{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:04:38Z","timestamp":1792206278697,"version":"4.4.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2022A0505050035"],"award-info":[{"award-number":["2022A0505050035"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["GZC20250510"],"award-info":[{"award-number":["GZC20250510"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110373"],"award-info":[{"award-number":["2023A1515110373"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010610"],"award-info":[{"award-number":["2022A1515010610"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013068","name":"Key Technologies Research and Development Program of Guangzhou Municipality","doi-asserted-by":"publisher","award":["2025B03J0133"],"award-info":[{"award-number":["2025B03J0133"]}],"id":[{"id":"10.13039\/501100013068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304177"],"award-info":[{"award-number":["82304177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073519"],"award-info":[{"award-number":["82073519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473661"],"award-info":[{"award-number":["82473661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273656"],"award-info":[{"award-number":["82273656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ecoenv.2025.119337","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:53:47Z","timestamp":1762203227000},"page":"119337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPAR\u03b3 activation in zebrafish: A comparative study with polymers and oligomers"],"prefix":"10.1016","volume":"306","author":[{"given":"Hongyi","family":"Xian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chudan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-8192","authenticated-orcid":false,"given":"Zhenlie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119337_bib1","first-page":"15831","article-title":"Determination of non-volatile components of a biodegradable food packaging material based on polyester and polylactic acid (PLA) and its migration to food simulants","author":"Aznar","year":"2019","journal-title":"J. Chromatogr. A."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119337_bib2","article-title":"Fate of so-called biodegradable polymers in seawater and freshwater","volume":"1","author":"Bagheri","year":"2017","journal-title":"Glob. Chall."},{"key":"10.1016\/j.ecoenv.2025.119337_bib3","article-title":"Abiotic degradation and accelerated aging of microplastics from biodegradable and recycled materials in artificial seawater","volume":"954176832","author":"Barlucchi","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119337_bib4","article-title":"GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease","volume":"133155233","author":"Baumann","year":"2022","journal-title":"Metabolism"},{"issue":"12","key":"10.1016\/j.ecoenv.2025.119337_bib5","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1021\/acs.est.1c08875","article-title":"Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish","volume":"56","author":"Chen","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"28","key":"10.1016\/j.ecoenv.2025.119337_bib6","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.1073\/pnas.1314705111","article-title":"Plastic debris in the open ocean","volume":"111","author":"C\u00f3zar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2025.119337_bib7","article-title":"Mechanisms regarding cardiac toxicity triggered by up-regulation of miR-144 in larval zebrafish upon exposure to triclosan","volume":"443","author":"Diao","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119337_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128332","article-title":"Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis","volume":"429","author":"Duan","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119337_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133604","article-title":"Plastic food? Energy compensation of zebrafish (Danio rerio) after long-term exposure to polylactic acid biomicroplastics","author":"Duan","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.ecoenv.2025.119337_bib10","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.celrep.2016.01.016","article-title":"Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid","volume":"14","author":"Fraher","year":"2016","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119337_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32125-7","article-title":"sox9b is required in cardiomyocytes for cardiac morphogenesis and function","volume":"8","author":"Gawdzik","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119337_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1021\/acs.est.9b05796","article-title":"Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate affects lipid metabolism in zebrafish larvae via dna methylation modification","volume":"54","author":"Guo","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.ecoenv.2025.119337_bib13","doi-asserted-by":"crossref","first-page":"77007","DOI":"10.1289\/EHP13667","article-title":"Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar Per- and Polyfluoroalkyl Substances (PFAS)","volume":"132","author":"Gutsfeld","year":"2024","journal-title":"Environ. Health Perspect."},{"issue":"37","key":"10.1016\/j.ecoenv.2025.119337_bib14","doi-asserted-by":"crossref","first-page":"16258","DOI":"10.1021\/acs.est.4c03053","article-title":"Perfluorohexanesulfonic Acid (PFHxS) impairs lipid homeostasis in zebrafish larvae through activation of PPAR\u03b1","volume":"58","author":"He","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.ecoenv.2025.119337_bib15","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1021\/acsbiomaterials.4c00693","article-title":"Moldable plastics (Polycaprolactone) can be acutely toxic to developing zebrafish and activate nuclear receptors in mammalian cells","volume":"10","author":"James","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.119337_bib16","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/j.1742-4658.2008.06455.x","article-title":"The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes","volume":"275","author":"Karanth","year":"2008","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119337_bib17","article-title":"PPAR\u03b1 activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119337_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.watres.2019.02.054","article-title":"Microplastics in freshwaters and drinking water: Critical review and assessment of data quality","volume":"155","author":"Koelmans","year":"2019","journal-title":"Water Res"},{"issue":"24","key":"10.1016\/j.ecoenv.2025.119337_bib19","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.3390\/ijms222413384","article-title":"Mitochondrial oxidative stress-a causative factor and therapeutic target in many diseases","volume":"22","author":"Kowalczyk","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ecoenv.2025.119337_bib20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jhep.2020.04.025","article-title":"Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages","volume":"73","author":"Lefere","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2025.119337_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119337_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.envpol.2019.04.122","article-title":"Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae","volume":"251","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119337_bib23","article-title":"Embryonic exposure of polystyrene nanoplastics affects cardiac development","volume":"906","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"28","key":"10.1016\/j.ecoenv.2025.119337_bib24","doi-asserted-by":"crossref","DOI":"10.4028\/b-qT7ius","article-title":"Gastrointestinal incomplete degradation exacerbates neurotoxic effects of pla microplastics via oligomer nanoplastics formation","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ecoenv.2025.119337_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.144969","article-title":"Review of the artificially-accelerated aging technology and ecological risk of microplastics","volume":"768","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119337_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.122731","article-title":"The degradation of polylactic acid face mask components in different environments","volume":"370","author":"Lyu","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ecoenv.2025.119337_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175716","article-title":"PFOS and PFOSA induce oxidative stress-mediated cardiac defects in zebrafish via PPAR\u03b3 and AHR pathways, respectively","volume":"951","author":"Ma","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.ecoenv.2025.119337_bib28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","article-title":"PPAR control of metabolism and cardiovascular functions","volume":"18","author":"Montaigne","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ecoenv.2025.119337_bib29","unstructured":"OECD. 2013. Test No. 236: Fish Embryo Acute Toxicity (FET) Test."},{"issue":"19","key":"10.1016\/j.ecoenv.2025.119337_bib30","doi-asserted-by":"crossref","first-page":"13774","DOI":"10.1021\/acs.est.2c04091","article-title":"Identification and quantification of micro-bioplastics in environmental samples by pyrolysis-gas chromatography-mass spectrometry","volume":"56","author":"Okoffo","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2025.119337_bib31","article-title":"Behavioral and biochemical consequences of Danio rerio larvae exposure to polylactic acid bioplastic","volume":"404","author":"de Oliveira","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119337_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fendo.2017.00319","article-title":"Lipid uptake, metabolism, and transport in the larval zebrafish","volume":"8","author":"Quinlivan","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2025.119337_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.809485","article-title":"Chronic lactate exposure decreases mitochondrial function by inhibition of fatty acid uptake and cardiolipin alterations in neonatal rat cardiomyocytes","volume":"9","author":"San-Millan","year":"2022","journal-title":"Front. Nutr."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.119337_bib34","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/liv.15716","article-title":"Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio)","volume":"43","author":"Shihana","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.ecoenv.2025.119337_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12870-017-1123-2","article-title":"A key enzyme of animal steroidogenesis can function in plants enhancing their immunity and accelerating the processes of growth and development","volume":"17","author":"Shpakovski","year":"2017","journal-title":"BMC Plant Biol."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119337_bib36","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI30335","article-title":"Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice","volume":"117","author":"Son","year":"2007","journal-title":"J. Clin. Invest"},{"issue":"9","key":"10.1016\/j.ecoenv.2025.119337_bib37","article-title":"Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl) methylene]-thiazolidine-2,4-dione derivatives","volume":"4","author":"Srikanth","year":"2018","journal-title":"Heliyon"},{"key":"10.1016\/j.ecoenv.2025.119337_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131124","article-title":"Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos","volume":"282","author":"Sun","year":"2021","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.119337_bib39","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/0734242X20982055","article-title":"Microplastic contamination in a conventional wastewater treatment plant in Thailand","volume":"39","author":"Tadsuwan","year":"2021","journal-title":"Waste Manag. Res."},{"key":"10.1016\/j.ecoenv.2025.119337_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. Rev. Biochem"},{"issue":"22","key":"10.1016\/j.ecoenv.2025.119337_bib41","doi-asserted-by":"crossref","first-page":"9515","DOI":"10.1021\/acs.est.3c10682","article-title":"Contribution of immune responses to the cardiotoxicity and hepatotoxicity of deltamethrin in early life stage zebrafish (Danio rerio)","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"18","key":"10.1016\/j.ecoenv.2025.119337_bib42","doi-asserted-by":"crossref","first-page":"13029","DOI":"10.1021\/acs.est.2c02221","article-title":"An in situ depolymerization and liquid chromatography-tandem mass spectrometry method for quantifying polylactic acid microplastics in environmental samples","volume":"56","author":"Wang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.ecoenv.2025.119337_bib43","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1021\/acs.est.9b07016","article-title":"Photodegradation elevated the toxicity of polystyrene microplastics to grouper (Epinephelus moara) through disrupting hepatic lipid homeostasis","volume":"54","author":"Wang","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2025.119337_bib44","article-title":"Environmental exposure to triazole fungicide causes left-right asymmetry defects and contributes to abnormal heart development in zebrafish embryos by activating PPAR\u03b3-coupled Wnt\/\u03b2-catenin signaling pathway","volume":"859","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119337_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.109981","article-title":"Early-life exposure to five biodegradable plastics impairs eye development and visually-mediated behavior through disturbing hypothalamus-pituitary-thyroid (HPT) axis in zebrafish larvae","volume":"284","author":"Wen","year":"2024","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharm."},{"issue":"13","key":"10.1016\/j.ecoenv.2025.119337_bib46","doi-asserted-by":"crossref","first-page":"E2563","DOI":"10.1073\/pnas.1621513114","article-title":"Structural basis for specific ligation of the peroxisome proliferator-activated receptor \u03b4","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ecoenv.2025.119337_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108679","article-title":"Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy","volume":"187","author":"Xin","year":"2024","journal-title":"Environ. Int."},{"issue":"24","key":"10.1016\/j.ecoenv.2025.119337_bib48","doi-asserted-by":"crossref","first-page":"13919","DOI":"10.1073\/pnas.241410198","article-title":"Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors","volume":"98","author":"Xu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.ecoenv.2025.119337_bib49","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2025.119337_bib50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/dbio.1999.9406","article-title":"Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish","volume":"214","author":"Yelon","year":"1999","journal-title":"Dev. Biol."},{"issue":"27","key":"10.1016\/j.ecoenv.2025.119337_bib51","doi-asserted-by":"crossref","first-page":"34524","DOI":"10.1021\/acsami.4c04416","article-title":"Polystyrene nanoplastics induce lipid metabolism disorder by activating the PERK-ATF4 signaling pathway in mice","volume":"16","author":"Yu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ecoenv.2025.119337_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108483","article-title":"Photoaging of biodegradable nanoplastics regulates their toxicity to aquatic insects (Chironomus kiinensis) by impairing gut and disrupting intestinal microbiota","volume":"185","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119337_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125321","article-title":"Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis","volume":"413","author":"Zhang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2025.119337_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-\u03baB-NLRP3-GSDMD and AMPK-PGC-1\u03b1 axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119337_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164073","article-title":"UV filter ethylhexyl salicylate affects cardiovascular development by disrupting lipid metabolism in zebrafish embryos","volume":"888","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119337_bib56","doi-asserted-by":"crossref","first-page":"123028","DOI":"10.1016\/j.watres.2024.123028","article-title":"Comparison of the combined toxicity of PFOA and emerging alternatives: A comprehensive evaluation of oxidative damage, apoptosis and immunotoxicity in embryonic and adult zebrafish","volume":"273","author":"Zhang","year":"2025","journal-title":"Water Res"},{"issue":"5","key":"10.1016\/j.ecoenv.2025.119337_bib57","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1021\/acsnano.4c15112","article-title":"Polylactic acid micro\/nanoplastic exposure induces male reproductive toxicity by disrupting spermatogenesis and mitochondrial dysfunction in mice","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ecoenv.2025.119337_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107662","article-title":"Micro- and nanoplastics: a new cardiovascular risk factor?","volume":"171","author":"Zhu","year":"2023","journal-title":"Environ. Int."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325016823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651325016823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:28:55Z","timestamp":1773844135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651325016823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":58,"alternative-id":["S0147651325016823"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119337","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPAR\u03b3 activation in zebrafish: A comparative study with polymers and oligomers","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119337"}}