{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:31:11Z","timestamp":1790706671455,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH051927"],"award-info":[{"award-number":["2023AH051927"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH040196"],"award-info":[{"award-number":["2024AH040196"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ecoenv.2025.119359","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:57:35Z","timestamp":1762642655000},"page":"119359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Metabolomics analysis reveals lipid metabolism disorders caused by triphenyltin via upregulation of PPAR\u03b3 pathway"],"prefix":"10.1016","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9043-6232","authenticated-orcid":false,"given":"Xuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-2322","authenticated-orcid":false,"given":"Xijuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6586-6870","authenticated-orcid":false,"given":"Penghui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-9162","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-0007","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2025.119359_bib1","doi-asserted-by":"crossref","first-page":"28890","DOI":"10.1007\/s11356-020-08821-1","article-title":"Protective potency of ascorbic acid supplementation against cytotoxicity and DNA fragmentation induced by triphenyltin on human liver carcinoma cells","volume":"27","author":"Alkahtane","year":"2020","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2025.119359_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells11243983","article-title":"Impact of Liver Inflammation on Bile Acid Side Chain Shortening and Amidation","volume":"11","author":"Alonso-Pe\u00f1a","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ecoenv.2025.119359_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s42003-023-05654-9","article-title":"Cholesterol modulates type I\/II TGF-\u03b2 receptor complexes and alters the balance between Smad and Akt signaling in hepatocytes","volume":"7","author":"Chaudhary","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib4","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.scitotenv.2018.09.310","article-title":"Organotin contamination in commercial and wild oysters from China: Increasing occurrence of triphenyltin","volume":"650","author":"Chen","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119359_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2022.113600","article-title":"Pulsed distribution of organotins in the turbidity maximum zone of the Yangtze Estuary throughout a tidal cycle","volume":"178","author":"Chen","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.119359_bib6","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbadis.2017.12.032","article-title":"A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase","volume":"1864","author":"Ferdinandusse","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ecoenv.2025.119359_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.chemosphere.2018.10.204","article-title":"Organotins in the aquatic media of secondary anabranches in the Three Gorges Reservoir Region, China","volume":"217","author":"Gao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119359_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.chemosphere.2018.08.016","article-title":"In utero exposure to triphenyltin disrupts rat fetal testis development","volume":"211","author":"Ge","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119359_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2006.01.008","article-title":"Effects of peripubertal exposure to triphenyltin on female sexual development of the rat","volume":"222","author":"Grote","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119359_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tox.2007.05.033","article-title":"Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspring","volume":"238","author":"Grote","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119359_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tox.2009.03.006","article-title":"Sex differences in effects on sexual development in rat offspring after pre- and postnatal exposure to triphenyltin chloride","volume":"260","author":"Grote","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2025.119359_bib12","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1038\/srep08520","article-title":"Structural basis for PPARgamma transactivation by endocrine-disrupting organotin compounds","volume":"5","author":"Harada","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2025.119359_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117751","article-title":"Triphenyltin exposure causes changes in health-associated gut microbiome and metabolites in marine medaka","volume":"288","author":"He","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119359_bib14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1039\/c5mt00086f","article-title":"Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation","volume":"7","author":"Hiromori","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2025.119359_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jsbmb.2014.10.010","article-title":"Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells","volume":"155","author":"Hiromori","year":"2016","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2020.108948","article-title":"Influence of triphenyltin on morphologic abnormalities and the thyroid hormone system in early-stage zebrafish (Danio rerio)","volume":"242","author":"Horie","year":"2021","journal-title":"Comp. Biochem Physiol. C. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119359_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116112","article-title":"Mitochondria-targeted iridium(III) complexes encapsulated in liposome induce cell death through ferroptosis and gasdermin-mediated pyroptosis","volume":"265","author":"Huang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ecoenv.2025.119359_bib18","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.marpolbul.2011.06.023","article-title":"Baseline of organotin pollution in fishes, clams, shrimps, squids and crabs collected from the west coast of India","volume":"62","author":"Jadhav","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2025.119359_bib19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1124\/mol.104.008409","article-title":"Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma\/retinoid X receptor pathway","volume":"67","author":"Kanayama","year":"2005","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119359_bib20","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.chemosphere.2016.08.141","article-title":"Health risk assessment of the intake of butyltin and phenyltin compounds from fish and seafood in Taiwanese population","volume":"164","author":"Lee","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119359_bib21","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s10695-020-00861-1","article-title":"Toxicity evaluation of triphenyltin in zebrafish larvae by embryonic malformation, retinal development, and GH\/IGF axis","volume":"46","author":"Li","year":"2020","journal-title":"Fish. Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2025.119359_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109776","article-title":"Effects of low concentrations of triphenyltin on neurobehavior and the thyroid endocrine system in zebrafish","volume":"186","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119359_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123079","article-title":"Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin","volume":"342","author":"Liu","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2025.119359_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108274","article-title":"Novel insights into perfluorinated compound-induced hepatotoxicity: Chronic dietary restriction exacerbates the effects of PFBS on hepatic lipid metabolism in mice","volume":"181","author":"Liu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2025.119359_bib25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0960-0760(03)00074-8","article-title":"Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism","volume":"84","author":"Lo","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.aquatox.2017.05.001","article-title":"Tributyltin and triphenyltin exposure promotes in vitro adipogenic differentiation but alters the adipocyte phenotype in rainbow trout","volume":"188","author":"Lutfi","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112039","article-title":"Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions","volume":"149","author":"Lv","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9185","article-title":"Effects of triphenyltin on cytosolic Na(+) and Ca(2+) response to glucose and acetylcholine in pancreatic beta-cells from hamster","volume":"174","author":"Miura","year":"2001","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119359_bib29","doi-asserted-by":"crossref","first-page":"R455","DOI":"10.1530\/ERC-16-0285","article-title":"Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases","volume":"23","author":"Moon","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ecoenv.2025.119359_bib30","first-page":"543","article-title":"The immunotoxicity of triphenyltin chloride in mice","volume":"13","author":"Nishida","year":"1990","journal-title":"J. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119359_bib31","doi-asserted-by":"crossref","DOI":"10.1039\/D3FO04269C","article-title":"Black soybean seed coat polyphenols have different effects on glucose and lipid metabolism in growing and young adult mice","author":"Nishijima","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2025.119359_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/biof.2028","article-title":"High-fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB\/N mice","author":"Ofosu-Boateng","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.ecoenv.2025.119359_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1055\/s-0029-1211476","article-title":"Triphenyltin chloride induces glucose intolerance by the suppression of insulin release from hamster pancreatic beta-cells","volume":"104","author":"Ogino","year":"1996","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.ecoenv.2025.119359_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0378-4274(95)03630-X","article-title":"Comparative study of the metabolism of triphenyltin in hamsters and rats after a single oral treatment with triphenyltin chloride","volume":"85","author":"Ohhira","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119359_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-4274(00)00255-1","article-title":"Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice","volume":"117","author":"Ohhira","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119359_bib36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.steroids.2005.03.005","article-title":"Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis","volume":"70","author":"Ohno","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.ecoenv.2025.119359_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.aquatox.2010.04.014","article-title":"Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator","volume":"99","author":"Pavlikova","year":"2010","journal-title":"Aquatic Toxicology (Amsterdam Netherlands)"},{"key":"10.1016\/j.ecoenv.2025.119359_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116209","article-title":"The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation","volume":"453","author":"Pu","year":"2022","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2025.119359_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.scitotenv.2008.03.017","article-title":"Blood levels of organotin compounds and their relation to fish consumption in Finland","volume":"399","author":"Rantakokko","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2025.119359_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1476-069X-13-45","article-title":"Association of placenta organotin concentrations with growth and ponderal index in 110 newborn boys from Finland during the first 18 months of life: a cohort study","volume":"13","author":"Rantakokko","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2025.119359_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2023.05.001","article-title":"Triphenyltin (TPT) exposure causes SD rat liver injury via lipid metabolism disorder and ER stress revealed by transcriptome analysis","volume":"381","author":"Ren","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2025.119359_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105739","article-title":"TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders","volume":"198","author":"Ren","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0045-6535(97)10011-X","article-title":"Distribution pattern of organotin compounds at different trophic levels of aquatic ecosystems","volume":"36","author":"Shawky","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119359_bib44","article-title":"Perylene-Mediated Cytoskeletal Dysfunction Remodels Cancer-Associated Fibroblasts to Augment Antitumor Immunotherapy","author":"Shi","year":"2024","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.ecoenv.2025.119359_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105484","article-title":"Aqua-(2-formylbenzoato)triphenyltin(IV) induces cell cycle arrest and apoptosis in hypoxic triple negative breast cancer cells","volume":"86","author":"Singh","year":"2023","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2025.119359_bib46","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00204-023-03512-5","article-title":"Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes","volume":"97","author":"Ticiani","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2025.119359_bib47","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/antiox13101173","article-title":"Protective Role of Sulforaphane against Physiological Toxicity of Triphenyltin in Common Carp (Cyprinus carpio haematopterus)","volume":"13","author":"Wang","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2025.119359_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125149","article-title":"Long-term triphenyltin exposure disrupts adrenal function in adult male rats","volume":"243","author":"Wu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2025.119359_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ecoenv.2018.03.028","article-title":"Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway","volume":"156","author":"Yan","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119359_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cbi.2004.01.006","article-title":"Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes","volume":"147","author":"You","year":"2004","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2025.119359_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116882","article-title":"Sulforaphane modulates some stress parameters in TPT-exposed Cyprinus carpio in relation to liver metabolome","volume":"284","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2025.119359_bib52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41419-022-04725-9","article-title":"Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2025.119359_bib53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aquatox.2012.05.015","article-title":"Exposure to tributyltin and triphenyltin induces DNA damage and alters nucleotide excision repair gene transcription in Sebastiscus marmoratus liver","volume":"122\u2013123","author":"Zuo","year":"2012","journal-title":"Aquat. Toxicol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132501704X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132501704X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:55:55Z","timestamp":1773838555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132501704X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":53,"alternative-id":["S014765132501704X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119359","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics analysis reveals lipid metabolism disorders caused by triphenyltin via upregulation of PPAR\u03b3 pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119359"}}