117","author":"Oladapo","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ecoenv.2025.119187_bib46","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.neuron.2022.05.009","article-title":"Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in parkinson's disease","volume":"110","author":"Panicker","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.ecoenv.2025.119187_bib47","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","article-title":"Cellular and molecular mechanisms of curcumin in prevention and treatment of disease","volume":"60","author":"Patel","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ecoenv.2025.119187_bib48","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12126","article-title":"Identification and validation of hub genes for diabetic retinopathy","volume":"9","author":"Peng","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.ecoenv.2025.119187_bib49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0143-148X(85)90004-7","article-title":"The mobility of soluble fluoride in soils","volume":"9","author":"Pickering","year":"1985","journal-title":"Environ. Pollut. Ser. B Chem. Phys."},{"key":"10.1016\/j.ecoenv.2025.119187_bib50","article-title":"Salicylalazine: a novel therapeutic agent targeting TLR4\/NLRP3\/GSDMD-mediated pyroptosis in rheumatoid arthritis","volume":"145","author":"Qasim","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105763","article-title":"Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride","volume":"140","author":"Qiu","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119187_bib52","first-page":"7101","article-title":"Neuroprotective effect of DUSP14 overexpression against isoflurane-induced inflammatory response, pyroptosis and cognitive impairment in aged rats through inhibiting the NLRP3 inflammasome","volume":"24","author":"Que","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119187_bib53","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/jispcd.JISPCD_201_17","article-title":"Effect of fluoride concentration in drinking water on intelligence quotient of 12-14-Year-Old children in mathura district: a Cross-Sectional study","volume":"7","author":"Razdan","year":"2017","journal-title":"J. Int Soc. Prev. Community Dent."},{"key":"10.1016\/j.ecoenv.2025.119187_bib54","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb J."},{"key":"10.1016\/j.ecoenv.2025.119187_bib55","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/emboj.2010.14","article-title":"A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome","volume":"29","author":"Richter","year":"2010","journal-title":"Embo J."},{"key":"10.1016\/j.ecoenv.2025.119187_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110335","article-title":"Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis","volume":"120","author":"Selim","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.ecoenv.2025.119187_bib58","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.molmed.2017.06.002","article-title":"Recent advances in mitochondrial Aminoacyl-tRNA synthetases and disease","volume":"23","author":"Sissler","year":"2017","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.ecoenv.2025.119187_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150601","article-title":"Fluoride occurrences, health problems, detection, and remediation methods for drinking water: a comprehensive review","volume":"807","author":"Solanki","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119187_bib60","doi-asserted-by":"crossref","first-page":"68730","DOI":"10.18632\/oncotarget.19612","article-title":"Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: early detection of treatment failure with companion diagnostics","volume":"8","author":"Sotgia","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ecoenv.2025.119187_bib61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13059-022-02732-9","article-title":"Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes","volume":"23","author":"Soto","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib62","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat. Genet"},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119187_bib63","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bph.13389","article-title":"Inflammation: maladies, models, mechanisms and molecules","volume":"173","author":"Stewart","year":"2016","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119187_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.777665","article-title":"Lactic Acid-Producing probiotic saccharomyces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113820","article-title":"Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways","volume":"21","author":"Tang","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119187_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120995","article-title":"Association between dental fluorosis prevalence and inflammation levels in school-aged children with low-to-moderate fluoride exposure","volume":"320","author":"Tang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119187_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120995","article-title":"Association between dental fluorosis prevalence and inflammation levels in school-aged children with low-to-moderate fluoride exposure","volume":"320","author":"Tang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119187_bib68","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00204-019-02651-y","article-title":"Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring","volume":"94","author":"Tian","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134331","article-title":"ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1\u03b1\/ERR\u03b1 axis","volume":"471","author":"Tian","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.119187_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249357","article-title":"Thioredoxin-Interacting protein (TXNIP) with focus on brain and neurodegenerative diseases","volume":"21","author":"Tsubaki","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2025.119187_bib71","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1093\/hmg\/ddae031","article-title":"Mitochondrial DNA release and sensing in innate immune responses","volume":"33","author":"VanPortfliet","year":"2024","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.ecoenv.2025.119187_bib72","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00000542-200703000-00007","article-title":"Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus","volume":"106","author":"Wan","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ecoenv.2025.119187_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105229","article-title":"Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children","volume":"134","author":"Wang","year":"2020","journal-title":"Environ. Int"},{"issue":"Rev 2","key":"10.1016\/j.ecoenv.2025.119187_bib74","first-page":"1","article-title":"The metabolism and toxicity of fluoride","volume":"16","author":"Whitford","year":"1996","journal-title":"Monogr. Oral. Sci."},{"key":"10.1016\/j.ecoenv.2025.119187_bib75","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1161\/CIRCRESAHA.116.308501","article-title":"Caspase-1 inflammasome activation mediates Homocysteine-Induced Pyrop-Apoptosis in endothelial cells","volume":"118","author":"Xi","year":"2016","journal-title":"Circ. Res"},{"key":"10.1016\/j.ecoenv.2025.119187_bib76","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/cam4.3907","article-title":"MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer","volume":"10","author":"Xu","year":"2021","journal-title":"Cancer Med"},{"key":"10.1016\/j.ecoenv.2025.119187_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144924","article-title":"Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats","volume":"767","author":"Yan","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119187_bib78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuro.2022.04.002","article-title":"Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy","volume":"90","author":"Y\u0131ld\u0131z","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2025.119187_bib79","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051635","article-title":"Monitoring mitochondrial translation in living cells","volume":"22","author":"Yousefi","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ecoenv.2025.119187_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.656172","article-title":"Prognostic value and related regulatory networks of MRPL15 in Non-Small-Cell lung cancer","volume":"11","author":"Zeng","year":"2021","journal-title":"Front Oncol."},{"issue":"2","key":"10.1016\/j.ecoenv.2025.119187_bib81","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/toxsci\/kfu311","article-title":"Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in tianjin, China","volume":"144","author":"Zhang","year":"2015","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102554","article-title":"ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation","volume":"58","author":"Zhang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.119187_bib83","article-title":"Mitochondrial-Targeted delivery of Polyphenol-Mediated antioxidases complexes against pyroptosis and inflammatory diseases","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ecoenv.2025.119187_bib84","article-title":"SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics","author":"Zhao","year":"2023","journal-title":"J. Adv. Res"},{"key":"10.1016\/j.ecoenv.2025.119187_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ecoenv.2025.119187_bib86","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2025.119187_bib87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325015325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325015325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:11:01Z","timestamp":1773144661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325015325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":87,"alternative-id":["S0147651325015325"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119187","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119187"}}