{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:32:44Z","timestamp":1773221564592,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["JKBK20249"],"award-info":[{"award-number":["JKBK20249"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["DTR2023012"],"award-info":[{"award-number":["DTR2023012"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930093"],"award-info":[{"award-number":["81930093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173565"],"award-info":[{"award-number":["82173565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304186"],"award-info":[{"award-number":["82304186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ecoenv.2025.119188","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:59:47Z","timestamp":1759921187000},"page":"119188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of inositol-requiring enzyme 1\u03b1 in gestational arsenic-induced \u03b1-KG collapse in male offspring"],"prefix":"10.1016","volume":"305","author":[{"given":"Shuang-Rui","family":"Bao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ping","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Ru","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-2675","authenticated-orcid":false,"given":"Yuan-Bao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-1936","authenticated-orcid":false,"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119188_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cmet.2020.08.004","article-title":"Alpha-Ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice","volume":"32","author":"Asadi Shahmirzadi","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2025.119188_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032414-112116","article-title":"Endoplasmic reticulum stress in immunity","volume":"33","author":"Bettigole","year":"2015","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2017.08.216","article-title":"Arsenic in groundwater of west bengal, India: a review of human health risks and assessment of possible intervention options","volume":"612","author":"Bhowmick","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119188_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","article-title":"Mitochondria as signaling organelles control mammalian stem cell fate","volume":"28","author":"Chakrabarty","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ecoenv.2025.119188_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/children11111387","article-title":"Developmental origins of Non-Communicable chronic diseases: role of fetal undernutrition and gut dysbiosis in infancy","volume":"11","author":"Chandra","year":"2024","journal-title":"Children"},{"key":"10.1016\/j.ecoenv.2025.119188_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pharmtox-030220-013418","article-title":"Arsenic: a global environmental challenge","volume":"61","author":"Chen","year":"2021","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103230","article-title":"alpha-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1alpha\/Nrf2 pathway","volume":"74","author":"Cheng","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1101\/gad.351428.123","article-title":"Psat1-generated \u03b1-ketoglutarate and glutamine promote muscle stem cell activation and regeneration","volume":"38","author":"Ciuffoli","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.ecoenv.2025.119188_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-024-06625-6","article-title":"Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression","volume":"15","author":"Cui","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.119188_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.envpol.2017.11.083","article-title":"Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water","volume":"234","author":"Du","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119188_bib11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.kjms.2011.05.003","article-title":"Chronic arsenic toxicity: studies in west bengal, India","volume":"27","author":"Guha Mazumder","year":"2011","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.ecoenv.2025.119188_bib12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2021.11.003","article-title":"Alpha-Ketoglutarate dietary supplementation to improve health in humans","volume":"33","author":"Gyanwali","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2025.119188_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/bmb.21552","article-title":"Real-time quantitative PCR: a tool for absolute and relative quantification","volume":"49","author":"Harshitha","year":"2021","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.ecoenv.2025.119188_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib15","first-page":"465","article-title":"Methylated metal(loid) species in humans","volume":"7","author":"Hirner","year":"2010","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.ecoenv.2025.119188_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/CRD.0000000000000357","article-title":"Association between arsenic exposure and cardiovascular disease","volume":"29","author":"Kononenko","year":"2021","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.ecoenv.2025.119188_bib17","first-page":"1","article-title":"Developmental programming of nonalcoholic fatty liver disease: the effect of early life nutrition on susceptibility and disease severity in later life","volume":"2015","author":"Li","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ecoenv.2025.119188_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102663","article-title":"The physiological metabolite alpha-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress","volume":"62","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ccell.2021.01.012","article-title":"Arsenic and an old place: rescuing p53 mutants in cancer","volume":"39","author":"Loh","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ecoenv.2025.119188_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112901","article-title":"Gestational arsenic exposure induces anxiety-like behaviors in adult offspring by reducing DNA hydroxymethylation in the developing brain","volume":"227","author":"Lv","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119188_bib21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib22","article-title":"\u03b1-ketoglutarate ameliorates colitis through modulation of inflammation, ER stress, and apoptosis","volume":"14","author":"Mandal","year":"2025","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ecoenv.2025.119188_bib23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Martinez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2025.119188_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2014.02.008","article-title":"Getting RIDD of RNA: IRE1 in cell fate regulation","volume":"39","author":"Maurel","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ecoenv.2025.119188_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124751","article-title":"Inorganic arsenic toxicity and alleviation strategies in rice","volume":"408","author":"Mawia","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119188_bib26","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/s41388-017-0077-z","article-title":"Wild-type and mutated IDH1\/2 enzymes and therapy responses","volume":"37","author":"Molenaar","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.ecoenv.2025.119188_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108488","article-title":"Gestational alpha-ketoglutarate supplementation ameliorates arsenic-induced hepatic lipid deposition via epigenetic reprogramming of beta-oxidation process in female offspring","volume":"185","author":"Qian","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119188_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41590-022-01145-x","article-title":"PERK is a critical metabolic hub for immunosuppressive function in macrophages","volume":"23","author":"Raines","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib30","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1021\/acs.jafc.2c04641","article-title":"\u03b1-Ketoglutarate restores intestinal barrier function through promoting intestinal stem cells-mediated epithelial regeneration in colitis","volume":"70","author":"Si","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2025.119188_bib31","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib32","doi-asserted-by":"crossref","first-page":"97004","DOI":"10.1289\/EHP12207","article-title":"Effects of gestational arsenic exposures on placental and fetal development in mice: the role of Cyr61 m6A","volume":"131","author":"Song","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.119188_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128511","article-title":"DNA hydroxymethylation reprogramming of beta-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice","volume":"430","author":"Song","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2025.119188_bib34","doi-asserted-by":"crossref","DOI":"10.1289\/EHP12785","article-title":"Molecular and metabolic analysis of Arsenic-exposed humanized AS3MT mice","volume":"131","author":"Todero","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2025.119188_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.semcancer.2021.04.004","article-title":"Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis","volume":"76","author":"Wadgaonkar","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ecoenv.2025.119188_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123565","article-title":"Endoplasmic reticulum stress responses and epigenetic alterations in arsenic carcinogenesis","volume":"347","author":"Wadgaonkar","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119188_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136397","article-title":"PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells","volume":"710","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119188_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131427","article-title":"Gestational 1-nitropyrene exposure causes anxiety-like behavior partially by altering hippocampal epigenetic reprogramming of synaptic plasticity in Male adult offspring","volume":"453","author":"Wang","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119188_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111473","article-title":"Zinc offers splenic protection through suppressing PERK\/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress","volume":"208","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119188_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121390","article-title":"Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway","volume":"384","author":"Wei","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119188_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116480","article-title":"Associations between metabolic syndrome and four heavy metals: a systematic review and meta-analysis","volume":"273","author":"Xu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119188_bib42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41401-021-00658-9","article-title":"Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1\/alpha-KG-mediated glycolysis","volume":"43","author":"Xu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ecoenv.2025.119188_bib43","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41419-022-05409-0","article-title":"Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis","volume":"13","author":"Yin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.119188_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn2879","article-title":"\u03b1-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling","volume":"8","author":"Yuan","year":"2022","journal-title":"Sci. Adv."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325015337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325015337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:11:38Z","timestamp":1773144698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325015337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":44,"alternative-id":["S0147651325015337"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119188","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of inositol-requiring enzyme 1\u03b1 in gestational arsenic-induced \u03b1-KG collapse in male offspring","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119188"}}